{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:14:52Z","timestamp":1792714492705,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-024-01991-5","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:02:00Z","timestamp":1724889720000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Single-cell transcriptome sequencing reveals altered peripheral blood immune cells in patients with severe tuberculosis"],"prefix":"10.1186","volume":"29","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"1991_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.ijtb.2020.02.005","volume":"67","author":"A Natarajan","year":"2020","unstructured":"Natarajan A, Beena PM, Devnikar AV, et al. A systemic review on tuberculosis. Indian J Tuberc. 2020;67:295\u2013311. https:\/\/doi.org\/10.1016\/j.ijtb.2020.02.005.","journal-title":"Indian J Tuberc"},{"key":"1991_CR2","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.2147\/IDR.S405987","volume":"16","author":"L Wang","year":"2023","unstructured":"Wang L, Ying R, Liu Y, et al. Metabolic profiles of clinical isolates of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis: a metabolomics-based study. Infect Drug Resist. 2023;16:2667\u201380. https:\/\/doi.org\/10.2147\/IDR.S405987.","journal-title":"Infect Drug Resist"},{"key":"1991_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002152","volume":"13","author":"RM Houben","year":"2016","unstructured":"Houben RM, Dodd PJ. The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS Med. 2016;13: e1002152. https:\/\/doi.org\/10.1371\/journal.pmed.1002152.","journal-title":"PLoS Med"},{"key":"1991_CR4","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/S0140-6736(19)30308-3","volume":"393","author":"J Furin","year":"2019","unstructured":"Furin J, Cox H, Pai M. Tuberculosis. Lancet. 2019;393:1642\u201356. https:\/\/doi.org\/10.1016\/S0140-6736(19)30308-3.","journal-title":"Lancet"},{"key":"1991_CR5","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.jinf.2023.03.020","volume":"86","author":"Y Wang","year":"2023","unstructured":"Wang Y, Sun Q, Zhang Y, et al. Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas. J Infect. 2023;86:421\u201338. https:\/\/doi.org\/10.1016\/j.jinf.2023.03.020.","journal-title":"J Infect"},{"key":"1991_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.989464","volume":"13","author":"I Geraldes","year":"2022","unstructured":"Geraldes I, Fernandes M, Fraga AG, et al. The impact of single-cell genomics on the field of mycobacterial infection. Front Microbiol. 2022;13: 989464. https:\/\/doi.org\/10.3389\/fmicb.2022.989464.","journal-title":"Front Microbiol"},{"key":"1991_CR7","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/s41590-020-0736-z","volume":"21","author":"X Xie","year":"2020","unstructured":"Xie X, Shi Q, Wu P, et al. Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection. Nat Immunol. 2020;21:1119\u201333. https:\/\/doi.org\/10.1038\/s41590-020-0736-z.","journal-title":"Nat Immunol"},{"key":"1991_CR8","doi-asserted-by":"publisher","first-page":"D721","DOI":"10.1093\/nar\/gky900","volume":"47","author":"X Zhang","year":"2019","unstructured":"Zhang X, Lan Y, Xu J, et al. Cell marker: a manually curated resource of cell markers in human and mouse. Nucleic Acids Res. 2019;47:D721\u20138. https:\/\/doi.org\/10.1093\/nar\/gky900.","journal-title":"Nucleic Acids Res"},{"key":"1991_CR9","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102:15545\u201350. https:\/\/doi.org\/10.1073\/pnas.0506580102.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1991_CR10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P, et al. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36:411\u201320. https:\/\/doi.org\/10.1038\/nbt.4096.","journal-title":"Nat Biotechnol"},{"key":"1991_CR11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/microbiolspec.BAI-0001-2019","volume":"7","author":"L Huang","year":"2019","unstructured":"Huang L, Nazarova EV, Russell DG. Mycobacterium tuberculosis: bacterial fitness within the host macrophage. Microbiol Spectr. 2019;7:10\u2013128. https:\/\/doi.org\/10.1128\/microbiolspec.BAI-0001-2019.","journal-title":"Microbiol Spectr"},{"key":"1991_CR12","doi-asserted-by":"publisher","first-page":"86","DOI":"10.15252\/emmm.201505790","volume":"8","author":"J Maertzdorf","year":"2016","unstructured":"Maertzdorf J, McEwen G, Weiner J 3rd, et al. Concise gene signature for point-of-care classification of tuberculosis. EMBO Mol Med. 2016;8:86\u201395. https:\/\/doi.org\/10.15252\/emmm.201505790.","journal-title":"EMBO Mol Med"},{"key":"1991_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102686","volume":"53","author":"Y Cai","year":"2020","unstructured":"Cai Y, Dai Y, Wang Y, et al. Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis. EBioMedicine. 2020;53: 102686. https:\/\/doi.org\/10.1016\/j.ebiom.2020.102686.","journal-title":"EBioMedicine"},{"key":"1991_CR14","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/CIRCRESAHA.120.315865","volume":"127","author":"G Marinkovic","year":"2020","unstructured":"Marinkovic G, Koenis DS, de Camp L, et al. S100A9 links inflammation and repair in myocardial infarction. Circ Res. 2020;127:664\u201376. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.315865.","journal-title":"Circ Res"},{"key":"1991_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.810338","volume":"13","author":"Y Li","year":"2022","unstructured":"Li Y, He Y, Chen S, et al. S100A12 as biomarker of disease severity and prognosis in patients with idiopathic pulmonary fibrosis. Front Immunol. 2022;13: 810338. https:\/\/doi.org\/10.3389\/fimmu.2022.810338.","journal-title":"Front Immunol"},{"key":"1991_CR16","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","volume":"9","author":"S Wang","year":"2018","unstructured":"Wang S, Song R, Wang Z, et al. S100A8\/A9 in inflammation. Front Immunol. 2018;9:1298. https:\/\/doi.org\/10.3389\/fimmu.2018.01298.","journal-title":"Front Immunol"},{"key":"1991_CR17","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3390\/cells11030538","volume":"11","author":"O Mirzalieva","year":"2022","unstructured":"Mirzalieva O, Juncker M, Schwartzenburg J, et al. ISG15 and ISGylation in human diseases. Cells. 2022;11:538. https:\/\/doi.org\/10.3390\/cells11030538.","journal-title":"Cells"},{"key":"1991_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12967-020-02698-x","volume":"19","author":"X Zhao","year":"2021","unstructured":"Zhao X, Zhang L, Wang J, et al. Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis. J Transl Med. 2021;19:35. https:\/\/doi.org\/10.1186\/s12967-020-02698-x.","journal-title":"J Transl Med"},{"key":"1991_CR19","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1007\/s13402-021-00651-8","volume":"44","author":"TH Li","year":"2021","unstructured":"Li TH, Zhao BB, Qin C, et al. IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt\/beta-catenin signaling. Cell Oncol. 2021;44:1425\u201337. https:\/\/doi.org\/10.1007\/s13402-021-00651-8.","journal-title":"Cell Oncol"},{"key":"1991_CR20","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s12015-018-9840-y","volume":"14","author":"A Eljaszewicz","year":"2018","unstructured":"Eljaszewicz A, Kleina K, Grubczak K, et al. Elevated numbers of circulating very small embryonic-like stem cells (VSELs) and intermediate CD14++CD16+ monocytes in IgA nephropathy. Stem Cell Rev Rep. 2018;14:686\u201393. https:\/\/doi.org\/10.1007\/s12015-018-9840-y.","journal-title":"Stem Cell Rev Rep"},{"key":"1991_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109696","volume":"36","author":"YJ Lu","year":"2021","unstructured":"Lu YJ, Barreira-Silva P, Boyce S, et al. CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection. Cell Rep. 2021;36: 109696. https:\/\/doi.org\/10.1016\/j.celrep.2021.109696.","journal-title":"Cell Rep"},{"key":"1991_CR22","doi-asserted-by":"publisher","first-page":"323","DOI":"10.4049\/jimmunol.1700172","volume":"199","author":"K Cerosaletti","year":"2017","unstructured":"Cerosaletti K, Barahmand-Pour-Whitman F, Yang J, et al. Single-cell RNA sequencing reveals expanded clones of islet antigen-reactive CD4(+) T cells in peripheral blood of subjects with type 1 diabetes. J Immunol. 2017;199:323\u201335. https:\/\/doi.org\/10.4049\/jimmunol.1700172.","journal-title":"J Immunol"},{"key":"1991_CR23","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.immuni.2017.11.020","volume":"48","author":"J Emgard","year":"2018","unstructured":"Emgard J, Kammoun H, Garcia-Cassani B, et al. Oxysterol sensing through the receptor GPR183 promotes the lymphoid-tissue-inducing function of innate lymphoid cells and colonic inflammation. Immunity. 2018;48:120-132.e8. https:\/\/doi.org\/10.1016\/j.immuni.2017.11.020.","journal-title":"Immunity"},{"key":"1991_CR24","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/978-1-4939-9650-6_8","volume":"2032","author":"A Saxena","year":"2019","unstructured":"Saxena A, Dagur PK, Biancotto A. Multiparametric flow cytometry analysis of naive, memory, and effector T cells. Methods Mol Biol. 2019;2032:129\u201340. https:\/\/doi.org\/10.1007\/978-1-4939-9650-6_8.","journal-title":"Methods Mol Biol"},{"key":"1991_CR25","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.cell.2017.05.035","volume":"169","author":"C Zheng","year":"2017","unstructured":"Zheng C, Zheng L, Yoo JK, et al. Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing. Cell. 2017;169:1342-1356.e16. https:\/\/doi.org\/10.1016\/j.cell.2017.05.035.","journal-title":"Cell"},{"key":"1991_CR26","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nri2297","volume":"8","author":"R Forster","year":"2008","unstructured":"Forster R, Davalos-Misslitz AC, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol. 2008;8:362\u201371. https:\/\/doi.org\/10.1038\/nri2297.","journal-title":"Nat Rev Immunol"},{"key":"1991_CR27","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2018.11.043","volume":"176","author":"H Li","year":"2019","unstructured":"Li H, van der Leun AM, Yofe I, et al. Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma. Cell. 2019;176:775-789.e18. https:\/\/doi.org\/10.1016\/j.cell.2018.11.043.","journal-title":"Cell"},{"key":"1991_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.12688\/gatesopenres.13472.2","volume":"5","author":"KL Fisher","year":"2021","unstructured":"Fisher KL, Rajkumar-Bhugeloo K, Moodley D, et al. Investigating neutrophil cell death in TB pathogenesis. Gates Open Res. 2021;5:175. https:\/\/doi.org\/10.12688\/gatesopenres.13472.2.","journal-title":"Gates Open Res"},{"key":"1991_CR29","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000363321","volume":"7","author":"S Esin","year":"2015","unstructured":"Esin S, Batoni G. Natural killer cells: a coherent model for their functional role in Mycobacterium tuberculosis infection. J Innate Immun. 2015;7:11\u201324. https:\/\/doi.org\/10.1159\/000363321.","journal-title":"J Innate Immun"},{"key":"1991_CR30","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3389\/fimmu.2020.00226","volume":"11","author":"JA Choreno-Parra","year":"2020","unstructured":"Choreno-Parra JA, Weinstein LI, Yunis EJ, et al. Thinking outside the box: innate- and B cell-memory responses as novel protective mechanisms against tuberculosis. Front Immunol. 2020;11:226. https:\/\/doi.org\/10.3389\/fimmu.2020.00226.","journal-title":"Front Immunol"},{"key":"1991_CR31","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1046\/j.1365-3083.2002.01063.x","volume":"55","author":"JE Moyron-Quiroz","year":"2002","unstructured":"Moyron-Quiroz JE, Partida-Sanchez S, Donis-Hernandez R, et al. Expression and function of CD22, a B-cell restricted molecule. Scand J Immunol. 2002;55:343\u201351. https:\/\/doi.org\/10.1046\/j.1365-3083.2002.01063.x.","journal-title":"Scand J Immunol"},{"key":"1991_CR32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ebiom.2017.01.042","volume":"16","author":"D Baker","year":"2017","unstructured":"Baker D, Marta M, Pryce G, et al. Memory B cells are major targets for effective immunotherapy in relapsing multiple sclerosis. EBioMedicine. 2017;16:41\u201350. https:\/\/doi.org\/10.1016\/j.ebiom.2017.01.042.","journal-title":"EBioMedicine"},{"key":"1991_CR33","doi-asserted-by":"publisher","first-page":"526","DOI":"10.4149\/neo_2009_06_526","volume":"56","author":"L Kovarova","year":"2009","unstructured":"Kovarova L, Buresova I, Buchler T, et al. Phenotype of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance. Neoplasma. 2009;56:526\u201332. https:\/\/doi.org\/10.4149\/neo_2009_06_526.","journal-title":"Neoplasma"},{"key":"1991_CR34","doi-asserted-by":"publisher","first-page":"4682","DOI":"10.1016\/j.cell.2022.10.025","volume":"185","author":"JL Flynn","year":"2022","unstructured":"Flynn JL, Chan J. Immune cell interactions in tuberculosis. Cell. 2022;185:4682\u2013702. https:\/\/doi.org\/10.1016\/j.cell.2022.10.025.","journal-title":"Cell"},{"key":"1991_CR35","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12:1088. https:\/\/doi.org\/10.1038\/s41467-021-21246-9.","journal-title":"Nat Commun"},{"key":"1991_CR36","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211777","volume":"219","author":"Y Cai","year":"2022","unstructured":"Cai Y, Wang Y, Shi C, et al. Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion. J Exp Med. 2022;219: e20211777. https:\/\/doi.org\/10.1084\/jem.20211777.","journal-title":"J Exp Med"},{"key":"1991_CR37","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/imr.12268","volume":"264","author":"Z Hmama","year":"2015","unstructured":"Hmama Z, Pena-Diaz S, Joseph S, et al. Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis. Immunol Rev. 2015;264:220\u201332. https:\/\/doi.org\/10.1111\/imr.12268.","journal-title":"Immunol Rev"},{"key":"1991_CR38","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1084\/jem.20172020","volume":"215","author":"L Huang","year":"2018","unstructured":"Huang L, Nazarova EV, Tan S, et al. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J Exp Med. 2018;215:1135\u201352. https:\/\/doi.org\/10.1084\/jem.20172020.","journal-title":"J Exp Med"},{"key":"1991_CR39","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1182\/blood-2016-01-688887","volume":"127","author":"C Silvestre-Roig","year":"2016","unstructured":"Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood. 2016;127:2173\u201381. https:\/\/doi.org\/10.1182\/blood-2016-01-688887.","journal-title":"Blood"},{"key":"1991_CR40","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat4579","volume":"3","author":"K Ley","year":"2018","unstructured":"Ley K, Hoffman HM, Kubes P, et al. Neutrophils: new insights and open questions. Sci Immunol. 2018;3: eaat4579. https:\/\/doi.org\/10.1126\/sciimmunol.aat4579.","journal-title":"Sci Immunol"},{"key":"1991_CR41","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41577-019-0141-8","volume":"19","author":"LG Ng","year":"2019","unstructured":"Ng LG, Ostuni R, Hidalgo A. Heterogeneity of neutrophils. Nat Rev Immunol. 2019;19:255\u201365. https:\/\/doi.org\/10.1038\/s41577-019-0141-8.","journal-title":"Nat Rev Immunol"},{"key":"1991_CR42","doi-asserted-by":"publisher","first-page":"473","DOI":"10.5483\/BMBRep.2022.55.10.115","volume":"55","author":"M Lee","year":"2022","unstructured":"Lee M, Lee SY, Bae YS. Emerging roles of neutrophils in immune homeostasis. BMB Rep. 2022;55:473\u201380. https:\/\/doi.org\/10.5483\/BMBRep.2022.55.10.115.","journal-title":"BMB Rep"},{"key":"1991_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.585293","volume":"11","author":"GR Kathamuthu","year":"2020","unstructured":"Kathamuthu GR, Moideen K, Sridhar R, et al. Diminished frequencies of cytotoxic marker expressing T- and NK cells at the site of Mycobacterium tuberculosis infection. Front Immunol. 2020;11: 585293. https:\/\/doi.org\/10.3389\/fimmu.2020.585293.","journal-title":"Front Immunol"},{"key":"1991_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010179","volume":"18","author":"CO Ogega","year":"2022","unstructured":"Ogega CO, Skinner NE, Flyak AI, et al. B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection. PLoS Pathog. 2022;18: e1010179. https:\/\/doi.org\/10.1371\/journal.ppat.1010179.","journal-title":"PLoS Pathog"},{"key":"1991_CR45","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00281-015-0490-8","volume":"37","author":"PL Lin","year":"2015","unstructured":"Lin PL. Flynn JL CD8 T cells and Mycobacterium tuberculosis infection. Semin Immunopathol. 2015;37:239\u201349. https:\/\/doi.org\/10.1007\/s00281-015-0490-8.","journal-title":"Semin Immunopathol"},{"key":"1991_CR46","doi-asserted-by":"publisher","first-page":"3500","DOI":"10.3390\/ijms20143500","volume":"20","author":"U Bommhardt","year":"2019","unstructured":"Bommhardt U, Schraven B, Simeoni L. Beyond TCR signaling: emerging functions of LCK in cancer and immunotherapy. Int J Mol Sci. 2019;20:3500. https:\/\/doi.org\/10.3390\/ijms20143500.","journal-title":"Int J Mol Sci"},{"key":"1991_CR47","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41556-020-00615-4","volume":"23","author":"J Wu","year":"2021","unstructured":"Wu J, Li G, Li L, et al. Asparagine enhances LCK signalling to potentiate CD8(+) T-cell activation and anti-tumour responses. Nat Cell Biol. 2021;23:75\u201386. https:\/\/doi.org\/10.1038\/s41556-020-00615-4.","journal-title":"Nat Cell Biol"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-024-01991-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-024-01991-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-024-01991-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:02:55Z","timestamp":1724889775000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-024-01991-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1991"],"URL":"https:\/\/doi.org\/10.1186\/s40001-024-01991-5","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"assertion":[{"value":"21 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of Tongji University affiliated Shanghai Pulmonary Hospital (No. K23-198), with the informed written consent of each participant. The study was conducted in accordance with the principles of the Declaration of Helsinki and the ethical and biosafety agreements of the institution.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"434"}}