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Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel noninvasive technique permitting incision-less ablative treatment, which may be effective for AUD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We present the case of a 54-year-old man diagnosed with AUD for 30\u2009years. After bilateral nucleus accumbens (NAc) MRgFUS, his craving for alcohol decreased markedly from 6 to 0, and he remained abstinent throughout the follow-up (12\u2009months). Moreover, psychiatric and neuropsychological assessments showed improvements in depression, anxiety, sleep, and quality of life. Besides, he did not have any serious adverse effects during the whole follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case report suggests the feasibility and potential of NAc ablation via MRgFUS in treating severe AUD. Subsequent multi-sample double-blind controlled trials need to be further studied. The effect of MRgFUS on the use disorders of other substances also requires further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13722-025-00644-0","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:23:10Z","timestamp":1768378990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of alcohol use disorder via magnetic resonance-guided focused ultrasound ablation surgery"],"prefix":"10.1186","volume":"21","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halimureti","family":"Paerhati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangbao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianyou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"issue":"9","key":"644_CR1","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1001\/jamapsychiatry.2017.1981","volume":"74","author":"MA Schuckit","year":"2017","unstructured":"Schuckit MA. 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