{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:24Z","timestamp":1787585964721,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802069"],"award-info":[{"award-number":["81802069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Planned Science and Technology Project of Wenzhou","award":["Y20180191"],"award-info":[{"award-number":["Y20180191"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antimicrob Resist Infect Control"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The study aimed to elucidate the species taxonomy, clinical manifestations, virulence gene profiles and antimicrobial susceptibilities of\n Aeromonas<\/jats:italic>\n strains isolated from life-threatening bacteremia in southeastern China.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Clinical samples of\n Aeromonas<\/jats:italic>\n causing bacteremia were isolated from a teaching hospital in Wenzhou from 2013 to 2018 and a retrospective cohort study was performed.\n Aeromonas<\/jats:italic>\n strains were identified at species level by housekeeping gene\n gyrB<\/jats:italic>\n . Virulence and drug resistance-associated genes were screened by polymerase chain reaction (PCR) and antimicrobial susceptibility testing (AST) was performed by the VITEK 2 Compact system.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 58\n Aeromonas<\/jats:italic>\n isolated from patients with bacteremia were collected during 6\u00a0years (2013\u20132018). 58 isolates were identified to five different species, where\n Aeromonas dhakensis<\/jats:italic>\n appeared to be the predominant species (26\/58), followed by\n Aeromonas veronii<\/jats:italic>\n (13\/58),\n Aeromonas caviae<\/jats:italic>\n (10\/58),\n Aeromonas hydrophila<\/jats:italic>\n (7\/58) and\n Aeromonas jandaei<\/jats:italic>\n (2\/58). 16 of 58 patients had poor prognosis. Poor prognosis was significantly associated with liver cirrhosis and inappropriate empirical antimicrobials therapy. The progression of bacteremia caused by\n Aeromonas<\/jats:italic>\n was extremely fast, especially in\n A. dhakensis<\/jats:italic>\n infections. Virulence genes\n aer<\/jats:italic>\n ,\n lip<\/jats:italic>\n ,\n hlyA<\/jats:italic>\n ,\n alt<\/jats:italic>\n ,\n ast<\/jats:italic>\n , and\n act<\/jats:italic>\n , were detected at ratios of 24.1% (14\/58), 62.1% (36\/58), 65.5% (38\/58), 58.6% (34\/58), 15.5% (9\/58) and 65.5% (38\/58), respectively. Antimicrobial susceptibility testing exhibited that 9 out of 58 isolates were identified as multi-drug resistant (MDR) organism. The\n bla<\/jats:italic>\n TEM<\/jats:sub>\n gene was identified in all 9 MDR isolates.\n bla<\/jats:italic>\n SHV<\/jats:sub>\n ,\n bla<\/jats:italic>\n AQU-1<\/jats:sub>\n ,\n bla<\/jats:italic>\n MOX<\/jats:sub>\n ,\n bla<\/jats:italic>\n CepH<\/jats:sub>\n ,\n bla<\/jats:italic>\n CphA<\/jats:sub>\n and\n aac(6\u2032)-Ib-cr<\/jats:italic>\n were detected in 4 isolates, 2 isolates, 1 isolate, 3 isolates, 8 isolates, and 3 isolates, respectively. The majority of\n Aeromonas<\/jats:italic>\n strains maintained susceptible to 3rd generation cephalosporins, aminoglycosides, fluoroquinolones and furantoin.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The prevalence and dangerousness of\n Aeromonas<\/jats:italic>\n infections, especially\n A. dhakensis<\/jats:italic>\n , are underestimated in clinic. Continuous monitoring is essential to keep track of MDR\n Aeromonas<\/jats:italic>\n due to the increasing prevalence recently and a more effective measure is required to control the spread of resistance determinants.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s13756-021-00911-0","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T07:02:56Z","timestamp":1614409376000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Taxonomy, virulence determinants and antimicrobial susceptibility of Aeromonas spp. isolated from bacteremia in southeastern China"],"prefix":"10.1186","volume":"10","author":[{"given":"Yao","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renchi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokuang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2171-4710","authenticated-orcid":false,"given":"Tieli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"911_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.micpath.2019.02.036","volume":"130","author":"RB Goncalves Pessoa","year":"2019","unstructured":"Goncalves Pessoa RB, de Oliveira WF, Marques DSC, Dos Santos Correia MT, de Carvalho E, Coelho L. 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