{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:08:58Z","timestamp":1783750138141,"version":"3.55.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acquired reactive perforating collagenosis (ARPC) is a rare form of transepithelial elimination in which altered collagen is extruded through the epidermis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 23-year-old male presented with cup-like ulcerated lesions on his limbs since 3\u00a0months. A series of serological and immunological tests showed no abnormalities. A diagnosis of ARPC was based on skin biopsy findings. The patient was cured using treatment with itraconazole for 8\u00a0weeks, in the absence of a fungal infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The anti-inflammatory and anti-angiogenic effects of itraconazole can have good therapeutic benefits for ARPC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-021-00542-6","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T08:03:25Z","timestamp":1626163405000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Successful treatment of acquired reactive perforating collagenosis with itraconazole"],"prefix":"10.1186","volume":"26","author":[{"given":"Binrong","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2471-211X","authenticated-orcid":false,"given":"Yi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"542_CR1","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1111\/jdv.14220","volume":"31","author":"AJ Garc\u00eda-Malinis","year":"2017","unstructured":"Garc\u00eda-Malinis AJ, Del Valle SE, S\u00e1nchez-Salas MP, Del Prado E, Coscojuela C, Gilaberte Y. 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Dermatol Ther. 2019;9:271\u201380.","journal-title":"Dermatol Ther"},{"key":"542_CR9","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1097\/PRS.0b013e31817d6179","volume":"122","author":"CHK Chui","year":"2008","unstructured":"Chui CHK. Treatment of keloids with itraconazole. Plast Reconstr Surg. 2008;122:681\u20132.","journal-title":"Plast Reconstr Surg"},{"key":"542_CR10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1529-8019.2008.01219.x","volume":"22","author":"MT V'Lckova-Laskoska","year":"2009","unstructured":"V\u2019Lckova-Laskoska MT, Caca-Biljanovska NG, Laskoski DS, Kamberova SJ. Palmoplantar pustulosis treated with itraconazole: a single, active-arm pilot study. 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