{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:10:12Z","timestamp":1783545012442,"version":"3.55.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Syst Rev"],"DOI":"10.1186\/s13643-024-02726-7","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T08:55:16Z","timestamp":1736758516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1186","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8996-7995","authenticated-orcid":false,"given":"Sumera","family":"Aziz Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine","family":"Genkinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka","family":"Kahe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Valeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayab","family":"Khowaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy F.","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"issue":"3","key":"2726_CR1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/MCO.0000000000000051","volume":"17","author":"RA Salam","year":"2014","unstructured":"Salam RA, Das JK, Bhutta ZA. Impact of intrauterine growth restriction on long-term health. Curr Opin Clin Nutr Metab Care. 2014;17(3):249\u201354.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"Suppl 1","key":"2726_CR2","first-page":"S5","volume":"52","author":"M de Onis","year":"1998","unstructured":"de Onis M, Bl\u00f6ssner M, Villar J. Levels and patterns of intrauterine growth retardation in developing countries. Eur J Clin Nutr. 1998;52(Suppl 1):S5-15.","journal-title":"Eur J Clin Nutr"},{"issue":"9946","key":"2726_CR3","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S0140-6736(14)61490-2","volume":"384","author":"AT Papageorghiou","year":"2014","unstructured":"Papageorghiou AT, Ohuma EO, Altman DG, Todros T, Ismail LC, Lambert A, Jaffer YA, Bertino E, Gravett MG, Purwar M. International standards for fetal growth based on serial ultrasound measurements: the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project. The Lancet. 2014;384(9946):869\u201379.","journal-title":"The Lancet"},{"key":"2726_CR4","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4137\/CMPed.S40070","volume":"10","author":"D Sharma","year":"2016","unstructured":"Sharma D, Shastri S, Sharma P. Intrauterine growth restriction: antenatal and postnatal aspects. Clinical medicine insights Pediatrics. 2016;10:67\u201383.","journal-title":"Clin Med Insights Pediatr"},{"issue":"9890","key":"2726_CR5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0140-6736(13)60937-X","volume":"382","author":"RE Black","year":"2013","unstructured":"Black RE, Victora CG, Walker SP, Bhutta ZA, Christian P, de Onis M, Ezzati M, Grantham-McGregor S, Katz J, Martorell R, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013;382(9890):427\u201351.","journal-title":"Lancet"},{"issue":"3","key":"2726_CR6","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/MCO.0b013e32835e8d9c","volume":"16","author":"I Cetin","year":"2013","unstructured":"Cetin I, Mand\u00f2 C, Calabrese S. Maternal predictors of intrauterine growth restriction. Curr Opin Clin Nutr Metab Care. 2013;16(3):310\u20139.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2726_CR7","unstructured":"UNICEF. The extension of the 2025 maternal, infant and young child nutrition targets to 2030: WHO."},{"issue":"2","key":"2726_CR8","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3390\/nu11020443","volume":"11","author":"A Mousa","year":"2019","unstructured":"Mousa A, Naqash A, Lim S. Macronutrient and micronutrient intake during pregnancy: an overview of recent evidence. Nutrients. 2019;11(2):443.","journal-title":"Nutrients"},{"issue":"5","key":"2726_CR9","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nrendo.2016.37","volume":"12","author":"AD Gernand","year":"2016","unstructured":"Gernand AD, Schulze KJ, Stewart CP, West KP Jr, Christian P. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol. 2016;12(5):274\u201389.","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"2726_CR10","first-page":"Cd008666","volume":"2015","author":"ME McCauley","year":"2015","unstructured":"McCauley ME, van den Broek N, Dou L, Othman M. Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database Syst Rev. 2015;2015(10):Cd008666.","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"2726_CR11","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.3390\/nu11071560","volume":"11","author":"RL Lander","year":"2019","unstructured":"Lander RL, Hambidge KM, Westcott JE, Tejeda G, Diba TS, Mastiholi SC, Khan US, Garc\u00e9s A, Figueroa L, Tshefu A, et al. Pregnant women in four low-middle income countries have a high prevalence of inadequate dietary intakes that are improved by dietary diversity. Nutrients. 2019;11(7):1560.","journal-title":"Nutrients"},{"issue":"9890","key":"2726_CR12","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/S0140-6736(13)60996-4","volume":"382","author":"ZA Bhutta","year":"2013","unstructured":"Bhutta ZA, Das JK, Rizvi A, Gaffey MF, Walker N, Horton S, Webb P, Lartey A, Black RE. Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? Lancet. 2013;382(9890):452\u201377.","journal-title":"Lancet"},{"issue":"6","key":"2726_CR13","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1093\/advances\/nmaa070","volume":"11","author":"D Moorthy","year":"2020","unstructured":"Moorthy D, Merrill R, Namaste S, Iannotti L. The impact of nutrition-specific and nutrition-sensitive interventions on hemoglobin concentrations and anemia: a meta-review of systematic reviews. Adv Nutr. 2020;11(6):1631\u201345.","journal-title":"Adv Nutr"},{"issue":"1","key":"2726_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12905-023-02291-6","volume":"23","author":"SA Ali","year":"2023","unstructured":"Ali SA, Razzaq S, Aziz S, Allana A, Ali AA, Naeem S, Khowaja N, Ur Rehman F. Role of iron in the reduction of anemia among women of reproductive age in low-middle income countries: insights from systematic review and meta-analysis. BMC Womens Health. 2023;23(1):1\u201322.","journal-title":"BMC Womens Health"},{"issue":"7","key":"2726_CR15","doi-asserted-by":"publisher","first-page":"1437s","DOI":"10.3945\/jn.115.223479","volume":"146","author":"JC King","year":"2016","unstructured":"King JC. A summary of pathways or mechanisms linking preconception maternal nutrition with birth outcomes. J Nutr. 2016;146(7):1437s\u201344s.","journal-title":"J Nutr"},{"issue":"3","key":"2726_CR16","doi-asserted-by":"publisher","first-page":"e1156","DOI":"10.3390\/nu12030606","volume":"12","author":"ZS Lassi","year":"2020","unstructured":"Lassi ZS, Kedzior SG, Tariq W, Jadoon Y, Das JK, Bhutta ZA. Effects of preconception care and periconception interventions on maternal nutritional status and birth outcomes in low- and middle-income countries: a systematic review. Nutrients. 2020;12(3):e1156.","journal-title":"Nutrients"},{"issue":"10132","key":"2726_CR17","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1016\/S0140-6736(18)30311-8","volume":"391","author":"J Stephenson","year":"2018","unstructured":"Stephenson J, Heslehurst N, Hall J, Schoenaker D, Hutchinson J, Cade JE, Poston L, Barrett G, Crozier SR, Barker M, et al. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet. 2018;391(10132):1830\u201341.","journal-title":"Lancet"},{"issue":"12","key":"2726_CR18","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.1210\/en.2013-1414","volume":"154","author":"S Zhang","year":"2013","unstructured":"Zhang S, Morrison JL, Gill A, Rattanatray L, MacLaughlin SM, Kleemann D, Walker SK, McMillen IC. Maternal dietary restriction during the periconceptional period in normal-weight or obese ewes results in adrenocortical hypertrophy, an up-regulation of the JAK\/STAT and down-regulation of the IGF1R signaling pathways in the adrenal of the postnatal lamb. Endocrinology. 2013;154(12):4650\u201362.","journal-title":"Endocrinology"},{"key":"2726_CR19","doi-asserted-by":"crossref","unstructured":"Rosales-Nieto CA, Ehrhardt R, Mantey A, Makela B. Byrem, Veiga-Lopez A: Preconceptional diet manipulation and fetus number can influence placenta endocrine function in sheep. Domest Anim Endocrinol. 2021;74: 106577.","DOI":"10.1016\/j.domaniend.2020.106577"},{"issue":"4","key":"2726_CR20","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/1471-0528.13202","volume":"122","author":"VA Hodgetts","year":"2015","unstructured":"Hodgetts VA, Morris RK, Francis A, Gardosi J, Ismail KM. Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: a population study, systematic review and meta-analysis. BJOG. 2015;122(4):478\u201390.","journal-title":"BJOG"},{"issue":"Suppl 1","key":"2726_CR21","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1365-3016.2012.01281.x","volume":"26","author":"U Ramakrishnan","year":"2012","unstructured":"Ramakrishnan U, Grant F, Goldenberg T, Zongrone A, Martorell R. Effect of women\u2019s nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol. 2012;26(Suppl 1):285\u2013301.","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"7","key":"2726_CR22","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.3390\/nu11071628","volume":"11","author":"M Li","year":"2019","unstructured":"Li M, Francis E, Hinkle SN, Ajjarapu AS, Zhang C. Preconception and prenatal nutrition and neurodevelopmental disorders: a systematic review and meta-analysis. Nutrients. 2019;11(7):1628.","journal-title":"Nutrients"},{"issue":"8","key":"2726_CR23","doi-asserted-by":"publisher","first-page":"e007537","DOI":"10.1136\/bmjgh-2021-007537","volume":"7","author":"U Partap","year":"2022","unstructured":"Partap U, Chowdhury R, Taneja S, Bhandari N, De Costa A, Bahl R, Fawzi W. Preconception and periconception interventions to prevent low birth weight, small for gestational age and preterm birth: a systematic review and meta-analysis. BMJ Glob Health. 2022;7(8): e007537.","journal-title":"BMJ Glob Health"},{"key":"2726_CR24","unstructured":"Higgins JPT, Lasserson T, Thomas J, Flemyng E, Churchill R. Methodological expectations of Cochrane intervention reviews (MECIR). Cochrane; 2023."},{"key":"2726_CR25","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372: n71.","journal-title":"BMJ"},{"key":"2726_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1472-6947-7-16","volume":"7","author":"C Schardt","year":"2007","unstructured":"Schardt C, Adams MB, Owens T, Keitz S, Fontelo P. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007;7:16.","journal-title":"BMC Med Inform Decis Mak"},{"issue":"9606","key":"2726_CR27","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","volume":"371","author":"RL Goldenberg","year":"2008","unstructured":"Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. The lancet. 2008;371(9606):75\u201384.","journal-title":"The lancet"},{"issue":"8760","key":"2726_CR28","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","volume":"338","author":"MRC Vitamin Study Research Group","year":"1991","unstructured":"MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the medical research council vitamin study. The lancet. 1991;338(8760):131\u20137.","journal-title":"The lancet"},{"issue":"3","key":"2726_CR29","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/BF02390940","volume":"255","author":"AE Czeizel","year":"1994","unstructured":"Czeizel AE, Dud\u00e1s I, M\u00e9tneki J. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Final Report Arch Gynecol Obstet. 1994;255(3):131\u20139.","journal-title":"Final Report Arch Gynecol Obstet"},{"issue":"2","key":"2726_CR30","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0301-2115(99)00084-6","volume":"87","author":"J Rolschau","year":"1999","unstructured":"Rolschau J, Kristoffersen K, Ulrich M, Grinsted P, Schaumburg E, Foged N. The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark: Part I. European Journal of Obstetrics & Gynecology and Reproductive Biology. 1999;87(2):105\u201310.","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"key":"2726_CR31","first-page":"206","volume":"112","author":"ICMR","year":"2000","unstructured":"ICMR. Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects from India. Indian J Med Res. 2000;112:206\u201311.","journal-title":"Indian J Med Res"},{"issue":"6","key":"2726_CR32","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1093\/ajcn\/71.6.1570","volume":"71","author":"J Katz","year":"2000","unstructured":"Katz J, West KP Jr, Khatry SK, Pradhan EK, LeClerq SC, Christian P, Wu LS-F, Adhikari RK, Shrestha SR, Sommer A. Maternal low-dose vitamin A or \u03b2-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal. Am J Clin Nutr. 2000;71(6):1570\u20136.","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"2726_CR33","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1046\/j.1365-277X.2001.00291.x","volume":"14","author":"D Gilgen","year":"2001","unstructured":"Gilgen D, Mascie-Taylor CG. The effect of weekly iron supplementation on anaemia and on iron deficiency among female tea pluckers in Bangladesh. J Hum Nutr Diet. 2001;14(3):185\u201390.","journal-title":"J Hum Nutr Diet"},{"issue":"5","key":"2726_CR34","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1093\/ajcn\/80.5.1308","volume":"80","author":"SE Moriarty-Craige","year":"2004","unstructured":"Moriarty-Craige SE, Ramakrishnan U, Neufeld L, Rivera J, Martorell R. Multivitamin-mineral supplementation is not as efficacious as is iron supplementation in improving hemoglobin concentrations in nonpregnant anemic women living in Mexico. Am J Clin Nutr. 2004;80(5):1308\u201311.","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"2726_CR35","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3945\/ajcn.2009.28350","volume":"90","author":"AZ Khambalia","year":"2009","unstructured":"Khambalia AZ, O\u2019Connor DL, Macarthur C, Dupuis A, Zlotkin SH. Periconceptional iron supplementation does not reduce anemia or improve iron status among pregnant women in rural Bangladesh. Am J Clin Nutr. 2009;90(5):1295\u2013302.","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"2726_CR36","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.3945\/ajcn.114.084921","volume":"100","author":"RD Potdar","year":"2014","unstructured":"Potdar RD, Sahariah SA, Gandhi M, Kehoe SH, Brown N, Sane H, Dayama M, Jha S, Lawande A, Coakley PJ, et al. Improving women\u2019s diet quality preconceptionally and during gestation: effects on birth weight and prevalence of low birth weight\u2013a randomized controlled efficacy trial in India (Mumbai Maternal Nutrition Project). Am J Clin Nutr. 2014;100(5):1257\u201368.","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"2726_CR37","doi-asserted-by":"publisher","first-page":"e0121552","DOI":"10.1371\/journal.pone.0121552","volume":"10","author":"NS Gunaratna","year":"2015","unstructured":"Gunaratna NS, Masanja H, Mrema S, Levira F, Spiegelman D, Hertzmark E, Saronga N, Irema K, Shuma M, Elisaria E. Multivitamin and iron supplementation to prevent periconceptional anemia in rural Tanzanian women: a randomized, controlled trial. PLoS ONE. 2015;10(4): e0121552.","journal-title":"PLoS ONE"},{"issue":"6","key":"2726_CR38","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.3945\/ajcn.113.072413","volume":"102","author":"S Owens","year":"2015","unstructured":"Owens S, Gulati R, Fulford AJ, Sosseh F, Denison FC, Brabin BJ, Prentice AM. Periconceptional multiple-micronutrient supplementation and placental function in rural Gambian women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2015;102(6):1450\u20139.","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"2726_CR39","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1093\/hmg\/dds026","volume":"21","author":"B Khulan","year":"2012","unstructured":"Khulan B, Cooper WN, Skinner BM, Bauer J, Owens S, Prentice AM, Belteki G, Constancia M, Dunger D, Affara NA. Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia. Hum Mol Genet. 2012;21(9):2086\u2013101.","journal-title":"Hum Mol Genet"},{"issue":"8","key":"2726_CR40","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/ejcn.2009.11","volume":"63","author":"R Gulati","year":"2009","unstructured":"Gulati R, Bailey R, Prentice AM, Brabin BJ, Owens S. Haematological effects of multimicronutrient supplementation in non-pregnant Gambian women. Eur J Clin Nutr. 2009;63(8):970\u20137.","journal-title":"Eur J Clin Nutr"},{"issue":"7","key":"2726_CR41","doi-asserted-by":"publisher","first-page":"1445s","DOI":"10.3945\/jn.115.223420","volume":"146","author":"U Ramakrishnan","year":"2016","unstructured":"Ramakrishnan U, Nguyen PH, Gonzalez-Casanova I, Pham H, Hao W, Nguyen H, Truong TV, Nguyen S, Harding KB, Reinhart GA, et al. Neither preconceptional weekly multiple micronutrient nor iron-folic acid supplements affect birth size and gestational age compared with a folic acid supplement alone in rural vietnamese women: a randomized controlled trial. J Nutr. 2016;146(7):1445s\u201352s.","journal-title":"J Nutr"},{"issue":"12","key":"2726_CR42","doi-asserted-by":"publisher","first-page":"e0167416","DOI":"10.1371\/journal.pone.0167416","volume":"11","author":"PH Nguyen","year":"2016","unstructured":"Nguyen PH, Young M, Gonzalez-Casanova I, Pham HQ, Nguyen H, Truong TV, Nguyen SV, Harding KB, Reinhart GA, Martorell R. Impact of preconception micronutrient supplementation on anemia and iron status during pregnancy and postpartum: a randomized controlled trial in rural Vietnam. PLoS ONE. 2016;11(12): e0167416.","journal-title":"PLoS ONE"},{"issue":"2","key":"2726_CR43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3923\/ajcn.2015.33.44","volume":"7","author":"S Sri","year":"2015","unstructured":"Sri S. Micronutrients supplementation during preconception period improves fetal survival and cord blood insulin-like growth factor 1. Asian J Clin Nutr. 2015;7(2):33\u201344.","journal-title":"Asian J Clin Nutr"},{"key":"2726_CR44","unstructured":"Sumarmi SSS, Melaniani S, Kuntoro K, Wirjatmadi B, Dachlan EG, Thaha AR, Soekirman S: Prolonging micronutrients supplementation 2\u20136 months prior to pregnancy significantly improves birth weight by increasing hPL production and controlling IL-12 concentration: a randomized double blind controlled study. In: Ann Nutr Metab: 2017: KARGER ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND; 2017: 554\u2013554."},{"issue":"2","key":"2726_CR45","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/ajcn\/nqy228","volume":"109","author":"KM Hambidge","year":"2019","unstructured":"Hambidge KM, Westcott JE, Garc\u00e9s A, Figueroa L, Goudar SS, Dhaded SM, Pasha O, Ali SA, Tshefu A, Lokangaka A. A multicountry randomized controlled trial of comprehensive maternal nutrition supplementation initiated before conception: the Women First trial. Am J Clin Nutr. 2019;109(2):457\u201369.","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"2726_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12936-019-2797-8","volume":"18","author":"B Brabin","year":"2019","unstructured":"Brabin B, Gies S, Roberts SA, Diallo S, Lompo OM, Kazienga A, Brabin L, Ouedraogo S, Tinto H. Excess risk of preterm birth with periconceptional iron supplementation in a malaria endemic area: analysis of secondary data on birth outcomes in a double blind randomized controlled safety trial in Burkina Faso. Malar J. 2019;18(1):1\u201314.","journal-title":"Malar J"},{"issue":"7","key":"2726_CR47","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1093\/infdis\/jiy257","volume":"218","author":"S Gies","year":"2018","unstructured":"Gies S, Diallo S, Roberts SA, Kazienga A, Powney M, Brabin L, Ouedraogo S, Swinkels DW, Geurts-Moespot AJ, Claeys Y, et al. Effects of weekly iron and folic acid supplements on malaria risk in nulliparous women in Burkina Faso: a periconceptional, double-blind, randomized controlled noninferiority trial. J Infect Dis. 2018;218(7):1099\u2013109.","journal-title":"J Infect Dis"},{"issue":"5","key":"2726_CR48","doi-asserted-by":"publisher","first-page":"e0232197","DOI":"10.1371\/journal.pone.0232197","volume":"15","author":"HT Nga","year":"2020","unstructured":"Nga HT, Quyen PN, Chaffee BW, Diep Anh NT, Ngu T, King JC. Effect of a nutrient-rich, food-based supplement given to rural Vietnamese mothers prior to and\/or during pregnancy on birth outcomes: A randomized controlled trial. PLoS ONE. 2020;15(5): e0232197.","journal-title":"PLoS ONE"},{"key":"2726_CR49","doi-asserted-by":"crossref","unstructured":"Sun L, Niu Z: A mushroom diet reduced the risk of pregnancy-inducedhypertension and macrosomia: a randomized clinical trial. Food Nutr Res 2020;64.","DOI":"10.29219\/fnr.v64.4451"},{"key":"2726_CR50","doi-asserted-by":"publisher","first-page":"338","DOI":"10.5958\/0976-5506.2019.00312.7","volume":"10","author":"L Widasari","year":"2019","unstructured":"Widasari L, Chalid MT, Jafar N, Thaha A. Effects of multimicronutrient and IFA supplementation in preconception period against birth length and birth weight: a randomized, double blind controlled trial in banggai regency, central Sulawesi. Indian J Public Health Res Dev. 2019;10:338\u201343.","journal-title":"Indian J Public Health Res Dev"},{"issue":"12","key":"2726_CR51","doi-asserted-by":"publisher","first-page":"4422","DOI":"10.3390\/nu13124422","volume":"13","author":"R Bortolus","year":"2021","unstructured":"Bortolus R, Filippini F, Cipriani S, Trevisanuto D, Cavallin F, Zanconato G, Somigliana E, Cesari E, Mastroiacovo P, Parazzini F. Efficacy of 4.0 mg versus 0.4 mg folic acid supplementation on the reproductive outcomes: a randomized controlled trial. Nutrients. 2021;13(12):4422.","journal-title":"Nutrients"},{"issue":"5","key":"2726_CR52","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.2337\/dc20-2515","volume":"44","author":"KM Godfrey","year":"2021","unstructured":"Godfrey KM, Barton SJ, El-Heis S, Kenealy T, Nield H, Baker PN, Chong YS, Cutfield W, Chan S-Y. Myo-inositol, probiotics, and micronutrient supplementation from preconception for glycemia in pregnancy: NiPPeR International multicenter double-blind randomized controlled trial. Diabetes Care. 2021;44(5):1091\u20139.","journal-title":"Diabetes Care"},{"key":"2726_CR53","first-page":"14898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366: l4898.","journal-title":"BMJ"},{"issue":"7650","key":"2726_CR54","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924\u20136.","journal-title":"BMJ"},{"key":"2726_CR55","doi-asserted-by":"crossref","unstructured":"Verhagen AP, Ferreira ML. Forest plots. J\u00a0Physiother. 2014;60(3):170\u20133.","DOI":"10.1016\/j.jphys.2014.06.021"},{"issue":"1","key":"2726_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.2041-210X.2010.00056.x","volume":"2","author":"F Harrison","year":"2011","unstructured":"Harrison F. Getting started with meta-analysis. Methods Ecol Evol. 2011;2(1):1\u201310.","journal-title":"Methods Ecol Evol"},{"key":"2726_CR57","doi-asserted-by":"crossref","unstructured":"Harrer M, Cuijpers P, Furukawa T, Ebert D: Doing meta-analysis with R:a hands-on guide: Chapman and Hall\/CRC; 2021.","DOI":"10.1201\/9781003107347"},{"key":"2726_CR58","unstructured":"Women First Preconception Nutrition Trial G: Effect of Preconception Nutrition supplement on maternal anemia during pregnancy: findings from Women First Preconception Nutrition Trial (Unpublished work). In. 2023."},{"issue":"1","key":"2726_CR59","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12963-020-00228-x","volume":"19","author":"D Kwesiga","year":"2021","unstructured":"Kwesiga D, Tawiah C, Imam MA, Tesega AK, Nareeba T, Enuameh YAK, Biks GA, Manu G, Beedle A, Delwar N, et al. Barriers and enablers to reporting pregnancy and adverse pregnancy outcomes in population-based surveys: EN-INDEPTH study. Popul Health Metrics. 2021;19(1):15.","journal-title":"Popul Health Metrics"},{"issue":"6","key":"2726_CR60","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1080\/17441692.2017.1316413","volume":"12","author":"VZ Kuuire","year":"2017","unstructured":"Kuuire VZ, Kangmennaang J, Atuoye KN, Antabe R, Boamah SA, Vercillo S, Amoyaw JA, Luginaah I. Timing and utilisation of antenatal care service in Nigeria and Malawi. Glob Public Health. 2017;12(6):711\u201327.","journal-title":"Glob Public Health"},{"key":"2726_CR61","doi-asserted-by":"publisher","first-page":"e12532","DOI":"10.1111\/mcn.12532","volume":"14","author":"K Siekmans","year":"2018","unstructured":"Siekmans K, Roche M, Kung\u2019u JK, Desrochers RE, De-Regil LM. Barriers and enablers for iron folic acid (IFA) supplementation in pregnant women. Matern Child Nutr. 2018;14: e12532.","journal-title":"Matern Child Nutr"},{"issue":"9","key":"2726_CR62","doi-asserted-by":"publisher","first-page":"e1001508","DOI":"10.1371\/journal.pmed.1001508","volume":"10","author":"S Dean","year":"2013","unstructured":"Dean S, Rudan I, Althabe F, Webb Girard A, Howson C, Langer A, Lawn J, Reeve ME, Teela KC, Toledano M, et al. Setting research priorities for preconception care in low- and middle-income countries: aiming to reduce maternal and child mortality and morbidity. PLoS Med. 2013;10(9): e1001508.","journal-title":"PLoS Med"},{"key":"2726_CR63","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev.physiol.69.031905.164337","volume":"69","author":"NC Andrews","year":"2007","unstructured":"Andrews NC, Schmidt PJ. Iron homeostasis. Annu Rev Physiol. 2007;69:69\u201385.","journal-title":"Annu Rev Physiol"},{"key":"2726_CR64","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.tifs.2020.02.021","volume":"99","author":"K Shubham","year":"2020","unstructured":"Shubham K, Anukiruthika T, Dutta S, Kashyap AV, Moses JA, Anandharamakrishnan C. Iron deficiency anemia: a comprehensive review on iron absorption, bioavailability and emerging food fortification approaches. Trends Food Sci Technol. 2020;99:58\u201375.","journal-title":"Trends Food Sci Technol"},{"issue":"3","key":"2726_CR65","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/MOH.0000000000000132","volume":"22","author":"A Kim","year":"2015","unstructured":"Kim A, Nemeth E. New insights into iron regulation and erythropoiesis. Curr Opin Hematol. 2015;22(3):199.","journal-title":"Curr Opin Hematol"},{"issue":"8","key":"2726_CR66","doi-asserted-by":"publisher","first-page":"566","DOI":"10.7326\/M14-2932","volume":"162","author":"AG Cantor","year":"2015","unstructured":"Cantor AG, Bougatsos C, Dana T, Blazina I, McDonagh M. Routine iron supplementation and screening for iron deficiency anemia in pregnancy: a systematic review for the US Preventive Services Task Force. Ann Intern Med. 2015;162(8):566\u201376.","journal-title":"Ann Intern Med"},{"key":"2726_CR67","doi-asserted-by":"publisher","first-page":"179827","DOI":"10.1155\/2012\/179827","volume":"2012","author":"S Lager","year":"2012","unstructured":"Lager S, Powell TL. Regulation of nutrient transport across the placenta. J Pregnancy. 2012;2012:179827\u2013179827.","journal-title":"J Pregnancy"},{"issue":"11","key":"2726_CR68","first-page":"Cd003402","volume":"11","author":"P Middleton","year":"2018","unstructured":"Middleton P, Gomersall JC, Gould JF, Shepherd E, Olsen SF, Makrides M. Omega-3 fatty acid addition during pregnancy. Cochrane Database Syst Rev. 2018;11(11):Cd003402.","journal-title":"Cochrane Database Syst Rev"},{"key":"2726_CR69","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/978-3-319-62414-3_5","volume":"1014","author":"TP Fleming","year":"2017","unstructured":"Fleming TP, Eckert JJ, Denisenko O. The role of maternal nutrition during the periconceptional period and its effect on offspring phenotype. Adv Exp Med Biol. 2017;1014:87\u2013105.","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"2726_CR70","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3945\/jn.109.114488","volume":"140","author":"KM Rasmussen","year":"2010","unstructured":"Rasmussen KM, Habicht JP. Maternal supplementation differentially affects the mother and newborn. J Nutr. 2010;140(2):402\u20136.","journal-title":"J Nutr"},{"issue":"11","key":"2726_CR71","doi-asserted-by":"publisher","first-page":"e1090","DOI":"10.1016\/S2214-109X(17)30371-6","volume":"5","author":"ER Smith","year":"2017","unstructured":"Smith ER, Shankar AH, Wu LS, Aboud S, Adu-Afarwuah S, Ali H, Agustina R, Arifeen S, Ashorn P, Bhutta ZA, et al. Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries. Lancet Glob Health. 2017;5(11):e1090\u2013100.","journal-title":"Lancet Glob Health"},{"issue":"10","key":"2726_CR72","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.3390\/nu11102534","volume":"11","author":"KM Hambidge","year":"2019","unstructured":"Hambidge KM, Bann CM, McClure EM, Westcott JE, Garc\u00e9s A, Figueroa L, Goudar SS, Dhaded SM, Pasha O, Ali SA, et al. Maternal characteristics affect fetal growth response in the women first preconception nutrition trial. Nutrients. 2019;11(10):2534.","journal-title":"Nutrients"},{"issue":"1","key":"2726_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ajhb.20994","volume":"22","author":"JC Wells","year":"2010","unstructured":"Wells JC. Maternal capital and the metabolic ghetto: an evolutionary perspective on the transgenerational basis of health inequalities. American Journal of Human Biology: The Official Journal of the Human Biology Association. 2010;22(1):1\u201317.","journal-title":"American Journal of Human Biology: The Official Journal of the Human Biology Association"},{"issue":"1","key":"2726_CR74","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1146\/annurev.nutr.27.061406.093705","volume":"27","author":"RA Waterland","year":"2007","unstructured":"Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007;27(1):363\u201388.","journal-title":"Annu Rev Nutr"},{"key":"2726_CR75","doi-asserted-by":"publisher","first-page":"71","DOI":"10.58496\/MJAIH\/2023\/014","volume":"2023","author":"AT Catherine","year":"2023","unstructured":"Catherine AT, Towfek S, Abdelhamid AA. An overview of the evolution and impact of chatbots in modern healthcare services. Mesopotamian J Artif Intell Healthc. 2023;2023:71\u20135.","journal-title":"Mesopotamian J Artif Intell Healthc"}],"container-title":["Systematic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13643-024-02726-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13643-024-02726-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13643-024-02726-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:23:28Z","timestamp":1736760208000},"score":1,"resource":{"primary":{"URL":"https:\/\/systematicreviewsjournal.biomedcentral.com\/articles\/10.1186\/s13643-024-02726-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2726"],"URL":"https:\/\/doi.org\/10.1186\/s13643-024-02726-7","relation":{},"ISSN":["2046-4053"],"issn-type":[{"value":"2046-4053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"20 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable as this was a systematic review and meta-analysis of published RCTs.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11"}}