{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:20:22Z","timestamp":1778260822623,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T00:00:00Z","timestamp":1420588800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s40001-014-0076-2","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T12:07:38Z","timestamp":1420546058000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["An immunohistochemical study of CD83- and CD1a-positive dendritic cells in the decidua of women with recurrent spontaneous abortion"],"prefix":"10.1186","volume":"20","author":[{"given":"Zhi-Da","family":"Qian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,7]]},"reference":[{"key":"76_CR1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0140-6736(06)69204-0","volume":"368","author":"R Rai","year":"2006","unstructured":"Rai R, Regan L: Recurrent miscarriage.\n                  Lancet 2006, 368:601\u2013611.","journal-title":"Lancet"},{"key":"76_CR2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1046\/j.8755-8920.2003.00120.x","volume":"51","author":"S Blois","year":"2004","unstructured":"Blois S, Alba Soto CD, Olmos S, Chuluyan E, Gentile T, Arck PC, Margni RA: Therapy with dendritic cells influences the spontaneous resorption rate in the CBA\/J x DBA\/2\u00a0J mouse model.\n                  Am J Reprod Immunol 2004, 51:40\u201348.","journal-title":"Am J Reprod Immunol"},{"key":"76_CR3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1159\/000087951","volume":"89","author":"U Kammerer","year":"2005","unstructured":"Kammerer U: Antigen-presenting cells in the decidua.\n                  Chem Immunol Allerg 2005, 89:96\u2013104.","journal-title":"Chem Immunol Allerg"},{"key":"76_CR4","first-page":"171","volume":"26","author":"D Sanguansermsri","year":"2008","unstructured":"Sanguansermsri D, Pongcharoen S: Pregnancy immunology: decidual immune cells.\n                  Asian Pac J Allergy Immunol 2008, 26:171\u2013181.","journal-title":"Asian Pac J Allergy Immunol"},{"key":"76_CR5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1146\/annurev.iy.09.040191.001415","volume":"9","author":"RM Steinman","year":"1991","unstructured":"Steinman RM: The dendritic cell system and its role in immunogenicity.\n                  Annu Rev Immunol 1991, 9:271\u2013296.","journal-title":"Annu Rev Immunol"},{"key":"76_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/32588","volume":"392","author":"J Banchereau","year":"1998","unstructured":"Banchereau J, Steinman RM: Dendritic cells and the control of immunity.\n                  Nature 1998, 392:245\u2013252.","journal-title":"Nature"},{"key":"76_CR7","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","volume":"18","author":"J Banchereau","year":"2000","unstructured":"Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K: Immunobiology of dendritic cells.\n                  Annu Rev Immunol 2000, 18:767\u2013811.","journal-title":"Annu Rev Immunol"},{"key":"76_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1196\/annals.1366.004","volume":"1088","author":"A Chorny","year":"2006","unstructured":"Chorny A, Gonzalez-Rey E, Delgado M: Regulation of dendritic cell differentiation by vasoactive intestinal peptide: therapeutic applications on autoimmunity and transplantation.\n                  Ann NY Acad Sci 2006, 1088:187\u2013194.","journal-title":"Ann NY Acad Sci"},{"key":"76_CR9","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1046\/j.1365-2141.2001.02626.x","volume":"112","author":"DC Reid","year":"2001","unstructured":"Reid DC: Dendritic cells and immunotherapy for malignant cells.\n                  Br J Haematol 2001, 112:874\u2013875.","journal-title":"Br J Haematol"},{"key":"76_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/(SICI)1098-2353(2000)13:3<177::AID-CA3>3.0.CO;2-7","volume":"13","author":"S Abraham","year":"2000","unstructured":"Abraham S, Indrasingh I, Vettivel S, Chandi G: Gross morphology and ultrastructure of dendritic cells in the normal human decidua.\n                  Clin Anat 2000, 13:177\u2013180.","journal-title":"Clin Anat"},{"key":"76_CR11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00403-007-0743-z","volume":"299","author":"AT Prechtel","year":"2007","unstructured":"Prechtel AT, Steinkasserer A: CD83: an update on functions and prospects of the maturation marker of dendritic cells.\n                  Arch Dermatol Res 2007, 299:59\u201369.","journal-title":"Arch Dermatol Res"},{"key":"76_CR12","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/978-1-4757-9966-8_92","volume":"417","author":"BJ Coventry","year":"1997","unstructured":"Coventry BJ, Austyn JM, Chryssidis S, Hankins D, Harris A: Identification and isolation of CD1a positive putative tumour infiltrating dendritic cells in human breast cancer.\n                  Adv Exp Med Biol 1997, 417:571\u2013577.","journal-title":"Adv Exp Med Biol"},{"key":"76_CR13","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1095\/biolreprod.103.017574","volume":"69","author":"L Gardner","year":"2003","unstructured":"Gardner L, Moffett A: Dendritic cells in the human decidua.\n                  Biol Reprod 2003, 69:1438\u20131446.","journal-title":"Biol Reprod"},{"key":"76_CR14","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1182\/blood-2005-08-3507","volume":"108","author":"MS von Bergwelt-Baildon","year":"2006","unstructured":"von Bergwelt-Baildon MS, Popov A, Saric T, Chemnitz J, Classen S, Stoffel MS, Fiore F, Roth U, Beyer M, Debey S, Wickenhauser C, Hanisch FG, Schultze JL: CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.\n                  Blood 2006, 108:228\u2013237.","journal-title":"Blood"},{"key":"76_CR15","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.jaci.2007.01.039","volume":"119","author":"T Koya","year":"2007","unstructured":"Koya T, Matsuda H, Takeda K, Matsubara S, Miyahara N, Balhorn A, Dakhama A, Gelfand EW: IL-10-treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice.\n                  J Allergy Clin Immunol 2007, 119:1241\u20131250.","journal-title":"J Allergy Clin Immunol"},{"key":"76_CR16","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.4049\/jimmunol.164.3.1346","volume":"164","author":"A Khanna","year":"2000","unstructured":"Khanna A, Morelli AE, Zhong C, Takayama T, Lu L, Thomson AW: Effects of liver-derived dendritic cell progenitors on Th1-and Th2-like cytokine responses in vitro and in vivo.\n                  J Immunol 2000, 164:1346\u20131354.","journal-title":"J Immunol"},{"key":"76_CR17","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s00109-008-0342-2","volume":"86","author":"SM Blois","year":"2008","unstructured":"Blois SM, Barrientos G, Garcia MG, Orsal AS, Tometten M, Cordo-Russo RI, Klapp BF, Santoni A, Fern\u00e1ndez N, Terness P, Arck PC: Interaction between dendritic cells and natural killer cells during pregnancy in mice.\n                  J Mol Med 2008, 86:837\u2013852.","journal-title":"J Mol Med"},{"key":"76_CR18","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/j.1365-3083.2006.01841.x","volume":"64","author":"S Miranda","year":"2006","unstructured":"Miranda S, Litwin S, Barrientos G, Szereday L, Chuluyan E, Bartho JS, Arck PC, Blois SM: Dendritic cells therapy confers a protective microenvironment in murine pregnancy.\n                  Scand J Immunol 2006, 64:493\u2013499.","journal-title":"Scand J Immunol"},{"key":"76_CR19","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S0143-4004(03)00182-6","volume":"25","author":"K Askelund","year":"2004","unstructured":"Askelund K, Liddell HS, Zanderigo AM, Fernando NS, Khong TY, Stone PR, Chamley LW: CD83(+) dendritic cells in the decidua of women with recurrent miscarriage and normal pregnancy.\n                  Placenta 2004, 25:140\u2013145.","journal-title":"Placenta"},{"key":"76_CR20","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0002-9440(10)64527-0","volume":"157","author":"U K\u00e4mmerer","year":"2000","unstructured":"K\u00e4mmerer U, Schoppet M, McLellan AD, Kapp M, Huppertz HI, K\u00e4mpgen E, Dietl J: Human decidua contains potent immunostimulatory CD83(+) dendritic cells.\n                  Am J Pathol 2000, 157:159\u2013169.","journal-title":"Am J Pathol"},{"key":"76_CR21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000024441","volume":"123","author":"GB Dealtry","year":"2000","unstructured":"Dealtry GB, O\u2019Farrell MK, Fernandez N: The Th2 cytokine environment of the placenta.\n                  Int Arch Allergy Immunol 2000, 123:107\u2013119.","journal-title":"Int Arch Allergy Immunol"},{"key":"76_CR22","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000074300","volume":"134","author":"G Chaouat","year":"2004","unstructured":"Chaouat G, Ledee-Bataille N, Dubanchet S, Zourbas S, Sandra O, Martal J: TH1\/TH2 paradigm in pregnancy: paradigm lost? Cytokines in pregnancy\/early abortion: reexamining the TH1\/TH2 paradigm.\n                  Int Arch Allergy Immunol 2004, 134:93\u2013119.","journal-title":"Int Arch Allergy Immunol"},{"key":"76_CR23","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/j.1582-4934.2007.00084.x","volume":"12","author":"N Cools","year":"2008","unstructured":"Cools N, Van Tendeloo VF, Smits EL, Lenjou M, Nijs G, Van Bockstaele DR, Berneman ZN, Ponsaerts P: Immuno-suppression induced by immature dendritic cells is mediated by TGF-beta\/IL-10 double - positive CD4\u2009+\u2009regulatory T cells.\n                  J Cell Mol Med 2008, 12:690\u2013700.","journal-title":"J Cell Mol Med"},{"key":"76_CR24","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1537-2995.2007.01103.x","volume":"47","author":"A Encabo","year":"2007","unstructured":"Encabo A, Solves P, Carbonell-Uberos F, Minana MD: The functional immaturity of dendritic cells can be relevant to increased tolerance associated with cord blood transplantation.\n                  Transfusion 2007, 47:272\u2013279.","journal-title":"Transfusion"},{"key":"76_CR25","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1095\/biolreprod.103.022640","volume":"70","author":"SM Blois","year":"2004","unstructured":"Blois SM, Alba Soto CD, Tometten M, Klapp BF, Margni RA, Arck PC: Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy.\n                  Biol Reprod 2004, 70:1018\u20131023.","journal-title":"Biol Reprod"},{"key":"76_CR26","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/molehr\/gah246","volume":"11","author":"N Miwa","year":"2005","unstructured":"Miwa N, Hayakawa S, Miyazaki S, Myojo S, Sasaki Y, Sakai M, Takikawa O, Saito S: IDO expression on decidual and peripheral blood dendritic cells and monocytes\/macrophages after treatment with CTLA-4 or interferon-\u03b3 increase in normal pregnancy but decrease in spontaneous abortion.\n                  Mol Hum Reprod 2005, 11:865\u2013870.","journal-title":"Mol Hum Reprod"},{"key":"76_CR27","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/j.1365-2249.2007.03576.x","volume":"151","author":"YL Ban","year":"2008","unstructured":"Ban YL, Kong BH, Qu X, Yang QF, Ma YY: BDCA-1+, BDCA-2+ and BDCA-3+ dendritic cells in early human pregnancy decidua.\n                  Clin Exp Immunol 2008, 151:399\u2013406.","journal-title":"Clin Exp Immunol"},{"key":"76_CR28","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/08820130802191334","volume":"37","author":"U Kammerer","year":"2008","unstructured":"Kammerer U, Kruse A, Barrientos G, Arck PC, Blois SM: Role of dendritic cells in the regulation of maternal immune responses to the fetus during mammalian gestation.\n                  Immunol Invest 2008, 37:499\u2013533.","journal-title":"Immunol Invest"},{"key":"76_CR29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jri.2005.01.003","volume":"65","author":"AC Zenclussen","year":"2005","unstructured":"Zenclussen AC: CD4\u2009+\u2009CD25+ regulatory T cells in murine pregnancy.\n                  J Reprod Immunol 2005, 65:101\u2013110.","journal-title":"J Reprod Immunol"},{"key":"76_CR30","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1365-2567.2004.01869.x","volume":"112","author":"DA Somerset","year":"2004","unstructured":"Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT: Normal human pregnancy is associated with an elevation in the immune suppressive CD25\u2009+\u2009CD4+ regulatory T-cell subset.\n                  Immunology 2004, 112:38\u201343.","journal-title":"Immunology"},{"key":"76_CR31","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1016\/j.fertnstert.2009.11.020","volume":"94","author":"S Mei","year":"2010","unstructured":"Mei S, Tan J, Chen H, Chen Y, Zhang J: Changes of CD4\u2009+\u2009CD25 high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients.\n                  Fertil Steril 2010, 94:2244\u20132247.","journal-title":"Fertil Steril"},{"key":"76_CR32","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.cell.2006.05.035","volume":"126","author":"A Savina","year":"2006","unstructured":"Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Moura IC, Lennon-Dum\u00e9nil AM, Seabra MC, Raposo G, Amigorena S: NOX2 controls phagosomal PH to regulate antigen processing during crosspresentation by dendritic cells.\n                  Cell 2006, 126:205\u2013218.","journal-title":"Cell"},{"key":"76_CR33","doi-asserted-by":"publisher","first-page":"4676","DOI":"10.4049\/jimmunol.172.8.4676","volume":"172","author":"N Misra","year":"2004","unstructured":"Misra N, Bayry J, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV: Cutting edge human CD4\u2009+\u2009CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells.\n                  J Immunol 2004, 172:4676\u20134680.","journal-title":"J Immunol"},{"key":"76_CR34","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ijgo.2009.09.019","volume":"108","author":"BY Zhang","year":"2010","unstructured":"Zhang BY, Wei YS, Niu JM, Li Y, Miao ZL, Wang ZN: Risk factors for unexplained recurrent spontaneous abortion in a population from southern China.\n                  Int J Gynaecol Obstet 2010, 108:135\u2013138.","journal-title":"Int J Gynaecol Obstet"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-014-0076-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s40001-014-0076-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-014-0076-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-014-0076-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T07:08:34Z","timestamp":1630566514000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-014-0076-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,7]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["76"],"URL":"https:\/\/doi.org\/10.1186\/s40001-014-0076-2","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,7]]},"assertion":[{"value":"20 January 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"2"}}