{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T05:46:02Z","timestamp":1743659162406},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Mega Project on Major Infectious Disease Prevention","award":["2017ZX10103011"],"award-info":[{"award-number":["2017ZX10103011"]}]},{"name":"the Guangdong Provincial Science and Technology Program","award":["2017A070713013"],"award-info":[{"award-number":["2017A070713013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Public Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Although several measures have been taken to control hand foot and mouth disease (HFMD) and herpangina (HA), these two diseases have been prevalent in China for 10\u2009years with high incidence. We suspected that adults\u2019 inapparent infection might be the cause of the continued prevalence of HFMD\/HA infection in mainland China.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>To explore the role of adults (especially caregivers) in the transmission process of HFMD\/HA among children, 330 HFMD\/HA cases and 330 healthy children (controls) were selected for a case\u2013control study. Then, data were analyzed by logistic regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Single-variable analyses revealed that caregivers who tested positive for enterovirus was a significant risk factor of HFMD\/HA transmission to children (adjusted odds ratio (OR)\u2009=\u20099.22; 95% CI, 1.16 to 73.23). In the final multivariable model, caregiver behavior, such as cooling children\u2019s food with mouth (OR\u2009=\u20091.85; 95% CI, 1.11 to 3.08) and feeding children with their own tableware (OR\u2009=\u20092.19; 95% CI, 1.07 to 4.45), significantly increased the risk of transmitting HFMD\/HA to children. On the contrary, washing hands before feeding children reduced such risk.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These results implied that the caregivers might be the infectious source or carriers of enterovirus. Therefore, preventing or treating the caregivers\u2019 enterovirus infection and improving their hygiene habits, especially when they are in contact with children, could provide a breakthrough for the effective control of HFMD\/HA.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13690-021-00574-8","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T10:04:14Z","timestamp":1619172254000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Caregivers: the potential infection resources for the sustaining epidemic of hand, foot, and mouth disease\/herpangina in Guangdong, China?"],"prefix":"10.1186","volume":"79","author":[{"given":"Jundi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qimin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinqiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanzhong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiji","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"issue":"1","key":"574_CR1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1186\/s12879-016-1690-0","volume":"16","author":"HT Zhou","year":"2016","unstructured":"Zhou HT, Guo YH, Chen MJ, Pan YX, Xue L, Wang B, et al. 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After learning the research subject matter and being promised to keep their personal information confidential, written informed consent was obtained from all caregivers and a parent or guardian for participants aged five years old or younger. Each participant could withdraw any time if they wanted to.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}