{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:47:20Z","timestamp":1780631240284,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-02877-w","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T08:40:43Z","timestamp":1752136843000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of FANCG as a prognostic factor for prostate cancer"],"prefix":"10.1186","volume":"30","author":[{"given":"Wenlong","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xinyue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"issue":"2","key":"2877_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.eururo.2023.04.021","volume":"84","author":"O Bergengren","year":"2023","unstructured":"Bergengren O, Pekala KR, Matsoukas K, et al. 2022 update on prostate cancer epidemiology and risk factors-a systematic review. Eur Urol. 2023;84(2):191\u2013206.","journal-title":"Eur Urol"},{"issue":"1","key":"2877_CR2","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1186\/s12913-022-07817-6","volume":"22","author":"C Ngcamphalala","year":"2022","unstructured":"Ngcamphalala C, \u00d6stensson E, Ginindza TG. The economic burden of prostate cancer in Eswatini. BMC Health Serv Res. 2022;22(1):483.","journal-title":"BMC Health Serv Res"},{"issue":"1","key":"2877_CR3","first-page":"60","volume":"8","author":"H Zi","year":"2021","unstructured":"Zi H, He SH, Leng XY, et al. Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990\u20132019. Mil Med Res. 2021;8(1):60.","journal-title":"Mil Med Res"},{"issue":"3","key":"2877_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/3093","volume":"20","author":"JP de Winter","year":"1998","unstructured":"de Winter JP, Waisfisz Q, Rooimans MA, et al. The Fanconi anaemia group G gene FANCG is identical with XRCC9. Nat Genet. 1998;20(3):281\u20133.","journal-title":"Nat Genet"},{"issue":"9","key":"2877_CR5","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1182\/blood.V96.9.3224","volume":"96","author":"I Garcia-Higuera","year":"2000","unstructured":"Garcia-Higuera I, Kuang Y, Denham J, D\u2019Andrea AD. The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex. Blood. 2000;96(9):3224\u201330.","journal-title":"Blood"},{"issue":"10","key":"2877_CR6","first-page":"2585","volume":"63","author":"MS van der Heijden","year":"2003","unstructured":"van der Heijden MS, Yeo CJ, Hruban RH, Kern SE. Fanconi anemia gene mutations in young-onset pancreatic cancer. Cancer Res. 2003;63(10):2585\u20138.","journal-title":"Cancer Res"},{"issue":"2","key":"2877_CR7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.4161\/cbt.3.2.609","volume":"3","author":"CD Rogers","year":"2004","unstructured":"Rogers CD, van der Heijden MS, Brune K, et al. The genetics of FANCC and FANCG in familial pancreatic cancer. Cancer Biol Ther. 2004;3(2):167\u20139.","journal-title":"Cancer Biol Ther"},{"issue":"6","key":"2877_CR8","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.3892\/ijo.2017.3974","volume":"50","author":"C T\u00fcrke","year":"2017","unstructured":"T\u00fcrke C, Horn S, Petto C, Labudde D, Lauer G, Wittenburg G. Loss of heterozygosity in FANCG, FANCF and BRIP1 from head and neck squamous cell carcinoma of the oral cavity. Int J Oncol. 2017;50(6):2207\u201320.","journal-title":"Int J Oncol"},{"issue":"24","key":"2877_CR9","first-page":"8596","volume":"63","author":"S Seal","year":"2003","unstructured":"Seal S, Barfoot R, Jayatilake H, et al. Breast Cancer Susceptibility Collaboration Evaluation of Fanconi Anemia genes in familial breast cancer predisposition. Cancer Res. 2003;63(24):8596\u20139.","journal-title":"Cancer Res"},{"issue":"12","key":"2877_CR10","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1038\/s41591-018-0241-1","volume":"24","author":"M Rotinen","year":"2018","unstructured":"Rotinen M, You S, Yang J, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018;24(12):1887\u201398.","journal-title":"Nat Med"},{"issue":"4","key":"2877_CR11","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.cell.2015.10.025","volume":"163","author":"Cancer Genome Atlas Research Network","year":"2015","unstructured":"Cancer Genome Atlas Research Network. The molecular taxonomy of primary prostate cancer. Cell. 2015;163(4):1011\u201325. https:\/\/doi.org\/10.1016\/j.cell.2015.10.025.","journal-title":"Cell"},{"issue":"6220","key":"2877_CR12","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhl\u00e9n","year":"2015","unstructured":"Uhl\u00e9n M, Fagerberg L, Hallstr\u00f6m BM, et al. Proteomics Tissue-based map of the human proteome. Science. 2015;347(6220):1260419.","journal-title":"Science"},{"issue":"12","key":"2877_CR13","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1038\/s41591-018-0241-1","volume":"24","author":"M Rotinen","year":"2018","unstructured":"Rotinen M, You S, Yang J, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018;24(12):1887\u201398. https:\/\/doi.org\/10.1038\/s41591-018-0241-1.","journal-title":"Nat Med"},{"issue":"4","key":"2877_CR14","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s12350-014-9908-2","volume":"21","author":"B George","year":"2014","unstructured":"George B, Seals S, Aban I. Survival analysis and regression models. J Nucl Cardiol. 2014;21(4):686\u201394. https:\/\/doi.org\/10.1007\/s12350-014-9908-2.","journal-title":"J Nucl Cardiol"},{"issue":"16","key":"2877_CR15","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1002\/pros.23437","volume":"77","author":"L Woods-Burnham","year":"2017","unstructured":"Woods-Burnham L, Basu A, Cajigas-Du Ross CK, et al. The 22Rv1 prostate cancer cell line carries mixed genetic ancestry: implications for prostate cancer health disparities research using pre-clinical models. Prostate. 2017;77(16):1601\u20138.","journal-title":"Prostate"},{"issue":"1","key":"2877_CR16","first-page":"17","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17\u201348.","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"2877_CR17","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41585-021-00442-8","volume":"18","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Mo M, Wei Y, et al. Epidemiology and genomics of prostate cancer in Asian men. Nat Rev Urol. 2021;18(5):282\u2013301.","journal-title":"Nat Rev Urol"},{"issue":"12","key":"2877_CR18","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/S1470-2045(13)70442-X","volume":"14","author":"R Luengo-Fernandez","year":"2013","unstructured":"Luengo-Fernandez R, Leal J, Gray A, Sullivan R. Economic burden of cancer across the European Union: a population-based cost analysis. Lancet Oncol. 2013;14(12):1165\u201374.","journal-title":"Lancet Oncol"},{"issue":"8","key":"2877_CR19","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1590\/1806-9282.63.08.722","volume":"63","author":"MV Sadi","year":"2017","unstructured":"Sadi MV. PSA screening for prostate cancer. Rev Assoc Med Bras. 2017;63(8):722\u20135.","journal-title":"Rev Assoc Med Bras"},{"issue":"10","key":"2877_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13148-018-0492-1","volume":"23","author":"H Wang","year":"2018","unstructured":"Wang H, Peng R, Wang J, Qin Z, Xue L. Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage. Clin Epigenetics. 2018;23(10):59.","journal-title":"Clin Epigenetics"},{"key":"2877_CR21","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1182\/asheducation-2011.1.492","volume":"2011","author":"J Soulier","year":"2011","unstructured":"Soulier J. Fanconi anemia. Hematol Am Soc Hematol Educ Program. 2011;2011:492\u20137.","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"2877_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1462810","author":"SK Rai","year":"2024","unstructured":"Rai SK, Du W, Zhang J, et al. Somatic gene mutations involved in DNA damage response\/Fanconi anemia signaling are tissue- and cell-type specific in human solid tumors. Front Med (Lausanne). 2024. https:\/\/doi.org\/10.3389\/fmed.2024.1462810.","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"2877_CR23","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/ajh.27520","volume":"100","author":"MJ Ram\u00edrez","year":"2025","unstructured":"Ram\u00edrez MJ, Pujol R, Minguill\u00f3n J, et al. Prognostic significance of mutation type and chromosome fragility in Fanconi anemia. Am J Hematol. 2025;100(2):272\u201384. https:\/\/doi.org\/10.1002\/ajh.27520.","journal-title":"Am J Hematol"},{"issue":"16","key":"2877_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70103","volume":"13","author":"J Soukupova","year":"2024","unstructured":"Soukupova J, Stastna B, Kanwal M, et al. A comprehensive study evaluating germline FANCG variants in predisposition to breast and ovarian cancer. Cancer Med. 2024;13(16): e70103. https:\/\/doi.org\/10.1002\/cam4.70103.","journal-title":"Cancer Med"},{"issue":"10","key":"2877_CR25","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.3390\/genes13101693","volume":"13","author":"K Meek","year":"2022","unstructured":"Meek K, Yang YT, Takada M, et al. Identification of a hypomorphic FANCG variant in Bernese mountain dogs. Genes (Basel). 2022;13(10):1693.","journal-title":"Genes (Basel)"},{"issue":"4","key":"2877_CR26","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1159\/000101542","volume":"69","author":"VB Wreesmann","year":"2007","unstructured":"Wreesmann VB, Estilo C, Eisele DW, Singh B, Wang SJ. Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 2007;69(4):218\u201325.","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"issue":"3","key":"2877_CR27","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.1365-2141.2006.05985.x","volume":"133","author":"S Meyer","year":"2006","unstructured":"Meyer S, Barber LM, White DJ, et al. Spectrum and significance of variants and mutations in the Fanconi anaemia group G gene in children with sporadic acute myeloid leukaemia. Br J Haematol. 2006;133(3):284\u201392.","journal-title":"Br J Haematol"},{"issue":"3","key":"2877_CR28","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nrc3678","volume":"14","author":"IG Mills","year":"2014","unstructured":"Mills IG. Maintaining and reprogramming genomic androgen receptor activity in prostate cancer. Nat Rev Cancer. 2014;14(3):187\u201398. https:\/\/doi.org\/10.1038\/nrc3678.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"2877_CR29","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.2741\/3666","volume":"15","author":"F Yuan","year":"2010","unstructured":"Yuan F, Song L, Qian L, et al. Assembling an orchestra: Fanconi anemia pathway of DNA repair. Front Biosci (Landmark Ed). 2010;15(3):1131\u201349. https:\/\/doi.org\/10.2741\/3666.","journal-title":"Front Biosci (Landmark Ed)"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-02877-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-02877-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-02877-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T01:41:33Z","timestamp":1757209293000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-02877-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2877"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-02877-w","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"7 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"602"}}