{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:49:30Z","timestamp":1791600570144,"version":"4.3.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202601CK070007"],"award-info":[{"award-number":["202601CK070007"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32671133"],"award-info":[{"award-number":["32671133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Regen"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mechanical forces are recognized as regulators of organ development, homeostasis, and regeneration, yet how physical cues are sensed in a region-specific manner within the liver remains unclear. In a\n                    <jats:italic>Science<\/jats:italic>\n                    article, Zhang and colleagues identify DPP4-positive zone 2 hepatocytes as a mechanosensory population, demonstrating that mechanical stress triggers the regenerative response through PIEZO1-mediated mechanotransduction. PIEZO1 activation in these cells induces NFATC3-dependent IGFBP2 expression, establishing a molecular link between tissue mechanics and spatially coordinated proliferation. This work provides a mechanistic explanation for why regeneration originates from the mid-lobule and introduces a druggable mechanotransduction axis that might be enhanced to accelerate liver repair.\n                  <\/jats:p>","DOI":"10.1186\/s13619-026-00305-w","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:01:45Z","timestamp":1791597705000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver regeneration governed by zonated PIEZO1 mechanotransduction"],"prefix":"10.1186","volume":"15","author":[{"given":"Lin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1028-8151","authenticated-orcid":false,"given":"Wenxiu","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"305_CR1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41392-023-01501-9.","volume":"8","author":"X Di","year":"2023","unstructured":"Di X, Gao X, Peng L, Ai J, Jin X, Qi S, Li H, Wang K, Luo D. Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets. Signal Transduct Target Ther. 2023;8:282. https:\/\/doi.org\/10.1038\/s41392-023-01501-9.","journal-title":"Signal Transduct Target Ther"},{"key":"305_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115400","volume":"44","author":"F Fang","year":"2025","unstructured":"Fang F, Li G, Li X, Wu J, Liu Y, Xin H, Wang Z, Fang J, Jiang Y, Qian W, Hou X, Song J. Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-\u03b2-catenin and programming fatty acid metabolism. Cell Rep. 2025;44: 115400. https:\/\/doi.org\/10.1016\/j.celrep.2025.115400.","journal-title":"Cell Rep"},{"key":"305_CR3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1126\/science.1244880","volume":"343","author":"J Hu","year":"2014","unstructured":"Hu J, Srivastava K, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG. Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science. 2014;343:416\u20139. https:\/\/doi.org\/10.1126\/science.1244880.","journal-title":"Science"},{"key":"305_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-01936-2","author":"J Ishikawa","year":"2021","unstructured":"Ishikawa J, Takeo M, Iwadate A, Koya J, Kihira M, Oshima M, et al. Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration. Commun Biol. 2021. https:\/\/doi.org\/10.1038\/s42003-021-01936-2.","journal-title":"Commun Biol"},{"key":"305_CR5","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41586-018-0522-3","volume":"562","author":"L Lorenz","year":"2018","unstructured":"Lorenz L, Axnick J, Buschmann T, Henning C, Urner S, Fang S, Nurmi H, Eichhorst N, Holtmeier R, B\u00f3dis K, Hwang J-H, M\u00fcssig K, Eberhard D, Stypmann J, Kuss O, Roden M, Alitalo K, H\u00e4ussinger D, Lammert E. Mechanosensing by \u03b21 integrin induces angiocrine signals for liver growth and survival. Nature. 2018;562:128\u201332. https:\/\/doi.org\/10.1038\/s41586-018-0522-3.","journal-title":"Nature"},{"key":"305_CR6","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.surg.2004.03.012","volume":"136","author":"S Marubashi","year":"2004","unstructured":"Marubashi S, Sakon M, Nagano H, Gotoh K, Hashimoto K, Kubota M, Kobayashi S, Yamamoto S, Miyamoto A, Dono K, Nakamori S, Umeshita K, Monden M. Effect of portal hemodynamics on liver regeneration studied in a novel portohepatic shunt rat model. Surgery. 2004;136:1028\u201337. https:\/\/doi.org\/10.1016\/j.surg.2004.03.012.","journal-title":"Surgery"},{"key":"305_CR7","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.stem.2020.11.002","volume":"28","author":"W Ning","year":"2021","unstructured":"Ning W, Muroyama A, Li H, Lechler T. Differentiated daughter cells regulate stem cell proliferation and fate through intra-tissue tension. Cell Stem Cell. 2021;28:436-452.e435. https:\/\/doi.org\/10.1016\/j.stem.2020.11.002.","journal-title":"Cell Stem Cell"},{"key":"305_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4862","author":"T Speicher","year":"2014","unstructured":"Speicher T, Siegenthaler B, Bogorad RL, Ruppert R, Petzold T, Padrissa-Altes S, et al. Knockdown and knockout of \u03b21-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling. Nat Commun. 2014. https:\/\/doi.org\/10.1038\/ncomms4862.","journal-title":"Nat Commun"},{"key":"305_CR9","doi-asserted-by":"publisher","first-page":"eadt2771","DOI":"10.1126\/sciadv.adt2771","volume":"11","author":"J Wang","year":"2025","unstructured":"Wang J, Fu C, Chang S, Stephens C, Li H, Wang D, Fu YC, Green KJ, Yan J, Yi R. PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence. Sci Adv. 2025;11:eadt2771. https:\/\/doi.org\/10.1126\/sciadv.adt2771.","journal-title":"Sci Adv"},{"key":"305_CR10","doi-asserted-by":"publisher","first-page":"eaef0825","DOI":"10.1126\/science.aef0825","volume":"393","author":"Y Zhang","year":"2026","unstructured":"Zhang Y, Sun Y, Xu G, Wu Y, Shi Z, Chang Z, Liu J, Pang K, Liu S, Wang H, Rong W, Shao Z, Liu X, He Y, Yan Y, Zhou B, Yuan Z, Zhang XF, Offermanns S, Wang S. Zonated mechanosensing by PIEZO1 controls liver regeneration. Science. 2026;393:eaef0825. https:\/\/doi.org\/10.1126\/science.aef0825.","journal-title":"Science"}],"container-title":["Cell Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13619-026-00305-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13619-026-00305-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13619-026-00305-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:01:47Z","timestamp":1791597707000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13619-026-00305-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["305"],"URL":"https:\/\/doi.org\/10.1186\/s13619-026-00305-w","relation":{},"ISSN":["2045-9769"],"issn-type":[{"value":"2045-9769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]},"assertion":[{"value":"10 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Wenxiu Ning is a member of the Early-Career Board for Cell Regeneration and was not involved in the journal\u2019s review of or decisions related to this manuscript.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"30"}}