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The aim of the present study was to determine the global status of resistance to this class of antibiotic among\n                      <jats:italic>V. cholera<\/jats:italic>\n                      isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      For the study, electronic databases were searched using the appropriate keywords including: \u2018\n                      <jats:italic>Vibrio<\/jats:italic>\n                      \u2019, \u2018\n                      <jats:italic>cholera<\/jats:italic>\n                      \u2019, \u2018\n                      <jats:italic>Vibrio cholerae<\/jats:italic>\n                      \u2019, \u2018\n                      <jats:italic>V. cholerae<\/jats:italic>\n                      \u2019, \u2018resistance\u2019, \u2018antibiotic resistance\u2019, \u2018antibiotic susceptibility\u2019, \u2018antimicrobial resistance\u2019, \u2018antimicrobial susceptibility\u2019, \u2018tetracycline\u2019, and \u2018doxycycline\u2019. Finally, after some exclusion, 52 studies from different countries were selected and included in the study and meta-analysis was performed on the collected data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average resistance rate for serogroup O1 to tetracycline and doxycycline was 50% and 28%, respectively (95% CI). A high level of heterogeneity (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009&gt;\u200950%,\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009&lt;\u20090.05) was observed in the studies representing resistance to tetracycline and doxycycline in O1 and non-O1, non-O139 serogroups. The Begg\u2019s tests did not indicate the publication bias (\n                      <jats:italic>p<\/jats:italic>\n                      -value\u2009&gt;\u20090.05). However, the Egger\u2019s tests showed some evidence of publication bias in the studies conducted on serogroup O1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results of the present study show that the overall resistance to tetracyclines is relatively high and prevalent among\n                      <jats:italic>V. cholerae<\/jats:italic>\n                      isolates, throughout the world. This highlights the necessity of performing standard antimicrobial susceptibility testing prior to treatment choice along with monitoring and management of antibiotic resistance patterns of\n                      <jats:italic>V. cholerae<\/jats:italic>\n                      strains in order to reduce the emergence and propagation of antibiotic resistant strains as well as the failure of treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13756-021-00985-w","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T04:03:01Z","timestamp":1628222581000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Global status of tetracycline resistance among clinical isolates of Vibrio cholerae: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7011-8827","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Ahmadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"985_CR1","doi-asserted-by":"crossref","unstructured":"Torane V, Kuyare S, Nataraj G, Mehta P, Dutta S, Sarkar B. 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