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Dr. Mahajan reports that the University of Adelaide receives on his behalf lecture and\/or consulting fees from Abbott and Medtronic.Prof. Seshadri reports that the Framingham Heart Study is supported by the following grants and contracts: NHLBI\u2019s Framingham Heart Study (N01-HC-25195; HHSN268201500001I), NIA grants (R01 033193, U01 AG049505, R01 AG049607, R01 AG054076, U01 AG052409), and NINDS (R01NS017950, UH2 NS100605).The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"163"}}