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However, the dynamic changes in the GM during three consecutive trimesters of pregnancy and their relationship with glucose and lipid metabolism have not been reported. In this study, we aimed to investigate the dynamic changes in the diversity and species of the GM during three consecutive trimesters in women who naturally conceived, and their relationships with abnormal fasting blood glucose (FBG) and serum lipid levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 30 pregnant women without any known chronic or autoimmune inflammatory disease history before pregnancy were enrolled during the first trimester. Serum and stool samples were collected during the first trimester, the second trimester, and the third trimester. Serum samples were tested for FBG and blood lipid levels, and stool specimens were analyzed by 16S rDNA sequencing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The abundance ratio of bacteroidetes\/firmicutes showed an increasing tendency in most of the subjects (19\/30, 63.3%) from the first to the third trimester. LEfSe analysis showed that the abundance of <jats:italic>Bilophila<\/jats:italic> was significantly increased from the first to the third trimester. In addition, at the genus level, the increased relative abundance of <jats:italic>Mitsuokella<\/jats:italic>, <jats:italic>Clostridium <\/jats:italic>sensu stricto and <jats:italic>Weissella<\/jats:italic> were potentially involved in the development of high FBG during pregnancy. The raised relative abundance of <jats:italic>Corynebacterium<\/jats:italic>, <jats:italic>Rothia<\/jats:italic> and <jats:italic>Granulicatella<\/jats:italic> potentially contributed to the occurrence of dyslipidemia during pregnancy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>There are dynamic changes in the GM during the three trimesters, and the alterations in some bacterium abundance may contribute to the development of high FBG and dyslipidemia during pregnancy. Monitoring enterotypes and correcting dysbiosis in the first trimester may become new strategies for predicting and preventing glucolipid metabolism disorders during pregnancy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-024-01702-0","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T07:02:08Z","timestamp":1707721328000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dynamic changes in the gut microbiota during three consecutive trimesters of pregnancy and their correlation with abnormal glucose and lipid metabolism"],"prefix":"10.1186","volume":"29","author":[{"given":"Yiyang","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"issue":"149","key":"1702_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ymeth.2018.04.029","volume":"1","author":"S Lamichhane","year":"2018","unstructured":"Lamichhane S, Sen P, Dickens AM, Ore\u0161i\u010d M, Bertram HC. 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