{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:13:26Z","timestamp":1778883206692,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Addict Sci Clin Pract"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13722-016-0068-3","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T23:56:02Z","timestamp":1483746962000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Opioid overdose prevention and naloxone rescue kits: what we know and what we don\u2019t know"],"prefix":"10.1186","volume":"12","author":[{"given":"Todd","family":"Kerensky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y.","family":"Walley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,7]]},"reference":[{"issue":"49","key":"68_CR1","doi-asserted-by":"crossref","first-page":"15078","DOI":"10.1073\/pnas.1518393112","volume":"112","author":"A Case","year":"2015","unstructured":"Case A, Deaton A. Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century. Proc Natl Acad Sci USA. 2015;112(49):15078\u201383.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"50\u201351","key":"68_CR2","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.15585\/mmwr.mm6450a3","volume":"64","author":"RA Rudd","year":"2016","unstructured":"Rudd RA, Aleshire N, Zibbell JE, Gladden RM. Increases in drug and opioid overdose deaths-United States, 2000\u20132014. MMWR Morb Mortal Wkly Rep. 2016;64(50\u201351):1378\u201382.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"2","key":"68_CR3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJMra1508490","volume":"374","author":"WM Compton","year":"2016","unstructured":"Compton WM, Jones CM, Baldwin GT. Relationship between nonmedical prescription-opioid use and heroin use. N Engl J Med. 2016;374(2):154\u201363.","journal-title":"N Engl J Med"},{"issue":"33","key":"68_CR4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.15585\/mmwr.mm6533a2","volume":"65","author":"RM Gladden","year":"2016","unstructured":"Gladden RM, Martinez P, Seth P. Fentanyl law enforcement submissions and increases in synthetic opioid-involved overdose deaths\u201427 States, 2013\u20132014. MMWR Morb Mortal Wkly Rep. 2016;65(33):837\u201343.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"33","key":"68_CR5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.15585\/mmwr.mm6533a3","volume":"65","author":"AB Peterson","year":"2016","unstructured":"Peterson AB, Gladden RM, Delcher C, et al. Increases in fentanyl-related overdose deaths\u2014Florida and Ohio, 2013\u20132015. MMWR Morb Mortal Wkly Rep. 2016;65(33):844\u20139.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"68_CR6","unstructured":"HHS takes strong steps to address opioid-drug related overdose, death and dependence. March 26, 2015. http:\/\/www.hhs.gov\/about\/news\/2015\/03\/26\/hhs-takes-strong-steps-to-address-opioid-drug-related-overdose-death-and-dependence.html . Accessed 29 June 2016."},{"issue":"22","key":"68_CR7","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1056\/NEJMp1402780","volume":"370","author":"ND Volkow","year":"2014","unstructured":"Volkow ND, Frieden TR, Hyde PS, Cha SS. Medication-assisted therapies\u2013tackling the opioid-overdose epidemic. N Engl J Med. 2014;370(22):2063\u20136.","journal-title":"N Engl J Med"},{"key":"68_CR8","doi-asserted-by":"crossref","unstructured":"McDonald R, Strang J. Are take-home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria. Addiction (Abingdon, England) 2016; 111(7): 1177\u201387.","DOI":"10.1111\/add.13326"},{"issue":"23","key":"68_CR9","first-page":"631","volume":"64","author":"E Wheeler","year":"2015","unstructured":"Wheeler E, Jones TS, Gilbert MK, Davidson PJ. Opioid overdose prevention programs providing naloxone to laypersons\u2014United States, 2014. MMWR Morb Mortal Wkly Rep. 2015;64(23):631\u20135.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"6","key":"68_CR10","first-page":"101","volume":"61","author":"E Wheeler","year":"2012","unstructured":"Wheeler E, Davidson PJ, Jones TS, Irwin KS. Community-based opioid overdose prevention programs providing naloxone\u2014United States, 2010. MMWR Morb Mortal Wkly Rep. 2012;61(6):101\u20135.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"68_CR11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.drugalcdep.2016.03.018","volume":"163","author":"AS Bohnert","year":"2016","unstructured":"Bohnert AS, Bonar EE, Cunningham R, et al. A pilot randomized clinical trial of an intervention to reduce overdose risk behaviors among emergency department patients at risk for prescription opioid overdose. Drug Alcohol Depend. 2016;163:40\u20137.","journal-title":"Drug Alcohol Depend"},{"issue":"8","key":"68_CR12","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.2105\/AJPH.2014.302062","volume":"104","author":"CS Davis","year":"2014","unstructured":"Davis CS, Ruiz S, Glynn P, Picariello G, Walley AY. Expanded access to naloxone among firefighters, police officers, and emergency medical technicians in Massachusetts. Am J Public Health. 2014;104(8):e7\u20139.","journal-title":"Am J Public Health"},{"issue":"4","key":"68_CR13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.7326\/M15-2771","volume":"165","author":"PO Coffin","year":"2016","unstructured":"Coffin PO, Behar E, Rowe C, et al. Nonrandomized intervention study of naloxone coprescription for primary care patients receiving long-term opioid therapy for pain. Ann Intern Med. 2016;165(4):245\u201352.","journal-title":"Ann Intern Med"},{"issue":"2","key":"68_CR14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/08897077.2014.989352","volume":"36","author":"SM Bagley","year":"2015","unstructured":"Bagley SM, Peterson J, Cheng DM, et al. Overdose education and naloxone rescue kits for family members of individuals who use opioids: characteristics, motivations, and naloxone use. Substance Abuse. 2015;36(2):149\u201354.","journal-title":"Substance Abuse"},{"issue":"9","key":"68_CR15","doi-asserted-by":"crossref","first-page":"592","DOI":"10.7326\/0003-4819-159-9-201311050-00005","volume":"159","author":"IA Binswanger","year":"2013","unstructured":"Binswanger IA, Blatchford PJ, Mueller SR, Stern MF. Mortality after prison release: opioid overdose and other causes of death, risk factors, and time trends from 1999 to 2009. Ann Intern Med. 2013;159(9):592\u2013600.","journal-title":"Ann Intern Med"},{"issue":"2","key":"68_CR16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJMsa064115","volume":"356","author":"IA Binswanger","year":"2007","unstructured":"Binswanger IA, Stern MF, Deyo RA, et al. Release from prison\u2014a high risk of death for former inmates. N Engl J Med. 2007;356(2):157\u201365.","journal-title":"N Engl J Med"},{"key":"68_CR17","doi-asserted-by":"crossref","unstructured":"Davoli M, Bargagli AM, Perucci CA, et al. Risk of fatal overdose during and after specialist drug treatment: the VEdeTTE study, a national multi-site prospective cohort study. Addiction (Abingdon, England) 2007; 102(12):1954\u20139.","DOI":"10.1111\/j.1360-0443.2007.02025.x"},{"issue":"2","key":"68_CR18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/10550880902772423","volume":"28","author":"SE Wakeman","year":"2009","unstructured":"Wakeman SE, Bowman SE, McKenzie M, Jeronimo A, Rich JD. Preventing death among the recently incarcerated: an argument for naloxone prescription before release. J Addict Dis. 2009;28(2):124\u20139.","journal-title":"J Addict Dis"},{"issue":"Suppl 1","key":"68_CR19","first-page":"19","volume":"43","author":"CS Davis","year":"2015","unstructured":"Davis CS, Walley AY, Bridger CM. Lessons learned from the expansion of naloxone access in Massachusetts and North Carolina. J Law Med Ethics J Am Soc Law Med Ethics. 2015;43(Suppl 1):19\u201322.","journal-title":"J Law Med Ethics J Am Soc Law Med Ethics"},{"issue":"4","key":"68_CR20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2105\/AJPH.2016.303062","volume":"106","author":"CM Jones","year":"2016","unstructured":"Jones CM, Lurie PG, Compton WM. Increase in naloxone prescriptions dispensed in US retail pharmacies since 2013. Am J Public Health. 2016;106(4):689\u201390.","journal-title":"Am J Public Health"},{"key":"68_CR21","first-page":"f174","volume":"346","author":"AY Walley","year":"2013","unstructured":"Walley AY, Xuan Z, Hackman HH, et al. Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis. BMJ (Clinical research ed). 2013;346:f174.","journal-title":"BMJ (Clinical research ed)"},{"key":"68_CR22","doi-asserted-by":"crossref","unstructured":"Bird SM, McAuley A, Perry S, Hunter C. Effectiveness of Scotland\u2019s National Naloxone Programme for reducing opioid-related deaths: a before (2006\u201310) versus after (2011\u201313) comparison. Addiction (Abingdon, England) 2016; 111(5): 883\u201391.","DOI":"10.1111\/add.13265"},{"issue":"1","key":"68_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-158-1-201301010-00003","volume":"158","author":"PO Coffin","year":"2013","unstructured":"Coffin PO, Sullivan SD. Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal. Ann Intern Med. 2013;158(1):1\u20139.","journal-title":"Ann Intern Med"},{"issue":"1","key":"68_CR24","first-page":"1","volume":"65","author":"D Dowell","year":"2016","unstructured":"Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain\u2014United States, 2016. MMWR Recomm Rep Morb Mortal Wkly Rep Recomm Rep. 2016;65(1):1\u201349.","journal-title":"MMWR Recomm Rep Morb Mortal Wkly Rep Recomm Rep"},{"issue":"12","key":"68_CR25","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s11606-015-3394-3","volume":"30","author":"IA Binswanger","year":"2015","unstructured":"Binswanger IA, Koester S, Mueller SR, Gardner EM, Goddard K, Glanz JM. Overdose education and naloxone for patients prescribed opioids in primary care: a qualitative study of primary care staff. J Gen Intern Med. 2015;30(12):1837\u201344.","journal-title":"J Gen Intern Med"},{"key":"68_CR26","unstructured":"Miller K. LePage vetoes bill aimed at increasing access to overdose antidote. 4\/21\/2016 2016. http:\/\/www.pressherald.com\/2016\/04\/20\/lepage-vetoes-bill-aimed-at-increasing-access-to-heroin-anti-overdose-drug\/ . Accessed 11 Oct 2016."},{"issue":"2","key":"68_CR27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/jurban\/jti053","volume":"82","author":"KH Seal","year":"2005","unstructured":"Seal KH, Thawley R, Gee L, et al. Naloxone distribution and cardiopulmonary resuscitation training for injection drug users to prevent heroin overdose death: a pilot intervention study. J Urban Health Bull N Y Acad Med. 2005;82(2):303\u201311.","journal-title":"J Urban Health Bull N Y Acad Med"},{"key":"68_CR28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/1471-2458-14-297","volume":"14","author":"M Doe-Simkins","year":"2014","unstructured":"Doe-Simkins M, Quinn E, Xuan Z, et al. Overdose rescues by trained and untrained participants and change in opioid use among substance-using participants in overdose education and naloxone distribution programs: a retrospective cohort study. BMC Public Health. 2014;14:297.","journal-title":"BMC Public Health"},{"issue":"16","key":"68_CR29","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1001\/jama.2015.3474","volume":"313","author":"G D\u2019Onofrio","year":"2015","unstructured":"D\u2019Onofrio G, O\u2019Connor PG, Pantalon MV, et al. Emergency department-initiated buprenorphine\/naloxone treatment for opioid dependence: a randomized clinical trial. JAMA. 2015;313(16):1636\u201344.","journal-title":"JAMA"},{"key":"68_CR30","unstructured":"Velasquez J. Bill would mandate rehab for addicts given Narcan. September 8, 2015. http:\/\/www.politico.com\/states\/new-york\/albany\/story\/2015\/09\/bill-would-mandate-rehab-for-addicts-given-narcan-025326 . Accessed 29 June 2016."},{"key":"68_CR31","unstructured":"Samuels E. Emergency department naloxone distribution: a Rhode Island department of health, recovery community, and emergency department partnership to reduce opioid overdose deaths. Rhode Island Med J (2013) 2014; 97(10): 38\u20139."},{"issue":"18 Suppl 2","key":"68_CR32","doi-asserted-by":"crossref","first-page":"S501","DOI":"10.1161\/CIR.0000000000000264","volume":"132","author":"EJ Lavonas","year":"2015","unstructured":"Lavonas EJ, Drennan IR, Gabrielli A, et al. Part 10: special circumstances of resuscitation: 2015 american heart association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132(18 Suppl 2):S501\u201318.","journal-title":"Circulation"}],"container-title":["Addiction Science & Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13722-016-0068-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T03:31:58Z","timestamp":1498361518000},"score":1,"resource":{"primary":{"URL":"http:\/\/ascpjournal.biomedcentral.com\/articles\/10.1186\/s13722-016-0068-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,7]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["68"],"URL":"https:\/\/doi.org\/10.1186\/s13722-016-0068-3","relation":{},"ISSN":["1940-0640"],"issn-type":[{"value":"1940-0640","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,7]]},"article-number":"4"}}