{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:01:20Z","timestamp":1788580880952,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-03392-8","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T18:36:39Z","timestamp":1763404599000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["METTL3 inhibits osteoporosis by promoting osteoblast differentiation through m6A-mediated activation of the FZD3\/RUNX1 signaling axis"],"prefix":"10.1186","volume":"30","author":[{"given":"Yunfeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"issue":"6","key":"3392_CR1","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.mcna.2021.05.016","volume":"105","author":"AK Anam","year":"2021","unstructured":"Anam AK, Insogna K. Update on osteoporosis screening and management. Med Clin North Am. 2021;105(6):1117\u201334.","journal-title":"Med Clin North Am"},{"key":"3392_CR2","doi-asserted-by":"publisher","first-page":"1005665","DOI":"10.3389\/fimmu.2022.1005665","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Zheng YL, Wang R, Wang XQ, Zhang H. Exercise for osteoporosis: a literature review of pathology and mechanism. Front Immunol. 2022;13:1005665.","journal-title":"Front Immunol"},{"issue":"5","key":"3392_CR3","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.mcna.2020.06.004","volume":"104","author":"CB Johnston","year":"2020","unstructured":"Johnston CB, Dagar M. Osteoporosis in older adults. Med Clin North Am. 2020;104(5):873\u201384.","journal-title":"Med Clin North Am"},{"key":"3392_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108168","volume":"237","author":"S Song","year":"2022","unstructured":"Song S, Guo Y, Yang Y, Fu D. Advances in pathogenesis and therapeutic strategies for osteoporosis. Pharmacol Ther. 2022;237:108168.","journal-title":"Pharmacol Ther"},{"issue":"2","key":"3392_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/03008207.2017.1290085","volume":"59","author":"X Chen","year":"2018","unstructured":"Chen X, Wang Z, Duan N, Zhu G, Schwarz EM, Xie C. Osteoblast-osteoclast interactions. Connect Tissue Res. 2018;59(2):99\u2013107.","journal-title":"Connect Tissue Res"},{"key":"3392_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169465","author":"A Aibar-Almaz\u00e1n","year":"2022","unstructured":"Aibar-Almaz\u00e1n A, Voltes-Mart\u00ednez A, Castellote-Caballero Y, Afanador-Restrepo DF, Carcel\u00e9n-Fraile MDC, L\u00f3pez-Ruiz E. Current status of the diagnosis and management of osteoporosis. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms23169465.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3392_CR7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s11658-022-00371-3","volume":"27","author":"B Liang","year":"2022","unstructured":"Liang B, Burley G, Lin S, Shi YC. Osteoporosis pathogenesis and treatment: existing and emerging avenues. Cell Mol Biol Lett. 2022;27(1):72.","journal-title":"Cell Mol Biol Lett"},{"issue":"3","key":"3392_CR8","doi-asserted-by":"publisher","first-page":"926","DOI":"10.3892\/etm.2021.10358","volume":"22","author":"Y Hu","year":"2021","unstructured":"Hu Y, Zhao X. Role of m6A in osteoporosis, arthritis and osteosarcoma (review). Exp Ther Med. 2021;22(3):926.","journal-title":"Exp Ther Med"},{"key":"3392_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.783322","volume":"9","author":"M Huang","year":"2021","unstructured":"Huang M, Xu S, Liu L, Zhang M, Guo J, Yuan Y, et al. M6a methylation regulates osteoblastic differentiation and bone remodeling. Front Cell Dev Biol. 2021;9:783322.","journal-title":"Front Cell Dev Biol"},{"key":"3392_CR10","doi-asserted-by":"publisher","first-page":"870","DOI":"10.3389\/fcell.2020.00870","volume":"8","author":"W Zhang","year":"2020","unstructured":"Zhang W, He L, Liu Z, Ren X, Qi L, Wan L, et al. Multifaceted functions and novel insight into the regulatory role of RNA N(6)-methyladenosine modification in musculoskeletal disorders. Front Cell Dev Biol. 2020;8:870.","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"3392_CR11","doi-asserted-by":"publisher","first-page":"4772","DOI":"10.1038\/s41467-018-06898-4","volume":"9","author":"Y Wu","year":"2018","unstructured":"Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, et al. Mettl3-mediated m(6)a rna methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. Nat Commun. 2018;9(1):4772.","journal-title":"Nat Commun"},{"key":"3392_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111038","volume":"115","author":"ZW Feng","year":"2024","unstructured":"Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, et al. METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition. Cell Signal. 2024;115:111038.","journal-title":"Cell Signal"},{"issue":"2","key":"3392_CR13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00441-022-03588-y","volume":"388","author":"J Peng","year":"2022","unstructured":"Peng J, Zhan Y, Zong Y. METTL3-mediated LINC00657 promotes osteogenic differentiation of mesenchymal stem cells via miR-144-3p\/BMPR1B axis. Cell Tissue Res. 2022;388(2):301\u201312.","journal-title":"Cell Tissue Res"},{"key":"3392_CR14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.omtn.2019.12.001","volume":"19","author":"G Yan","year":"2020","unstructured":"Yan G, Yuan Y, He M, Gong R, Lei H, Zhou H, et al. M(6)A methylation of precursor-miR-320\/RUNX2 controls osteogenic potential of bone marrow-derived mesenchymal stem cells. Mol Ther Nucleic Acids. 2020;19:421\u201336.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"4","key":"3392_CR15","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/acel.12484","volume":"15","author":"S Weilner","year":"2016","unstructured":"Weilner S, Schraml E, Wieser M, Messner P, Schneider K, Wassermann K, et al. Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells. Aging Cell. 2016;15(4):744\u201354.","journal-title":"Aging Cell"},{"issue":"17","key":"3392_CR16","doi-asserted-by":"publisher","first-page":"11603","DOI":"10.1074\/jbc.M600713200","volume":"281","author":"WA Yanfeng","year":"2006","unstructured":"Yanfeng WA, Tan C, Fagan RJ, Klein PS. Phosphorylation of frizzled-3. J Biol Chem. 2006;281(17):11603\u20139.","journal-title":"J Biol Chem"},{"key":"3392_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/biom13030483","author":"Y Gao","year":"2023","unstructured":"Gao Y, Chen N, Fu Z, Zhang Q. Progress of Wnt signaling pathway in osteoporosis. Biomolecules. 2023. https:\/\/doi.org\/10.3390\/biom13030483.","journal-title":"Biomolecules"},{"issue":"15","key":"3392_CR18","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1158\/0008-5472.CAN-20-3543","volume":"81","author":"HJ Li","year":"2021","unstructured":"Li HJ, Ke FY, Lin CC, Lu MY, Kuo YH, Wang YP, et al. ENO1 promotes lung cancer metastasis via HGFR and WNT signaling-driven epithelial-to-mesenchymal transition. Cancer Res. 2021;81(15):4094\u2013109.","journal-title":"Cancer Res"},{"issue":"11","key":"3392_CR19","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1080\/15476286.2014.996462","volume":"11","author":"P Tang","year":"2014","unstructured":"Tang P, Xiong Q, Ge W, Zhang L. The role of microRNAs in osteoclasts and osteoporosis. RNA Biol. 2014;11(11):1355\u201363.","journal-title":"RNA Biol"},{"issue":"4","key":"3392_CR20","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1432-0436.2007.00225.x","volume":"76","author":"VL Battula","year":"2008","unstructured":"Battula VL, Treml S, Abele H, B\u00fchring HJ. Prospective isolation and characterization of mesenchymal stem cells from human placenta using a frizzled-9-specific monoclonal antibody. Differentiation. 2008;76(4):326\u201336.","journal-title":"Differentiation"},{"issue":"4","key":"3392_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1432-0436.2006.00139.x","volume":"75","author":"VL Battula","year":"2007","unstructured":"Battula VL, Bareiss PM, Treml S, Conrad S, Albert I, Hojak S, et al. Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation. 2007;75(4):279\u201391.","journal-title":"Differentiation"},{"key":"3392_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3389\/fcvm.2019.00056","volume":"6","author":"B Burja","year":"2019","unstructured":"Burja B, Kuret T, Janko T, Topalovi\u0107 D, \u017divkovi\u0107 L, Mrak-Polj\u0161ak K, et al. Olive leaf extract attenuates inflammatory activation and DNA damage in human arterial endothelial cells. Front Cardiovasc Med. 2019;6:56.","journal-title":"Front Cardiovasc Med"},{"key":"3392_CR23","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.2147\/OTT.S234751","volume":"13","author":"K Wang","year":"2020","unstructured":"Wang K, Jiang L, Zhang Y, Chen C. Progression of thyroid carcinoma is promoted by the m6A methyltransferase METTL3 through regulating m(6)a methylation on TCF1. Onco Targets Ther. 2020;13:1605\u201312.","journal-title":"Onco Targets Ther"},{"issue":"4","key":"3392_CR24","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/clr.12178","volume":"25","author":"N Chakravorty","year":"2014","unstructured":"Chakravorty N, Hamlet S, Jaiprakash A, Crawford R, Oloyede A, Alfarsi M, et al. Pro-osteogenic topographical cues promote early activation of osteoprogenitor differentiation via enhanced TGF\u03b2, Wnt, and Notch signaling. Clin Oral Implants Res. 2014;25(4):475\u201386.","journal-title":"Clin Oral Implants Res"},{"issue":"9","key":"3392_CR25","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/s41574-023-00866-9","volume":"19","author":"I Foessl","year":"2023","unstructured":"Foessl I, Dimai HP, Obermayer-Pietsch B. Long-term and sequential treatment for osteoporosis. Nat Rev Endocrinol. 2023;19(9):520\u201333.","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"3392_CR26","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","volume":"6","author":"X Jiang","year":"2021","unstructured":"Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, et al. The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther. 2021;6(1):74.","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"3392_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13294","volume":"55","author":"J Han","year":"2022","unstructured":"Han J, Kong H, Wang X, Zhang XA. Novel insights into the interaction between N6-methyladenosine methylation and noncoding RNAs in musculoskeletal disorders. Cell Prolif. 2022;55(10):e13294.","journal-title":"Cell Prolif"},{"issue":"4","key":"3392_CR28","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.ygeno.2018.05.001","volume":"111","author":"JG Letarouilly","year":"2019","unstructured":"Letarouilly JG, Broux O, Clabaut A. New insights into the epigenetics of osteoporosis. Genomics. 2019;111(4):793\u20138.","journal-title":"Genomics"},{"key":"3392_CR29","doi-asserted-by":"publisher","first-page":"1222129","DOI":"10.3389\/fimmu.2023.1222129","volume":"14","author":"J Xu","year":"2023","unstructured":"Xu J, Yu L, Liu F, Wan L, Deng Z. The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review. Front Immunol. 2023;14:1222129.","journal-title":"Front Immunol"},{"key":"3392_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092073","author":"JM Kim","year":"2020","unstructured":"Kim JM, Lin C, Stavre Z, Greenblatt MB, Shim JH. Osteoblast-osteoclast communication and bone homeostasis. Cells. 2020. https:\/\/doi.org\/10.3390\/cells9092073.","journal-title":"Cells"},{"issue":"11","key":"3392_CR31","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1002\/jcp.25969","volume":"232","author":"N Maruotti","year":"2017","unstructured":"Maruotti N, Corrado A, Cantatore FP. Osteoblast role in osteoarthritis pathogenesis. J Cell Physiol. 2017;232(11):2957\u201363.","journal-title":"J Cell Physiol"},{"issue":"10","key":"3392_CR32","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13291","volume":"55","author":"Y Li","year":"2022","unstructured":"Li Y, Zhuang Q, Tao L, Zheng K, Chen S, Yang Y, et al. Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK\/NF-\u03baB pathway. Cell Prolif. 2022;55(10):e13291.","journal-title":"Cell Prolif"},{"issue":"19","key":"3392_CR33","doi-asserted-by":"publisher","first-page":"23361","DOI":"10.18632\/aging.203630","volume":"13","author":"J Liu","year":"2021","unstructured":"Liu J, Chen M, Ma L, Dang X, Du G. Pirna-36741 regulates BMP2-mediated osteoblast differentiation via METTL3 controlled m6A modification. Aging (Albany NY). 2021;13(19):23361\u201375.","journal-title":"Aging (Albany NY)"},{"key":"3392_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.127757","volume":"261","author":"D Li","year":"2020","unstructured":"Li D, Zhu X, Li Y, Zeng X. Novel insights into the roles of RNA N(6)-methyladenosine modification in regulating gene expression during environmental exposures. Chemosphere. 2020;261:127757.","journal-title":"Chemosphere"},{"issue":"7","key":"3392_CR35","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41419-023-05933-7","volume":"14","author":"J Yin","year":"2023","unstructured":"Yin J, Ding F, Cheng Z, Ge X, Li Y, Zeng A, et al. METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt\/\u03b2-catenin signaling. Cell Death Dis. 2023;14(7):417.","journal-title":"Cell Death Dis"},{"issue":"6","key":"3392_CR36","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1053\/j.gastro.2023.01.041","volume":"164","author":"J Wang","year":"2023","unstructured":"Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, et al. N6-methyladenosine-mediated up-regulation of FZD10 regulates liver cancer stem cells\u2019 properties and lenvatinib resistance through WNT\/\u03b2-catenin and hippo signaling pathways. Gastroenterology. 2023;164(6):990\u20131005.","journal-title":"Gastroenterology"},{"issue":"1","key":"3392_CR37","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13046-021-01934-6","volume":"40","author":"X Liu","year":"2021","unstructured":"Liu X, Su K, Sun X, Jiang Y, Wang L, Hu C, et al. Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt\/\u03b2-catenin pathway. J Exp Clin Cancer Res. 2021;40(1):132.","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"3392_CR38","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s12015-007-0006-6","volume":"3","author":"M Katoh","year":"2007","unstructured":"Katoh M. Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. Stem Cell Rev. 2007;3(1):30\u20138.","journal-title":"Stem Cell Rev"},{"issue":"7","key":"3392_CR39","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.leukres.2010.02.009","volume":"34","author":"Z Sercan","year":"2010","unstructured":"Sercan Z, Pehlivan M, Sercan HO. Expression profile of WNT, FZD and sFRP genes in human hematopoietic cells. Leuk Res. 2010;34(7):946\u20139.","journal-title":"Leuk Res"},{"issue":"12","key":"3392_CR40","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1016\/j.leukres.2010.04.013","volume":"34","author":"J Reins","year":"2010","unstructured":"Reins J, Mossner M, Neumann M, Platzbecker U, Schumann C, Thiel E, et al. Transcriptional down-regulation of the Wnt antagonist SFRP1 in haematopoietic cells of patients with different risk types of MDS. Leuk Res. 2010;34(12):1610\u20136.","journal-title":"Leuk Res"},{"issue":"9","key":"3392_CR41","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1002\/jbmr.2504","volume":"30","author":"K Kato","year":"2015","unstructured":"Kato K, Bhattaram P, Penzo-M\u00e9ndez A, Gadi A, Lefebvre V. SOXC transcription factors induce cartilage growth plate formation in mouse embryos by promoting noncanonical WNT signaling. J Bone Miner Res. 2015;30(9):1560\u201371.","journal-title":"J Bone Miner Res"},{"issue":"7","key":"3392_CR42","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41419-019-1693-z","volume":"10","author":"H Long","year":"2019","unstructured":"Long H, Zhu Y, Lin Z, Wan J, Cheng L, Zeng M, et al. Mir-381 modulates human bone mesenchymal stromal cells (BMSCs) osteogenesis via suppressing Wnt signaling pathway during atrophic nonunion development. Cell Death Dis. 2019;10(7):470.","journal-title":"Cell Death Dis"},{"issue":"6","key":"3392_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156788","volume":"11","author":"C Herencia","year":"2016","unstructured":"Herencia C, Diaz-Tocados JM, Jurado L, Montes de Oca A, Rodr\u00edguez-Ortiz ME, Mart\u00edn-Alonso C, et al. Procaine inhibits osteo\/odontogenesis through Wnt\/\u03b2-catenin inactivation. PLoS ONE. 2016;11(6):e0156788.","journal-title":"PLoS ONE"},{"issue":"1","key":"3392_CR44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41413-022-00231-y","volume":"10","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zuo T, McVicar A, Yang HL, Li YP, Chen W. Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGF\u03b2, and Wnt signaling in articular cartilage formation and osteoarthritis. Bone Res. 2022;10(1):63.","journal-title":"Bone Res"},{"issue":"1","key":"3392_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009233","volume":"17","author":"CY Tang","year":"2021","unstructured":"Tang CY, Wu M, Zhao D, Edwards D, McVicar A, Luo Y, et al. Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways. PLoS Genet. 2021;17(1):e1009233.","journal-title":"PLoS Genet"},{"key":"3392_CR46","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.archoralbio.2018.10.028","volume":"97","author":"Y Luo","year":"2019","unstructured":"Luo Y, Zhang Y, Miao G, Zhang Y, Liu Y, Huang Y. Runx1 regulates osteogenic differentiation of BMSCs by inhibiting adipogenesis through Wnt\/\u03b2-catenin pathway. Arch Oral Biol. 2019;97:176\u201384.","journal-title":"Arch Oral Biol"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03392-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-03392-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03392-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T07:02:55Z","timestamp":1763449375000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-03392-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3392"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-03392-8","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"1 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were ratified by the Institutional Animal Care and Use Committee of The Affiliated Hospital of Qingdao University (QYFY WZLL28860).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent received from all individual participants (including OP patients and non-OP patients with proximal femur or femoral neck fractures), and the sample (bone tissues) collection was ratified by the Medical Ethical Committee of the Affiliated Hospital of Qingdao University (QYFY WZLL28849).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights and informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"1131"}}