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However, data on <jats:italic>S. aureus<\/jats:italic> colonization in animals, particularly on ruminants in close contact with humans, is limited. The West African Dwarf (WAD) goat is among the earliest domesticated ruminant associated with rural dwellers and small-holder farmers in sub-Saharan Africa. This study aimed to investigate the population structure, antibiotic resistance, and virulence gene determinants of <jats:italic>S. aureus<\/jats:italic> from the WAD goat in Nigeria.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Nasal samples were obtained from the WAD goat in five markets in Osun State, South-West Nigeria. <jats:italic>S. aureus<\/jats:italic> was characterized by antibiotic susceptibility testing, detection of virulence determinants, <jats:italic>spa<\/jats:italic> typing, and multilocus sequence typing (MLST). Representative isolates were selected for whole-genome sequencing, biofilm, and cytotoxicity assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 726 nasal samples obtained from the WAD goat, 90 <jats:italic>S. aureus<\/jats:italic> (12.4%) were recovered. Overall, 86 isolates were methicillin-susceptible, and four were <jats:italic>mecA<\/jats:italic>-positive (i.e., methicillin-resistant <jats:italic>S. aureus<\/jats:italic> [MRSA]). A diverse <jats:italic>S. aureus<\/jats:italic> clonal population was observed (20 sequence types [STs] and 37 <jats:italic>spa<\/jats:italic> types), while 35% (13\/37) and 40% (8\/20) were new <jats:italic>spa<\/jats:italic> types and STs, respectively. Eleven MLST clonal complexes (CC) were identified (CC1, CC5, CC8, CC15, CC30, CC45, CC97, CC121, CC133, CC152, CC522). The MRSA isolates were designated as t127-ST852-CC1-SCC<jats:italic>mec<\/jats:italic> type VII, t4690-ST152-CC152-SCC<jats:italic>mec<\/jats:italic> type Vc, and t8821-ST152-CC152-SCC<jats:italic>mec<\/jats:italic> type Vc. Phylogenetic analysis revealed that 60% (54\/90) of all isolates were associated with ruminant lineages (i.e., CC133, CC522). Panton-Valentine Leukocidin (PVL)-positive <jats:italic>S. aureus<\/jats:italic> was identified in CC1, CC30, CC121, and CC152. For the CC522 isolates, we illustrate their pathogenic potential by the detection of the toxic shock syndrome gene and hemolysins, as well as their strong cytotoxicity and ability to form biofilms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This is the first detailed investigation on the genomic content of <jats:italic>S. aureus<\/jats:italic> from the WAD goat in Nigeria. The <jats:italic>S. aureus<\/jats:italic> population of the WAD goat consists mainly of ruminant-associated lineages (e.g., CC133, CC522), interspersed with human-associated clones, including PVL-positive MRSA CC1 and CC152.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13756-021-00987-8","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T07:05:09Z","timestamp":1629356709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Genomic analysis of Staphylococcus aureus from the West African Dwarf (WAD) goat in Nigeria"],"prefix":"10.1186","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-4123","authenticated-orcid":false,"given":"Adebayo Osagie","family":"Shittu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadekemi Funmilayo","family":"Taiwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neele Judith","family":"Frob\u00f6se","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Schwartbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Niemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Mellmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frieder","family":"Schaumburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"987_CR1","doi-asserted-by":"crossref","unstructured":"Heaton CJ, Gerbig GR, Sensius LD, Patel V, Smith TC. 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