{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:23:39Z","timestamp":1763983419678,"version":"3.45.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010526","name":"NHS Greater Glasgow and Clyde","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010526","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011733","name":"Glasgow Children's Hospital Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Public Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stigmatized behaviours are often underreported, especially in pregnancy, making them challenging to address. The Alcohol and Child Development Study (ACDS) seeks to inform prevention of foetal alcohol harm, linking self-report as well as a maternal blood alcohol biomarker with child developmental outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Maternity records from all pregnant women in the study city who presented for maternity care during the 12-month period June 2017 \u2013 June 2018 were transferred to the safe data facility creating the baseline cohort. Health Visitor routinely recorded child developmental screening data collected when the offspring were 30 months of age were transferred and linkage analysis performed on the cohort with a final linked sample of 10,876 records. Anonymous analysis was performed to assess associations between self-reported alcohol intake collected at maternity presentation with child development concerns and looked after by the local authority status of offspring at 30 months of age. Chi2 tests of association were used with limited multivariate regression to control for confounding variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      14919 maternity records were transferred and 10,876 could be linked to developmental screening data collected at 30 months of age. As expected self-reported current alcohol use after conception measured at presentation to maternity care was associated with offspring being looked after by the local authority (chi\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20097.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) at age 30 months. 6.6% of children in care were attributable to self-report of current alcohol use during pregnancy. Developmental outcomes were generally inversely associated with self-report of current alcohol use notably concern regarding Social Development (chi\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20094.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043) and Speech, Language or Communication Development (chi\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20094.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This unexpected inverse relationship could be due to underreporting of alcohol use (the risk) and inaccurate developmental and behavioural problems reported (the outcome) or effective intervention for women who self-report current alcohol intake at maternity presentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13690-025-01766-2","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:19:00Z","timestamp":1763983140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective cohort study to assess if alcohol intake measured by routine pregnancy self-report predicts developmental concerns uncovered by routine health visitor screening of children at 30 months of age"],"prefix":"10.1186","volume":"83","author":[{"given":"David","family":"Tappin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"issue":"11","key":"1766_CR1","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1111\/acer.14705","volume":"45","author":"R McCarthy","year":"2021","unstructured":"McCarthy R, Mukherjee RAS, Fleming KM, Green J, Clayton-Smith J, Price AD, et al. Prevalence of fetal alcohol spectrum disorder in greater Manchester, UK: an active case ascertainment study. Alcohol Clin Exp Res. 2021;45(11):2271\u201381.","journal-title":"Alcohol Clin Exp Res"},{"issue":"10","key":"1766_CR2","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1001\/jamapediatrics.2017.1919","volume":"171","author":"S Lange","year":"2017","unstructured":"Lange S, Probst C, Gmel G, Rehm J, Burd L, Popova S. Global prevalence of fetal alcohol spectrum disorder among children and youth. JAMA Pediatr. 2017;171(10):948\u201356.","journal-title":"JAMA Pediatr"},{"issue":"2","key":"1766_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1542\/peds.2014-2171","volume":"135","author":"IJ Chasnoff","year":"2015","unstructured":"Chasnoff IJ, Wells AM, King L. Misdiagnosis and missed diagnoses in foster and adopted children with prenatal alcohol exposure. 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Public Health guideline. 2010 NICE guideline PH26."}],"container-title":["Archives of Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13690-025-01766-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13690-025-01766-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13690-025-01766-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:19:04Z","timestamp":1763983144000},"score":1,"resource":{"primary":{"URL":"https:\/\/archpublichealth.biomedcentral.com\/articles\/10.1186\/s13690-025-01766-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1766"],"URL":"https:\/\/doi.org\/10.1186\/s13690-025-01766-2","relation":{},"ISSN":["2049-3258"],"issn-type":[{"value":"2049-3258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"7 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"was granted by the local NHS Research Ethics Committee (28\/10\/2010 - approval number provided but not published to protect the identity of the study site). This has been previously discussed in detail [\n                      \n                      ]. The ethics committee approved the use of \u2018passive consent\u2019 where each appointment letter for first maternity clinic during the study period included a Patient Information Sheet(PIS). Midwives were asked to collect an extra \u2018study\u2019 blood sample at the time of routine venepuncture \u2018as a routine\u2019 without formal consent procedures unless the person spontaneously opted out of the study after reading the PIS. This aspect is discussed at length in the article [\n                      \n                      ]. Permission for outcome data, from the 27\u201330 month Health Visitor developmental assessment held by the health board, to be passed to the safe data facility was given by the Director of Public Health. Ethics approval for linking this data with the maternity booking data was provided by the ethics committee within the safe data facility (03\/11\/2021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We agree to conditions of submission, BioMed Central\u2019s copyright and license agreement and article-processing charge (APC).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"283"}}