{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:22:25Z","timestamp":1789078945897,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"crossref","award":["LZ22H080002"],"award-info":[{"award-number":["LZ22H080002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-02465-y","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T16:30:07Z","timestamp":1743179407000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of splenectomy on prognosis in lymphoma with splenic involvement"],"prefix":"10.1186","volume":"30","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"issue":"18","key":"2465_CR1","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1182\/blood.2023021786","volume":"144","author":"L de Leval","year":"2024","unstructured":"de Leval L, Gaulard P, Dogan A. A practical approach to the modern diagnosis and classification of T- and NK-cell lymphomas. Blood. 2024;144(18):1855\u201372. https:\/\/doi.org\/10.1182\/blood.2023021786.","journal-title":"Blood"},{"key":"2465_CR2","doi-asserted-by":"publisher","first-page":"1059914","DOI":"10.3389\/fonc.2023.1059914","volume":"13","author":"Y Chu","year":"2023","unstructured":"Chu Y, et al. The epidemiological patterns of non-Hodgkin lymphoma: global estimates of disease burden, risk factors, and temporal trends. Front Oncol. 2023;13:1059914. https:\/\/doi.org\/10.3389\/fonc.2023.1059914.","journal-title":"Front Oncol"},{"issue":"1","key":"2465_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13045-022-01281-9","volume":"15","author":"J Huang","year":"2022","unstructured":"Huang J, et al. Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis. J Hematol Oncol. 2022;15(1):57. https:\/\/doi.org\/10.1186\/s13045-022-01281-9.","journal-title":"J Hematol Oncol"},{"issue":"9","key":"2465_CR4","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1182\/blood-2010-09-271437","volume":"117","author":"E Iannitto","year":"2011","unstructured":"Iannitto E, Tripodo C. How I diagnose and treat splenic lymphomas. Blood. 2011;117(9):2585\u201395. https:\/\/doi.org\/10.1182\/blood-2010-09-271437.","journal-title":"Blood"},{"issue":"9","key":"2465_CR5","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/j.1440-1827.2012.02844.x","volume":"62","author":"K Shimizu-Kohno","year":"2012","unstructured":"Shimizu-Kohno K, et al. Malignant lymphoma of the spleen in Japan: a clinicopathological analysis of 115 cases. Pathol Int. 2012;62(9):577\u201382. https:\/\/doi.org\/10.1111\/j.1440-1827.2012.02844.x.","journal-title":"Pathol Int"},{"issue":"3","key":"2465_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/his.14124","volume":"77","author":"A Zam\u00f2","year":"2020","unstructured":"Zam\u00f2 A, Johnston P, Attygalle AD, Laurent C, Arber DA, Fend F. Aggressive B-cell lymphomas with a primary bone marrow presentation. Histopathology. 2020;77(3):369\u201379. https:\/\/doi.org\/10.1111\/his.14124.","journal-title":"Histopathology"},{"issue":"3","key":"2465_CR7","first-page":"208","volume":"40","author":"R Zhang","year":"2002","unstructured":"Zhang R, Wang D, Li Q, Sun T, Hao X. Primary lymphoma of the spleen: clinical analysis of 23 cases. Zhonghua Wai Ke Za Zhi. 2002;40(3):208\u20139.","journal-title":"Zhonghua Wai Ke Za Zhi"},{"issue":"2","key":"2465_CR8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1188\/11.CJON.189-193","volume":"15","author":"GA McNally","year":"2011","unstructured":"McNally GA. B-cell lymphoma, unclassifiable: a review of the literature. Clin J Oncol Nurs. 2011;15(2):189\u201393. https:\/\/doi.org\/10.1188\/11.CJON.189-193.","journal-title":"Clin J Oncol Nurs"},{"issue":"10","key":"2465_CR9","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1007\/s00277-014-2115-z","volume":"93","author":"JH Park","year":"2014","unstructured":"Park JH, et al. The highest prognostic impact of LDH among international prognostic indices (IPIs): an explorative study of five IPI factors among patients with DLBCL in the era of rituximab. Ann Hematol. 2014;93(10):1755\u201364. https:\/\/doi.org\/10.1007\/s00277-014-2115-z.","journal-title":"Ann Hematol"},{"key":"2465_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-94-017-7215-0_8","volume":"867","author":"V Jurisic","year":"2015","unstructured":"Jurisic V, Radenkovic S, Konjevic G. The actual role of LDH as tumor marker, biochemical and clinical aspects. Adv Exp Med Biol. 2015;867:115\u201324. https:\/\/doi.org\/10.1007\/978-94-017-7215-0_8.","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"2465_CR11","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1385\/MO:21:2:179","volume":"21","author":"V Jurisi\u0107","year":"2004","unstructured":"Jurisi\u0107 V, et al. The comparison of spontaneous LDH release activity from cultured PBMC with sera LDH activity in non-Hodgkin\u2019s lymphoma patients. Med Oncol. 2004;21(2):179\u201385. https:\/\/doi.org\/10.1385\/MO:21:2:179.","journal-title":"Med Oncol"},{"issue":"11","key":"2465_CR12","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.annonc.2021.08.1991","volume":"32","author":"GA Croci","year":"2021","unstructured":"Croci GA, et al. SPARC-positive macrophages are the superior prognostic factor in the microenvironment of diffuse large B-cell lymphoma and independent of MYC rearrangement and double-\/triple-hit status. Ann Oncol. 2021;32(11):1400\u20139. https:\/\/doi.org\/10.1016\/j.annonc.2021.08.1991.","journal-title":"Ann Oncol"},{"issue":"9","key":"2465_CR13","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1080\/14789450.2020.1845654","volume":"17","author":"V Jurisic","year":"2020","unstructured":"Jurisic V. Multiomic analysis of cytokines in immuno-oncology. Expert Rev Proteom. 2020;17(9):663\u201374. https:\/\/doi.org\/10.1080\/14789450.2020.1845654.","journal-title":"Expert Rev Proteom"},{"issue":"2","key":"2465_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s00277-003-0731-0","volume":"83","author":"V Jurisic","year":"2004","unstructured":"Jurisic V, Bumbasirevic V, Konjevic G, Djuricic B, Spuzic I. TNF-alpha induces changes in LDH isotype profile following triggering of apoptosis in PBL of non-Hodgkin\u2019s lymphomas. Ann Hematol. 2004;83(2):84\u201391. https:\/\/doi.org\/10.1007\/s00277-003-0731-0.","journal-title":"Ann Hematol"},{"issue":"23","key":"2465_CR15","doi-asserted-by":"publisher","first-page":"7001","DOI":"10.7150\/jca.47816","volume":"11","author":"Y Fei","year":"2020","unstructured":"Fei Y, et al. Plasma soluble PD-L1 and STAT3 predict the prognosis in diffuse large B cell lymphoma patients. J Cancer. 2020;11(23):7001\u20138. https:\/\/doi.org\/10.7150\/jca.47816.","journal-title":"J Cancer"},{"issue":"9","key":"2465_CR16","first-page":"5738","volume":"7","author":"MC Smith","year":"2014","unstructured":"Smith MC, et al. The ambiguous boundary between EBV-related hemophagocytic lymphohistiocytosis and systemic EBV-driven T cell lymphoproliferative disorder. Int J Clin Exp Pathol. 2014;7(9):5738\u201349.","journal-title":"Int J Clin Exp Pathol"},{"key":"2465_CR17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/1471-2407-14-153","volume":"14","author":"X He","year":"2014","unstructured":"He X, et al. Ki-67 is a valuable prognostic predictor of lymphoma but its utility varies in lymphoma subtypes: evidence from a systematic meta-analysis. BMC Cancer. 2014;14:153. https:\/\/doi.org\/10.1186\/1471-2407-14-153.","journal-title":"BMC Cancer"},{"issue":"20","key":"2465_CR18","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1200\/JCO.2015.65.3469","volume":"34","author":"BE Appel","year":"2016","unstructured":"Appel BE, et al. Minimal treatment of low-risk, pediatric lymphocyte-predominant hodgkin lymphoma: a report from the children\u2019s oncology group. J Clin Oncol. 2016;34(20):2372\u20139. https:\/\/doi.org\/10.1200\/JCO.2015.65.3469.","journal-title":"J Clin Oncol"},{"issue":"2","key":"2465_CR19","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/bjh.15444","volume":"185","author":"D Chihara","year":"2019","unstructured":"Chihara D, et al. Stage I Non-Hodgkin Lymphoma: difference in survival outcome by primary extranodal site of involvement. Br J Haematol. 2019;185(2):334\u20138. https:\/\/doi.org\/10.1111\/bjh.15444.","journal-title":"Br J Haematol"},{"issue":"2","key":"2465_CR20","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/modpathol.2017.134","volume":"31","author":"M Miyaoka","year":"2018","unstructured":"Miyaoka M, et al. Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and\/or BCL6 rearrangements. Mod Pathol. 2018;31(2):313\u201326. https:\/\/doi.org\/10.1038\/modpathol.2017.134.","journal-title":"Mod Pathol"},{"issue":"8","key":"2465_CR21","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.leukres.2014.04.009","volume":"38","author":"AJ Olszewski","year":"2014","unstructured":"Olszewski AJ, Winer ES, Castillo JJ. Improved survival with rituximab-based chemoimmunotherapy in older patients with extranodal diffuse large B-cell lymphoma. Leuk Res. 2014;38(8):866\u201373. https:\/\/doi.org\/10.1016\/j.leukres.2014.04.009.","journal-title":"Leuk Res"},{"issue":"1","key":"2465_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1053\/j.sult.2006.10.001","volume":"28","author":"S Lieberman","year":"2007","unstructured":"Lieberman S, Libson E, Sella T, Lebensart P, Sosna J. Percutaneous image-guided splenic procedures: update on indications, technique, complications, and outcomes. Semin Ultrasound CT MR. 2007;28(1):57\u201363. https:\/\/doi.org\/10.1053\/j.sult.2006.10.001.","journal-title":"Semin Ultrasound CT MR"},{"issue":"10","key":"2465_CR23","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1001\/jamasurg.2014.285","volume":"149","author":"N Bagrodia","year":"2014","unstructured":"Bagrodia N, Button AM, Spanheimer PM, Belding-Schmitt ME, Rosenstein LJ, Mezhir JJ. Morbidity and mortality following elective splenectomy for benign and malignant hematologic conditions: analysis of the American college of surgeons national surgical quality improvement program data. JAMA Surg. 2014;149(10):1022\u20139. https:\/\/doi.org\/10.1001\/jamasurg.2014.285.","journal-title":"JAMA Surg"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-02465-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-02465-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-02465-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T16:30:09Z","timestamp":1743179409000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-02465-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2465"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-02465-y","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"20 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed written consent was obtained from all subjects and\/or their legal guardian(s) for participation in the study. This study was approved by the Institutional Ethics Committee of the First Affiliated Hospital of Zhejiang University. All methods were carried out in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"213"}}