{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T21:44:14Z","timestamp":1748641454835},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority","award":["XTCX201820"],"award-info":[{"award-number":["XTCX201820"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>This study aimed to present the case of a boy with acute distress syndrome (ARDS) treated with low-dose umbilical cord blood (UCB) therapy and explore the underlying possible mechanism.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A 7-year-old boy with severe <jats:italic>Pneumocystis carinii <\/jats:italic>pneumonia and severe ARDS was treated with allogeneic UCB as salvage therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The patient did not improve after being treated with lung protective ventilation, pulmonary surfactant replacement, and extracorporeal membrane oxygenation (ECMO) for 30\u00a0days. However, his disease reversed 5\u00a0days after allogeneic UCB infusion, and he weaned from ECMO after 7\u00a0days of infusion. Bioinformatics confirmed that his Toll-like receptor (TLR) was abnormal before UCB infusion. However, after the infusion, his immune system was activated and repaired, and the TLR4\/MyD88\/NF-\u03baB signaling pathway was recovered.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Allogenic UCB could treat ARDS by repairing the TLR4\/MyD88\/NF-\u03baB signaling pathway, thereby achieving stability of the immune system.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-021-00548-0","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T04:02:48Z","timestamp":1630123368000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["First case of low-dose umbilical cord blood therapy for pediatric acute respiratory distress syndrome induced by Pneumocystis carinii pneumonia"],"prefix":"10.1186","volume":"26","author":[{"given":"Shuang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"issue":"2","key":"548_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/jcm8020231","volume":"8","author":"S-C Kung","year":"2019","unstructured":"Kung S-C, Hung Y-L, Chen W-L, et al. 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ECMO was the last treatment for this patient, but he could not recover from it. At a multidisciplinary conference, we decided to use MSCs on a compassionate use basis under the approval of the chief medical officer of the hospital, the hospital ethics committee, and the patients\u2019 relatives. This study has been approved by the ethics committee of the Capital Institute of Pediatrics (Ethics number: SHERLLM2020003). All authors had access to the data and a significant role in the preparation of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There are no competing interests to declare for all authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"100"}}