{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:50:02Z","timestamp":1740167402312,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Perioper Med"],"DOI":"10.1186\/s13741-024-00452-1","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T13:02:11Z","timestamp":1727701331000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of single bolus versus bolus followed by infusion of tranexamic acid with blood loss in adolescent idiopathic scoliosis surgery"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7493-7416","authenticated-orcid":false,"given":"Mohd Shahnaz","family":"Hasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mew Har","family":"Leong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Yii","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee Kidd","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris Yin Wei","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mun Keong","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti Nadzrah","family":"Yunus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"452_CR1","doi-asserted-by":"publisher","first-page":"e308","DOI":"10.1097\/SLA.0000000000003634","volume":"274","author":"SW de Jonge","year":"2021","unstructured":"de Jonge SW, Boldingh QJJ, Koch AH, Daniels L, de Vries EN, Spijkerman IJB, Ankum WM, Kerkhoffs GMMJ, Dijkgraaf MG, Hollmann MW, Boermeester MA. Timing of preoperative antibiotic prophylaxis and surgical site infection: TAPAS, an observational cohort study. Ann Surg. 2021;274:e308\u201314.","journal-title":"Ann Surg"},{"key":"452_CR2","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.accpm.2015.04.003","volume":"34","author":"C Dupuis","year":"2015","unstructured":"Dupuis C, Michelet D, Hilly J, Diallo T, Vidal C, Delivet H, Nivoche Y, Mazda K, Dahmani S. Predictive factors for homologous transfusion during paediatric scoliosis surgery. Anaesth Crit Care Pain Med. 2015;34:327\u201332.","journal-title":"Anaesth Crit Care Pain Med"},{"key":"452_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/BF00558210","volume":"7","author":"O Eriksson","year":"1974","unstructured":"Eriksson O, Kjellman H, Pilbrant A, Schannong M. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers. Eur J Clin Pharmacol. 1974;7:375\u201380.","journal-title":"Eur J Clin Pharmacol"},{"key":"452_CR4","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1097\/ANA.0b013e31822914a1","volume":"23","author":"MR Farrokhi","year":"2011","unstructured":"Farrokhi MR, Kazemi AP, Eftekharian HR, Akbari K. Efficacy of prophylactic low dose of tranexamic acid in spinal fixation surgery: a randomized clinical trial. J Neurosurg Anesthesiol. 2011;23:290\u20136.","journal-title":"J Neurosurg Anesthesiol"},{"key":"452_CR5","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/ACO.0000000000000728","volume":"32","author":"SM Goobie","year":"2019","unstructured":"Goobie SM, Faraoni D. Tranexamic acid and perioperative bleeding in children: what do we still need to know? Curr Opin Anaesthesiol. 2019;32:343\u201352.","journal-title":"Curr Opin Anaesthesiol"},{"key":"452_CR6","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.2106\/JBJS.18.00314","volume":"100","author":"SM Goobie","year":"2018","unstructured":"Goobie SM, Zurakowski D, Glotzbecker MP, McCann ME, Hedequist D, Brustowicz RM, Sethna NF, Karlin LI, Emans JB, Hresko MT. Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial. J Bone Joint Surg Am. 2018;100:2024\u201332.","journal-title":"J Bone Joint Surg Am"},{"key":"452_CR7","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1093\/bja\/aet255","volume":"111","author":"S Grassin-Delyle","year":"2013","unstructured":"Grassin-Delyle S, Tremey B, Abe E, Fischler M, Alvarez JC, Devillier P, Urien S. Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Br J Anaesth. 2013;111:916\u201324.","journal-title":"Br J Anaesth"},{"key":"452_CR8","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/anae.14184","volume":"73","author":"S Grassin-Delyle","year":"2018","unstructured":"Grassin-Delyle S, Theusinger OM, Albrecht R, Mueller S, Spahn DR, Urien S, Stein P. Optimisation of the dosage of tranexamic acid in trauma patients with population pharmacokinetic analysis. Anaesthesia. 2018;73:719\u201329.","journal-title":"Anaesthesia"},{"key":"452_CR9","doi-asserted-by":"publisher","first-page":"E1170","DOI":"10.1097\/BRS.0000000000004076","volume":"46","author":"MS Hasan","year":"2021","unstructured":"Hasan MS, Yunus SN, Ng CC, Chan CYW, Chiu CK, Kwan MK. Tranexamic acid in pediatric scoliosis surgery: a prospective randomized trial comparing high-dose and low-dose tranexamic acid in adolescent idiopathic scoliosis undergoing posterior spinal fusion surgery. Spine. 2021;46:E1170\u20137.","journal-title":"Spine"},{"key":"452_CR10","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1182\/blood-2014-08-588442","volume":"125","author":"N Hijazi","year":"2015","unstructured":"Hijazi N, Abu Fanne R, Abramovitch R, Yarovoi S, Higazi M, Abdeen S, Basheer M, Maraga E, Cines DB, Higazi AA. Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. Blood. 2015;125:2558\u201367.","journal-title":"Blood"},{"key":"452_CR11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.14444\/4027","volume":"11","author":"KE Jones","year":"2017","unstructured":"Jones KE, Butler EK, Barrack T, Ledonio CT, Forte ML, Cohn CS, Polly DW Jr. Tranexamic acid reduced the percent of total blood volume lost during adolescent idiopathic scoliosis surgery. Int J Spine Surg. 2017;11:27.","journal-title":"Int J Spine Surg"},{"key":"452_CR12","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1089\/sur.2016.164","volume":"18","author":"N Kasatpibal","year":"2017","unstructured":"Kasatpibal N, Whitney JD, Dellinger EP, Nair BG, Pike KC. Failure to redose antibiotic prophylaxis in long surgery increases risk of surgical site infection. Surg Infect. 2017;18:474\u201384.","journal-title":"Surg Infect"},{"key":"452_CR13","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1097\/00007632-199709010-00014","volume":"22","author":"KL Kesling","year":"1997","unstructured":"Kesling KL, Reinker KA. Scoliosis in twins. A meta-analysis of the literature and report of six cases. Spine. 1997;22:2009\u201314.","journal-title":"Spine."},{"key":"452_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.seizure.2016.02.011","volume":"36","author":"Z Lin","year":"2016","unstructured":"Lin Z, Xiaoyi Z. Tranexamic acid-associated seizures: a meta-analysis. Seizure. 2016;36:70\u20133.","journal-title":"Seizure"},{"key":"452_CR15","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/S0140-6736(94)90572-X","volume":"344","author":"JE Lonstein","year":"1994","unstructured":"Lonstein JE. Adolescent idiopathic scoliosis. Lancet. 1994;344:1407\u201312.","journal-title":"Lancet"},{"key":"452_CR16","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.2106\/00004623-198466070-00013","volume":"66","author":"JE Lonstein","year":"1984","unstructured":"Lonstein JE, Carlson JM. The prediction of curve progression in untreated idiopathic scoliosis during growth. J Bone Joint Surg Am. 1984;66:1061\u201371.","journal-title":"J Bone Joint Surg Am"},{"key":"452_CR17","doi-asserted-by":"publisher","first-page":"559","DOI":"10.14444\/8251","volume":"16","author":"N Mehta","year":"2022","unstructured":"Mehta N, Garg B, Bansal T, Aryal A, Arora N, Gupta V. Predictors of operative duration in posterior spinal fusion for adolescent idiopathic scoliosis: a retrospective cohort study. Int J Spine Surg. 2022;16:559\u201366.","journal-title":"Int J Spine Surg"},{"key":"452_CR18","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1097\/00007632-200003010-00010","volume":"25","author":"GA Nuttall","year":"2000","unstructured":"Nuttall GA, Horlocker TT, Santrach PJ, Oliver WC Jr, Dekutoski MB, Bryant S. Predictors of blood transfusions in spinal instrumentation and fusion surgery. Spine. 2000;25:596\u2013601.","journal-title":"Spine"},{"key":"452_CR19","first-page":"529","volume":"54","author":"S Parent","year":"2005","unstructured":"Parent S, Newton PO, Wenger DR. Adolescent idiopathic scoliosis: etiology, anatomy, natural history, and bracing. Instr Course Lect. 2005;54:529\u201336.","journal-title":"Instr Course Lect"},{"key":"452_CR20","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1097\/00000542-200504000-00006","volume":"102","author":"NF Sethna","year":"2005","unstructured":"Sethna NF, Zurakowski D, Brustowicz RM, Bacsik J, Sullivan LJ, Shapiro F. Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery. Anesthesiology. 2005;102:727\u201332.","journal-title":"Anesthesiology"},{"key":"452_CR21","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1097\/ALN.0b013e3182a443e8","volume":"120","author":"S Sigaut","year":"2014","unstructured":"Sigaut S, Tremey B, Ouattara A, Couturier R, Taberlet C, Grassin-Delyle S, Dreyfus JF, Schlumberger S, Fischler M. Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology. 2014;120:590\u2013600.","journal-title":"Anesthesiology"},{"key":"452_CR22","first-page":"73","volume":"2","author":"T Stief","year":"2009","unstructured":"Stief T. Tranexamic acid triggers thrombin generation. Hemost Lab. 2009;2:73\u201382.","journal-title":"Hemost Lab"},{"key":"452_CR23","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1097\/BRS.0b013e31817bd889","volume":"33","author":"GH Thompson","year":"2008","unstructured":"Thompson GH, Florentino-Pineda I, Poe-Kochert C, Armstrong DG, Son-Hing JP. The role of Amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis. Spine. 2008;33:2237\u201342.","journal-title":"Spine"},{"key":"452_CR24","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1097\/SLA.0000000000005436","volume":"275","author":"N Wolfhagen","year":"2022","unstructured":"Wolfhagen N, Boldingh QJJ, de Lange M, Boermeester MA, de Jonge SW. Intraoperative redosing of surgical antibiotic prophylaxis in addition to preoperative prophylaxis versus single-dose prophylaxis for the prevention of surgical site infection: a meta-analysis and GRADE Recommendation. Ann Surg. 2022;275:1050\u20137.","journal-title":"Ann Surg"},{"key":"452_CR25","doi-asserted-by":"publisher","first-page":"S172","DOI":"10.21037\/atm.2019.05.36","volume":"7","author":"JS Yoo","year":"2019","unstructured":"Yoo JS, Ahn J, Karmarkar SS, Lamoutte EH, Singh K. The use of tranexamic acid in spine surgery. Ann Transl Med. 2019;7:S172.","journal-title":"Ann Transl Med"}],"container-title":["Perioperative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13741-024-00452-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13741-024-00452-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13741-024-00452-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T13:02:13Z","timestamp":1727701333000},"score":1,"resource":{"primary":{"URL":"https:\/\/perioperativemedicinejournal.biomedcentral.com\/articles\/10.1186\/s13741-024-00452-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["452"],"URL":"https:\/\/doi.org\/10.1186\/s13741-024-00452-1","relation":{},"ISSN":["2047-0525"],"issn-type":[{"type":"electronic","value":"2047-0525"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"12 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study received approval by the Medical Research Ethics Committee of University Malaya Medical Centre (MREC ID: 202057\u20138602) and waived the requirement for informed consent because of the retrospective observational nature of this study. All procedures were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"94"}}