{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:30:00Z","timestamp":1791685800202,"version":"4.3.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Antimicrob Resist Infect Control"],"DOI":"10.1186\/s13756-025-01618-2","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:38:45Z","timestamp":1758875925000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of central line-specific dwell-times for neonatal central line associated bloodstream infections"],"prefix":"10.1186","volume":"14","author":[{"given":"Martina","family":"Buttera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Luhmann-Lunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Buettcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Lehnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"1618_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.4103\/2229-5151.164940","volume":"5","author":"C Kornbau","year":"2015","unstructured":"Kornbau C, Lee KC, Hughes GD, et al. Central line complications. Int J Crit Illn Inj Sci. 2015;5:170\u20138.","journal-title":"Int J Crit Illn Inj Sci"},{"key":"1618_CR2","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/ANC.0b013e31827e1d01","volume":"13","author":"DD Wrightson","year":"2013","unstructured":"Wrightson DD. Peripherally inserted central catheter complications in neonates with upper versus lower extremity insertion sites. Adv Neonatal Care. 2013;13:198\u2013204.","journal-title":"Adv Neonatal Care"},{"key":"1618_CR3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020352","volume":"99","author":"FKY Santos","year":"2020","unstructured":"Santos FKY, Flumignan RLG, Areias LL, et al. Peripherally inserted central catheter versus central venous catheter for intravenous access: a protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020;99: e20352.","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"1618_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S2352-4642(17)30010-X","volume":"1","author":"PKA Agyeman","year":"2017","unstructured":"Agyeman PKA, Schlapbach LJ, Giannoni E, et al. Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. Lancet Child Adolesc Health. 2017;1(2):124\u201333.","journal-title":"Lancet Child Adolesc Health"},{"key":"1618_CR5","doi-asserted-by":"publisher","first-page":"595e602","DOI":"10.1542\/peds.2005-0552","volume":"116","author":"MJ Bizzarro","year":"2005","unstructured":"Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG. Seventy-five years of neonatal sepsis at Yale: 1928\u20132003. Pediatrics. 2005;116:595e602.","journal-title":"Pediatrics"},{"key":"1618_CR6","doi-asserted-by":"publisher","first-page":"1352e8","DOI":"10.1007\/s00134-013-2927-7","volume":"39","author":"CA Smulders","year":"2013","unstructured":"Smulders CA, van Gestel JP, Bos AP. Are central line bundles and ventilator bundles effective in critically ill neonates and children? Intensive Care Med. 2013;39:1352e8.","journal-title":"Intensive Care Med"},{"key":"1618_CR7","doi-asserted-by":"publisher","first-page":"591e9","DOI":"10.1038\/jp.2009.18","volume":"29","author":"J Schulman","year":"2009","unstructured":"Schulman J, Stricof RL, Stevens TP, et al. Development of a statewide collaborative to decrease NICU central line-associated bloodstream infections. J Perinatol. 2009;29:591e9.","journal-title":"J Perinatol"},{"key":"1618_CR8","first-page":"15","volume":"15","author":"CW Trotter","year":"1996","unstructured":"Trotter CW. Percutaneous central venous catheter-related sepsis in the neonate: an analysis of the literature from 1990 to 1994. Neonatal Netw. 1996;15:15\u201328.","journal-title":"Neonatal Netw"},{"key":"1618_CR9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/00005237-199609000-00006","volume":"10","author":"CW Trotter","year":"1996","unstructured":"Trotter CW. Percutaneous central venous catheters in neonates: a descriptive analysis and evaluation of predictors for sepsis. J Perinat Neonatal Nurs. 1996;10:56\u201371.","journal-title":"J Perinat Neonatal Nurs"},{"key":"1618_CR10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1086\/501913","volume":"22","author":"LM Mahieu","year":"2001","unstructured":"Mahieu LM, De Dooy JJ, De Muynck AO, Van Melckebeke G, Ieven MM, Van Reempts PJ. Microbiology and risk factors for catheter exit-site and -hub colonization in neonatal intensive care unit patients. Infect Control Hosp Epidemiol. 2001;22:357\u201362.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1618_CR11","doi-asserted-by":"publisher","first-page":"F504","DOI":"10.1136\/adc.2004.049189","volume":"89","author":"DW Cartwright","year":"2004","unstructured":"Cartwright DW. Central venous lines in neonates: a study of 2186 catheters. Arch Dis Child Fetal Neonatal Ed. 2004;89:F504\u20138.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"1618_CR12","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jhin.2005.03.014","volume":"61","author":"WC van der Zwet","year":"2005","unstructured":"van der Zwet WC, Kaiser AM, van Elburg RM, et al. Nosocomial infections in a Dutch neonatal intensive care unit: surveillance study with definitions for infection specifically adapted for neonates. J Hosp Infect. 2005;61:300\u201311.","journal-title":"J Hosp Infect"},{"key":"1618_CR13","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1086\/526439","volume":"29","author":"JS Garland","year":"2008","unstructured":"Garland JS, Alex CP, Sevallius JM, et al. Cohort study of the pathogenesis and molecular epidemiology of catheter- related bloodstream infection in neonates with peripherally inserted central venous catheters. Infect Control Hosp Epidemiol. 2008;29:243\u20139.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1618_CR14","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1111\/j.1651-2227.2009.01322.x","volume":"98","author":"AL Olsen","year":"2009","unstructured":"Olsen AL, Reinholdt J, Jensen AM, Andersen LP, Jensen ET. Nosocomial infection in a Danish Neonatal Intensive Care Unit: a prospective study. Acta Paediatr. 2009;98:1294\u20139.","journal-title":"Acta Paediatr"},{"issue":"1","key":"1618_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1188\/13.CJON.21-24","volume":"17","author":"A Whited","year":"2013","unstructured":"Whited A, Lowe JM. Central Line-Associated Bloodstream Infection: Not Just an Intensive Care Unit Problem. Oncology Nursing Society. 2013;17(1):21\u20134.","journal-title":"Oncology Nursing Society"},{"issue":"5","key":"1618_CR16","doi-asserted-by":"publisher","first-page":"F422","DOI":"10.1136\/archdischild-2017-313362","volume":"103","author":"V Payne","year":"2018","unstructured":"Payne V, Hall M, Prieto J, Johnson M. Care bundles to reduce central line-associated bloodstream infections in the neonatal unit: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2018;103(5):F422\u20139.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"1618_CR17","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00431-020-03844-9","volume":"180","author":"S Bierlaire","year":"2021","unstructured":"Bierlaire S, Danhaive O, Carkeek K, Piersigilli F. How to minimize central line-associated bloodstream infections in a neonatal intensive care unit: a quality improvement intervention based on a retrospective analysis and the adoption of an evidence-based bundle. Eur J Pediatr. 2021;180(2):449\u201360.","journal-title":"Eur J Pediatr"},{"issue":"6","key":"1618_CR18","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1542\/peds.2015-2710","volume":"136","author":"M Shalabi","year":"2015","unstructured":"Shalabi M, Adel M, Yoon E, et al. Risk of infection using peripherally inserted central and umbilical catheters in preterm neonates. Pediatrics. 2015;136(6):1073\u20139.","journal-title":"Pediatrics"},{"issue":"3","key":"1618_CR19","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jhin.2017.06.023","volume":"97","author":"E Sanderson","year":"2017","unstructured":"Sanderson E, Yeo KT, Wang AY, et al. Dwell time and risk of central-line-associated bloodstream infection in neonates. J Hosp Infect. 2017;97(3):267\u201374.","journal-title":"J Hosp Infect"},{"issue":"4","key":"1618_CR20","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/apa.13240","volume":"105","author":"S Lindquist","year":"2016","unstructured":"Lindquist S, Hentz E, Tessin I, Elfvin A. Very low birthweight infants face an increased risk of bloodstream infections following the removal of umbilical catheters. Acta Paediatr. 2016;105(4):391\u20136.","journal-title":"Acta Paediatr"},{"issue":"4","key":"1618_CR21","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1542\/peds.2009-2559","volume":"125","author":"A Sengupta","year":"2010","unstructured":"Sengupta A, Lehmann C, Diener-West M, Perl TM, Milstone AM. Catheter duration and risk of CLA-BSI in neonates with PICCs. Pediatrics. 2010;125(4):648\u201353.","journal-title":"Pediatrics"},{"issue":"6","key":"1618_CR22","doi-asserted-by":"publisher","first-page":"e1609","DOI":"10.1542\/peds.2013-1645","volume":"132","author":"AM Milstone","year":"2013","unstructured":"Milstone AM, Reich NG, Advani S, et al. Catheter dwell time and CLABSIs in neonates with PICCs: a multicenter cohort study. Pediatrics. 2013;132(6):e1609\u201315.","journal-title":"Pediatrics"},{"key":"1618_CR23","doi-asserted-by":"publisher","first-page":"F518","DOI":"10.1136\/archdischild-2012-303149","volume":"98","author":"L Folgori","year":"2013","unstructured":"Folgori L, Bielicki J, Sharland M. A systematic review of strategies for reporting of neonatal hospital-acquired bloodstream infections. Archives of Disease in Childhood - Fetal and Neonatal Edition. 2013;98:F518\u201323.","journal-title":"Archives of Disease in Childhood - Fetal and Neonatal Edition"},{"key":"1618_CR24","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jhin.2023.11.020","volume":"144","author":"SJ Jansen","year":"2024","unstructured":"Jansen SJ, Broer SDL, Hemels MAC, et al. Central-line-associated bloodstream infection burden among Dutch neonatal intensive care units. J Hosp Infect. 2024;144:20\u20137.","journal-title":"J Hosp Infect"},{"issue":"11","key":"1618_CR25","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1007\/s10096-022-04502-8","volume":"41","author":"SJ Jansen","year":"2022","unstructured":"Jansen SJ, van der Hoeven A, van den Akker T, et al. A longitudinal analysis of nosocomial bloodstream infections among preterm neonates. Eur J Clin Microbiol Infect Dis. 2022;41(11):1327\u201336.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"5","key":"1618_CR26","first-page":"A05210463","volume":"69","author":"CL Nielsen","year":"2022","unstructured":"Nielsen CL, Zachariassen G, Holm KG. Central line-associated bloodstream infection in infants admitted to a level lllneonatal intensive care unit. Dan Med J. 2022;69(5):A05210463.","journal-title":"Dan Med J"},{"issue":"6","key":"1618_CR27","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1542\/peds.2015-0573","volume":"136","author":"RG Greenberg","year":"2015","unstructured":"Greenberg RG, Cochran KM, Smith PB, et al. Effect of catheter dwell time on risk of central line-associated bloodstream infection in infants. Pediatrics. 2015;136(6):1080\u20136.","journal-title":"Pediatrics"},{"key":"1618_CR28","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-058866","volume":"12","author":"MAA Bayoumi","year":"2022","unstructured":"Bayoumi MAA, van Rens R, Chandra P, et al. Peripherally inserted central catheters versus non-tunnelled ultrasound-guided central venous catheters in newborns: a retrospective observational study. BMJ Open. 2022;12: e058866.","journal-title":"BMJ Open"},{"issue":"8","key":"1618_CR29","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00134-017-4852-7","volume":"43","author":"RS Yamaguchi","year":"2017","unstructured":"Yamaguchi RS, Noritomi DT, Degaspare NV, et al. Peripherally inserted central catheters are associated with lower risk of bloodstream infection compared with central venous catheters in paediatric intensive care patients: a propensity-adjusted analysis. Intensive Care Med. 2017;43(8):1097\u2013104.","journal-title":"Intensive Care Med"},{"key":"1618_CR30","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jhin.2023.06.011","volume":"139","author":"G Catho","year":"2023","unstructured":"Catho G, Rosa Mangeret F, Sauvan V, et al. Risk of catheter-associated bloodstream infection by catheter type in a neonatal intensive care unit: a large cohort study of more than 1100 intravascular catheters. J Hosp Infect. 2023;139:6\u201310.","journal-title":"J Hosp Infect"},{"issue":"4","key":"1618_CR31","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/ped4.12403","volume":"7","author":"X Zheng","year":"2023","unstructured":"Zheng X, He D, Yang Z, et al. Dwell time and bloodstream infection incidence of umbilical venous catheterization in China. Pediatr Investig. 2023;7(4):239\u201346.","journal-title":"Pediatr Investig"},{"issue":"7","key":"1618_CR32","doi-asserted-by":"publisher","first-page":"e293","DOI":"10.1111\/apa.12256","volume":"102","author":"DF Yumani","year":"2013","unstructured":"Yumani DF, van den Dungen FA, van Weissenbruch MM. Incidence and risk factors for catheter-associated bloodstream infections in neonatal intensive care. Acta Paediatr. 2013;102(7):e293\u20138.","journal-title":"Acta Paediatr"},{"key":"1618_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2023.105752","volume":"179","author":"S Hess","year":"2023","unstructured":"Hess S, Poryo M, Ruckes C, et al. Assessment of an umbilical venous catheter dwell-time of 8\u201314 days versus 1\u20137 days in very low birth weight infacts (UVC - You Will See): a pilot single-center, randomized controlled trial. Early Hum Dev. 2023;179: 105752.","journal-title":"Early Hum Dev"},{"issue":"1","key":"1618_CR34","volume":"13","author":"L Corso","year":"2022","unstructured":"Corso L, Buttera M, Candia F, et al. Infectious risks related to umbilical venous catheter dwell time and its replacement in newborns: a narrative review of current evidence. Life (Basel). 2022;13(1): 123.","journal-title":"Life (Basel)"},{"key":"1618_CR35","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jpeds.2021.12.059","volume":"244","author":"F Grasso","year":"2022","unstructured":"Grasso F, Capasso A, Pacella D, et al. Ultrasound Guided Catheter Tip Location in Neonates: A Prospective Cohort Study. J Pediatr. 2022;244:86-91.e2.","journal-title":"J Pediatr"},{"issue":"1","key":"1618_CR36","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3233\/NPM-180205","volume":"13","author":"R Sabouneh","year":"2020","unstructured":"Sabouneh R, Akiki P, Al Bizri A, El Helou S, Zeidan S, Al Hamod D. Ultrasound guided central line insertion in neonates: pain score results from a prospective study. J Neonatal Perinatal Med. 2020;13(1):129\u201334.","journal-title":"J Neonatal Perinatal Med"},{"issue":"2","key":"1618_CR37","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/pr.2016.74","volume":"80","author":"CS Lau","year":"2016","unstructured":"Lau CS, Chamberlain RS. Ultrasound-guided central venous catheter placement increases success rates in pediatric patients: a meta-analysis. Pediatr Res. 2016;80(2):178\u201384.","journal-title":"Pediatr Res"},{"issue":"12","key":"1618_CR38","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1017\/ice.2016.203","volume":"37","author":"M Dahan","year":"2016","unstructured":"Dahan M, O\u2019Donnell S, Hebert J, et al. CLABSI Risk Factors in the NICU: Potential for Prevention: A PICNIC Study. Infect Control Hosp Epidemiol. 2016;37(12):1446\u201352.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1618_CR39","first-page":"63e71","volume":"129","author":"BJ Stoll","year":"1996","unstructured":"Stoll BJ, Gordon T, Korones SB, et al. Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Develop- ment Neonatal Research Network. J Pediatr. 1996;129:63e71.","journal-title":"J Pediatr"},{"key":"1618_CR40","doi-asserted-by":"publisher","first-page":"42e9","DOI":"10.1086\/657634","volume":"32","author":"W Zingg","year":"2011","unstructured":"Zingg W, Posfay-Barbe KM, Pfister RE, Touveneau S, Pittet D. Individualised catheter surveillance among neonates: a prospective, 8-year, single-center experience. Infect Control Hosp Epidemiol. 2011;32:42e9.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1618_CR41","doi-asserted-by":"publisher","first-page":"547e9","DOI":"10.1038\/sj.jp.7210792","volume":"22","author":"S Struthers","year":"2002","unstructured":"Struthers S, Underhill H, Albersheim S, Greenberg D, Dobson S. A comparison of two versus one blood culture in the diagnosis and treatment of coagulase-negative staphylococcus in the neonatal intensive care unit. J Perinatol. 2002;22:547e9.","journal-title":"J Perinatol"},{"issue":"6","key":"1618_CR42","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3389\/fped.2018.00294","volume":"12","author":"KE Steinmann","year":"2018","unstructured":"Steinmann KE, Lehnick D, Buettcher M, et al. Impact of Empowering Leadership on Antimicrobial Stewardship: A Single Center Study in a Neonatal and Pediatric Intensive Care Unit and a Literature Review. Front Pediatr. 2018;12(6):294.","journal-title":"Front Pediatr"},{"issue":"S 02","key":"1618_CR43","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1055\/s-0040-1713605","volume":"37","author":"SA Pearlman","year":"2020","unstructured":"Pearlman SA. Quality improvement to reduce neonatal CLABSI: the journey to zero. Am J Perinatol. 2020;37(S 02):S14\u20137.","journal-title":"Am J Perinatol"}],"container-title":["Antimicrobial Resistance &amp; Infection Control"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13756-025-01618-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13756-025-01618-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13756-025-01618-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:05:40Z","timestamp":1758881140000},"score":1,"resource":{"primary":{"URL":"https:\/\/aricjournal.biomedcentral.com\/articles\/10.1186\/s13756-025-01618-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1618"],"URL":"https:\/\/doi.org\/10.1186\/s13756-025-01618-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6633395\/v1","asserted-by":"object"}]},"ISSN":["2047-2994"],"issn-type":[{"value":"2047-2994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"10 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Regional Ethics Committee (EKNZ) in Switzerland and the need for an informed consent was waived by the EKNZ (Project ID: 2022\u201302209).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"106"}}