{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:14:08Z","timestamp":1784823248182,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Key Research and Development Project","award":["2017YFC1200800"],"award-info":[{"award-number":["2017YFC1200800"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hematological comparison of coronavirus disease (COVID-19) and other viral pneumonias can provide insights into COVID-19 treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this retrospective case\u2013control single-center study, we compared the data of 126 patients with viral pneumonia during different outbreaks [severe acute respiratory syndrome (SARS) in 2003, influenza A (H1N1) in 2009, human adenovirus type 7 in 2018, and COVID-19 in 2020].<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One of the COVID-19 characteristics was a continuous decline in the hemoglobin level. The neutrophil count was related to the aggravation of COVID-19 and SARS. Thrombocytopenia occurred in patients with SARS and severe COVID-19 even at the recovery stage. Lymphocytes were related to the entire course of adenovirus infection, recovery of COVID-19, and disease development of SARS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Dynamic changes in hematological counts could provide a reference for the pathogenesis and prognosis of pneumonia caused by respiratory viruses in clinics.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-021-00515-9","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T08:03:06Z","timestamp":1620979386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patient hematology during hospitalization for viral pneumonia caused by SARS-CoV-2 and non-SARS-CoV-2 agents: a retrospective study"],"prefix":"10.1186","volume":"26","author":[{"given":"Bingke","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengtao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenv","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panyong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"515_CR1","unstructured":"World Health Organization. Coronavirus disease (COVID-19) pandemic. https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019. Accessed 12 May 2020."},{"key":"515_CR2","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1172\/JCI137244","volume":"130","author":"G Chen","year":"2020","unstructured":"Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130:2620\u20139.","journal-title":"J Clin Invest"},{"key":"515_CR3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","volume":"395","author":"N Chen","year":"2020","unstructured":"Chen N, Zhou M, Dong X, Qu JM, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507\u201313.","journal-title":"Lancet"},{"key":"515_CR4","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1001\/jama.2020.12839","volume":"324","author":"WJ Wiersinga","year":"2020","unstructured":"Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. JAMA. 2020;324:782\u201393.","journal-title":"JAMA"},{"key":"515_CR5","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1002\/hed.26269","volume":"42","author":"LA Vaira","year":"2020","unstructured":"Vaira LA, Hopkins C, Salzano G, Petrocelli M, Melis A, Cucurullo M, et al. Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head Neck. 2020;42:1560\u20139.","journal-title":"Head Neck"},{"key":"515_CR6","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/hed.26204","volume":"42","author":"LA Vaira","year":"2020","unstructured":"Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: single-center experience on 72 cases. Head Neck. 2020;42:1252\u20138.","journal-title":"Head Neck"},{"key":"515_CR7","first-page":"7861","volume":"24","author":"A De Vito","year":"2020","unstructured":"De Vito A, Geremia N, Fiore V, Princic E, Babudieri S, Madeddu G. Clinical features, laboratory findings and predictors of death in hospitalized patients with COVID-19 in Sardinia, Italy. Eur Rev Med Pharmacol Sci. 2020;24:7861\u20138.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"515_CR8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/S1473-3099(20)30402-3","volume":"21","author":"C Guarneri","year":"2021","unstructured":"Guarneri C, Rullo EV, Pavone P, Berretta M, Ceccarelli M, Natale A, et al. Silent COVID-19: what your skin can reveal. Lancet Infect Dis. 2021;21:24\u20135.","journal-title":"Lancet Infect Dis"},{"key":"515_CR9","doi-asserted-by":"publisher","first-page":"e13427","DOI":"10.1111\/eci.13427","volume":"51","author":"A Zinellu","year":"2021","unstructured":"Zinellu A, Arru F, De Vito A, Sassu A, Valdes G, Scano V, et al. The de ritis ratio as prognostic biomarker of in-hospital mortality in COVID-19 patients. Eur J Clin Invest. 2021;51:e13427.","journal-title":"Eur J Clin Invest"},{"key":"515_CR10","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3389\/fncel.2018.00386","volume":"12","author":"K Bohmwald","year":"2018","unstructured":"Bohmwald K, Galvez NMS, Rios M, Kalergis AM. Neurologic alterations due to respiratory virus infections. Front Cell Neurosci. 2018;12:386.","journal-title":"Front Cell Neurosci"},{"key":"515_CR11","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/MCP.0b013e328351f8d4","volume":"18","author":"T Jartti","year":"2012","unstructured":"Jartti T, Jartti L, Ruuskanen O, Soderlund-Venermo M. New respiratory viral infections. Curr Opin Pulm Med. 2012;18:271\u20138.","journal-title":"Curr Opin Pulm Med"},{"key":"515_CR12","doi-asserted-by":"publisher","first-page":"ftz018","DOI":"10.1093\/femspd\/ftz018","volume":"77","author":"N Vonesch","year":"2019","unstructured":"Vonesch N, Binazzi A, Bonafede M, Melis P, Ruggieri A, Iavicoli S, et al. Emerging zoonotic viral infections of occupational health importance. Pathog Dis. 2019;77:ftz018.","journal-title":"Pathog Dis"},{"key":"515_CR13","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nature05495","volume":"445","author":"D Kobasa","year":"2007","unstructured":"Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, et al. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature. 2007;445:319\u201323.","journal-title":"Nature"},{"key":"515_CR14","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1503\/cmaj.109-2028","volume":"181","author":"VC McAlister","year":"2009","unstructured":"McAlister VC. H1N1-related SIRS? CMAJ. 2009;181:616\u20137.","journal-title":"CMAJ"},{"key":"515_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa465","author":"SA Kujawski","year":"2020","unstructured":"Kujawski SA, Lu X, Schneider E, Blythe D, Boktor S, Farrehi J, et al. Outbreaks of adenovirus-associated respiratory illness on five college campuses in the United States. Clin Infect Dis. 2020. https:\/\/doi.org\/10.1093\/cid\/ciaa465.","journal-title":"Clin Infect Dis"},{"key":"515_CR16","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1002\/jmv.20441","volume":"77","author":"B Chmielewicz","year":"2005","unstructured":"Chmielewicz B, Benzler J, Pauli G, Krause G, Bergmann F, Schweiger B. Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey. J Med Virol. 2005;77:232\u20137.","journal-title":"J Med Virol"},{"key":"515_CR17","first-page":"566","volume":"221","author":"KK Coleman","year":"2020","unstructured":"Coleman KK, Wong CC, Jayakumar J, Nguyen TT, Wong AWL, Yadana S, et al. Adenoviral infections in Singapore: should new antiviral therapies and vaccines be adopted? J Infect Dis. 2020;221:566\u201377.","journal-title":"J Infect Dis"},{"key":"515_CR18","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1186\/s12879-018-3520-z","volume":"18","author":"L Xu","year":"2018","unstructured":"Xu L, Liu J, Liu C, Duan Y, Zhu Y, Xu B, et al. Case-control study of the epidemiological and clinical features of human adenovirus 55 and human adenovirus 7 infection in children with acute lower respiratory tract infections in Beijing, China, 2008\u20132013. BMC Infect Dis. 2018;18:634.","journal-title":"BMC Infect Dis"},{"key":"515_CR19","first-page":"311","volume":"14","author":"M Yang","year":"2004","unstructured":"Yang M, Li CK, Li K, Hon KLE, Ng MHL, Chan PKS, et al. Hematological findings in SARS patients and possible mechanisms (review). Int J Mol Med. 2004;14:311\u20135.","journal-title":"Int J Mol Med"},{"key":"515_CR20","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1515\/cclm-2020-0377","volume":"58","author":"Y Zheng","year":"2020","unstructured":"Zheng Y, Zhang Y, Chi H, Chen S, Peng M, Luo L, et al. The hemocyte counts as a potential biomarker for predicting disease progression in COVID-19: a retrospective study. Clin Chem Lab Med. 2020;58:1106\u201315.","journal-title":"Clin Chem Lab Med"},{"key":"515_CR21","doi-asserted-by":"publisher","first-page":"5725","DOI":"10.3390\/molecules25235725","volume":"25","author":"AG Fois","year":"2020","unstructured":"Fois AG, Paliogiannis P, Scano V, Gau S, Babudieri S, Perra R, et al. The systemic inflammation index on admission predicts in-hospital mortality in COVID-19 patients. Molecules. 2020;25:5725.","journal-title":"Molecules"},{"key":"515_CR22","first-page":"1","volume":"28","author":"P Paliogiannis","year":"2021","unstructured":"Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clin Exp Med. 2021;28:1\u201312.","journal-title":"Clin Exp Med"},{"key":"515_CR23","doi-asserted-by":"publisher","first-page":"e53614","DOI":"10.1371\/journal.pone.0053614","volume":"8","author":"CY Lai","year":"2013","unstructured":"Lai CY, Lee CJ, Lu CY, Lee PI, Shao PL, Wu ET, et al. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010\u20132011. PLoS ONE. 2013;8:e53614.","journal-title":"PLoS ONE"},{"key":"515_CR24","doi-asserted-by":"publisher","first-page":"685","DOI":"10.3855\/jidc.12879","volume":"14","author":"P Paliogiannis","year":"2020","unstructured":"Paliogiannis P, Zinellu A, Scano V, Mulas G, De Riu G, Pascale RM, et al. Laboratory test alterations in patients with COVID-19 and non COVID-19 interstitial pneumonia: a preliminary report. J Infect Dev Ctries. 2020;14:685\u201390.","journal-title":"J Infect Dev Ctries"},{"key":"515_CR25","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.2214\/AJR.20.23214","volume":"215","author":"Z Yin","year":"2020","unstructured":"Yin Z, Kang Z, Yang D, Ding S, Luo H, Xiao E. A comparison of clinical and chest CT findings in patients with influenza A (H1N1) virus infection and coronavirus disease (COVID-19). AJR Am J Roentgenol. 2020;215:1065\u201371.","journal-title":"AJR Am J Roentgenol"},{"key":"515_CR26","doi-asserted-by":"publisher","first-page":"3401","DOI":"10.2147\/IDR.S264132","volume":"13","author":"J Jiang","year":"2020","unstructured":"Jiang J, Wan R, Pan P, Hu C, Zhou R, Yin Y, et al. Comparison of clinical, laboratory and radiological characteristics between COVID-19 and adenovirus pneumonia: a retrospective study. Infect Drug Resist. 2020;13:3401\u20138.","journal-title":"Infect Drug Resist"},{"key":"515_CR27","doi-asserted-by":"publisher","first-page":"m1071","DOI":"10.1136\/bmj.m1071","volume":"368","author":"E Mahase","year":"2020","unstructured":"Mahase E. Covid-19: outbreak could last until Spring 2021 and see 7.9 million hospitalised in the UK. BMJ. 2020;368:m1071.","journal-title":"BMJ"},{"key":"515_CR28","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.3201\/eid2606.200299","volume":"26","author":"X Wu","year":"2020","unstructured":"Wu X, Cai Y, Huang X, Yu X, Zhao L, Wang F, et al. Co-infection with SARS-CoV-2 and influenza A virus in patient with pneumonia. China Emerg Infect Dis. 2020;26:1324\u20136.","journal-title":"China Emerg Infect Dis"},{"key":"515_CR29","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.jinf.2019.04.006","volume":"78","author":"R M\u00e9ndez","year":"2019","unstructured":"M\u00e9ndez R, Men\u00e9ndez R, Amara-Elori I, Feced L, Piro A, Ramirez P, et al. Lymphopenic community acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality. J Infect. 2019;78:423\u201331.","journal-title":"J Infect"},{"key":"515_CR30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.rmed.2017.11.017","volume":"134","author":"F Zhou","year":"2018","unstructured":"Zhou F, Li H, Gu L, Liu M, Xue CX, Cao B, et al. Risk factors for nosocomial infection among hospitalised severe influenza A (H1N1)pdm09 patients. Respir Med. 2018;134:86\u201391.","journal-title":"Respir Med"},{"key":"515_CR31","doi-asserted-by":"publisher","first-page":"17809","DOI":"10.1038\/srep17809","volume":"5","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Huang T, Yu F, Liu X, Zhao C, Chen X, et al. Infectious progeny of 2009 A (H1N1) influenza virus replicated in and released from human neutrophils. Sci Rep. 2015;5:17809.","journal-title":"Sci Rep"},{"key":"515_CR32","doi-asserted-by":"publisher","first-page":"e00567","DOI":"10.1128\/mSphereDirect.00567-17","volume":"3","author":"N Malachowa","year":"2018","unstructured":"Malachowa N, Freedman B, Sturdevant DE, Kobayashi SD, Nair V, Feldman F, et al. Differential ability of pandemic and seasonal H1N1 influenza A viruses to alter the function of human neutrophils. mSphere. 2018;3:e00567-e617.","journal-title":"mSphere"},{"key":"515_CR33","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1128\/JVI.01210-07","volume":"82","author":"H Fujisawa","year":"2008","unstructured":"Fujisawa H. Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice. J Virol. 2008;82:2772\u201383.","journal-title":"J Virol"},{"key":"515_CR34","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.3389\/fimmu.2019.02204","volume":"10","author":"L Guo","year":"2019","unstructured":"Guo L, Rondina MT. The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases. Front Immunol. 2019;10:2204.","journal-title":"Front Immunol"},{"key":"515_CR35","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cca.2020.03.022","volume":"506","author":"G Lippi","year":"2020","unstructured":"Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145\u20138.","journal-title":"Clin Chim Acta"},{"key":"515_CR36","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.2741\/4633","volume":"23","author":"S Subramaniam","year":"2018","unstructured":"Subramaniam S, Scharrer I. Procoagulant activity during viral infections. Front Biosci. 2018;23:1060\u201381.","journal-title":"Front Biosci"},{"key":"515_CR37","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/10245330400026170","volume":"10","author":"M Yang","year":"2005","unstructured":"Yang M, Ng MHL, Li CK. Thrombocytopenia in patients with severe acute respiratory syndrome (review). Hematology. 2005;10:101\u20135.","journal-title":"Hematology"},{"key":"515_CR38","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1203\/01.PDR.0000079186.86219.29","volume":"54","author":"J Yang","year":"2003","unstructured":"Yang J, Yang M, Xu F, Li K, Lee SKM, Ng PC, et al. Effects of oxygen-induced lung damage on megakaryocytopoiesis and platelet homeostasis in a rat model. Pediatr Res. 2003;54:344\u201352.","journal-title":"Pediatr Res"},{"key":"515_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0196-0644(03)00817-5","volume":"43","author":"SY Chen","year":"2004","unstructured":"Chen SY, Su CP, Ma MH, Chiang WC, Hsu CY, Ko CI, et al. Predictive model of diagnosing probable cases of severe acute respiratory syndrome in febrile patients with exposure risk. Ann Emerg Med. 2004;43:1\u20135.","journal-title":"Ann Emerg Med"},{"key":"515_CR40","first-page":"58","volume":"36","author":"PP Lamichhane","year":"2018","unstructured":"Lamichhane PP, Boonnak K, Changsom D, Noisumdaeng P, Sangsiriwut K, Pattanakistakul SN, et al. H5N1 NS genomic segment distinctly governs the influenza virus infectivity and cytokine induction in monocytic cells. Asian Pac J Allergy Immunol. 2018;36:58\u201368.","journal-title":"Asian Pac J Allergy Immunol"},{"key":"515_CR41","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1099\/jgv.0.000922","volume":"98","author":"TD Cline","year":"2017","unstructured":"Cline TD, Beck D, Bianchini E. Influenza virus replication in macrophages: balancing protection and pathogenesis. J Gen Virol. 2017;98:2401\u201312.","journal-title":"J Gen Virol"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-021-00515-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-021-00515-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-021-00515-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T08:03:37Z","timestamp":1620979417000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-021-00515-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,14]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["515"],"URL":"https:\/\/doi.org\/10.1186\/s40001-021-00515-9","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,14]]},"assertion":[{"value":"1 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Medical Ethical Committee of the Fifth Medical Center of PLA General Hospital. All patients provided written informed consent to participate in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"45"}}