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RR was started at 10 breaths\/min, and 2 breaths\/min were added every 60\u00a0min until 16 breaths\/min was reached. At every point, central venous and arterial blood gas measurements were obtained simultaneously.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In this study, gapCO<jats:sub>2<\/jats:sub> induced by hyperventilation significantly increased, while the central venous carbon dioxide pressure (PvCO<jats:sub>2<\/jats:sub>) and the partial pressure of CO<jats:sub>2<\/jats:sub> (PaCO<jats:sub>2<\/jats:sub>) in arteries decreased. The decreasing trend of the PaCO<jats:sub>2<\/jats:sub> was more obvious than that of the PvCO<jats:sub>2<\/jats:sub>. HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> and ctCO<jats:sub>2<\/jats:sub> were markedly decreased, when the RR was increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Central venous oxygen saturation (S<jats:sub>cv<\/jats:sub>O<jats:sub>2<\/jats:sub>) had a decreasing trend between 14 (77.1\u2009\u00b1\u20098.3%) and 16 (75.2\u2009\u00b1\u20098.7%) breaths\/min; however, the difference was not significant.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In septic patients undergoing ventilation, respiratory alkalosis induced by hyperventilation caused an increase in the gapCO<jats:sub>2<\/jats:sub>. Clinicians should cautiously interpret the gapCO<jats:sub>2<\/jats:sub> in hemodynamically stable ventilated septic shock patients and its relationship with low cardiac output and inadequate perfusion.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s40001-020-00402-9","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T11:02:39Z","timestamp":1584442959000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of respiratory rate on venous-to-arterial CO2 tension difference in septic shock patients undergoing volume mechanical ventilation"],"prefix":"10.1186","volume":"25","author":[{"given":"Zhixiang","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yapeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guofang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuedong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"issue":"2","key":"402_CR1","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","volume":"41","author":"RP Dellinger","year":"2013","unstructured":"Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. 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