{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:28:35Z","timestamp":1788517715835,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006388","name":"University Hospitals of Geneva","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006388","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Saniswiss SA"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antimicrob Resist Infect Control"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Healthcare workers often experience skin dryness and irritation from performing hand hygiene frequently. Low acceptability and tolerability of a formulation are barriers to hand hygiene compliance, though little research has been conducted on what specific types of formulation have higher acceptability than others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the acceptability and tolerability of an ethanol-based handrub gel with superfatting agents to the isopropanol-based formulations (a rub and a gel formulation) currently used by healthcare workers at the University of Geneva Hospitals, Geneva, Switzerland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty-two participants were randomized to two sequences, testing the isopropanol-based formulation that they are using currently (Hopirub\u00ae or Hopigel\u00ae), and the ethanol-based formulation containing superfatting agents (Saniswiss Sanitizer Hands H1). Participants tested each of the formulations over 7\u201310\u00a0day work shifts, after which skin condition was assessed and feedback was collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>H1 scored significantly better than the control formulations for skin dryness (<jats:italic>P<\/jats:italic>\u2009=\u20090.0209), and participants felt less discomfort in their hands when using that formulation (<jats:italic>P<\/jats:italic>\u2009=\u20090.0448). H1 caused less skin dryness than Hopirub\u00ae\/Hopigel\u00ae (<jats:italic>P<\/jats:italic>\u2009=\u20090.0210). Though overall preference was quite polarized, 21 participants preferred H1 intervention formulation and 17 preferred the Hopirub\u00ae\/Hopigel\u00ae formulation that they normally used in their care activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a difference in acceptability and strongly polarized preferences among the participants' reactions to the formulations tested. These results indicate that giving healthcare workers a choice between different high-quality products is important to ensure maximum acceptability.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13756-022-01129-4","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T08:02:54Z","timestamp":1657872174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acceptability of an alcohol-based handrub gel with superfatting agents among healthcare workers: a randomized crossover controlled study"],"prefix":"10.1186","volume":"11","author":[{"given":"Alexandra","family":"Peters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Carry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Sauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Pittet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"1129_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jhin.2009.04.019","volume":"73","author":"B Allegranzi","year":"2009","unstructured":"Allegranzi B, Pittet D. Role of hand hygiene in healthcare-associated infection prevention. J Hosp Infect. 2009;73:305\u201315.","journal-title":"J Hosp Infect"},{"key":"1129_CR2","unstructured":"World Health Organization. World Health Organization. WHO guidelines on hand hygiene in health care: first global patient safety challenge: clean care is safer care Geneva, Switzerland. WHO (2009). https:\/\/www.who.int\/publications\/i\/item\/9789241597906 Accessed October 15, 2021."},{"key":"1129_CR3","unstructured":"World Health Organization. Tools for evaluation and feedback: Protocol for Evaluation of Tolerability and Acceptability of Alcohol-based Handrub in Use or Planned to be Introduced: Method 1. WHO (2009). http:\/\/www.who.int\/entity\/gpsc\/5may\/Protocol_for_Evaluation_of_Handrub_Meth1.doc?ua=1 Accessed October 20, 2021."},{"key":"1129_CR4","unstructured":"World Health Organization. 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The first source of funding comes from HUG. HUG financed the control products as well as the assistance given to the principal investigator (laboratory facilities, research assistants, biostatistician). The test product and part of the principal investigator's (AP) time was funded by the manufacturer of the test formulation (Saniswiss SA). Saniswiss SA was not involved in any part of the study at any time, and agreed to publication of the results regardless of whether the outcome would be favorable for their product or not. Saniswiss SA provided the alcohol-based handrub to test.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"97"}}