{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:47:44Z","timestamp":1781880464642,"version":"3.54.5"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Science Foundation of Putian Technology Division","award":["2018S3Y004"],"award-info":[{"award-number":["2018S3Y004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-02809-8","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T06:23:15Z","timestamp":1751350995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of tumour-associated macrophages on cardia carcinoma progression"],"prefix":"10.1186","volume":"30","author":[{"given":"Zhixiong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"1","key":"2809_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40364-024-00720-8","volume":"13","author":"N Qin","year":"2025","unstructured":"Qin N, Fan Y, Yang T, et al. The burden of Gastric Cancer and possible risk factors from 1990 to 2021, and projections until 2035: findings from the Global Burden of Disease Study 2021. Biomark Res. 2025;13(1):5.","journal-title":"Biomark Res"},{"issue":"3","key":"2809_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"10","key":"2809_CR3","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1016\/j.dld.2024.02.008","volume":"56","author":"F Farinati","year":"2024","unstructured":"Farinati F, Pelizzaro F. Gastric cancer screening in Western countries: a call to action. Dig Liver Dis. 2024;56(10):1653\u201362.","journal-title":"Dig Liver Dis"},{"issue":"13","key":"2809_CR4","doi-asserted-by":"publisher","first-page":"6114","DOI":"10.1002\/cam4.2497","volume":"8","author":"E Abdi","year":"2019","unstructured":"Abdi E, Latifi-Navid S, Zahri S, et al. Risk factors predisposing to cardia gastric adenocarcinoma: insights and new perspectives. Cancer Med. 2019;8(13):6114\u201326.","journal-title":"Cancer Med"},{"key":"2809_CR5","unstructured":"Cai Q, Yang J, Shen H, et al. TAM Progress of in gastric cancer development and drug resistance. Chin J Comp Med. 2025:1\u201312."},{"issue":"1","key":"2809_CR6","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1186\/s12889-024-19104-6","volume":"24","author":"J Lin","year":"2024","unstructured":"Lin J, Lin J, Lin G, et al. Global incidence and mortality trends of gastric cancer and predicted mortality of gastric cancer by 2035. BMC Public Health. 2024;24(1):1763.","journal-title":"BMC Public Health"},{"issue":"Suppl 2","key":"2809_CR7","first-page":"A379","volume":"73","author":"J Huang","year":"2024","unstructured":"Huang J, Wang M, Li Z, et al. IDDF2024-ABS-0428 Global incidence of cardia and non-cardia gastric cancer: a population-based study. Gut. 2024;73(Suppl 2):A379.","journal-title":"Gut"},{"issue":"4","key":"2809_CR8","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1002\/hep.31432","volume":"73","author":"J Wu","year":"2021","unstructured":"Wu J, Gao W, Tang Q, et al. M2 macrophage-derived exosomes facilitate HCC metastasis by transferring alpha(M) beta(2) integrin to tumor cells. Hepatology. 2021;73(4):1365\u201380.","journal-title":"Hepatology"},{"issue":"1","key":"2809_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12957-018-1312-y","volume":"16","author":"RR Yao","year":"2018","unstructured":"Yao RR, Li JH, Zhang R, et al. M2-polarized tumour-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4\/STAT3 signaling pathway. World J Surg Oncol. 2018;16(1):9.","journal-title":"World J Surg Oncol"},{"issue":"1","key":"2809_CR10","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3390\/ijms23010146","volume":"23","author":"S Niland","year":"2021","unstructured":"Niland S, Riscanevo AX, Eble JA. Matrix metalloproteinases shape the tumour microenvironment in cancer progression. Int J Mol Sci. 2021;23(1):146.","journal-title":"Int J Mol Sci"},{"issue":"17","key":"2809_CR11","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1242\/jcs.034561","volume":"122","author":"R Poincloux","year":"2009","unstructured":"Poincloux R, Liz\u00e1rraga F, Chavrier P. Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. J Cell Sci. 2009;122(17):3015\u201324.","journal-title":"J Cell Sci"},{"issue":"24","key":"2809_CR12","doi-asserted-by":"publisher","first-page":"9739","DOI":"10.3390\/ijms21249739","volume":"21","author":"GA Cabral-Pacheco","year":"2020","unstructured":"Cabral-Pacheco GA, Garza-Veloz I, Castruita-De La Rosa C, et al. The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci. 2020;21(24):9739.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"2809_CR13","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1016\/j.celrep.2019.07.068","volume":"28","author":"D Di Mitri","year":"2019","unstructured":"Di Mitri D, Mirenda M, Vasilevska J, et al. Re-education of tumour-associated macrophages by CXCR2 Blockade drives senescence and tumour inhibition in advanced prostate cancer. Cell Rep. 2019;28(8):2156\u201368.","journal-title":"Cell Rep"},{"issue":"1","key":"2809_CR14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13024-017-0175-y","volume":"12","author":"R Natoli","year":"2017","unstructured":"Natoli R, Fernando N, Madigan M, et al. Microglia-derived IL-1\u03b2 promotes chemokine expression by M\u00fcller cells and RPE in focal retinal degeneration. Mol Neurodegener. 2017;12(1):31.","journal-title":"Mol Neurodegener"},{"key":"2809_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.737061","volume":"11","author":"M Liu","year":"2021","unstructured":"Liu M, Zhang L, Zhou Q, et al. The distinct impact of TAM infiltration on the prognosis of patients with cardia and non-cardia gastric cancer and its association with H pylori infection. Front Oncol. 2021;11: 737061.","journal-title":"Front Oncol"},{"key":"2809_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102015","volume":"86","author":"V Gambardella","year":"2020","unstructured":"Gambardella V, Castillo J, Tarazona N, et al. The role of tumour-associated macrophages in gastric cancer development and their potential as a therapeutic target. Cancer Treat Rev. 2020;86: 102015.","journal-title":"Cancer Treat Rev"},{"issue":"6","key":"2809_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002636","volume":"95","author":"J Zhang","year":"2016","unstructured":"Zhang J, Yan Y, Yang Y, et al. High infiltration of tumour-associated macrophages influences poor prognosis in human gastric cancer patients, associates with the phenomenon of EMT. Medicine (Baltimore). 2016;95(6): e2636.","journal-title":"Medicine (Baltimore)"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-02809-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-02809-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-02809-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T06:23:18Z","timestamp":1751350998000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-02809-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2809"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-02809-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5944882\/v1","asserted-by":"object"}]},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"2 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of First Hospital of Putian City, Fujian Province, China (approval number 2023-095. All procedures involving human participants were conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have consented to publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"537"}}