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However, the relationship remains unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Bidirectional Mendelian randomization (MR) analysis and statistical methods, including inverse variance weighting, weighted median, and MR-Egger tests, were performed using data from genome-wide association studies to detect a causal relationship between PSC and SLE. Sensitivity analyses were subsequently performed to assess the robustness of the results. Univariate MR methods were also investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Results of MR analysis suggested that PSC was associated with an increased risk for SLE (odds ratio: 1.33, 95% confidence interval: 1.10\u20131.61, P=0.0039) However, SLE had no significant causal relationship with PSC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Results of MR analysis revealed that patients with PSC were at an increased risk for SLE, which provides new insights into the relationship between these two autoimmune diseases.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s40001-024-01941-1","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T05:02:36Z","timestamp":1719550956000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal relationship between primary sclerosing cholangitis and systemic lupus erythematosus: a bidirectional Mendelian randomization study"],"prefix":"10.1186","volume":"29","author":[{"given":"Ziwen","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"issue":"10","key":"1941_CR1","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1111\/liv.15007","volume":"41","author":"TI Mehta","year":"2021","unstructured":"Mehta TI, Weissman S, Fung BM, Sotiriadis J, Lindor KD, Tabibian JH. 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