{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:40:29Z","timestamp":1787740829933,"version":"build-2784847793"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81602297"],"award-info":[{"award-number":["81602297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"guangxi zhuang autonomous natural science foundation","award":["2018JJB140322"],"award-info":[{"award-number":["2018JJB140322"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Brain abscess due to the\n                      <jats:italic>Nocardia<\/jats:italic>\n                      genus is rarely reported and it is usually found in immunocompromised patients. Treatment of\n                      <jats:italic>Nocardia<\/jats:italic>\n                      brain abscess is troublesome and requires consideration of the severity of the underlying systemic disease. The difficulties in identifying the bacterium and the frequent delay in initiating adequate therapy often influence the prognosis of patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      Here, we report a rare case of brain abscess caused by\n                      <jats:italic>Nocardia farcinica.<\/jats:italic>\n                      The patient\u2019s medical history was complicated: he was hospitalized several times, but no pathogens were found. At last, bacteria were found in the culture of brain abscess puncture fluid; the colony was identified as\n                      <jats:italic>Nocardia farcinica<\/jats:italic>\n                      by mass spectrometry. Targeted antibiotic treatment was implemented, brain abscess tended to alleviate, but the patient eventually developed fungal pneumonia and died of acute respiratory distress syndrome (ARDS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Brain abscess caused by\n                      <jats:italic>Nocardia farcinica<\/jats:italic>\n                      can appear in non-immunocompromised individuals. Early diagnosis, reasonable surgical intervention, and targeted antibiotic treatment are critical for\n                      <jats:italic>Nocardia<\/jats:italic>\n                      brain abscess treatment. In the treatment of\n                      <jats:italic>Nocardia<\/jats:italic>\n                      brain abscess, attention should paid be to the changes in patients\u2019 immunity and infection with other pathogens, especially fungi, avoided.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40001-021-00562-2","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T05:03:24Z","timestamp":1627967004000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A case report of brain abscess caused by Nocardia farcinica"],"prefix":"10.1186","volume":"26","author":[{"given":"Jiangqin","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6999-0781","authenticated-orcid":false,"given":"Junyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"562_CR1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.micpath.2017.11.012","volume":"114","author":"M Fatahi-Bafghi","year":"2018","unstructured":"Fatahi-Bafghi M. 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A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"83"}}