{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T05:09:02Z","timestamp":1738300142000,"version":"3.35.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shaanxi Province Key Research and Development Plan","award":["2024SF-YBXM-114"],"award-info":[{"award-number":["2024SF-YBXM-114"]}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2021JM-256"],"award-info":[{"award-number":["2021JM-256"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-02290-3","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T05:34:42Z","timestamp":1738215282000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CCDC154 knockdown inhibits growth of liver cancer via suppressing expression of Snail"],"prefix":"10.1186","volume":"30","author":[{"given":"Rulan","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caijing","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"2290_CR1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","author":"H Sung","year":"2020","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2020.","journal-title":"CA Cancer J Clin"},{"key":"2290_CR2","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1159\/000509424","volume":"9","author":"J Zhou","year":"2020","unstructured":"Zhou J, Sun H, Wang Z, Cong W, Wang J, Zeng M, et al. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition). Liver Cancer. 2020;9:682\u2013720.","journal-title":"Liver Cancer"},{"key":"2290_CR3","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","volume":"16","author":"JD Yang","year":"2019","unstructured":"Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16:589\u2013604.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2290_CR4","doi-asserted-by":"publisher","first-page":"18296","DOI":"10.18632\/oncotarget.15433","volume":"8","author":"JH Zhong","year":"2017","unstructured":"Zhong JH, Peng NF, You XM, Ma L, Xiang X, Wang YY, et al. Tumor stage and primary treatment of hepatocellular carcinoma at a large tertiary hospital in China: a real-world study. Oncotarget. 2017;8:18296\u2013302.","journal-title":"Oncotarget"},{"key":"2290_CR5","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/1471-2148-5-66","volume":"5","author":"A Rose","year":"2005","unstructured":"Rose A, Schraegle SJ, Stahlberg EA, Meier I. Coiled-coil protein composition of 22 proteomes\u2013differences and common themes in subcellular infrastructure and traffic control. BMC Evol Biol. 2005;5:66.","journal-title":"BMC Evol Biol"},{"key":"2290_CR6","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1007\/s43032-021-00595-2","volume":"28","author":"PP Priyanka","year":"2021","unstructured":"Priyanka PP, Yenugu S. Coiled-coil domain-containing (CCDC) proteins: functional roles in general and male reproductive physiology. Reprod Sci. 2021;28:2725\u201334.","journal-title":"Reprod Sci"},{"key":"2290_CR7","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/bies.201600062","volume":"38","author":"L Truebestein","year":"2016","unstructured":"Truebestein L, Leonard TA. Coiled-coils: the long and short of it. BioEssays. 2016;38:903\u201316.","journal-title":"BioEssays"},{"key":"2290_CR8","doi-asserted-by":"publisher","first-page":"25856","DOI":"10.18632\/oncotarget.4624","volume":"6","author":"Y Gong","year":"2015","unstructured":"Gong Y, Qiu W, Ning X, Yang X, Liu L, Wang Z, et al. CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration. Oncotarget. 2015;6:25856\u201367.","journal-title":"Oncotarget"},{"key":"2290_CR9","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s13046-016-0466-0","volume":"35","author":"A Tanouchi","year":"2016","unstructured":"Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, et al. CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells. J Exp Clin Cancer Res. 2016;35:190.","journal-title":"J Exp Clin Cancer Res"},{"key":"2290_CR10","doi-asserted-by":"publisher","first-page":"5830","DOI":"10.18632\/oncotarget.6709","volume":"7","author":"DT Yin","year":"2016","unstructured":"Yin DT, Xu J, Lei M, Li H, Wang Y, Liu Z, et al. Characterization of the novel tumor-suppressor gene CCDC67 in papillary thyroid carcinoma. Oncotarget. 2016;7:5830\u201341.","journal-title":"Oncotarget"},{"key":"2290_CR11","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1093\/carcin\/bgs178","volume":"33","author":"SJ Park","year":"2012","unstructured":"Park SJ, Jang HR, Kim M, Kim JH, Kwon OH, Park JL, et al. Epigenetic alteration of CCDC67 and its tumor suppressor function in gastric cancer. Carcinogenesis. 2012;33:1494\u2013501.","journal-title":"Carcinogenesis"},{"key":"2290_CR12","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1038\/leu.2009.144","volume":"23","author":"A Farfsing","year":"2009","unstructured":"Farfsing A, Engel F, Seiffert M, Hartmann E, Ott G, Rosenwald A, et al. Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia. Leukemia. 2009;23:2018\u201326.","journal-title":"Leukemia"},{"key":"2290_CR13","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/carcin\/bgn288","volume":"30","author":"M Chen","year":"2009","unstructured":"Chen M, Ni J, Chang HC, Lin CY, Muyan M, Yeh S. CCDC62\/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. Carcinogenesis. 2009;30:841\u201350.","journal-title":"Carcinogenesis"},{"key":"2290_CR14","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/nsmb1277","volume":"14","author":"H Kim","year":"2007","unstructured":"Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol. 2007;14:710\u20135.","journal-title":"Nat Struct Mol Biol"},{"key":"2290_CR15","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2020.31.e11","volume":"31","author":"H Kunitomi","year":"2020","unstructured":"Kunitomi H, Kobayashi Y, Wu RC, Takeda T, Tominaga E, Banno K, et al. LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer. J Gynecol Oncol. 2020;31: e11.","journal-title":"J Gynecol Oncol"},{"key":"2290_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cancergencyto.2010.04.018","volume":"201","author":"MV Yusenko","year":"2010","unstructured":"Yusenko MV, Nagy A, Kovacs G. Molecular analysis of germline t(3;6) and t(3;12) associated with conventional renal cell carcinomas indicates their rate-limiting role and supports the three-hit model of carcinogenesis. Cancer Genet Cytogenet. 2010;201:15\u201323.","journal-title":"Cancer Genet Cytogenet"},{"key":"2290_CR17","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1074\/mcp.M115.055723","volume":"15","author":"SV Kozlov","year":"2016","unstructured":"Kozlov SV, Waardenberg AJ, Engholm-Keller K, Arthur JW, Graham ME, Lavin M. Reactive oxygen species (ROS)-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large-scale phosphoproteomics screen. Mol Cell Proteomics. 2016;15:1032\u201347.","journal-title":"Mol Cell Proteomics"},{"key":"2290_CR18","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.18632\/aging.202382","volume":"13","author":"PS Chen","year":"2021","unstructured":"Chen PS, Hsu HP, Phan NN, Yen MC, Chen FW, Liu YW, et al. CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer. Aging (Albany NY). 2021;13:4157\u201381.","journal-title":"Aging (Albany NY)"},{"key":"2290_CR19","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.7150\/jca.76050","volume":"13","author":"T Wu","year":"2022","unstructured":"Wu T, Jiang X, Xu B, Zhong Q, Zheng J, Zhang X, et al. High expression of CCDC6 in relation to unfavorable outcome and immune cells infiltration in hepatobiliary carcinoma. J Cancer. 2022;13:3378\u201395.","journal-title":"J Cancer"},{"key":"2290_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.878648","volume":"9","author":"H Deng","year":"2022","unstructured":"Deng H, Zhang J, Zheng Y, Li J, Xiao Q, Wei F, et al. CCDC25 may be a potential diagnostic and prognostic marker of hepatocellular carcinoma: results from microarray analysis. Front Surg. 2022;9: 878648.","journal-title":"Front Surg"},{"key":"2290_CR21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2147\/OTT.S237399","volume":"13","author":"Z Lin","year":"2020","unstructured":"Lin Z, Qu S, Peng W, Yang P, Zhang R, Zhang P, et al. Up-regulated CCDC34 contributes to the proliferation and metastasis of hepatocellular carcinoma. Onco Targets Ther. 2020;13:51\u201360.","journal-title":"Onco Targets Ther"},{"key":"2290_CR22","doi-asserted-by":"publisher","first-page":"7745315","DOI":"10.1155\/2022\/7745315","volume":"2022","author":"S Liu","year":"2022","unstructured":"Liu S, Jia L, Quan B, Rong G, Li M, Xie R, et al. Coiled-coil domain-containing protein 45 is a potential prognostic biomarker and is associated with immune cell enrichment of hepatocellular carcinoma. Dis Markers. 2022;2022:7745315.","journal-title":"Dis Markers"},{"key":"2290_CR23","first-page":"7424","volume":"15","author":"C Li","year":"2023","unstructured":"Li C, Jia Y, Li N, Zhou Q, Liu R, Wang Q. DNA methylation-mediated high expression of CCDC50 correlates with poor prognosis and hepatocellular carcinoma progression. Aging (Albany NY). 2023;15:7424\u201339.","journal-title":"Aging (Albany NY)"},{"key":"2290_CR24","first-page":"2568","volume":"15","author":"L Chen","year":"2023","unstructured":"Chen L, Zhang J, Yang Y, Shu J, Zheng J, Zhan X, et al. Coiled-coil domain-containing protein 58 (CCDC58) is a novel prognostic biomarker correlated with mitochondrial functions in hepatocellular carcinoma. Am J Transl Res. 2023;15:2568\u201384.","journal-title":"Am J Transl Res"},{"key":"2290_CR25","doi-asserted-by":"publisher","first-page":"5638675","DOI":"10.1155\/2022\/5638675","volume":"2022","author":"L Bai","year":"2022","unstructured":"Bai L, Yang ZX, Liu JS, Wang DS, Yu HC. Prognostic significance of CCDC137 expression and its association with immune infiltration in hepatocellular carcinoma. Dis Markers. 2022;2022:5638675.","journal-title":"Dis Markers"},{"key":"2290_CR26","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1038\/onc.2017.10","volume":"36","author":"X Hu","year":"2017","unstructured":"Hu X, Zhao Y, Wei L, Zhu B, Song D, Wang J, et al. CCDC178 promotes hepatocellular carcinoma metastasis through modulation of anoikis. Oncogene. 2017;36:4047\u201359.","journal-title":"Oncogene"},{"key":"2290_CR27","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.4161\/cc.21642","volume":"11","author":"W Liao","year":"2012","unstructured":"Liao W, Zhao R, Lu L, Zhang R, Zou J, Xu T, et al. Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2\/M arrest. Cell Cycle. 2012;11:3270\u20139.","journal-title":"Cell Cycle"},{"key":"2290_CR28","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1186\/s12885-020-07069-9","volume":"20","author":"Q Pu","year":"2020","unstructured":"Pu Q, Lv YR, Dong K, Geng WW, Gao HD. Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells. BMC Cancer. 2020;20:583.","journal-title":"BMC Cancer"},{"key":"2290_CR29","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12967-021-03100-0","volume":"19","author":"R Ma","year":"2021","unstructured":"Ma R, Zhu K, Yuan D, Gong M, Li Y, Li K, et al. Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA. J Transl Med. 2021;19:425.","journal-title":"J Transl Med"},{"key":"2290_CR30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.canlet.2019.12.030","volume":"473","author":"H Ying","year":"2020","unstructured":"Ying H, Ji L, Xu Z, Fan X, Tong Y, Liu H, et al. TRIM59 promotes tumor growth in hepatocellular carcinoma and regulates the cell cycle by degradation of protein phosphatase 1B. Cancer Lett. 2020;473:13\u201324.","journal-title":"Cancer Lett"},{"key":"2290_CR31","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12935-022-02515-z","volume":"22","author":"D Yuan","year":"2022","unstructured":"Yuan D, Ma R, Sun T, Zhu K, Dang C, Ye H, et al. Knockdown of RSPH14 inhibits proliferation, migration, and invasion and promotes apoptosis of hepatocellular carcinoma via RelA. Cancer Cell Int. 2022;22:129.","journal-title":"Cancer Cell Int"},{"key":"2290_CR32","first-page":"2099","volume":"12","author":"J Chao","year":"2020","unstructured":"Chao J, Zhao S, Sun H. Dedifferentiation of hepatocellular carcinoma: molecular mechanisms and therapeutic implications. Am J Transl Res. 2020;12:2099\u2013109.","journal-title":"Am J Transl Res"},{"key":"2290_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.985815","volume":"13","author":"Q Han","year":"2022","unstructured":"Han Q, Wang M, Dong X, Wei F, Luo Y, Sun X. Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential. Front Immunol. 2022;13: 985815.","journal-title":"Front Immunol"},{"key":"2290_CR34","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.neo.2019.04.009","volume":"21","author":"D Wangsa","year":"2019","unstructured":"Wangsa D, Braun R, Stuelten CH, Brown M, Bauer KM, Emons G, et al. Induced chromosomal aneuploidy results in global and consistent deregulation of the transcriptome of cancer cells. Neoplasia. 2019;21:721\u20139.","journal-title":"Neoplasia"},{"key":"2290_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204912","volume":"13","author":"VG Wang","year":"2018","unstructured":"Wang VG, Kim H, Chuang JH. Whole-exome sequencing capture kit biases yield false negative mutation calls in TCGA cohorts. PLoS ONE. 2018;13: e0204912.","journal-title":"PLoS ONE"},{"key":"2290_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003876","volume":"9","author":"AE Gylfe","year":"2013","unstructured":"Gylfe AE, Katainen R, Kondelin J, Tanskanen T, Cajuso T, H\u00e4nninen U, et al. Eleven candidate susceptibility genes for common familial colorectal cancer. PLoS Genet. 2013;9: e1003876.","journal-title":"PLoS Genet"},{"key":"2290_CR37","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.1038\/s41388-022-02477-6","volume":"41","author":"X Wang","year":"2022","unstructured":"Wang X, Liu Y, Han A, Tang C, Xu R, Feng L, et al. The NQO1\/p53\/SREBP1 axis promotes hepatocellular carcinoma progression and metastasis by regulating Snail stability. Oncogene. 2022;41:5107\u201320.","journal-title":"Oncogene"},{"key":"2290_CR38","doi-asserted-by":"publisher","first-page":"4120","DOI":"10.1111\/cas.15571","volume":"113","author":"S Peng","year":"2022","unstructured":"Peng S, Chen Y, Li T, Mao J, Yang P, Zou B, et al. Hsa-microRNA-370\u20133p targeting Snail and Twist1 suppresses IL-8\/STAT3-driven hepatocellular carcinoma metastasis. Cancer Sci. 2022;113:4120\u201334.","journal-title":"Cancer Sci"},{"key":"2290_CR39","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41419-022-05135-7","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zuo D, Qiu J, Li K, Niu Y, Yuan Y, et al. NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3. Cell Death Dis. 2022;13:676.","journal-title":"Cell Death Dis"},{"issue":"5","key":"2290_CR40","volume":"2024","author":"X Li","year":"2020","unstructured":"Li X, Han M, Zhu H, Zhang H, Pan Y, Liang H, et al. N6-methyladenosine reader YTHDF3-mediated zinc finger protein 41 inhibits hepatocellular carcinoma progression by transcriptional repression of Snail. MedComm. 2020;2024(5): e763.","journal-title":"MedComm"},{"key":"2290_CR41","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1007\/s12072-024-10696-0","volume":"18","author":"SS Zheng","year":"2024","unstructured":"Zheng SS, Wu JF, Wu WX, Hu JW, Zhang D, Huang C, et al. CBX1 is involved in hepatocellular carcinoma progression and resistance to sorafenib and lenvatinib via IGF-1R\/AKT\/SNAIL signaling pathway. Hepatol Int. 2024;18:1499\u2013515.","journal-title":"Hepatol Int"},{"key":"2290_CR42","doi-asserted-by":"publisher","first-page":"565","DOI":"10.2147\/JHC.S452924","volume":"11","author":"YQ Du","year":"2024","unstructured":"Du YQ, Yuan B, Ye YX, Zhou FL, Liu H, Huang JJ, et al. Plumbagin regulates snail to inhibit hepatocellular carcinoma epithelial-mesenchymal transition in vivo and in vitro. J Hepatocell Carcinoma. 2024;11:565\u201380.","journal-title":"J Hepatocell Carcinoma"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-02290-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-02290-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-02290-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T05:36:40Z","timestamp":1738215400000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-02290-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,30]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2290"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-02290-3","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,30]]},"assertion":[{"value":"16 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments in this study complied with the ethical guidelines for animal experiments, and the conduct of animal experiments was supervised and approved by the Institutional Animal Care Committee of the Animal Experimental Centre of Xi\u2019an Jiaotong University (Ethical approval number: XJTULAC2021-1341).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agree to publish this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"59"}}