{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:44:57Z","timestamp":1792853097191,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To explore the mechanism of huankuile (HKL) in colon injury repair in rats with ulcerative colitis (UC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty SPF Wistar male rats were divided randomly into a normal group, a negative control group, an HKL intervention group (\u2018HKL group\u2019) and a 5-aminosalicylic acid intervention group (\u20185-ASA group\u2019). After 14\u00a0days of intervention with corresponding drugs, pathological scores were obtained using the results of immunohistochemical staining; morphological changes were observed by hematoxylin\u2013eosin staining, and the mRNA expression levels of tumour necrosis factor-\u03b1 (TNF-\u03b1), matrix metalloproteinase 9 (MMP9) and interleukin-13 (IL-13) were detected by real-time quantitative PCR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After the successful construction of the rat model, it was compared with the rats in the normal group. In the negative group, it was found that the expression of TNF-\u03b1 and MMP9 was significantly increased in the colonic mucosal epithelia of the rats, the pathological score was significantly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the mRNA expression levels of TNF-\u03b1, MMP9 and IL-13 were increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). After treatment with HKL, the colonic morphology of the rats returned to normal, the expression of TNF-\u03b1 and MMP9 in the colonic mucosal epithelium of the rats returned to normal, the pathological score grade was significantly reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the mRNA expression levels of TNF-\u03b1, MMP9 and IL-13 were reduced; these results were largely consistent with those of the normal group, with no statistically significant difference.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>HKL effectively improved the general symptoms and tissue injury in UC rats, and the therapeutic effect was better than that of 5-ASA group. Ulcerative colitis in rats increased the expression of TNF-\u03b1, MMP9 and IL-13. HKL repaired UC-induced colonic injury in rats by decreasing the expression of TNF-\u03b1, MMP9 and IL-13.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-024-01695-w","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T06:02:14Z","timestamp":1707199334000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of huankuile on colon injury in rats with ulcerative colitis by reducing TNF-\u03b1 and MMP9"],"prefix":"10.1186","volume":"29","author":[{"given":"Xilinguli","family":"Wushouer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasimujiang","family":"Aximujiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafeisha","family":"Kadeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abulaiti","family":"Aihemaiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurexi","family":"Yunusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"issue":"5","key":"1695_CR1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1136\/gut.2010.224154","volume":"60","author":"C Mowat","year":"2011","unstructured":"Mowat C, Cole A, Windsor A, et al. 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