{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:30:19Z","timestamp":1779114619000,"version":"3.51.4"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Mucormycosis is a rare fungal infection occurring chiefly in the lung or the rhino-orbital-cerebral compartment, particularly in patients with immunodeficiency or diabetes mellitus. Among\n                      <jats:italic>Mucorales<\/jats:italic>\n                      fungi,\n                      <jats:italic>Rhizopus<\/jats:italic>\n                      spp. are the most common cause of mucormycosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      We report a case of pulmonary mucormycosis caused by\n                      <jats:italic>Rhizopus microsporus<\/jats:italic>\n                      in a young patient with diabetes but no other apparent risk factors. The diagnosis mainly relied on clinical manifestation, positive pulmonary tissue biopsy, and fungal culture. The patient was successfully treated with posaconazole oral suspension and remains asymptomatic at one-year follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Pulmonary mucormycosis is a life-threatening condition and posaconazole is an effective treatment for pulmonary mucormycosis caused by\n                      <jats:italic>Rhizopus microspores<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40001-021-00602-x","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T16:02:19Z","timestamp":1636905739000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole"],"prefix":"10.1186","volume":"26","author":[{"given":"F.","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. C.","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. T.","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,14]]},"reference":[{"issue":"1","key":"602_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/mmy\/myx017","volume":"56","author":"DE Corzo-Le\u00f3n","year":"2018","unstructured":"Corzo-Le\u00f3n DE, Chora-Hern\u00e1ndez LD, Walsh TJ, et al. Diabetes mellitus as the major risk factor for mucormycosis in Mexico: epidemiology, diagnosis, and outcomes of reported cases. Med Mycol. 2018;56(1):29\u201343. https:\/\/doi.org\/10.1093\/mmy\/myx017.","journal-title":"Med Mycol"},{"key":"602_CR2","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3201\/eid2007.140087","volume":"20","author":"D Bitar","year":"2014","unstructured":"Bitar D, Lortholary O, Le Strat Y, et al. Population-based analysis of invasive fungal infections, France, 2001\u20132010. Emerg Infect Dis. 2014;20:1149\u201355. https:\/\/doi.org\/10.3201\/eid2007.140087.","journal-title":"Emerg Infect Dis"},{"issue":"24","key":"602_CR3","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1097\/MD.0000000000000221","volume":"93","author":"L Lelievre","year":"2014","unstructured":"Lelievre L, Garcia-Hermoso D, French Mycosis Study Group, et al. Posttraumatic mucormycosis: a nationwide study in France and review of the literature. Medicine. 2014;93(24):395\u2013404. https:\/\/doi.org\/10.1097\/MD.0000000000000221.","journal-title":"Medicine"},{"key":"602_CR4","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1086\/432579","volume":"41","author":"MM Roden","year":"2005","unstructured":"Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41:634\u201353. https:\/\/doi.org\/10.1086\/432579.","journal-title":"Clin Infect Dis"},{"key":"602_CR5","volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard. NCCLS document M38-A","author":"National Committee for Clinical Laboratory Standards","year":"2002","unstructured":"National Committee for Clinical Laboratory Standards. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard. NCCLS document M38-A. Villanova: Clinical and Laboratory Standards Institute; 2002."},{"issue":"12","key":"602_CR6","doi-asserted-by":"publisher","first-page":"e405","DOI":"10.1016\/S1473-3099(19)30312-3","volume":"19","author":"OA Cornely","year":"2019","unstructured":"Cornely OA, Alastruey-Izquierdo A, Mucormycosis ECMM MSG Global Guideline Writing Group, et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis. 2019;19(12):e405\u201321. https:\/\/doi.org\/10.1016\/S1473-3099(19)30312-3.","journal-title":"Lancet Infect Dis"},{"issue":"14","key":"602_CR7","doi-asserted-by":"publisher","first-page":"477","DOI":"10.2217\/fmb-2018-0344","volume":"04","author":"S Zhang","year":"2019","unstructured":"Zhang S, Zhang P, Feng S, et al. Posaconazole oral suspension as salvage therapy for invasive fungal disease in patients with hematological diseases. Future Microbiol. 2019;04(14):477\u201388. https:\/\/doi.org\/10.2217\/fmb-2018-0344.","journal-title":"Future Microbiol"},{"issue":"4","key":"602_CR8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1159\/000236133","volume":"97","author":"W Eduard","year":"1992","unstructured":"Eduard W, Sandven P, Levy F. Relationships between exposure to spores from Rhizopus microsporus and Paecilomyces variotii and serum IgG antibodies in wood trimmers. Int Arch Allergy Imm. 1992;97(4):274\u201382. https:\/\/doi.org\/10.1159\/000236133.","journal-title":"Int Arch Allergy Imm"},{"key":"602_CR9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00893-18","author":"JP Furuno","year":"2018","unstructured":"Furuno JP, Tallman GB, McGregor JC, et al. Clinical outcomes of oral suspension versus delayed-release tablet formulations of posaconazole for prophylaxis of invasive fungal infections. Antimicrob Agents Chemother. 2018. https:\/\/doi.org\/10.1128\/AAC.00893-18.","journal-title":"Antimicrob Agents Chemother"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-021-00602-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-021-00602-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-021-00602-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T16:02:22Z","timestamp":1636905742000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-021-00602-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,14]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["602"],"URL":"https:\/\/doi.org\/10.1186\/s40001-021-00602-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-302265\/v1","asserted-by":"object"}]},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,14]]},"assertion":[{"value":"7 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent has been obtained from the patient for publication of this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"131"}}