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This study investigated the cardioprotective effects of VX765-coated polyethyleneimine (PEI)\/sodium alginate (AG) composite nanogels (AG\/PEI-VX765 NGs) in a rat model of MI. Additionally, AG-VX765 NGs and PEI-VX765 nanospheres (NPs) were synthesized and tested to compare their efficacy. MI was caused in rats by ligating the left anterior descending branch of the coronary artery, and the rats were grouped and set as Sham, MI, MI\u2009+\u2009VX765, MI\u2009+\u2009AG-VX765NGs, MI\u2009+\u2009PEI-VX765NPs, and MI\u2009+\u2009AG\/PEI-VX765NGs. Results demonstrate that AG\/PEI-VX765NGs were non-toxic and exhibited a sustained release of VX765. In vivo, experiments demonstrated that all treatment groups significantly enhanced cardiac function, reduced infarct size, fibrosis, and apoptosis in rats with MI, with the MI\u2009+\u2009AG\/PEI-VX765NGs group exhibiting the most favorable outcomes. Our findings indicate that AG\/PEI-VX765NGs represent a promising therapeutic approach for MI treatment.<\/jats:p>","DOI":"10.1186\/s40001-024-01765-z","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T06:43:33Z","timestamp":1710225813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats"],"prefix":"10.1186","volume":"29","author":[{"given":"Jianlong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"1765_CR1","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.amjmed.2019.05.002","volume":"132","author":"B Pva","year":"2019","unstructured":"Pva B, Dka B, Mma B, Kca B, Hvaa B, Saa B, Pba B, Rws B, A, Abhijeet Dhoble AB,. 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For the implementation of the experimental protocols, we adhered to the ethical principles outlined in the Guide for the Care and Use of Laboratory Animals: Eighth Edition. We have taken all steps to minimize the animals\u2019 pain and suffering. Euthanasia was administered by an overdose of pentobarbital sodium via intraperitoneal injection according to the American Veterinary Medical Association (AVMA) Guidelines for the Euthanasia of Animals, 2020 Edition.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"169"}}