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In everyday clinical practice a few microlitres of blood (arterial, mixed venous or venous) are sufficient for optimal diagnostics of any metabolic acidosis or alkalosis.<\/jats:p><jats:p>The same applies to a <jats:italic>therapeutic<\/jats:italic> tool\u2014then referred to as potential base excess (BEpot)\u2014for several in vitro assessments, e.g., solutions for infusion, sodium bicarbonate, blood products, packed red blood cells, plasma. Thus, BE or BEpot has been a parameter with exceptional clinical significance since 2007.<\/jats:p>","DOI":"10.1186\/s40001-024-01796-6","type":"journal-article","created":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:01:43Z","timestamp":1715533303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Base excess (BE): reloaded"],"prefix":"10.1186","volume":"29","author":[{"given":"Rolf","family":"Zander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"1796_CR1","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMra1711860","volume":"378","author":"K Berend","year":"2018","unstructured":"Berend K. Diagnostic use of base excess in acid-base disorders. 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