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We investigated the relationship between SRC and renal function in Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The medical records of 41,842 individuals who underwent physical examinations at the Health Check-up Center at our institution in 2018 were reviewed. According to whether with SRC, they were divided into no-SRC and SRC groups. SRCs were classified into subgroups based on number (&lt;\u20092 vs.\u2009\u2265\u20092) and size (&lt;\u20092\u00a0cm vs.\u2009\u2265\u20092\u00a0cm). Logistic\u00a0regression was used to examine the relationship between SRC and estimated glomerular filtration rate (eGFR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multinomial logistic regression analysis showed that the adjusted odds ratio (OR) for eGFR slight decline in subjects with SRC was 1.26(95% confidence interval (95% CI):1.17\u20131.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and the OR for eGFR severe decline was 1.35(95% CI: 1.16\u20131.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with no-SRC. The adjusted OR of SRC number\u2009\u2265\u20092 and\u2009\u2265\u20092\u00a0cm on the risk of eGFR severe decline was the highest (OR:1.68, 95% CI:1.25\u20132.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) of four SRC subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SRC is related to eGFR decline, especially when the person with one more SRCs and the size of SRC is more than 2\u00a0cm. SRC could be a warning sign for clinicians to judge the decline of renal function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s40001-023-01552-2","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T01:02:07Z","timestamp":1704243727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multiple and large simple renal cysts are associated with glomerular filtration rate decline: a cross-sectional study of Chinese population"],"prefix":"10.1186","volume":"29","author":[{"given":"Cheng","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhu","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"1552_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12994","author":"G Lee","year":"2019","unstructured":"Lee G, Uddin MJ, Kim Y, Ko M, Yu I, Ha H. 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