{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:35:46Z","timestamp":1772001346264,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-03121-1","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:18:55Z","timestamp":1759234735000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skeletal muscle abnormalities negatively linked to sleep disturbances in patients with liver cirrhosis: a cross-sectional study"],"prefix":"10.1186","volume":"30","author":[{"given":"Shuangzhe","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0745-6401","authenticated-orcid":false,"given":"Yangyang","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-7999","authenticated-orcid":false,"given":"Chao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"issue":"8","key":"3121_CR1","first-page":"897","volume":"9","author":"M Pennisi","year":"2017","unstructured":"Pennisi M, Bertino G, Gagliano C, Malaguarnera M, Bella R, Borz\u00ec AM, et al. Resveratrol in hepatitis C patients treated with pegylated-interferon-\u03b1-2b and ribavirin reduces sleep disturbance. Nut. 2017;9(8):897.","journal-title":"Nut"},{"key":"3121_CR2","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1111\/hepr.12694","volume":"46","author":"K Yoh","year":"2016","unstructured":"Yoh K, Nishikawa H, Enomoto H, Iwata Y, Kishino K, Shimono Y, et al. Comparison of sleep disorders in chronic hepatitis C patients treated with interferon-based therapy and direct acting antivirals using actigraphy. Hepatol Res. 2016;46:1358\u201366.","journal-title":"Hepatol Res"},{"key":"3121_CR3","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1001\/jamapsychiatry.2017.0226","volume":"74","author":"A Erlangsen","year":"2017","unstructured":"Erlangsen A, Runeson B, Bolton JM, Wilcox HC, Forman JL, Krogh J, et al. Association between spousal suicide and mental, physical, and social health outcomes: a longitudinal and nationwide register-based study. JAMA Psychiat. 2017;74:456\u201364.","journal-title":"JAMA Psychiat"},{"key":"3121_CR4","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.orcp.2018.05.002","volume":"12","author":"YT Chou","year":"2018","unstructured":"Chou YT, Cheng HJ, Wu JS, Yang YC, Chou CY, Chang CJ, et al. The association of sleep duration and sleep quality with non-alcoholic fatty liver disease in a Taiwanese population. Obes Res Clin Pract. 2018;12:500\u20135.","journal-title":"Obes Res Clin Pract"},{"key":"3121_CR5","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/apt.14824","volume":"48","author":"C Labenz","year":"2018","unstructured":"Labenz C, Baron JS, Toenges G, Schattenberg JM, Nagel M, Sprinzl MF, et al. Prospective evaluation of the impact of covert hepatic encephalopathy on quality of life and sleep in cirrhotic patients. Aliment Pharmacol Ther. 2018;48:313\u201321.","journal-title":"Aliment Pharmacol Ther"},{"key":"3121_CR6","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1111\/liv.13745","volume":"38","author":"M Iwasa","year":"2018","unstructured":"Iwasa M, Karino Y, Kawaguchi T, Nakanishi H, Miyaaki H, Shiraki M, et al. Relationship of muscle cramps to quality of life and sleep disturbance in patients with chronic liver diseases: a nationwide study. Liver Int. 2018;38:2309\u201316.","journal-title":"Liver Int"},{"issue":"1271\u20138","key":"3121_CR7","volume":"15","author":"M Ghabril","year":"2017","unstructured":"Ghabril M, Jackson M, Gotur R, Weber R, Orman E, Vuppalanchi R, et al. most individuals with advanced cirrhosis have sleep disturbances, which are associated with poor quality of life. Clin Gastroenterol Hepatol. 2017;15(1271\u20138):e6.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"3121_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11011-024-01446-0","volume":"40","author":"L Lapenna","year":"2024","unstructured":"Lapenna L, Di Cola S, Merli M. The crucial role of risk factors when dealing with hepatic encephalopathy. Metab Brain Dis. 2024;40:29.","journal-title":"Metab Brain Dis"},{"key":"3121_CR9","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1111\/j.1478-3231.2009.02089.x","volume":"29","author":"S Montagnese","year":"2009","unstructured":"Montagnese S, Middleton B, Skene DJ, Morgan MY. Night-time sleep disturbance does not correlate with neuropsychiatric impairment in patients with cirrhosis. Liver Int. 2009;29:1372\u201382.","journal-title":"Liver Int"},{"key":"3121_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58060741","author":"H Kawaratani","year":"2022","unstructured":"Kawaratani H, Miyaaki H, Hiraoka A, Nakao K, Hiasa Y, Yoshiji H, et al. The usefulness of the Athens insomnia scale for evaluating sleep disturbance in patients with chronic liver disease comparing with Pittsburgh sleep quality index and Epworth sleepiness scale. Medicina. 2022. https:\/\/doi.org\/10.3390\/medicina58060741.","journal-title":"Medicina"},{"key":"3121_CR11","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jhep.2021.11.006","volume":"76","author":"X Tantai","year":"2022","unstructured":"Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E, Hamaguchi Y, et al. Effect of sarcopenia on survival in patients with cirrhosis: a meta-analysis. J Hepatol. 2022;76:588\u201399.","journal-title":"J Hepatol"},{"key":"3121_CR12","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet. 2019;393:2636\u201346.","journal-title":"Lancet"},{"key":"3121_CR13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/jcsm.12039","volume":"7","author":"AJ Montano-Loza","year":"2016","unstructured":"Montano-Loza AJ, Angulo P, Meza-Junco J, Prado CM, Sawyer MB, Beaumont C, et al. Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis. J Cachexia Sarcopenia Muscle. 2016;7:126\u201335.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3121_CR14","first-page":"491","volume":"31","author":"M Kalafateli","year":"2018","unstructured":"Kalafateli M, Karatzas A, Tsiaoussis G, Koutroumpakis E, Tselekouni P, Koukias N, et al. Muscle fat infiltration assessed by total psoas density on computed tomography predicts mortality in cirrhosis. Ann Gastroenterol. 2018;31:491\u20138.","journal-title":"Ann Gastroenterol"},{"key":"3121_CR15","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/jcsm.12901","volume":"13","author":"CW Li","year":"2022","unstructured":"Li CW, Yu K, Shyh-Chang N, Jiang Z, Liu T, Ma S, et al. Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review. J Cachexia Sarcopenia Muscle. 2022;13:781\u201394.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3121_CR16","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1159\/000371847","volume":"61","author":"MY Chien","year":"2015","unstructured":"Chien MY, Wang LY, Chen HC. The relationship of sleep duration with obesity and sarcopenia in community-dwelling older adults. Gerontol. 2015;61:399\u2013406.","journal-title":"Gerontol"},{"key":"3121_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006268","volume":"96","author":"X Hu","year":"2017","unstructured":"Hu X, Jiang J, Wang H, Zhang L, Dong B, Yang M. Association between sleep duration and sarcopenia among community-dwelling older adults: a cross-sectional study. Med. 2017;96:e6268.","journal-title":"Med"},{"key":"3121_CR18","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.5664\/jcsm.6732","volume":"13","author":"YJ Kwon","year":"2017","unstructured":"Kwon YJ, Jang SY, Park EC, Cho AR, Shim JY, Linton JA. Long sleep duration is associated with sarcopenia in Korean adults based on data from the 2008\u20132011 knhanes. J Clin Sleep Med. 2017;13:1097\u2013104.","journal-title":"J Clin Sleep Med"},{"key":"3121_CR19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.4082\/kjfm.17.0030","volume":"39","author":"RH Kim","year":"2018","unstructured":"Kim RH, Kim KI, Kim JH, Park YS. Association between sleep duration and body composition measures in Korean adults: the Korea National Health and Nutrition Examination Survey 2010. Korean J Fam Med. 2018;39:219\u201324.","journal-title":"Korean J Fam Med"},{"issue":"1","key":"3121_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010016","volume":"8","author":"H Nishikawa","year":"2018","unstructured":"Nishikawa H, Enomoto H, Yoh K, Iwata Y, Sakai Y, Kishino K, et al. Effect of sarcopenia on sleep disturbance in patients with chronic liver diseases. J Clin Med. 2018;8(1):16.","journal-title":"J Clin Med"},{"key":"3121_CR21","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/hepr.13731","volume":"52","author":"H Miyaaki","year":"2022","unstructured":"Miyaaki H, Hiraoka A, Haraguchi M, Uojima H, Kawaratani H, Hiramatsu A, et al. Proposal for new sleep disorder criteria in patients with chronic liver disease: influence of liver-related complications. Hepatol Res. 2022;52:364\u201370.","journal-title":"Hepatol Res"},{"key":"3121_CR22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/ajg.2017.443","volume":"113","author":"JC Lai","year":"2018","unstructured":"Lai JC, Covinsky KE, McCulloch CE, Feng S. The liver frailty index improves mortality prediction of the subjective clinician assessment in patients with cirrhosis. Am J Gastroenterol. 2018;113:235\u201342.","journal-title":"Am J Gastroenterol"},{"key":"3121_CR23","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1097\/TP.0000000000002025","volume":"102","author":"L Puchades","year":"2018","unstructured":"Puchades L, Chau S, Dodson JA, Mohamad Y, Mustain R, Lebsack A, et al. Association of cardiac abnormalities to the frail phenotype in cirrhotic patients on the waitlist: from the functional assessment in liver transplantation study. Transplant. 2018;102:e101\u20137.","journal-title":"Transplant"},{"key":"3121_CR24","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1007\/s11136-005-4346-x","volume":"14","author":"PS Tsai","year":"2005","unstructured":"Tsai PS, Wang SY, Wang MY, Su CT, Yang TT, Huang CJ, et al. Psychometric evaluation of the Chinese version of the Pittsburgh Sleep Quality Index (CPSQI) in primary insomnia and control subjects. Qual Life Res. 2005;14:1943\u201352.","journal-title":"Qual Life Res"},{"key":"3121_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","volume":"28","author":"DJ Buysse","year":"1989","unstructured":"Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193\u2013213.","journal-title":"Psychiatry Res"},{"key":"3121_CR26","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015867","volume":"98","author":"SS Kim","year":"2019","unstructured":"Kim SS, Kim JH, Jeong WK, Lee J, Kim YK, Choi D, et al. Semiautomatic software for measurement of abdominal muscle and adipose areas using computed tomography: A STROBE-compliant article. Med. 2019;98:e15867.","journal-title":"Med"},{"key":"3121_CR27","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/jpen.1841","volume":"45","author":"L Hou","year":"2021","unstructured":"Hou L, Deng Y, Fan X, Zhao T, Cui B, Lin L, et al. A sex-stratified prognostic nomogram incorporating body compositions for long-term mortality in cirrhosis. JPEN J Parenter Enteral Nutr. 2021;45:403\u201313.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"3121_CR28","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/jcsm.12276","volume":"9","author":"Y Hamaguchi","year":"2018","unstructured":"Hamaguchi Y, Kaido T, Okumura S, Kobayashi A, Shirai H, Yao S, et al. Proposal for new selection criteria considering pre-transplant muscularity and visceral adiposity in living donor liver transplantation. J Cachexia Sarcopenia Muscle. 2018;9:246\u201354.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3121_CR29","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jhep.2018.06.024","volume":"70","author":"European Association for the Study of the Liver","year":"2019","unstructured":"European Association for the Study of the Liver. EASL clinical practice guidelines on nutrition in chronic liver disease. J Hepatol. 2019;70:172\u201393.","journal-title":"J Hepatol"},{"key":"3121_CR30","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/apt.13765","volume":"44","author":"CF Tsai","year":"2016","unstructured":"Tsai CF, Chu CJ, Wang YP, Liu PY, Huang YH, Lin HC, et al. Increased serum interleukin-6, not minimal hepatic encephalopathy, predicts poor sleep quality in nonalcoholic cirrhotic patients. Aliment Pharmacol Ther. 2016;44:836\u201345.","journal-title":"Aliment Pharmacol Ther"},{"key":"3121_CR31","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1177\/0148607114529597","volume":"39","author":"GL Jensen","year":"2015","unstructured":"Jensen GL. Malnutrition and inflammation-\"burning down the house\": inflammation as an adaptive physiologic response versus self-destruction? JPEN J Parenter Enteral Nutr. 2015;39:56\u201362.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"3121_CR32","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.jhep.2024.05.020","volume":"81","author":"S Di Cola","year":"2024","unstructured":"Di Cola S, D\u2019Amico G, Caraceni P, Schepis F, Loredana S, Lampertico P, et al. Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis. J Hepatol. 2024;81:641\u201350.","journal-title":"J Hepatol"},{"issue":"4","key":"3121_CR33","doi-asserted-by":"publisher","first-page":"A5690","DOI":"10.1016\/j.chest.2024.06.3379","volume":"166","author":"A Smith","year":"2024","unstructured":"Smith A, Frank M, Fryman C, Weber A, Rabascall Ayoub CX, Kamper M, et al. Using ultrasound to evaluate the respiratory mechanics of the diaphragm in patients with tense ascites. Chest. 2024;166(4):A5690\u20131.","journal-title":"Chest"},{"issue":"11","key":"3121_CR34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143293","volume":"10","author":"C Bernsmeier","year":"2015","unstructured":"Bernsmeier C, Weisskopf DM, Pflueger MO, Mosimann J, Campana B, Terracciano L, et al. Sleep disruption and daytime sleepiness correlating with disease severity and insulin resistance in non-alcoholic fatty liver disease: a comparison with healthy controls. PLoS ONE. 2015;10(11):e0143293.","journal-title":"PLoS ONE"},{"issue":"630","key":"3121_CR35","first-page":"e1","volume":"16","author":"TW Auyeung","year":"2015","unstructured":"Auyeung TW, Kwok T, Leung J, Lee JS, Ohlsson C, Vandenput L, et al. Sleep duration and disturbances were associated with testosterone level, muscle mass, and muscle strength\u2013a cross-sectional study in 1274 older men. J Am Med Dir Assoc. 2015;16(630):e1-6.","journal-title":"J Am Med Dir Assoc"},{"key":"3121_CR36","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","volume":"98","author":"MC Petersen","year":"2018","unstructured":"Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98:2133\u2013223.","journal-title":"Physiol Rev"},{"key":"3121_CR37","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s11033-018-4551-7","volume":"46","author":"BA Jana","year":"2019","unstructured":"Jana BA, Chintamaneni PK, Krishnamurthy PT, Wadhwani A, Mohankumar SK. Cytosolic lipid excess-induced mitochondrial dysfunction is the cause or effect of high fat diet-induced skeletal muscle insulin resistance: a molecular insight. Mol Biol Rep. 2019;46:957\u201363.","journal-title":"Mol Biol Rep"},{"key":"3121_CR38","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13098-023-01022-z","volume":"15","author":"ZJ Liu","year":"2023","unstructured":"Liu ZJ, Zhu CF. Causal relationship between insulin resistance and sarcopenia. Diabetol Metab Syndr. 2023;15:46.","journal-title":"Diabetol Metab Syndr"},{"key":"3121_CR39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.sleep.2018.12.007","volume":"55","author":"DB Kay","year":"2019","unstructured":"Kay DB, Karim HT, Hasler BP, James JA, Germain A, Hall MH, et al. Impact of acute sleep restriction on cerebral glucose metabolism during recovery non-rapid eye movement sleep among individuals with primary insomnia and good sleeper controls. Sleep Med. 2019;55:81\u201391.","journal-title":"Sleep Med"},{"key":"3121_CR40","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/B978-0-444-64032-1.00025-4","volume":"160","author":"JV Rundo","year":"2019","unstructured":"Rundo JV, Downey R 3rd. Polysomnography. Handb Clin Neurol. 2019;160:381\u201392.","journal-title":"Handb Clin Neurol"},{"key":"3121_CR41","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s10072-008-0973-7","volume":"29","author":"B Mostacci","year":"2008","unstructured":"Mostacci B, Ferlisi M, Baldi Antognini A, Sama C, Morelli C, Mondini S, et al. Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study. Neurol Sci. 2008;29:237\u201340.","journal-title":"Neurol Sci"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03121-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-03121-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03121-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:19:04Z","timestamp":1759234744000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-03121-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3121"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-03121-1","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"2 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Ethics Committee of Tianjin Medical University General Hospital (IRB2023-YX-004-01). Written informed consent was obtained from all participants involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable. This manuscript does not contain any individual person\u2019s data in any form (such as individual details, images, or videos).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"917"}}