{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:09:26Z","timestamp":1773389366372,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Syst Rev"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Liver resection (LR) in patients with liver metastasis from colorectal cancer remains the only curative treatment. Perioperative chemotherapy improves prognosis of these patients. However, there are concerns regarding the effect of preoperative chemotherapy on liver regeneration, which is a key event in avoiding liver failure after LR. The primary objective of this systematic review is to assess the effect of neoadjuvant chemotherapy on liver regeneration after (LR) or portal vein embolization (PVE) in patients with liver metastasis from colorectal cancer. The secondary objectives are to evaluate the impact of the type of chemotherapy, number of cycles, and time between end of treatment and procedure (LR or PVE) and to investigate whether there is an association between degree of hypertrophy and postoperative liver failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This meta-analysis will include studies reporting liver regeneration rates in patients submitted to LR or PVE. Pubmed, Scopus, Web of Science, Embase, and Cochrane databases will be searched. Only studies comparing neoadjuvant vs no chemotherapy, or comparing chemotherapy characteristics (bevacizumab administration, number of cycles, and time from finishing chemotherapy until intervention), will be included. We will select studies from 1990 to present. Two researchers will individually screen the identified records, according to a list of inclusion and exclusion criteria. Primary outcome will be future liver remnant regeneration rate. Bias of the studies will be evaluated with the ROBINS-I tool, and quality of evidence for all outcomes will be determined with the GRADE system. The data will be registered in a predesigned database. If selected studies are sufficiently homogeneous, we will perform a meta-analysis of reported results. In the event of a substantial heterogeneity, a qualitative systematic review will be performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results of this systematic review may help to better identify the patients affected by liver metastasis that could present low regeneration rates after neoadjuvant chemotherapy. These patients are at risk to develop liver failure after extended hepatectomies and therefore are not good candidates for such aggressive procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      PROSPERO registration number:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?RecordID=178481\">CRD42020178481<\/jats:ext-link>\n                      (July 5, 2020).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13643-020-01545-w","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T14:08:19Z","timestamp":1607090899000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effect of preoperative chemotherapy on liver regeneration after portal vein embolization\/ligation or liver resection in patients with colorectal liver metastasis: a systematic review protocol"],"prefix":"10.1186","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2370-6842","authenticated-orcid":false,"given":"Mihai-Calin","family":"Pavel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Estalella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Memba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Ll\u00e0cer-Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Achalandabaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Juli\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Geoghegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Jorba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"issue":"1","key":"1545_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7\u201334.","journal-title":"CA Cancer J Clin."},{"issue":"14","key":"1545_CR2","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/j.ejca.2006.04.012","volume":"42","author":"E Van Cutsem","year":"2006","unstructured":"Van Cutsem E, Nordlinger B, Adam R, K\u00f6hne CH, Pozzo C, Poston G, et al. Towards a pan-European consensus on the treatment of patients with colorectal liver metastases. Eur J Cancer. 2006;42(14):2212\u201321.","journal-title":"Eur J Cancer."},{"issue":"6","key":"1545_CR3","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1023\/A:1008353227103","volume":"10","author":"MM Borner","year":"1999","unstructured":"Borner MM. Neoadjuvant chemotherapy for unresectable liver metastases of colorectal cancer - too good to be true? Editorial. Ann Oncol. 1999;10(6):623\u20136.","journal-title":"Editorial. Ann Oncol."},{"key":"1545_CR4","unstructured":"Recently updated NCCN Clinical Practice Guidelines in OncologyTM [Internet]. Available from: https:\/\/www.nccn.org\/professionals\/physician_gls\/recently_updated.aspx. [cited 2020 Mar 19]."},{"issue":"8","key":"1545_CR5","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","volume":"27","author":"E Van Cutsem","year":"2016","unstructured":"Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol. 2016;27(8):1386\u2013422 Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27380959. [cited 2018 Dec 5].","journal-title":"Ann Oncol"},{"issue":"1","key":"1545_CR6","first-page":"283","volume":"4","author":"GP Kanas","year":"2012","unstructured":"Kanas GP, Taylor A, Primrose JN, Langeberg WJ, Kelsh MA, Mowat FS, et al. Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors. Clin Epidemiol. 2012;4(1):283\u2013301.","journal-title":"Clin Epidemiol."},{"issue":"29","key":"1545_CR7","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1200\/JCO.2007.11.0833","volume":"25","author":"JS Tomlinson","year":"2007","unstructured":"Tomlinson JS, Jarnagin WR, DeMatteo RP, Fong Y, Kornprat P, Gonen M, et al. Actual 10-year survival after resection of colorectal liver metastases defines cure. J Clin Oncol. 2007;25(29):4575\u201380.","journal-title":"J Clin Oncol."},{"issue":"2","key":"1545_CR8","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1245\/s10434-006-9146-1","volume":"14","author":"A Muratore","year":"2007","unstructured":"Muratore A, Zorzi D, Bouzari H, Amisano M, Massucco P, Sperti E, et al. Asymptomatic colorectal cancer with un-resectable liver metastases: immediate colorectal resection or up-front systemic chemotherapy? Ann Surg Oncol. 2007;14(2):766\u201370.","journal-title":"Ann Surg Oncol."},{"issue":"36","key":"1545_CR9","doi-asserted-by":"publisher","first-page":"9243","DOI":"10.1200\/JCO.2005.07.740","volume":"23","author":"SR Alberts","year":"2005","unstructured":"Alberts SR, Horvath WL, Sternfeld WC, Goldberg RM, Mahoney MR, Dakhil SR, et al. Oxaliplatin, fluorouracil, and leucovorin for patients with unresectable liver-only metastases from colorectal cancer: a North Central Cancer Treatment Group phase II study. J Clin Oncol. 2005;23(36):9243\u20139.","journal-title":"J Clin Oncol."},{"issue":"6","key":"1545_CR10","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1093\/annonc\/mdh217","volume":"15","author":"C Pozzo","year":"2004","unstructured":"Pozzo C, Basso M, Cassano A, Quirino M, Schinzari G, Trigila N, et al. Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients. Ann Oncol. 2004 Jun;15(6):933\u20139.","journal-title":"Ann Oncol."},{"issue":"4","key":"1545_CR11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.sla.0000141198.92114.f6","volume":"240","author":"R Adam","year":"2004","unstructured":"Adam R, Delvart V, Pascal G, Valeanu A, Castaing D, Azoulay D, et al. Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Ann Surg. 2004;240(4):644\u201358.","journal-title":"Ann Surg."},{"issue":"1","key":"1545_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S1470-2045(09)70330-4","volume":"11","author":"G Folprecht","year":"2010","unstructured":"Folprecht G, Gruenberger T, Bechstein WO, Raab HR, Lordick F, Hartmann JT, et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol. 2010;11(1):38\u201347.","journal-title":"Lancet Oncol."},{"issue":"16","key":"1545_CR13","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1200\/JCO.2012.44.8308","volume":"31","author":"LC Ye","year":"2013","unstructured":"Ye LC, Liu TS, Ren L, Wei Y, Zhu DX, Zai SY, et al. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol. 2013;31(16):1931\u20138.","journal-title":"J Clin Oncol."},{"issue":"35","key":"1545_CR14","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.1200\/JCO.19.01340","volume":"37","author":"DP Modest","year":"2019","unstructured":"Modest DP, Martens UM, Riera-Knorrenschild J, Greeve J, Florsch\u00fctz A, Wessendorf S, et al. FOLFOXIRI plus panitumumab as first-line treatment of RAS wild-type metastatic colorectal cancer: the randomized, open-label, phase II Volfi study (AIO KRK0109). J Clin Oncol. 2019;37(35):3401\u201311.","journal-title":"J Clin Oncol."},{"issue":"2","key":"1545_CR15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.4254\/wjh.v11.i2.150","volume":"11","author":"FCL Chow","year":"2019","unstructured":"Chow FCL, Chok KSH. Colorectal liver metastases: an update on multidisciplinary approach. World J Hepatol. 2019;11(2):150\u201372.","journal-title":"World J Hepatol."},{"issue":"6","key":"1545_CR16","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1097\/01.sla.0000189131.90876.9e","volume":"242","author":"S Balzan","year":"2005","unstructured":"Balzan S, Belghiti J, Farges O, Ogata S, Sauvanet A, Delefosse D, et al. The 50-50 criteria on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg. 2005;242(6):824\u20138 discussion 828-9. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16327492. [cited 2017 Mar 10].","journal-title":"Ann Surg"},{"issue":"3","key":"1545_CR17","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/SLA.0000000000002627","volume":"269","author":"JJ Idrees","year":"2019","unstructured":"Idrees JJ, Johnston FM, Canner JK, Dillhoff M, Schmidt C, Haut ER, et al. Cost of major complications after liver resection in the United States: are high-volume centers cost-effective? Ann Surg. 2019;269(3):503\u201310.","journal-title":"Ann Surg."},{"issue":"10","key":"1545_CR18","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1007\/s11605-018-3826-6","volume":"22","author":"JJ Idrees","year":"2018","unstructured":"Idrees JJ, Kimbrough CW, Rosinski BF, Schmidt C, Dillhoff ME, Beal EW, et al. The cost of failure: assessing the cost-effectiveness of rescuing patients from major complications after liver resection using the National Inpatient Sample. J Gastrointest Surg. 2018;22(10):1688\u201396.","journal-title":"J Gastrointest Surg."},{"issue":"15","key":"1545_CR19","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1056\/NEJMra065156","volume":"356","author":"P-A Clavien","year":"2007","unstructured":"Clavien P-A, Petrowsky H, DeOliveira ML, Graf R. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med. 2007;356(15):1545\u201359 Available from: http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMra065156. [cited 2018 Dec 11].","journal-title":"N Engl J Med"},{"issue":"11","key":"1545_CR20","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s11605-015-2872-6","volume":"19","author":"K Lafaro","year":"2015","unstructured":"Lafaro K, Buettner S, Maqsood H, Wagner D, Bagante F, Spolverato G, et al. Defining post hepatectomy liver insufficiency: where do we stand? J Gastrointest Surg. 2015;19(11):2079\u201392.","journal-title":"J Gastrointest Surg."},{"key":"1545_CR21","doi-asserted-by":"publisher","unstructured":"Zorzi D, Laurent A, Pawlik TM, Lauwers GY, Vauthey J-N, Abdalla EK. Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg. 2007 ;94(3):274\u2013286. Available from: https:\/\/doi.org\/10.1002\/bjs.5719. [cited 2018 Dec 11].","DOI":"10.1002\/bjs.5719"},{"issue":"2","key":"1545_CR22","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.suronc.2014.02.002","volume":"23","author":"RP Jones","year":"2014","unstructured":"Jones RP, St\u00e4ttner S, Sutton P, Dunne DF, McWhirter D, Fenwick SW, et al. Controversies in the oncosurgical management of liver limited stage IV colorectal cancer. Surg Oncol. 2014;23(2):53\u201360.","journal-title":"Surg Oncol."},{"issue":"3","key":"1545_CR23","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1007\/s00268-017-4181-6","volume":"42","author":"D Moris","year":"2018","unstructured":"Moris D, Ronnekleiv-Kelly S, Kostakis ID, Tsilimigras DI, Beal EW, Papalampros A, et al. Operative results and oncologic outcomes of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) versus two-stage hepatectomy (TSH) in patients with unresectable colorectal liver metastases: a systematic review and meta-anal. World J Surg. 2018;42(3):806\u201315.","journal-title":"World J Surg."},{"issue":"6","key":"1545_CR24","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jamcollsurg.2005.01.024","volume":"200","author":"FG Fernandez","year":"2005","unstructured":"Fernandez FG, Ritter J, Goodwin JW, Linehan DC, Hawkins WG, Strasberg SM. Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases. J Am Coll Surg. 2005;200(6):845\u201353.","journal-title":"J Am Coll Surg."},{"issue":"13","key":"1545_CR25","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1200\/JCO.2005.05.3074","volume":"24","author":"JN Vauthey","year":"2006","unstructured":"Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, et al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol. 2006;24(13):2065\u201372.","journal-title":"J Clin Oncol."},{"issue":"4","key":"1545_CR26","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.trsl.2014.01.005","volume":"163","author":"SA Mao","year":"2014","unstructured":"Mao SA, Glorioso JM, Nyberg SL. Liver regeneration. Transl Res. 2014;163(4):352\u201362.","journal-title":"Transl Res."},{"issue":"1","key":"1545_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/lt.23966","volume":"21","author":"KM Olthoff","year":"2015","unstructured":"Olthoff KM, Emond JC, Shearon TH, Everson G, Baker TB, Fisher RA, et al. Liver regeneration after living donor transplantation: adult-to-adult living donor liver transplantation cohort study. Liver Transplant. 2015;21(1):79\u201388.","journal-title":"Liver Transplant."},{"issue":"8","key":"1545_CR28","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","volume":"13","author":"SJ Forbes","year":"2016","unstructured":"Forbes SJ, Newsome PN. Liver regeneration-mechanisms and models to clinical application. Nat Rev Gastroenterol Hepatol. 2016;13(8):473\u201385.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"issue":"1","key":"1545_CR29","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/01.sla.0000225253.84501.0e","volume":"245","author":"R Vetel\u00e4inen","year":"2007","unstructured":"Vetel\u00e4inen R, Van Vliet AK, Van Gulik TM. Severe steatosis increases hepatocellular injury and impairs liver regeneration in a rat model of partial hepatectomy. Ann Surg. 2007;245(1):44\u201350.","journal-title":"Ann Surg."},{"issue":"5","key":"1545_CR30","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1097\/SLA.0b013e3182a61a22","volume":"258","author":"S Truant","year":"2013","unstructured":"Truant S, Bouras AF, Petrovai G, Buob D, Ernst O, Boleslawski E, et al. Volumetric gain of the liver after major hepatectomy in obese patients: a case-matched study in 84 patients. Ann Surg. 2013;258(5):696\u2013704.","journal-title":"Ann Surg."},{"issue":"4","key":"1545_CR31","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/jso.24139","volume":"113","author":"E Simoneau","year":"2016","unstructured":"Simoneau E, Alanazi R, Alshenaifi J, Molla N, Aljiffry M, Medkhali A, et al. Neoadjuvant chemotherapy does not impair liver regeneration following hepatectomy or portal vein embolization for colorectal cancer liver metastases. J Surg Oncol. 2016;113(4):449\u201355 Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26955907. [cited 2020 Apr 17].","journal-title":"J Surg Oncol"},{"issue":"1","key":"1545_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00595-010-4414-x","volume":"41","author":"M Narita","year":"2011","unstructured":"Narita M, Oussoultzoglou E, Chenard MP, Rosso E, Casnedi S, Pessaux P, et al. Sinusoidal obstruction syndrome compromises liver regeneration in patients undergoing two-stage hepatectomy with portal vein embolization. Surg Today. 2011;41(1):7\u201317.","journal-title":"Surg Today."},{"issue":"10","key":"1545_CR33","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1007\/s00268-018-4590-1","volume":"42","author":"Y Inoue","year":"2018","unstructured":"Inoue Y, Fujii K, Tashiro K, Ishii M, Masubuchi S, Yamamoto M, et al. Preoperative chemotherapy may not influence the remnant liver regenerations and outcomes after hepatectomy for colorectal liver metastasis. World J Surg. 2018;42(10):3316\u201330.","journal-title":"World J Surg."},{"issue":"2","key":"1545_CR34","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00268-013-2278-0","volume":"38","author":"SAWG Dello","year":"2014","unstructured":"Dello SAWG, Kele PGS, Porte RJ, Van Dam RM, Klaase JM, Verhoef C, et al. Influence of preoperative chemotherapy on CT volumetric liver regeneration following right hemihepatectomy. World J Surg. 2014;38(2):497\u2013504.","journal-title":"World J Surg."},{"issue":"10","key":"1545_CR35","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1245\/s10434-008-0035-7","volume":"15","author":"D Zorzi","year":"2008","unstructured":"Zorzi D, Chun YS, Madoff DC, Abdalla EK, Vauthey JN. Chemotherapy with bevacizumab does not affect liver regeneration after portal vein embolization in the treatment of colorectal liver metastases. Ann Surg Oncol. 2008;15(10):2765\u201372.","journal-title":"Ann Surg Oncol."},{"key":"1545_CR36","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1200\/JCO.2005.06.081","volume":"23","author":"DJ Hicklin","year":"2005","unstructured":"Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23:1011\u201327.","journal-title":"J Clin Oncol"},{"issue":"4","key":"1545_CR37","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1093\/annonc\/mdu580","volume":"26","author":"T Gruenberger","year":"2015","unstructured":"Gruenberger T, Bridgewater J, Chau I, Garcia Alfonso P, Rivoire M, Mudan S, et al. Bevacizumab plus mFOLFOX-6 or FOLFOXIRI in patients with initially unresectable liver metastases from colorectal cancer: the OLIVIA Multinational Randomised Phase II Trial - PubMed. Ann Oncol Off J Eur Soc Med Oncol. 2015;26(4):702\u20138 Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/25538173\/?from_term=Ann+Oncol+2014%3B+26%3A+702\u2013708&from_filter=pubt.review. [cited 2020 Apr 14].","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"issue":"1","key":"1545_CR38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/002215540104900112","volume":"49","author":"E Taniguchi","year":"2001","unstructured":"Taniguchi E, Sakisaka S, Matsuo K, Tanikawa K, Sata M. Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats. J Histochem Cytochem. 2001;49(1):121\u20139.","journal-title":"J Histochem Cytochem."},{"key":"1545_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","volume":"4","author":"D Moher","year":"2015","unstructured":"Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1 Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4320440\/. [cited 2020 Apr 7].","journal-title":"Syst Rev"},{"key":"1545_CR40","unstructured":"Definition of neoadjuvant therapy - NCI Dictionary of Cancer Terms - National Cancer Institute. Available from: https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/neoadjuvant-therapy. [cited 2020 Apr 27]."},{"issue":"5","key":"1545_CR41","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.jamcollsurg.2006.12.032","volume":"204","author":"JT Mullen","year":"2007","unstructured":"Mullen JT, Ribero D, Reddy SK, Donadon M, Zorzi D, Gautam S, et al. Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy. J Am Coll Surg. 2007;204(5):854\u201362 discussion 862-4. Available from: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1072751506018369. [cited 2018 Oct 19].","journal-title":"J Am Coll Surg"},{"issue":"5","key":"1545_CR42","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","volume":"149","author":"NN Rahbari","year":"2011","unstructured":"Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R, et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011;149(5):713\u201324 Available from: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606010005659. [cited 2019 Feb 22].","journal-title":"Surgery"},{"key":"1545_CR43","doi-asserted-by":"crossref","unstructured":"Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, et al. Cochrane Handbook for Systematic Reviews of Interventions. 6.1(update. Cochrane 2020; 2020. Available from: www.training.cochrane.org\/handbook. [cited 2020 Apr 8].","DOI":"10.1002\/9781119536604"},{"key":"1545_CR44","doi-asserted-by":"publisher","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, Savovi\u0107 J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919. https:\/\/doi.org\/10.1136\/bmj.i4919.","DOI":"10.1136\/bmj.i4919"},{"key":"1545_CR45","doi-asserted-by":"publisher","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898.","DOI":"10.1136\/bmj.l4898"},{"issue":"7650","key":"1545_CR46","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924\u20136.","journal-title":"BMJ."},{"key":"1545_CR47","unstructured":"Deeks JJ, Higgins JPT, Altman DG, on behalf of the Cochrane Statistical Methods Group. Cochrane Handbook for Systematic Reviews of Interventions. Chapter 10: analysing data and undertaking meta-analyses | Cochrane Training. Available from: https:\/\/training.cochrane.org\/handbook\/current\/chapter-10. [cited 2020 Nov 7]."},{"issue":"15","key":"1545_CR48","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015229","volume":"98","author":"Y Liu","year":"2019","unstructured":"Liu Y, Yang Y, Gu S, Tang K. A systematic review and meta-analysis of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) versus traditional staged hepatectomy. Medicine (Baltimore). 2019;98(15):e15229.","journal-title":"Medicine (Baltimore)."},{"issue":"12","key":"1545_CR49","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","volume":"14","author":"B Nordlinger","year":"2013","unstructured":"Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14(12):1208\u201315.","journal-title":"Lancet Oncol."},{"issue":"6","key":"1545_CR50","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S1470-2045(14)70105-6","volume":"15","author":"J Primrose","year":"2014","unstructured":"Primrose J, Falk S, Finch-Jones M, Valle J, O\u2019Reilly D, Siriwardena A, et al. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial. Lancet Oncol. 2014;15(6):601\u201311.","journal-title":"Lancet Oncol."}],"container-title":["Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13643-020-01545-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13643-020-01545-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13643-020-01545-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T12:21:15Z","timestamp":1618575675000},"score":1,"resource":{"primary":{"URL":"https:\/\/systematicreviewsjournal.biomedcentral.com\/articles\/10.1186\/s13643-020-01545-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1545"],"URL":"https:\/\/doi.org\/10.1186\/s13643-020-01545-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-50168\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-50168\/v3","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-50168\/v4","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-50168\/v1","asserted-by":"object"}]},"ISSN":["2046-4053"],"issn-type":[{"value":"2046-4053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"27 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"279"}}