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All meta-analyses that had focused on assessing the risk factors associated with placental abruption were included. We calculated summary effect estimates, 95% CI, heterogeneity <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>, 95% prediction interval, small-study effects, excess significance biases, and sensitive analysis. The quality of the meta-analyses was evaluated with A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR 2).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There was no risk factor in the present umbrella review with the high level of evidence (class I or II). Eight risk factors including maternal asthma (RR 1.29 95% CI 1.14, 1.47), prior cesarean section (RR 1.38, 95% CI 1.35\u20131.42), cocaine using (RR 4.55, 95% CI 1.78\u20136.50), endometriosis (OR 1.40, 95% CI 1.12\u20131.76), chronic hypertension (OR 3.13, 95% CI 2.04\u20134.80), advanced maternal age (OR 1.44, 95% CI 1.35\u20131.54), maternal smoking (OR 1.80, 95% CI 1.75\u20131.85) (RR 1.65, 95% CI 1.51\u20131.80), and use of assisted reproductive techniques (ART) (OR 1.87, 95% CI 1.70\u20132.06) were graded as suggestive evidence (class III). The other four risk factors including pre-pregnancy underweight (OR 1.38, 95% CI 1.12\u20131.70), preeclampsia (OR 1.73, 95% CI 1.47\u20132.04), uterine leiomyoma (OR 2.63, 95% CI 1.38\u20133.88), and marijuana use (OR 1.78, 95% CI 1.32\u20132.40) were graded as risk factors with weak evidence (class IV).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Maternal asthma, prior cesarean section, cocaine use, endometriosis, chronic hypertension, advanced maternal age, maternal smoking, and use of ART, pre-pregnancy underweight, preeclampsia, uterine leiomyoma, and marijuana use were risk factors associated with placental abruption. Although factors associated with placental abruption have been investigated, the current meta-analytic associations cannot disentangle the complex etiology of placental abruption mainly due to their low quality of evidence.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13643-022-01915-6","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T10:13:27Z","timestamp":1648808007000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The environmental risk factors prior to conception associated with placental abruption: an umbrella review"],"prefix":"10.1186","volume":"11","author":[{"given":"Ensiyeh","family":"Jenabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5125-9512","authenticated-orcid":false,"given":"Zohreh","family":"Salimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfan","family":"Ayubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Bashirian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Mohammad","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"issue":"2","key":"1915_CR1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1600-0412.2010.01030.x","volume":"90","author":"M Tikkanen","year":"2011","unstructured":"Tikkanen M. 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