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Resistance of\n                      <jats:italic>Candida<\/jats:italic>\n                      to antifungal therapy has been reported as a public health problem. So, the objective of our current study is to detect resistance profile of different candidal strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, isolated\n                      <jats:italic>Candida<\/jats:italic>\n                      strains were identified by conventional methods, confirmed by internal transcribed spacer (ITS) sequencing, and phylogenetically analyzed with reference strains in GenBank. Also, sensitivity of different Candida strains to common antifungal agents was evaluated by disc diffusion method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      was identified as the most frequent strain (63%) followed by non-\n                      <jats:italic>albicans<\/jats:italic>\n                      strains, such as\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      (20%),\n                      <jats:italic>C. tropicalis<\/jats:italic>\n                      (13%), and\n                      <jats:italic>C. krusei<\/jats:italic>\n                      (4%). Sensitivity of\n                      <jats:italic>Candida<\/jats:italic>\n                      strains (\n                      <jats:italic>C. albicans<\/jats:italic>\n                      ,\n                      <jats:italic>C. tropicalis<\/jats:italic>\n                      and\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      ) to commonly used antifungal agents was evaluated through the disc diffusion method.\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      was the most resistant strain and considered to be a multidrug-resistant pathogen, while both,\n                      <jats:italic>C. albicans<\/jats:italic>\n                      and\n                      <jats:italic>C. tropicalis<\/jats:italic>\n                      showed high susceptibility to terbinafine. In contrast,\n                      <jats:italic>C. albicans<\/jats:italic>\n                      showed resistance to fluconazole, clotrimazole, and nystatin, while\n                      <jats:italic>C. tropicalis,<\/jats:italic>\n                      considered as the most sensitive strain, was susceptible to all the antifungal agents tested except nystatin. Terbinafine was the most effective antifungal agent against both\n                      <jats:italic>C. tropicalis<\/jats:italic>\n                      and\n                      <jats:italic>C. albicans,<\/jats:italic>\n                      and hence its minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for\n                      <jats:italic>C. albicans<\/jats:italic>\n                      and\n                      <jats:italic>C. tropicalis<\/jats:italic>\n                      were evaluated. MICs of terbinafine against\n                      <jats:italic>C. albicans<\/jats:italic>\n                      and\n                      <jats:italic>C. tropicalis<\/jats:italic>\n                      were 5\u00a0\u03bcg\/ml and 2.5\u00a0\u03bcg\/ml, while their MFCs were 10\u00a0\u03bcg\/ml and 5\u00a0\u03bcg\/ml, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The emergence of resistant\n                      <jats:italic>Candida<\/jats:italic>\n                      strains necessitates conduction of the antifungal susceptibility test prior to deciding the medication regime.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40001-019-0399-0","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T04:03:11Z","timestamp":1578110591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["In vitro antifungal resistance profile of Candida strains isolated from Saudi women suffering from vulvovaginitis"],"prefix":"10.1186","volume":"25","author":[{"given":"Mohamed T.","family":"Yassin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf A.","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz A.","family":"Al-Askar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashad","family":"Bdeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,4]]},"reference":[{"issue":"2","key":"399_CR1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.immuni.2015.01.008","volume":"42","author":"SW Kashem","year":"2015","unstructured":"Kashem SW, Igy\u00e1rt\u00f3 BZ, Gerami-Nejad M, Kumamoto Y, Mohammed J, Jarrett E, Drummond RA, Zurawski SM, Zurawski G, Berman J. 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