{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T04:48:00Z","timestamp":1771390080524,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Talus osteochondral lesion is commonly associated with trauma, avascular necrosis or even genetic factors, but gouty tophus as a cause of Hepple stage V type talus osteochondral lesion is rare.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Here, we report a case of an 18-year-old man who complained of left medial deep ankle pain on ambulation. This young man had an extreme liking of sea food rich in purines and also sugar-sweetened drinks. He was diagnosed with a Hepple stage V type talus osteochondral lesion and was treated with medial malleolus osteotomy and an osteochondral graft. The talus osteochondral lesion was found to be a gouty tophus and was completely removed. Hypouricemic therapy was prescribed for 2\u00a0months, which allowed the patient to walk with a visual analogue score (VAS) score of 1. He was followed up for 12\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Young people with an extreme liking of sea food rich in purines and also sugar-sweetened drinks may be at a risk of developing gout. Acute onset of ankle atraumatic pain, swelling with a high level of serum uric acid and a talus osteochondral lesion with cyst formation should make physicians consider a diagnosis of gout.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-021-00597-5","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T09:18:16Z","timestamp":1634635096000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gouty tophus as a rare cause of a Hepple stage V osteochondral lesion of the talus"],"prefix":"10.1186","volume":"26","author":[{"given":"Bo","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6478-038X","authenticated-orcid":false,"given":"Cheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"597_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-021-03823-7","author":"JB Guimar\u00e3es","year":"2021","unstructured":"Guimar\u00e3es JB, da Cruz IAN, Nery C, et al. Osteochondral lesions of the talar dome: an up-to-date approach to multimodality imaging and surgical techniques. Skeletal Radiol. 2021. https:\/\/doi.org\/10.1007\/s00256-021-03823-7.","journal-title":"Skeletal Radiol"},{"issue":"1","key":"597_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.fcl.2020.10.002","volume":"26","author":"QGH Rikken","year":"2021","unstructured":"Rikken QGH, Kerkhoffs GMMJ. Osteochondral lesions of the talus: an individualized treatment paradigm from the amsterdam perspective. Foot Ankle Clin. 2021;26(1):121\u201336.","journal-title":"Foot Ankle Clin"},{"issue":"10","key":"597_CR3","doi-asserted-by":"publisher","first-page":"884","DOI":"10.21037\/atm-21-2006","volume":"9","author":"S Li","year":"2021","unstructured":"Li S, Lu R, Zhang J, et al. Outcomes of arthroscopic bone graft transplantation for Hepple stage V osteochondral lesions of the talus. Ann Transl Med. 2021;9(10):884.","journal-title":"Ann Transl Med"},{"key":"597_CR4","volume":"27","author":"L Zhang","year":"2021","unstructured":"Zhang L, Luo Y, Zhou X, et al. Outcomes from Osteochondral Autograft Transplant or Mosaicplasty in 26 Patients with Type V Osteochondral Lesions of the Talus. Med Sci Monit. 2021;27: e930527.","journal-title":"Med Sci Monit"},{"issue":"14","key":"597_CR5","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1177\/0363546519881420","volume":"47","author":"A Nguyen","year":"2019","unstructured":"Nguyen A, Ramasamy A, Walsh M, et al. Autologous osteochondral transplantation for large osteochondral lesions of the talus is a viable option in an athletic population. Am J Sports Med. 2019;47(14):3429\u201335.","journal-title":"Am J Sports Med"},{"key":"597_CR6","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s40266-017-0512-4","volume":"34","author":"A Abhishek","year":"2017","unstructured":"Abhishek A. Managing gout flares in the elderly: practical considerations. Drugs Aging. 2017;34:873\u201380.","journal-title":"Drugs Aging"},{"key":"597_CR7","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nrrheum.2015.91","volume":"11","author":"CF Kuo","year":"2015","unstructured":"Kuo CF, Grainge MJ, Zhang W, et al. Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol. 2015;11:649\u201362.","journal-title":"Nat Rev Rheumatol"},{"key":"597_CR8","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1056\/NEJMoa035700","volume":"350","author":"HK Choi","year":"2004","unstructured":"Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med. 2004;350:1093\u2013103.","journal-title":"N Engl J Med"},{"issue":"7","key":"597_CR9","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1002\/art.40103","volume":"69","author":"S Thomson","year":"2017","unstructured":"Thomson S, Urbanski S, MacMullan P. Clinical images: gouty tophus as an unusual cause of talus fracture. Arthritis Rheumatol. 2017;69(7):1508.","journal-title":"Arthritis Rheumatol"},{"issue":"17","key":"597_CR10","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.12998\/wjcc.v8.i17.3814","volume":"8","author":"T Kim","year":"2020","unstructured":"Kim T, Choi Y-R. Osteochondral lesion of talus with gout tophi deposition: a case report. World J Clin Cases. 2020;8(17):3814\u201320.","journal-title":"World J Clin Cases"},{"issue":"7","key":"597_CR11","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1177\/0363546516668292","volume":"45","author":"L Ramponi","year":"2017","unstructured":"Ramponi L, Yasui Y, Murawski C, et al. Lesion size is a predictor of clinical outcomes after bone marrow stimulation for osteochondral lesions of the talus: a systematic review. Am J Sports Med. 2017;45(7):1698\u2013705.","journal-title":"Am J Sports Med"},{"key":"597_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.foot.2021.101805","volume":"47","author":"M Qulaghassi","year":"2021","unstructured":"Qulaghassi M, Cho YS, Khwaja M, et al. Treatment strategies for osteochondral lesions of the talus: a review of the recent evidence. Foot. 2021;47: 101805.","journal-title":"Foot"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-021-00597-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-021-00597-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-021-00597-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T09:33:41Z","timestamp":1634636021000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-021-00597-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["597"],"URL":"https:\/\/doi.org\/10.1186\/s40001-021-00597-5","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,19]]},"assertion":[{"value":"20 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the institutional research\u00a0ethics\u00a0committee\u00a0of Xining First People\u2019s Hospital, and written informed consent was obtained from the patient.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written inform consent was obtained from the patient for publication of this case report and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"124"}}