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We aimed to overview the results of all previous systematic reviews and meta-analyses to examine the net effect of PP on oxygenation, the rate of TI and mortality in COVID-19 patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We searched PubMed, Scopus, Web of Science, Google Scholar, and Cochrane Library databases from December 2019 through 2022 without publication language restriction for systematic reviews and meta-analysis studies on PP vs. supine position (SP) in conscious patients with hypoxic respiratory failure COVID-19. After study selection, data were extracted from published meta-analyses and pooled by comprehensive meta-analysis (CMA) software version 2.2.064 to achieve effect sizes. They were analyzed for TI and mortality rates dichotomous variables, and the results were shown as pooled odds ratios (OR) with a 95% confidence interval (CI). Continuous variables such as oxygenation indices (PaO2\/FiO2 and SpO2) were also analyzed, and the data were shown as mean differences (MD) with lower and upper CI. The level of statistical significance was set at <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twelve systematic reviews and meta-analyses with 19,651 patients and six systematic reviews with 2,911 patients were included in this Review of Reviews (total: 22,562). PP treatment significantly reduced the rate of TI (OR\u2009=\u20090.639, %95 CI (0.492, 0.829); <jats:italic>P<\/jats:italic>-value\u2009=\u20090.001) and decreased mortality (OR\u2009=\u20090.363, %95 CI (0.240, 0.549), <jats:italic>P<\/jats:italic>-value\u2009&lt;\u20090.001). There was no difference in PaO2\/FiO2 (MD\u2009=\u20093.591[\u2212\u00a040.881, 48.062]; <jats:italic>P<\/jats:italic>-value\u2009=\u20090.874) and SpO2 percent (MD\u2009=\u20091.641[\u2212\u00a04.441, 7.723]; <jats:italic>P<\/jats:italic>-value\u2009=\u20090.597).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Prone positioning can be recommended in conscious ICU patients with COVID-19 pneumonia to reduce mortality and intubation.<\/jats:p>\n                <jats:p><jats:italic>Systematic review registration:<\/jats:italic> PROSPERO registration number: CRD42022326951. Registered 25 April 2022.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s40001-024-01661-6","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T05:02:17Z","timestamp":1705726937000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prone positioning effect on tracheal intubation rate, mortality and oxygenation parameters in awake non-intubated severe COVID-19-induced respiratory failure: a review of reviews"],"prefix":"10.1186","volume":"29","author":[{"given":"Sepideh Tahsini","family":"Tekantapeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader D.","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Ghojazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Fereidouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Soleimanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"issue":"4","key":"1661_CR1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.115827","volume":"11","author":"K Shahsavarinia","year":"2021","unstructured":"Shahsavarinia K, Ghojazadeh M, Ghabousian A, Hatefnia F, Soleimanpour M, Soleimanpour H. 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