{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:18:30Z","timestamp":1791818310068,"version":"4.3.4"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007102","name":"Zagazig University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007102","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Low levels of the enzyme ADAMTS13 and elevated inflammatory markers such as interleukin-6 (IL-6) are associated with worse outcomes in patients with acute myeloid leukaemia (AML). IL-6 produced by leukaemia cells suppresses ADAMTS13 activity and impairs hematopoietic differentiation. Vitamin D, which has known for its immunomodulatory effects, may reduce IL-6 levels. This study investigated the impact of vitamin D supplementation on IL-6 and ADAMTS13 levels in patients newly diagnosed with AML.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patients and method<\/jats:title>\n            <jats:p>A total of 38 newly diagnosed AML patients and 14 healthy individuals were included. IL-6 and ADAMTS13 levels were measured in both groups at baseline. Among AML patients, 34 were found to have vitamin D deficiency. Seventeen of these patients received oral vitamin D supplementation for 28 days in addition to their standard chemotherapy. Serum levels of IL-6, ADAMTS13 and vitamin D were measured on the 1st and 28th days of chemotherapy. Statistical analyses included Mann\u2013Whitney U test, Wilcoxon signed-rank test, and Spearman correlation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>AML patients had significantly higher IL-6 (7.19 vs. 1.15 pg\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.00001) and lower ADAMTS13 (684 vs. 1205 ng\/mL; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) compared to controls. ADAMTS13 significantly increased by Day 28 (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001), while IL-6 showed no overall change. However, among vitamin D-deficient patients receiving supplementation, IL-6 levels decreased significantly by Day 28 (<jats:italic>p<\/jats:italic>\u2009=\u20090.049). A negative correlation was found between vitamin D and IL-6 on Day 28 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.485; <jats:italic>p<\/jats:italic>\u2009=\u20090.035). No significant effect of vitamin D status was observed on ADAMTS13 levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Vitamin D supplementation was associated with a reduction in IL-6 levels, but did not influence ADAMTS13 levels in patients with AML. These findings support the potential role of vitamin D as an adjunct anti-inflammatory agent during induction chemotherapy. Further studies with larger samples and longer follow-up are recommended to clarify its therapeutic relevance.<\/jats:p>\n            <jats:p>\n              <jats:italic>Trial registration number NCT05149339<\/jats:italic> in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrial.gov\" ext-link-type=\"uri\">www.clinicaltrial.gov<\/jats:ext-link> registered on 25\/11\/2021 'retrospectively registered\u2019 with URL; <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/register.clinicaltrials.gov\/prs\/app\/action\/SelectProtocol?sid=S000BKX8&amp;selectaction=Edit&amp;uid=U0005ZGQ&amp;ts=98&amp;cx=avh64j\" ext-link-type=\"uri\">https:\/\/register.clinicaltrials.gov\/prs\/app\/action\/SelectProtocol?sid=S000BKX8&amp;selectaction=Edit&amp;uid=U0005ZGQ&amp;ts=98&amp;cx=avh64j<\/jats:ext-link>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s40001-025-02879-8","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T16:36:45Z","timestamp":1752683805000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of vitamin D status on a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and interleukin 6 in patients with acute myeloid leukaemia"],"prefix":"10.1186","volume":"30","author":[{"given":"Dina Ashraf","family":"Abdelhady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervat Mostafa Mohamed","family":"Azab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Alnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"issue":"44","key":"2879_CR1","doi-asserted-by":"publisher","first-page":"41059","DOI":"10.1074\/jbc.C100515200","volume":"276","author":"X Zheng","year":"2001","unstructured":"Zheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, Fujikawa K. 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