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We received the search results from the Cochrane Pregnancy and Childbirth\u2019s Specialised Register of Controlled Trials, searched on 31st July 2020. At least two review authors independently selected the included studies and extracted the data and the methodological quality. The comparative risk ratios (RR) and 95% confidence intervals (CI) were analyzed using pairwise and network meta-analyses, and treatment rankings were estimated by the surface under the cumulative ranking curve for preventing preeclampsia (PE), gestational hypertension (GHT), and superimposed preeclampsia (SPE). Safety of the medications is also important for decision-making along with effectiveness which will be reported in a separate review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This network meta-analysis included 83 randomized studies, involving 93,864 women across global regions. Three medications, either alone or in combination, probably prevented PE in high-risk pregnant women when compared with a placebo or no treatment from network analysis: antiplatelet agents with calcium (<jats:italic>RR<\/jats:italic>0.19, 95%<jats:italic>CI<\/jats:italic>0.04 to 0.86; 1 study; low-quality evidence), calcium (<jats:italic>RR<\/jats:italic>0.61, 95%<jats:italic>CI<\/jats:italic>0.47 to 0.80; 13 studies; moderate-quality evidence), antiplatelet agents (<jats:italic>RR<\/jats:italic>0.69, 95%<jats:italic>CI<\/jats:italic>0.57 to 0.82; 31 studies; moderate-quality evidence), and antioxidants (<jats:italic>RR<\/jats:italic>0.77, 95%<jats:italic>CI<\/jats:italic>0.63 to 0.93; 25 studies; moderate-quality evidence). Calcium probably prevented PE (<jats:italic>RR<\/jats:italic>0.63, 95%<jats:italic>CI<\/jats:italic>0.46 to 0.86; 11 studies; moderate-quality evidence) and GHT (<jats:italic>RR<\/jats:italic>0.89, 95%<jats:italic>CI<\/jats:italic>0.84 to 0.95; 8 studies; high-quality evidence) in nulliparous\/primigravida women. Few included studies for the outcome of superimposed preeclampsia were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antiplatelet agents, calcium, and their combinations were most effective medications for preventing hypertensive disorders in high-risk pregnant women when compared with a placebo or no treatment. Any high-risk characteristics for women are important in deciding the best medications. The qualities of evidence were mostly rated to be moderate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p>PROSPERO<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=96276\">CRD42018096276<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1186\/s13643-022-01978-5","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T14:04:52Z","timestamp":1656684292000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Medications for preventing hypertensive disorders in high-risk pregnant women: a systematic review and network meta-analysis"],"prefix":"10.1186","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7687-5629","authenticated-orcid":false,"given":"Tippawan","family":"Liabsuetrakul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanon","family":"Kongkamol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rintaro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Noma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"1978_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","volume":"170","author":"E Abalos","year":"2013","unstructured":"Abalos E, Cuesta C, Grosso AL, Chou D, Say L. 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