{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:43:03Z","timestamp":1790624583794,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008678","name":"Universit\u00e4t Leipzig","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008678","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>A uniform\u00a0definition of continence\u00a0is urgently needed to allow the comparison of study results and to estimate patient outcomes after radical prostatectomy (RP). To identify a practical definition that includes both objective and subjective aspects in a tangible way, we assessed different continence definitions and evaluated which best reflects the patients\u2019 subjective perception of continence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Our analyses included 718 patients that underwent either robot-assisted radical prostatectomy (RARP) or laparoscopic radical prostatectomy (LRP) in a multicenter randomized patient-blinded trial.  Continence was assessed through patient questionnaires prior to and at 3, 6 and 12\u00a0months after surgery which included the number of pads used per day, the ICIQ-SF\u00a0and the question \u201cDo you suffer from incontinence? (yes\/no)\u201d to assess subjective continence. We used Krippendorff\u2019s Alpha to calculate the agreement of different continence definitions with the subjective perception.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At 3\u00a0months, the \u201c0\/safety pad\u201d definition shows the highest agreement by alpha\u2009=\u20090.70 (vs. 0.63 for \u201c0 pads\u201d and 0.37 for \u201c0\u20131 pad\u201d). At 6 and 12\u00a0months \u201c0 pads\u201d is the better match, with alpha values of 0.69 (vs. 0.62 and 0.31) after 6\u00a0months and 0.70 (vs. 0.65 and 0.32) after 12\u00a0months. The ICIQ-SF score shows good correlation with the subjective continence at 3\u00a0months (alpha\u2009=\u2009\u2212\u20090.79), the coefficient then decreasing to \u2212\u20090.69 and \u2212\u20090.59 at 6 and 12\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The best continence definition according to the patients\u2019 perspective changes over time, \u201c0 pads\u201d being the superior criterion in the long-term. We recommend using the 0-pad definition for standardized continence reporting, as it is simple yet as accurate as possible given the inevitably high subjectivity of continence perception.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic> The LAP-01 trial was registered with the U.S. National Library of Medicine clinical trial registry (clinicaltrials.gov), NCT number: NCT03682146, and with the German Clinical Trial registry (Deutsches Register Klinischer Studien), DRKS ID number: DRKS00007138<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-024-01662-5","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T10:02:20Z","timestamp":1705572140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of different continence definitions in the context of the randomized multicenter prospective LAP-01 trial\u2014Does the best definition change over time?"],"prefix":"10.1186","volume":"29","clinical-trial-number":[{"clinical-trial-number":"nct03682146","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Sigrun","family":"Holze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Sophie","family":"Kuntze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinhard","family":"Mende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Neuhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Truss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Minh","family":"Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Dietel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Uwe","family":"Stolzenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"1662_CR1","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.ejca.2021.07.039","volume":"157","author":"T Dyba","year":"2021","unstructured":"Dyba T, Randi G, Bray F, et al. 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