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Endectocides and especially ivermectin will be available as a vector control tool soon. The current review could be valuable for trial design and clinical studies to control malaria transmission.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>PubMed\/MEDLINE, Scopus, Web of Science, and Science Direct were searched for original English published papers on (\u201cMalaria chemical control\u201d OR \u201cMalaria elimination\u201d OR \u201c<jats:italic>Anopheles<\/jats:italic> vector control\u201d OR \u201cMalaria zooprophylaxis\u201d) AND (\u201cSystemic insecticides\u201d OR \u201cEndectocides\u201d OR \u201cIvermectin\u201d). The last search was from 19 June 2019 to 31 December 2019. It was updated on 17 November 2020. Two reviewers (SG and FGK) independently reviewed abstracts and full-text articles. Data were extracted by one person and checked by another. As meta-analyses were not possible, a qualitative summary of results was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirty-six published papers have used systemic insecticides\/endectocides for mosquito control. Most of the studies (56.75%) were done on <jats:italic>Anopheles gambiae<\/jats:italic> complex species on doses from 150\u2009\u03bcg\/kg to 400\u2009\u03bcg\/kg in several studies. Target hosts for employing systemic insecticides\/drugs were animals (44.2%, including rabbit, cattle, pig, and livestock) and humans (32.35%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Laboratory and field studies have highlighted the potential of endectocides in malaria control. Ivermectin and other endectocides could soon serve as novel malaria transmission control tools by reducing the longevity of <jats:italic>Anopheles<\/jats:italic> mosquitoes that feed on treated hosts, potentially decreasing <jats:italic>Plasmodium<\/jats:italic> parasite transmission when used as mass drug administration (MDA).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13643-021-01578-9","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T01:02:45Z","timestamp":1610931765000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Endectocides as a complementary intervention in the malaria control program: a systematic review"],"prefix":"10.1186","volume":"10","author":[{"given":"Fereshteh Ghahvechi","family":"Khaligh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Silivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Levchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahlol","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-8098","authenticated-orcid":false,"given":"Saber","family":"Gholizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"1578_CR1","unstructured":"WHO. 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