{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:43:21Z","timestamp":1793065401629,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Hospital-level project of Taizhou People's Hospital","award":["ZL201942"],"award-info":[{"award-number":["ZL201942"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-024-02166-y","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:52:55Z","timestamp":1732686775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Baicalin alleviates the injury of human retinal pigment epithelium cells and improves branch retinal vein occlusion in rats by inhibiting the HIF-1\u03b1\/VEGFA axis"],"prefix":"10.1186","volume":"29","author":[{"given":"Shiyue","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"2166_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100964","volume":"85","author":"SS Hayreh","year":"2021","unstructured":"Hayreh SS. Photocoagulation for retinal vein occlusion. Prog Retin Eye Res. 2021;85: 100964.","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"2166_CR2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.09.010427","volume":"9","author":"P Song","year":"2019","unstructured":"Song P, et al. Global epidemiology of retinal vein occlusion: a systematic review and meta-analysis of prevalence, incidence, and risk factors. J Glob Health. 2019;9(1): 010427.","journal-title":"J Glob Health"},{"issue":"4","key":"2166_CR3","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1159\/000494224","volume":"241","author":"JQ Li","year":"2019","unstructured":"Li JQ, et al. Prevalence of retinal vein occlusion in Europe: a systematic review and meta-analysis. Ophthalmologica. 2019;241(4):183\u20139.","journal-title":"Ophthalmologica"},{"key":"2166_CR4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.atherosclerosis.2016.02.024","volume":"247","author":"C Zhong","year":"2016","unstructured":"Zhong C, et al. Retinal vein occlusion and risk of cerebrovascular disease and myocardial infarction: a meta-analysis of cohort studies. Atherosclerosis. 2016;247:170\u20136.","journal-title":"Atherosclerosis"},{"issue":"2","key":"2166_CR5","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00417-020-04932-0","volume":"259","author":"JV Costa","year":"2021","unstructured":"Costa JV, et al. Macular edema secondary to retinal vein occlusion in a real-life setting: a multicenter, nationwide, 3-year follow-up study. Graefes Arch Clin Exp Ophthalmol. 2021;259(2):343\u201350.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"5","key":"2166_CR6","doi-asserted-by":"publisher","first-page":"13622","DOI":"10.1080\/21655979.2022.2081755","volume":"13","author":"L Kong","year":"2022","unstructured":"Kong L, et al. Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1\u03b1\/vascular endothelial growth factor\/STAT3 pathway. Bioengineered. 2022;13(5):13622\u201331.","journal-title":"Bioengineered"},{"key":"2166_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.exer.2018.09.014","volume":"178","author":"M Inada","year":"2019","unstructured":"Inada M, et al. Protective effects of dexamethasone on hypoxia-induced retinal edema in a mouse model. Exp Eye Res. 2019;178:82\u201390.","journal-title":"Exp Eye Res"},{"issue":"9","key":"2166_CR8","doi-asserted-by":"publisher","first-page":"3818","DOI":"10.1167\/iovs.16-21187","volume":"58","author":"MI Uddin","year":"2017","unstructured":"Uddin MI, et al. In vivo imaging of retinal hypoxia using HYPOX-4-dependent fluorescence in a mouse model of laser-induced retinal vein occlusion (RVO). Invest Ophthalmol Vis Sci. 2017;58(9):3818\u201324.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"2166_CR9","doi-asserted-by":"publisher","first-page":"3457","DOI":"10.3390\/jcm9113457","volume":"9","author":"H Noma","year":"2020","unstructured":"Noma H, Yasuda K, Shimura M. Cytokines and pathogenesis of central retinal vein occlusion. J Clin Med. 2020;9(11):3457.","journal-title":"J Clin Med"},{"key":"2166_CR10","doi-asserted-by":"publisher","first-page":"1162934","DOI":"10.3389\/fnut.2023.1162934","volume":"10","author":"S Lee","year":"2023","unstructured":"Lee S, et al. Inhibitory effect of fucoidan on TNF-\u03b1-induced inflammation in human retinal pigment epithelium cells. Front Nutr. 2023;10:1162934.","journal-title":"Front Nutr"},{"issue":"10","key":"2166_CR11","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/s41419-020-03076-7","volume":"11","author":"A Sui","year":"2020","unstructured":"Sui A, et al. Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1\u03b2\/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model. Cell Death Dis. 2020;11(10):901.","journal-title":"Cell Death Dis"},{"issue":"1","key":"2166_CR12","doi-asserted-by":"publisher","first-page":"5330","DOI":"10.1038\/s41598-023-32472-0","volume":"13","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, et al. Exploring the components and mechanisms of Shen-qi-wang-mo granule in the treatment of retinal vein occlusion by UPLC-triple TOF MS\/MS and network pharmacology. Sci Rep. 2023;13(1):5330.","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"2166_CR13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000502614","volume":"105","author":"HJ Sun","year":"2020","unstructured":"Sun HJ, et al. Baicalin alleviates age-related macular degeneration via miR-223\/NLRP3-regulated pyroptosis. Pharmacology. 2020;105(1\u20132):28\u201338.","journal-title":"Pharmacology"},{"key":"2166_CR14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.yexmp.2019.01.002","volume":"106","author":"C Dai","year":"2019","unstructured":"Dai C, et al. Baicalin protects human retinal pigment epithelial cell lines against high glucose-induced cell injury by up-regulation of microRNA-145. Exp Mol Pathol. 2019;106:123\u201330.","journal-title":"Exp Mol Pathol"},{"key":"2166_CR15","first-page":"9521379","volume":"2019","author":"P Long","year":"2019","unstructured":"Long P, et al. Therapeutic effect of traditional Chinese medicine on a rat model of branch retinal vein occlusion. J Ophthalmol. 2019;2019:9521379.","journal-title":"J Ophthalmol"},{"issue":"2","key":"2166_CR16","doi-asserted-by":"publisher","first-page":"10187","DOI":"10.1080\/21655979.2021.2001217","volume":"12","author":"N Zhao","year":"2021","unstructured":"Zhao N, et al. Baicalin suppresses glaucoma pathogenesis by regulating the PI3K\/AKT signaling in vitro and in vivo. Bioengineered. 2021;12(2):10187\u201398.","journal-title":"Bioengineered"},{"issue":"19","key":"2166_CR17","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1080\/15384101.2022.2087277","volume":"21","author":"K Zhao","year":"2022","unstructured":"Zhao K, et al. Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p\/HIF-1\u03b1\/VEGF pathway. Cell Cycle. 2022;21(19):2091\u2013108.","journal-title":"Cell Cycle"},{"key":"2166_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100921","volume":"83","author":"PA Campochiaro","year":"2021","unstructured":"Campochiaro PA, Akhlaq A. Sustained suppression of VEGF for treatment of retinal\/choroidal vascular diseases. Prog Retin Eye Res. 2021;83: 100921.","journal-title":"Prog Retin Eye Res"},{"key":"2166_CR19","doi-asserted-by":"publisher","first-page":"873","DOI":"10.3389\/fphar.2020.00873","volume":"11","author":"M V\u00e4h\u00e4tupa","year":"2020","unstructured":"V\u00e4h\u00e4tupa M, J\u00e4rvinen TAH, Uusitalo-J\u00e4rvinen H. Exploration of oxygen-induced retinopathy model to discover new therapeutic drug targets in retinopathies. Front Pharmacol. 2020;11:873.","journal-title":"Front Pharmacol"},{"key":"2166_CR20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI139202","author":"J Zhang","year":"2021","unstructured":"Zhang J, et al. HIF-1\u03b1 and HIF-2\u03b1 redundantly promote retinal neovascularization in patients with ischemic retinal disease. J Clin Invest. 2021. https:\/\/doi.org\/10.1172\/JCI139202.","journal-title":"J Clin Invest"},{"issue":"9","key":"2166_CR21","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1172\/JCI126655","volume":"129","author":"A Rattner","year":"2019","unstructured":"Rattner A, Williams J, Nathans J. Roles of HIFs and VEGF in angiogenesis in the retina and brain. J Clin Invest. 2019;129(9):3807\u201320.","journal-title":"J Clin Invest"},{"issue":"8","key":"2166_CR22","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.18240\/ijo.2022.08.11","volume":"15","author":"HF Qin","year":"2022","unstructured":"Qin HF, et al. Anti-VEGF reduces inflammatory features in macular edema secondary to retinal vein occlusion. Int J Ophthalmol. 2022;15(8):1296\u2013304.","journal-title":"Int J Ophthalmol"},{"issue":"11","key":"2166_CR23","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1007\/s00417-021-05211-2","volume":"259","author":"H Yong","year":"2021","unstructured":"Yong H, et al. The correlation between cytokine levels in the aqueous humor and the prognostic value of anti-vascular endothelial growth factor therapy for treating macular edema resulting from retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 2021;259(11):3243\u201350.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"7","key":"2166_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236928","volume":"15","author":"T Neo","year":"2020","unstructured":"Neo T, et al. Gene expression profile analysis of the rabbit retinal vein occlusion model. PLoS ONE. 2020;15(7): e0236928.","journal-title":"PLoS ONE"},{"key":"2166_CR25","first-page":"2265725","volume":"2022","author":"L Chen","year":"2022","unstructured":"Chen L, et al. Luteolin alleviates epithelial\u2013mesenchymal transformation induced by oxidative injury in ARPE-19 cell via Nrf2 and AKT\/GSK-3\u03b2 pathway. Oxid Med Cell Longev. 2022;2022:2265725.","journal-title":"Oxid Med Cell Longev"},{"key":"2166_CR26","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.biopha.2016.11.089","volume":"88","author":"C Zhu","year":"2017","unstructured":"Zhu C, et al. Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2\/HO-1 signal pathway in ARPE-19 cells. Biomed Pharmacother. 2017;88:124\u201333.","journal-title":"Biomed Pharmacother"},{"key":"2166_CR27","doi-asserted-by":"publisher","first-page":"7962393","DOI":"10.1155\/2020\/7962393","volume":"2020","author":"Z Yuan","year":"2020","unstructured":"Yuan Z, et al. Tribulus terrestris ameliorates oxidative stress-induced ARPE-19 cell injury through the PI3K\/Akt-Nrf2 signaling pathway. Oxid Med Cell Longev. 2020;2020:7962393.","journal-title":"Oxid Med Cell Longev"},{"key":"2166_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.927898","volume":"13","author":"C Park","year":"2022","unstructured":"Park C, et al. Fisetin attenuated oxidative stress-induced cellular damage in ARPE-19 human retinal pigment epithelial cells through Nrf2-mediated activation of heme oxygenase-1. Front Pharmacol. 2022;13: 927898.","journal-title":"Front Pharmacol"},{"issue":"2","key":"2166_CR29","first-page":"305","volume":"40","author":"B Lu","year":"2020","unstructured":"Lu B, Wu X. Effect of Lingqi Huangban granule plus intravitreal ranibizumab on macular edema induced by retinal vein occlusion: a randomized controlled clinical trial. J Tradit Chin Med. 2020;40(2):305\u201310.","journal-title":"J Tradit Chin Med"},{"issue":"7","key":"2166_CR30","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1007\/s00417-020-05068-x","volume":"259","author":"T Kida","year":"2021","unstructured":"Kida T, et al. Retinal venous pressure is decreased after anti-VEGF therapy in patients with retinal vein occlusion-related macular edema. Graefes Arch Clin Exp Ophthalmol. 2021;259(7):1853\u20138.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"2166_CR31","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s12886-023-02921-5","volume":"23","author":"YC Wang","year":"2023","unstructured":"Wang YC, et al. The role of serum metrics in anti- VEGF treatment for macular edema induced by retinal vein occlusion. BMC Ophthalmol. 2023;23(1):173.","journal-title":"BMC Ophthalmol"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-024-02166-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-024-02166-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-024-02166-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T06:03:30Z","timestamp":1732687410000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-024-02166-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2166"],"URL":"https:\/\/doi.org\/10.1186\/s40001-024-02166-y","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"3 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All samples obtained in this study were approved by the ethics committee of the Taizhou People\u2019s Hospital and abided by the ethical guidelines of the Declaration of Helsinki. All animal experiments comply with the guidelines for the care and use of laboratory animals established by the National Institutes of Health (Bethesda, Maryland, USA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"564"}}