{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:44:37Z","timestamp":1792115077878,"version":"4.4.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Key project of Anhui University Scientific Research Program","award":["2024AH051969"],"award-info":[{"award-number":["2024AH051969"]}]},{"name":"Mid-Young Research Fund of Wan-nan Medical College","award":["WK2023ZQNZ52"],"award-info":[{"award-number":["WK2023ZQNZ52"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-024-02125-7","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T13:03:05Z","timestamp":1730898185000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Homocysteine aggravates intestinal inflammation through promotion of 5-LOX and COX-2 in IBD"],"prefix":"10.1186","volume":"29","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"issue":"1","key":"2125_CR1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1159\/000441665","volume":"93","author":"Y Arai","year":"2016","unstructured":"Arai Y, Matsuura T, Matsuura M, Fujiwara M, Okayasu I, Ito S, Arihiro SJD. Prostaglandin E-major urinary metabolite as a biomarker for inflammation in ulcerative colitis: prostaglandins revisited. Digestion. 2016;93(1):32\u20139.","journal-title":"Digestion"},{"issue":"6","key":"2125_CR2","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/ibd.20403","volume":"14","author":"F Stanke-Labesque","year":"2008","unstructured":"Stanke-Labesque F, Pofelski J, Moreau-Gaudry A, Bessard G, Bonaz B. Urinary leukotriene E4 excretion: a biomarker of inflammatory bowel disease activity. Inflamm Bowel Dis. 2008;14(6):769\u201374.","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"2125_CR3","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1093\/intimm\/dxz044","volume":"31","author":"F Sasaki","year":"2019","unstructured":"Sasaki F, Yokomizo T. The leukotriene receptors as therapeutic targets of inflammatory diseases. Int Immunol. 2019;31(9):607\u201315.","journal-title":"Int Immunol"},{"key":"2125_CR4","doi-asserted-by":"publisher","first-page":"113735","DOI":"10.1016\/j.jep.2020.113735","volume":"269","author":"R Oliveira","year":"2021","unstructured":"Oliveira R, Damazo A, Antonielli L, Miyajima F, Pavan E, Duckworth C, Lima J, Arunachalam K, Martins D, Bipinnatum Radlk DJ. extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-\u03b1 and IL-1\u03b2 concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant effect. J Ethnopharmacol. 2021;269:113735.","journal-title":"J Ethnopharmacol"},{"key":"2125_CR5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10787-016-0263-6","volume":"24","author":"A Rashidian","year":"2016","unstructured":"Rashidian A, Muhammadnejad A, Dehpour A-R, Mehr SE, Akhavan MM, Shirkoohi R, Chamanara M, Mousavi S-E, Rezayat S-M. Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4\/NF-kB signaling pathway. Inflammopharmacology. 2016;24:109\u201318.","journal-title":"Inflammopharmacology"},{"issue":"6","key":"2125_CR6","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1007\/s10753-019-01085-z","volume":"42","author":"X-X Wu","year":"2019","unstructured":"Wu X-X, Huang X-L, Chen R-R, Li T, Ye H-J, Xie W, Huang Z-M, Cao G-Z. Paeoniflorin prevents intestinal barrier disruption and inhibits lipopolysaccharide (LPS)-induced inflammation in Caco-2 cell monolayers. Inflammation. 2019;42(6):2215\u201325.","journal-title":"Inflammation"},{"issue":"4","key":"2125_CR7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1136\/gut.51.4.529","volume":"51","author":"E Rijcken","year":"2002","unstructured":"Rijcken E, Krieglstein C, Anthoni C, Laukoetter M, Mennigen R, Spiegel H, Senninger N, Bennett C, Schuermann G. ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease. Gut. 2002;51(4):529\u201335.","journal-title":"Gut"},{"issue":"3","key":"2125_CR8","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.3233\/JAD-170700","volume":"62","author":"A Di Meco","year":"2018","unstructured":"Di Meco A, Li J-G, Pratico D. Dissecting the role of 5-lipoxygenase in the homocysteine-induced Alzheimer\u2019s disease pathology. J Alzheimer\u2019s Dis. 2018;62(3):1337\u201344.","journal-title":"J Alzheimer's Dis"},{"issue":"3","key":"2125_CR9","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1093\/gastro\/gou022","volume":"2","author":"H Ding","year":"2014","unstructured":"Ding H, Mei Q, Gan H-Z, Cao L-Y, Liu X-C, Xu J-M. Effect of homocysteine on intestinal permeability in rats with experimental colitis, and its mechanism. Gastroenterol Report. 2014;2(3):215\u201320.","journal-title":"Gastroenterol Report"},{"issue":"2","key":"2125_CR10","first-page":"103","volume":"57","author":"F Yang","year":"2005","unstructured":"Yang F, Tan HM, Wang H. Hyperhomocysteinemia and atherosclerosis. Acta Physiol Sinica-Chinese Edition. 2005;57(2):103.","journal-title":"Acta Physiol Sinica-Chinese Edition"},{"issue":"1","key":"2125_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3109\/03009742.2013.811537","volume":"43","author":"A Nowakowska-Plaza","year":"2014","unstructured":"Nowakowska-Plaza A, Potaczek DP, Gluszko P, Undas A. Antibodies to N-homocysteinylated albumin and haemoglobin in patients with rheumatoid arthritis: a potential new marker of disease severity. Scandinavian J Rheumatol. 2014;43(1):17\u201321.","journal-title":"Scandinavian J Rheumatol"},{"key":"2125_CR12","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s00415-007-0668-7","volume":"255","author":"C Russo","year":"2008","unstructured":"Russo C, Morabito F, Luise F, Piromalli A, Battaglia L, Vinci A, Trapani Lombardo V, De Marco V, Morabito P, Condino F, Quattrone A. Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis. J Neurol. 2008;255:64\u20139.","journal-title":"J Neurol"},{"key":"2125_CR13","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1007\/s10620-018-5177-2","volume":"63","author":"X Gao","year":"2018","unstructured":"Gao X, Li J, Chen MJ. Effect of homocysteine on the differentiation of CD4+ T cells into Th17 cells. Dig Dis Sci. 2018;63:3339\u201347.","journal-title":"Dig Dis Sci"},{"key":"2125_CR14","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s10753-018-0873-9","volume":"42","author":"H Hu","year":"2019","unstructured":"Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H. Catalpol inhibits homocysteine-induced oxidation and inflammation via inhibiting Nox4\/NF-\u03baB and GRP78\/PERK pathways in human aorta endothelial cells. Inflammation. 2019;42:64\u201380.","journal-title":"Inflammation"},{"issue":"7","key":"2125_CR15","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1111\/j.1572-0241.2001.03950.x","volume":"96","author":"J Romagnuolo","year":"2001","unstructured":"Romagnuolo J, Fedorak RN, Dias VC, Bamforth F, Teltscher M. Hyperhomocysteinemia and inflammatory bowel disease: prevalence and predictors in a cross-sectional study. Off J Am Coll Gastroenterol ACG. 2001;96(7):2143\u20139.","journal-title":"Off J Am Coll Gastroenterol ACG"},{"issue":"1","key":"2125_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/ibd.21048","volume":"16","author":"CN Bernstein","year":"2010","unstructured":"Bernstein CN, Fried M, Krabshuis J, Cohen H, Eliakim R, Fedail S, Gearry R, Goh K, Hamid S, Khan AG. World gastroenterology organization practice guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis. 2010;16(1):112\u201324.","journal-title":"Inflamm Bowel Dis"},{"key":"2125_CR17","first-page":"2083","volume":"48","author":"I Morgenstern","year":"2003","unstructured":"Morgenstern I, Raijmakers M, Peters W, Hoensch H, Kirch W. Homocysteine, cysteine, and glutathione in human colonic mucosa: elevated levels of homocysteine in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2003;48:2083\u201390.","journal-title":"Inflamm Bowel Dis"},{"issue":"8","key":"2125_CR18","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1111\/bph.13988","volume":"175","author":"Y Fu","year":"2018","unstructured":"Fu Y, Wang X, Kong W. Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets. British J Pharmacol. 2018;175(8):1173\u201389.","journal-title":"British J Pharmacol"},{"issue":"3","key":"2125_CR19","doi-asserted-by":"publisher","first-page":"C451","DOI":"10.1152\/ajpcell.2000.278.3.C451","volume":"278","author":"C Jobin","year":"2000","unstructured":"Jobin C, Sartor RB. The I\u03baB\/NF-\u03baB system: a key determinant of mucosal inflammation and protection. Am J Physiol Cell Physiol. 2000;278(3):C451\u201362.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"2125_CR20","doi-asserted-by":"publisher","first-page":"H2344","DOI":"10.1152\/ajpheart.00432.2007","volume":"293","author":"MA Carluccio","year":"2007","unstructured":"Carluccio MA, Ancora MA, Massaro M, Carluccio M, Scoditti E, Distante A, Storelli C, De Caterina R. Homocysteine induces VCAM-1 gene expression through NF-\u03baB and NAD (P) H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants. Am J Physiol Heart Circ Physiol. 2007;293(4):H2344\u201354.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2125_CR21","doi-asserted-by":"publisher","first-page":"100269","DOI":"10.1016\/j.hermed.2019.100269","volume":"17","author":"BH Cheng","year":"2019","unstructured":"Cheng BH, Hu TY, Ma L, Hu WH, Chen YY, Zeng XH, Zhao HL, Liu ZQ, Qiu SQ. Anti-inflammatory action of YHQ by regulating 5-LOX\/COX-2\/NF-\u03baB\/MAPKs\/Akt signaling pathways in RAW 264.7 macrophage cells. J Herbal Med. 2019;17:100269.","journal-title":"J Herbal Med"},{"issue":"12","key":"2125_CR22","first-page":"3S","volume":"17","author":"SE Wenzel","year":"1997","unstructured":"Wenzel SE. Arachidonic acid metabolites: mediators of inflammation in asthma. Pharmacother J Human Pharmacol Drug Ther. 1997;17(12):3S-12S.","journal-title":"Pharmacother J Human Pharmacol Drug Ther"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-024-02125-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-024-02125-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-024-02125-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T13:04:40Z","timestamp":1730898280000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-024-02125-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2125"],"URL":"https:\/\/doi.org\/10.1186\/s40001-024-02125-7","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,6]]},"assertion":[{"value":"28 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was reported in accordance with Declaration of Helsinki. This study was approved by the Institutional Review Board (IRB) at The First Affiliated Hospital of Anhui Medical University. Patients were consented by an informed consent process that was reviewed by the IRB. All animal studies and experimental procedures were approved by the Animal Care and Use Committee of the animal facility at The First Affiliated Hospital of Anhui Medical University. All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"537"}}