{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:14:56Z","timestamp":1770754496001,"version":"3.50.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81873761"],"award-info":[{"award-number":["81873761"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81672026"],"award-info":[{"award-number":["81672026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"youan foundation of liver disease and aids","award":["YNKTTS20180123"],"award-info":[{"award-number":["YNKTTS20180123"]}]},{"name":"beijing fengtai health system research project","award":["2018-63"],"award-info":[{"award-number":["2018-63"]}]},{"name":"national science and technology major special program of the 13th five-year plan of china","award":["2018ZX10302104"],"award-info":[{"award-number":["2018ZX10302104"]}]},{"name":"national science and technology major special program of the 13th five-year plan of china","award":["2018ZX10302205-002-002"],"award-info":[{"award-number":["2018ZX10302205-002-002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>For a patient presenting with fever, multiple lymphadenopathy and splenomegaly, pathogen infection should be preferentially considered, followed by lymphoid malignancies. When traditional laboratory and pathological detection cannot find the pathogenic microorganism, metagenomic sequencing (MGS) which targets the person\u2019s genome for exceptional genetic disorders may detect a rare pathogen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Here, we introduced the diagnostic clue of a case of multicentric Castleman disease (MCD) with hemophagocytic syndrome which was elicited from the detection of human herpesvirus-8 in the blood of a HIV-1 infected person by MGS technology during pathogen inspection. This case highlights the need to increase the awareness of MCD among clinicians and pathologists.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>MGS technology may play a pivotal role in providing diagnostic clues during pathogen inspection, especially when pathogens are not detectable by conventional methods.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-021-00589-5","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T16:25:31Z","timestamp":1633364731000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of Castleman disease with hemophagocytic syndrome derived from HHV8 infection"],"prefix":"10.1186","volume":"26","author":[{"given":"Xiao","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingmin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-594X","authenticated-orcid":false,"given":"Yulin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,3]]},"reference":[{"issue":"16","key":"589_CR1","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1182\/blood.2019000931","volume":"135","author":"A Dispenzieri","year":"2020","unstructured":"Dispenzieri A, Fajgenbaum DC. Overview of Castleman disease. Blood. 2020;135(16):1353\u201364.","journal-title":"Blood"},{"issue":"1","key":"589_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.hoc.2017.09.002","volume":"32","author":"DC Fajgenbaum","year":"2018","unstructured":"Fajgenbaum DC, Shilling D. Castleman disease pathogenesis. Hematol Oncol Clin North Am. 2018;32(1):11\u201321.","journal-title":"Hematol Oncol Clin North Am"},{"issue":"4","key":"589_CR3","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1182\/blood.V86.4.1276.bloodjournal8641276","volume":"86","author":"J Soulier","year":"1995","unstructured":"Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, et al. Kaposi\u2019s sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman\u2019s disease. Blood. 1995;86(4):1276\u201380.","journal-title":"Blood"},{"issue":"1","key":"589_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12981-019-0230-6","volume":"16","author":"L Campogiani","year":"2019","unstructured":"Campogiani L, Cerva C, Maffongelli G, Teti E, Pupo L, Vaccarini S, et al. Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir. AIDS Res Ther. 2019;16(1):15.","journal-title":"AIDS Res Ther"},{"key":"589_CR5","doi-asserted-by":"crossref","unstructured":"The Human Microbiome Project Consortium. A framework for human microbiome research. Nature 2012; 486(7402):215\u2013221.","DOI":"10.1038\/nature11209"},{"issue":"9","key":"589_CR6","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1046\/j.1440-1827.2001.01266.x","volume":"51","author":"T Suda","year":"2001","unstructured":"Suda T, Katano H, Delsol G, Kakiuchi C, Nakamura T, Shiota M, et al. HHV-8 infection status of AIDS-unrelated and AIDS-associated multicentric Castleman\u2019s disease. Pathol Int. 2001;51(9):671\u20139.","journal-title":"Pathol Int"},{"issue":"12","key":"589_CR7","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/S1473-3099(07)70290-6","volume":"7","author":"NG Rouphael","year":"2007","unstructured":"Rouphael NG, Talati NJ, Vaughan C, Cunningham K, Moreira R, Gould C. Infections associated with haemophagocytic syndrome. Lancet Infect Dis. 2007;7(12):814\u201322.","journal-title":"Lancet Infect Dis"},{"issue":"9927","key":"589_CR8","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/S0140-6736(13)61048-X","volume":"383","author":"M Ramos-Casals","year":"2014","unstructured":"Ramos-Casals M, Brito-Zer\u00f3n P, L\u00f3pez-Guillermo A, Khamashta MA, Bosch X. Adult haemophagocytic syndrome. Lancet (London, England). 2014;383(9927):1503\u201316.","journal-title":"Lancet (London, England)"},{"key":"589_CR9","first-page":"3297463","volume":"2019","author":"N Osakwe","year":"2019","unstructured":"Osakwe N, Johnson D, Klein N, Azim DA. A rare case of HHV-8 associated hemophagocytic lymphohistiocytosis in a stable HIV Patient. Case Rep Infect Dis. 2019;2019:3297463.","journal-title":"Case Rep Infect Dis"},{"issue":"4","key":"589_CR10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s12185-015-1928-4","volume":"103","author":"TC Zondag","year":"2016","unstructured":"Zondag TC, Rokx C, van Lom K, van den Berg AR, Sonneveld P, Dik WA, et al. Cytokine and viral load kinetics in human herpesvirus 8-associated multicentric Castleman\u2019s disease complicated by hemophagocytic lymphohistiocytosis. Int J Hematol. 2016;103(4):469\u201372.","journal-title":"Int J Hematol"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-021-00589-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-021-00589-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-021-00589-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T16:25:55Z","timestamp":1633364755000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-021-00589-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,3]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["589"],"URL":"https:\/\/doi.org\/10.1186\/s40001-021-00589-5","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,3]]},"assertion":[{"value":"11 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with regulations issued by the National Health Commission of China and was approved by the local Commission of Ethics (reference number LL 2019-053-K). Informed consent was obtained from the participant included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and materials"}}],"article-number":"119"}}