{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:20:10Z","timestamp":1790180410906,"version":"4.1.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100011635","name":"Fuwai Hospital, Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2016-CXGC01-3"],"award-info":[{"award-number":["2016-CXGC01-3"]}],"id":[{"id":"10.13039\/501100011635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antimicrob Resist Infect Control"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Mycobacterium chimaera<\/jats:italic> infections subsequent to cardiac surgery are related to contaminated heater-cooler devices, with high mortality. Nevertheless, few studies have been reported in Asia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We described the case of a 55-year-old man with <jats:italic>Mycobacterium chimaera<\/jats:italic> infection following cardiac surgery in the mainland of China. He was diagnosed with endocarditis caused by <jats:italic>Mycobacterium chimaera<\/jats:italic> subsequent to open heart surgery. Metagenomic next-generation sequencing (mNGS) and 16S rRNA gene PCR analysis were used to identify potential pathogens. The patient underwent redo valve replacement surgery and received combination therapy with azithromycin, ethambutol, linezolid, and amikacin. No signs of relapse were observed during the 11-month follow-up visit.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This is the first documented case of <jats:italic>Mycobacterium chimaera<\/jats:italic> infection following cardiac surgery in the mainland of China and the first documented transnational imported case worldwide. Moreover, mNGS is a novel diagnostic technology that can guide antimicrobial therapy prior to obtaining fluid\/tissue culture results for <jats:italic>Mycobacterium chimaera<\/jats:italic>, providing a new approach for the detection of potential <jats:italic>Mycobacterium chimaera<\/jats:italic> infection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13756-021-01003-9","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T13:22:00Z","timestamp":1633612920000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Case report of the first cured patient with Mycobacterium Chimaera infection following cardiac valve replacement in the mainland of China"],"prefix":"10.1186","volume":"10","author":[{"given":"Di","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Feng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia-Fei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Cong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-7831","authenticated-orcid":false,"given":"Yun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"issue":"3","key":"1003_CR1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jiac.2019.11.004","volume":"26","author":"R Niccol\u00f2","year":"2020","unstructured":"Niccol\u00f2 R, Jacopo M, Roberta M, et al. Mycobacterium chimaera infections: an update. J Infect Chemother. 2020;26(3):199\u2013205. https:\/\/doi.org\/10.1016\/j.jiac.2019.11.004.","journal-title":"J Infect Chemother"},{"key":"1003_CR2","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1093\/eurheartj\/ehv342","volume":"36","author":"P Kohler","year":"2015","unstructured":"Kohler P, Kuster SP, Bloemberg G, et al. Healthcare-associated prosthetic heart valve, aortic vascular graft and disseminated mycobacterium chimaera infections subsequent to open heart surgery. Eur Heart J. 2015;36:2745\u201353. https:\/\/doi.org\/10.1093\/eurheartj\/ehv342.","journal-title":"Eur Heart J."},{"key":"1003_CR3","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.cmi.2018.04.027","volume":"24","author":"JE Scriven","year":"2018","unstructured":"Scriven JE, Scobie A, Verlander NQ, et al. Mycobacterium chimaera infection following cardiac surgery in the United Kingdom Clinical features and outcome of the first 30 cases. Clin Microbiol Infect. 2018;24:1164\u201370. https:\/\/doi.org\/10.1016\/j.cmi.2018.04.027.","journal-title":"Clin Microbiol Infect."},{"key":"1003_CR4","doi-asserted-by":"crossref","unstructured":"Achermann Y, Rossle M, Hoffmann M, et al. Prosthetic valve endocarditis and bloodstream infection.due to mycobacterium chimaera. J Clin Microbiol. 2013;51:1769\u201373","DOI":"10.1128\/JCM.00435-13"},{"key":"1003_CR5","unstructured":"Chiesi S, Piacentin D, Salerno ND, et al. Disseminated mycobacterium chimaera infection after open heart surgery in an italian woman: a case report and a review of the literature. Infez Med 2017; 25:267\u2013269. https:\/\/www.infezmed.it\/index.php\/article?Anno=2017&numero=3&ArticoloDaVisualizzare=Vol_25_3_2017_267."},{"key":"1003_CR6","doi-asserted-by":"publisher","first-page":"e412","DOI":"10.1161\/CIR.0000000000000457","volume":"134","author":"WR Wilson","year":"2016","unstructured":"Wilson WR, Bower TC, Creager MA, et al. Vascular graft infections, mycotic aneurysms, and endovascular infections. A scientific statement from the American heart association. Circulation. 2016;134:e412\u201360. https:\/\/doi.org\/10.1161\/CIR.0000000000000457.","journal-title":"Circulation."},{"key":"1003_CR7","doi-asserted-by":"publisher","unstructured":"van Ingen J, Kohl TA, Kranzer K, et al. Global outbreak of severe mycobacterium chimaera disease.after cardiac surgery. A molecular epidemiological study. Lancet Infect Dis. 2017;17:1033\u201341. https:\/\/doi.org\/10.1016\/S1473-3099(17)30324-9.","DOI":"10.1016\/S1473-3099(17)30324-9"},{"key":"1003_CR8","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.ophtha.2016.09.032","volume":"124","author":"SA Zweifel","year":"2017","unstructured":"Zweifel SA, Mihic-Probst D, Curcio CA, et al. Clinical and histopathologic ocular findings in disseminated mycobacterium chimaera infection after cardiothoracic surgery. Ophthalmology. 2017;124:178\u201388. https:\/\/doi.org\/10.1016\/j.ophtha.2016.09.032.","journal-title":"Ophthalmology"},{"key":"1003_CR9","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jhin.2019.10.009","volume":"104","author":"B Hasse","year":"2020","unstructured":"Hasse B, Hannan MM, Keller PM, et al. International society of cardiovascular infectious diseases guidelines for the diagnosis, treatment and prevention of disseminated mycobacterium chimaera infection following cardiac surgery with cardiopulmonary bypass. J Hosp Infect. 2020;104:214\u201335. https:\/\/doi.org\/10.1016\/j.jhin.2019.10.009.","journal-title":"J Hosp Infect"}],"container-title":["Antimicrobial Resistance &amp; Infection Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13756-021-01003-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13756-021-01003-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13756-021-01003-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T13:59:38Z","timestamp":1633615178000},"score":1,"resource":{"primary":{"URL":"https:\/\/aricjournal.biomedcentral.com\/articles\/10.1186\/s13756-021-01003-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,7]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1003"],"URL":"https:\/\/doi.org\/10.1186\/s13756-021-01003-9","relation":{},"ISSN":["2047-2994"],"issn-type":[{"value":"2047-2994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,7]]},"assertion":[{"value":"5 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from the patient for publication of this case report and respective images","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent has been provided by the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests in this work, nor do they have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"141"}}