{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T06:12:14Z","timestamp":1794031934847,"version":"4.8.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Perioper Med"],"DOI":"10.1186\/s13741-026-00682-5","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:36:39Z","timestamp":1776926199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of postoperative tranexamic acid administration in patients undergoing proximal femoral tumor endoprosthesis reconstruction"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-2223","authenticated-orcid":false,"given":"Muhammet Salih","family":"Ayas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8386-096X","authenticated-orcid":false,"given":"Faruk","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2380-0788","authenticated-orcid":false,"given":"Fevzi G\u00fcrkan","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5574-816X","authenticated-orcid":false,"given":"Muhammed Burak","family":"Usta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"682_CR1","doi-asserted-by":"publisher","unstructured":"Al-Attar N, Johnston S, Jamous N, Mistry S, Ghosh E, Gangoli G, et al. Impact of bleeding complications on length of stay and critical care utilization in cardiac surgery patients in England. Available from: https:\/\/doi.org\/10.1186\/s13019-019-0881-3. Cited 11 May 2025.","DOI":"10.1186\/s13019-019-0881-3"},{"issue":"2","key":"682_CR2","first-page":"275","volume":"29","author":"L Andreani","year":"2022","unstructured":"Andreani L, Del Chiaro A, Ipponi E, Di Sacco F, Caterino M, Capanna R. Use of tranexamic acid to reduce postOperative bleeding in orthopaedic oncology. Acta Med Lituan. 2022;29(2):275\u201383.","journal-title":"Acta Med Lituan"},{"key":"682_CR3","doi-asserted-by":"crossref","unstructured":"Cai J, Ribkoff J, Olson S, Raghunathan V, Al-Samkari H, DeLoughery TG, et al. The many roles of tranexamic acid: An overview of the clinical indications for TXA in medical and surgical patients. Eur J Haematol . 2019;104(2):79. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7023891\/. Cited 16 Apr 2025.","DOI":"10.1111\/ejh.13348"},{"key":"682_CR4","doi-asserted-by":"crossref","unstructured":"Colomina MJ, Contreras L, Guilabert P, Koo M, M.ndez E, Sabate A. Clinical use of tranexamic acid: evidences and controversies. Braz J Anesthesiol . 2022;72(6):795\u2013812. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/34626756\/. Cited 16 Apr 2025.","DOI":"10.1016\/j.bjane.2021.08.022"},{"key":"682_CR5","doi-asserted-by":"crossref","unstructured":"Dunn CJ, Goa KL. Tranexamic acid: A review of its use in surgery and other indications. Drugs . 1999;57(6):1005\u201332. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/10400410\/. Cited 11 May 2025.","DOI":"10.2165\/00003495-199957060-00017"},{"key":"682_CR6","doi-asserted-by":"crossref","unstructured":"Fillingham YA, Ramkumar DB, Jevsevar DS, Yates AJ, Shores P, Mullen K, et al. The Efficacy of Tranexamic Acid in Total Knee Arthroplasty: A Network Meta-Analysis. J Arthroplasty . 2018;33(10):3090\u20133098.e1. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29805106\/. Cited 16 Apr 2025.","DOI":"10.1016\/j.arth.2018.04.043"},{"key":"682_CR7","doi-asserted-by":"crossref","unstructured":"Grocott MPW, Murphy M, Roberts I, Sayers R, Toh CH. Tranexamic acid for safer surgery: the time is now. Br J Anaesth . 2022;129(4):459\u201361. Available from: https:\/\/www.bjanaesthesia.org\/action\/showFullText?pii=S0007091222003440. Cited 11 May 2025.","DOI":"10.1016\/j.bja.2022.06.024"},{"key":"682_CR8","doi-asserted-by":"crossref","unstructured":"Guerreiro JPF, Badaro BS, Balbino JRM, Danieli MV, Queiroz AO, Cataneo DC. Application of Tranexamic Acid in Total Knee Arthroplasty \u2013 Prospective Randomized Trial. Open Orthop J . 2017;11(1):1049. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5612028\/. Cited 17 Apr 2025.","DOI":"10.2174\/1874325001711011049"},{"issue":"4","key":"682_CR9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.aott.2019.03.001","volume":"53","author":"D Gulabi","year":"2019","unstructured":"Gulabi D, Yuce Y, Erkal KH, Saglam N, Camur S. The combined administration of systemic and topical tranexamic acid for total hip arthroplasty: is it better than systemic? Acta Orthop Traumatol Turc. 2019;53(4):297\u2013300.","journal-title":"Acta Orthop Traumatol Turc"},{"key":"682_CR10","doi-asserted-by":"crossref","unstructured":"Haase DR, Templeton KJ, Rosenthal HG, Sweeney KR. Tranexamic Acid in Patients with Cancer Undergoing Endoprosthetic Reconstruction: A Retrospective Review. Journal of the American Academy of Orthopaedic Surgeons . 2020;28(6):248\u201355. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32142488\/. Cited 11 May 2025.","DOI":"10.5435\/JAAOS-D-18-00798"},{"key":"682_CR11","doi-asserted-by":"crossref","unstructured":"Haratian A, Shelby T, Hasan LK, Bolia IK, Weber AE, Petrigliano FA. Utilization of Tranexamic Acid in Surgical Orthopaedic Practice: Indications and Current Considerations. Orthop Res Rev . 2021;13:187. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8541761\/. Cited 11 May 2025.","DOI":"10.2147\/ORR.S321881"},{"key":"682_CR12","doi-asserted-by":"crossref","unstructured":"Kawai A, Kadota H, Yamaguchi U, Morimoto Y, Ozaki T, Beppu Y. Blood loss and transfusion associated with musculoskeletal tumor surgery. J Surg Oncol . 2005;92(1):52\u20138. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/16180233\/. Cited 20 Jan 2026.","DOI":"10.1002\/jso.20375"},{"key":"682_CR13","doi-asserted-by":"crossref","unstructured":"Kim C, Park SSH, Roderick Davey J. Tranexamic acid for the prevention and management of orthopedic surgical hemorrhage: current evidence. J Blood Med . 2015;6:239. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4556304\/. Cited 16 Apr 2025.","DOI":"10.2147\/JBM.S61915"},{"key":"682_CR14","doi-asserted-by":"crossref","unstructured":"Knowlton LM, Arnow K, Trickey AW, Sauaia A, Knudson MM. Does tranexamic acid increase venous thromboembolism risk among trauma patients? A prospective multicenter analysis across 17 level I trauma centers. Injury . 2023;54(11). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/37669883\/. Cited 17 Apr 2025.","DOI":"10.1016\/j.injury.2023.111008"},{"key":"682_CR15","doi-asserted-by":"crossref","unstructured":"Konarski W, Pobo\u017cy T, Hordowicz M. Tranexamic acid in total knee replacement and total hip replacement - a single-center retrospective, observational study. Orthop Rev (Pavia) . 2022;14(3):33875. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35775036. Cited 17 Apr 2025.","DOI":"10.52965\/001c.33875"},{"key":"682_CR16","doi-asserted-by":"crossref","unstructured":"Murao S, Nakata H, Roberts I, Yamakawa K. Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis. Crit Care . 2021;25(1). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/34724964\/. Cited 11 May 2025.","DOI":"10.1186\/s13054-021-03799-9"},{"issue":"4","key":"682_CR17","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.suronc.2008.08.007","volume":"18","author":"BK Potter","year":"2009","unstructured":"Potter BK, Chow VE, Adams SC, Letson GD, Temple HT. Endoprosthetic proximal femur replacement: metastatic versus primary tumors. Surg Oncol. 2009;18(4):343\u20139.","journal-title":"Surg Oncol"},{"issue":"2","key":"682_CR18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.4274\/BTDMJB.galenos.2018.20180423062907","volume":"15","author":"Y Sa\u011flam","year":"2019","unstructured":"Sa\u011flam Y, G\u00fclen\u00e7 B, Biri\u015fik F, Tunal\u0131 O, Salduz A, Yaz\u0131c\u0131o\u011flu \u00d6. Pathological fractures of the proximal femur due to metastatic lesions: a single institution experience of patient characteristics and methods of surgical treatment. Med J Bakirkoy. 2019;15(2):155\u20139.","journal-title":"Med J Bakirkoy"},{"key":"682_CR19","doi-asserted-by":"crossref","unstructured":"Samama CM. A direct antifibrinolytic agent in major orthopedic surgery. Orthopedics . 2004;27(6 Suppl). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/15239556\/. Cited 16 Apr 2025.","DOI":"10.3928\/0147-7447-20040602-09"},{"key":"682_CR20","doi-asserted-by":"crossref","unstructured":"Shah N, Khetan V, Sivanadan H. Should tranexamic acid be used for 3 days after total knee replacement? A randomized study in 250 patients. Acta Orthop Belg . 2021;87(4):697\u2013703. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35172436\/. Cited 16 Apr 2025.","DOI":"10.52628\/87.4.14"},{"issue":"10084","key":"682_CR21","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","volume":"389","author":"H Shakur","year":"2017","unstructured":"Shakur H, Roberts I, Fawole B, Chaudhri R, El-Sheikh M, Akintan A, et al. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. The Lancet. 2017;389(10084):2105\u201316.","journal-title":"The Lancet"},{"key":"682_CR22","doi-asserted-by":"crossref","unstructured":"Shehadeh A, Noveau J, Malawer M, Henshaw R. Late Complications and Survival of Endoprosthetic Reconstruction after Resection of Bone Tumors. Clin Orthop Relat Res . 2010;468(11):2885. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2947697\/. Cited 26 May 2025.","DOI":"10.1007\/s11999-010-1454-x"},{"key":"682_CR23","doi-asserted-by":"crossref","unstructured":"Stoicea N, Moran K, Mahmoud AR, Glassman A, Ellis T, Ryan J, et al. Tranexamic acid use during total hip arthroplasty: A single center retrospective analysis. Medicine . 2018;97(21):e10720. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6392984\/. Cited 16 Apr 2025.","DOI":"10.1097\/MD.0000000000010720"},{"key":"682_CR24","doi-asserted-by":"crossref","unstructured":"Taeuber I, Weibel S, Herrmann E, Neef V, Schlesinger T, Kranke P, et al. Association of Intravenous Tranexamic Acid with Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression. JAMA Surg . 2021;156(6). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/33851983\/. Cited 11 May 2025.","DOI":"10.1001\/jamasurg.2021.0884"},{"key":"682_CR25","doi-asserted-by":"crossref","unstructured":"Tengborn L, Blomb\u00e4ck M, Berntorp E. Tranexamic acid \u2013 an old drug still going strong and making a revival. Thromb Res . 2015;135(2):231\u201342. Available from: https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0049384814006215. Cited 11 May 2025.","DOI":"10.1016\/j.thromres.2014.11.012"},{"key":"682_CR26","doi-asserted-by":"crossref","unstructured":"Tsantes AG, Trikoupis IG, Papadopoulos D V., Goumenos S, Piovani D, Nikolopoulos GK, et al. The safety and efficacy of tranexamic acid in oncology patients undergoing endoprosthetic reconstruction and a rotem-based evaluation of their hemostatic profile: A pilot study. Cancers (Basel). 2021;13(16):3951. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8392365\/. Cited 17 Apr 2025.","DOI":"10.3390\/cancers13163951"},{"key":"682_CR27","doi-asserted-by":"crossref","unstructured":"Vera-Llonch M, Hagiwara M, Oster G. Clinical and economic consequences of bleeding following major orthopedic surgery. Thromb Res . 2006;117(5):569\u201377. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/15913715\/. Cited 17 Apr 2025.","DOI":"10.1016\/j.thromres.2005.04.018"},{"issue":"2","key":"682_CR28","doi-asserted-by":"publisher","first-page":"250","DOI":"10.5505\/aot.2019.62134","volume":"52","author":"S Y\u0131lmaz","year":"2019","unstructured":"Y\u0131lmaz S, Atalay \u0130B, \u00d6zt\u00fcrk R, G\u00fcng\u00f6r B\u015e. The evaluation of the surgical and functional reseults of the tumor resection prothesis in proximal femur malignant bone tumors. Acta Oncol Turc. 2019;52(2):250\u20135.","journal-title":"Acta Oncol Turc"},{"issue":"3","key":"682_CR29","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5505\/aot.2023.67689","volume":"56","author":"\u00d6\u00c7 Y\u00fcce","year":"2023","unstructured":"Y\u00fcce \u00d6\u00c7, Kalayc\u0131 D, O\u011fuz G, \u00dcnver S, Y\u00fcce \u00d6\u00c7, Kalayc\u0131 D, et al. Primer ve Metastatik Kemik T\u00fcm\u00f6rlerinde T\u00fcm\u00f6r Rezeksiyon Protezi ile Rekonstr\u00fcksiyon Cerrahisi Yap\u0131lan Hastalarda Anestezi Uygulamalar\u0131 ve Postoperatif Bak\u0131m Sonu\u00e7lar\u0131n\u0131n De\u011ferlendirilmesi. Acta Haematologica Oncologica Turcica. 2023;56(3):210\u20139.","journal-title":"Acta Haematologica Oncologica Turcica"},{"key":"682_CR30","doi-asserted-by":"crossref","unstructured":"Zec T, Di Napoli R, Fievez L, Aziz M Ben, Ottaiano A, Vittori A, et al. Efficacy and Safety of Tranexamic Acid in Cancer Surgery. An Update of Clinical Findings and Ongoing Research. J Multidiscip Healthc . 2022;15:1427. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9270886\/. Cited 20 Jan 2026.","DOI":"10.2147\/JMDH.S337250"},{"key":"682_CR31","doi-asserted-by":"crossref","unstructured":"Zhao Z, Ma J, Ma X. Comparative efficacy and safety of different hemostatic methods in total hip arthroplasty: a network meta-analysis. J Orthop Surg Res . 2019;14(1):3. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6319007\/. Cited 11 May 2025.","DOI":"10.1186\/s13018-018-1028-2"}],"container-title":["Perioperative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13741-026-00682-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13741-026-00682-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13741-026-00682-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:55:37Z","timestamp":1780620937000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13741-026-00682-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["682"],"URL":"https:\/\/doi.org\/10.1186\/s13741-026-00682-5","relation":{},"ISSN":["2047-0525"],"issn-type":[{"value":"2047-0525","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"22 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the current Declaration of Helsinki. The study was approved as a retrospective study by the ethics committee of Karadeniz Technical University Faculty of Medicine [No: 2025\/204]. In addition, written and verbal consent was obtained and recorded from each patient and participant to be published in the article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"55"}}