{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:57:12Z","timestamp":1793422632210,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jinan Health Commission Science and Technology Development Plan","award":["No. 2024301006"],"award-info":[{"award-number":["No. 2024301006"]}]},{"name":"Jinan Health Commission Science and Technology Development Plan","award":["No. 2025301007"],"award-info":[{"award-number":["No. 2025301007"]}]},{"name":"Taian Science and Technology Development Plan","award":["No. 2023NS164"],"award-info":[{"award-number":["No. 2023NS164"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-03462-x","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:12:38Z","timestamp":1764169958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The TREM1\u2013AQP4 axis mediates neuroinflammatory injury and brain edema after experimental subarachnoid hemorrhage"],"prefix":"10.1186","volume":"30","author":[{"given":"Jianxin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"issue":"10355","key":"3462_CR1","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/S0140-6736(22)00938-2","volume":"400","author":"J Claassen","year":"2022","unstructured":"Claassen J, Park S. Spontaneous subarachnoid haemorrhage. Lancet. 2022;400(10355):846\u201362.","journal-title":"Lancet"},{"issue":"10069","key":"3462_CR2","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0140-6736(16)30668-7","volume":"389","author":"RL Macdonald","year":"2017","unstructured":"Macdonald RL, Schweizer TA. Spontaneous subarachnoid haemorrhage. Lancet. 2017;389(10069):655\u201366.","journal-title":"Lancet"},{"issue":"9558","key":"3462_CR3","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/S0140-6736(07)60153-6","volume":"369","author":"J van Gijn","year":"2007","unstructured":"van Gijn J, Kerr RS, Rinkel GJ. Subarachnoid haemorrhage. Lancet. 2007;369(9558):306\u201318.","journal-title":"Lancet"},{"issue":"10","key":"3462_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11910-019-0990-3","volume":"19","author":"V Rass","year":"2019","unstructured":"Rass V, Helbok R. Early brain injury after poor-grade subarachnoid hemorrhage. Curr Neurol Neurosci Rep. 2019;19(10):78.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"3462_CR5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s12028-023-01747-9","volume":"39","author":"VA Shah","year":"2023","unstructured":"Shah VA, Gonzalez LF, Suarez JI. Therapies for delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2023;39(1):36\u201350.","journal-title":"Neurocrit Care"},{"key":"3462_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063102","author":"H Suzuki","year":"2022","unstructured":"Suzuki H, Kawakita F, Asada R. Neuroelectric mechanisms of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms23063102.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3462_CR7","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s12028-023-01812-3","volume":"39","author":"A Abdulazim","year":"2023","unstructured":"Abdulazim A, Heilig M, Rinkel G, Etminan N. Diagnosis of delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage and triggers for intervention. Neurocrit Care. 2023;39(2):311\u20139.","journal-title":"Neurocrit Care"},{"issue":"1","key":"3462_CR8","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12964-023-01274-2","volume":"21","author":"J Shao","year":"2023","unstructured":"Shao J, Meng Y, Yuan K, Wu Q, Zhu S, Li Y, et al. RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS\/STING\/NF-\u03baB pathway. Cell Commun Signal. 2023;21(1):264.","journal-title":"Cell Commun Signal"},{"issue":"8","key":"3462_CR9","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s11910-023-01282-2","volume":"23","author":"DL Alsbrook","year":"2023","unstructured":"Alsbrook DL, Di Napoli M, Bhatia K, Biller J, Andalib S, Hinduja A, et al. Neuroinflammation in acute ischemic and hemorrhagic stroke. Curr Neurol Neurosci Rep. 2023;23(8):407\u201331.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"39","key":"3462_CR10","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq2423","volume":"8","author":"D Feng","year":"2022","unstructured":"Feng D, Zhou J, Liu H, Wu X, Li F, Zhao J, et al. Astrocytic NDRG2-PPM1A interaction exacerbates blood\u2013brain barrier disruption after subarachnoid hemorrhage. Sci Adv. 2022;8(39):eabq2423.","journal-title":"Sci Adv"},{"issue":"1","key":"3462_CR11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s12028-023-01752-y","volume":"39","author":"A Addis","year":"2023","unstructured":"Addis A, Baggiani M, Citerio G. Intracranial pressure monitoring and management in aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2023;39(1):59\u201369.","journal-title":"Neurocrit Care"},{"issue":"3","key":"3462_CR12","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3171\/2019.12.JNS192744","volume":"134","author":"M Eibach","year":"2021","unstructured":"Eibach M, Won SY, Bruder M, Keil F, Herrmann E, Berkefeld J, et al. Age dependency and modification of the subarachnoid hemorrhage early brain edema score. J Neurosurg. 2021;134(3):946\u201352.","journal-title":"J Neurosurg"},{"key":"3462_CR13","doi-asserted-by":"publisher","first-page":"1547858","DOI":"10.3389\/fimmu.2025.1547858","volume":"16","author":"K Yu","year":"2025","unstructured":"Yu K, Wang D, Yu W. Astrocyte\u2013microglia crosstalk in subarachnoid hemorrhage: mechanisms and treatments. Front Immunol. 2025;16:1547858.","journal-title":"Front Immunol"},{"issue":"7","key":"3462_CR14","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.4103\/1673-5374.330589","volume":"17","author":"J Chen","year":"2022","unstructured":"Chen J, Zheng ZV, Lu G, Chan WY, Zhang Y, Wong GKC. Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage. Neural Regen Res. 2022;17(7):1404\u201311.","journal-title":"Neural Regen Res"},{"issue":"2","key":"3462_CR15","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","volume":"179","author":"M Prinz","year":"2019","unstructured":"Prinz M, Jung S, Priller J. Microglia biology: one century of evolving concepts. Cell. 2019;179(2):292\u2013311.","journal-title":"Cell"},{"issue":"6","key":"3462_CR16","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s12975-022-01099-0","volume":"14","author":"J Tang","year":"2023","unstructured":"Tang J, Jin Y, Jia F, Lv T, Manaenko A, Zhang LF, et al. Gas6 promotes microglia efferocytosis and suppresses inflammation through activating Axl\/Rac1 signaling in subarachnoid hemorrhage mice. Transl Stroke Res. 2023;14(6):955\u201369.","journal-title":"Transl Stroke Res"},{"issue":"7","key":"3462_CR17","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.4103\/NRR.NRR-D-24-00241","volume":"20","author":"W Ning","year":"2025","unstructured":"Ning W, Lv S, Wang Q, Xu Y. The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage. Neural Regen Res. 2025;20(7):1829\u201348.","journal-title":"Neural Regen Res"},{"key":"3462_CR18","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.semcdb.2019.05.004","volume":"94","author":"CS Subhramanyam","year":"2019","unstructured":"Subhramanyam CS, Wang C, Hu Q, Dheen ST. Microglia-mediated neuroinflammation in neurodegenerative diseases. Semin Cell Dev Biol. 2019;94:112\u201320.","journal-title":"Semin Cell Dev Biol"},{"key":"3462_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107212","volume":"204","author":"C Li","year":"2024","unstructured":"Li C, Cai C, Xu D, Chen X, Song J. TREM1: activation, signaling, cancer and therapy. Pharmacol Res. 2024;204:107212.","journal-title":"Pharmacol Res"},{"issue":"1","key":"3462_CR20","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1186\/s12951-025-03652-z","volume":"23","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Ji R, Liu Z, Jiang Z, Chu M, Wang Y, et al. HUMSC-exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke. J Nanobiotechnology. 2025;23(1):572.","journal-title":"J Nanobiotechnology"},{"issue":"5","key":"3462_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26852","volume":"10","author":"L Chen","year":"2024","unstructured":"Chen L, Huang F, Luo X, Chen Z. TREM1 promotes cancer associated malignant phenotype through activated MAPK signaling pathway and predicts poor prognosis in gastric cancer. Heliyon. 2024;10(5):e26852.","journal-title":"Heliyon"},{"key":"3462_CR22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI167951","author":"A Ajith","year":"2023","unstructured":"Ajith A, Mamouni K, Horuzsko DD, Musa A, Dzutsev AK, Fang JR, et al. Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti-PD-1 resistance. J Clin Invest. 2023. https:\/\/doi.org\/10.1172\/JCI167951.","journal-title":"J Clin Invest"},{"issue":"2","key":"3462_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113773","volume":"43","author":"J Giraud","year":"2024","unstructured":"Giraud J, Chalopin D, Ramel E, Boyer T, Zouine A, Derieppe MA, et al. THBS1(+) myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1. Cell Rep. 2024;43(2):113773.","journal-title":"Cell Rep"},{"key":"3462_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122626","author":"H Sun","year":"2020","unstructured":"Sun H, Feng J, Tang L. Function of TREM1 and TREM2 in liver-related diseases. Cells. 2020. https:\/\/doi.org\/10.3390\/cells9122626.","journal-title":"Cells"},{"key":"3462_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113692","volume":"341","author":"XG Sun","year":"2021","unstructured":"Sun XG, Zhang MM, Liu SY, Chu XH, Xue GQ, Zhang BC, et al. Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage. Exp Neurol. 2021;341:113692.","journal-title":"Exp Neurol"},{"issue":"2","key":"3462_CR26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jneumeth.2007.08.004","volume":"167","author":"T Sugawara","year":"2008","unstructured":"Sugawara T, Ayer R, Jadhav V, Zhang JH. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 2008;167(2):327\u201334.","journal-title":"J Neurosci Methods"},{"issue":"6","key":"3462_CR27","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s12975-020-00801-4","volume":"11","author":"BE Gr\u00fcter","year":"2020","unstructured":"Gr\u00fcter BE, Croci D, Sch\u00f6pf S, Nevzati E, d\u2019Allonzo D, Lattmann J, et al. Systematic review and meta-analysis of methodological quality in in vivo animal studies of subarachnoid hemorrhage. Transl Stroke Res. 2020;11(6):1175\u201384.","journal-title":"Transl Stroke Res"},{"issue":"5","key":"3462_CR28","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s12975-023-01180-2","volume":"15","author":"DG Lynch","year":"2024","unstructured":"Lynch DG, Shah KA, Powell K, Wadolowski S, Tambo W, Strohl JJ, et al. Neurobehavioral impairments predict specific cerebral damage in rat model of subarachnoid hemorrhage. Transl Stroke Res. 2024;15(5):950\u201369.","journal-title":"Transl Stroke Res"},{"issue":"1","key":"3462_CR29","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s12975-021-00918-0","volume":"13","author":"J Zhang","year":"2022","unstructured":"Zhang J, Peng K, Ye F, Koduri S, Hua Y, Keep RF, et al. Acute T2*-weighted magnetic resonance imaging detectable cerebral thrombosis in a rat model of subarachnoid hemorrhage. Transl Stroke Res. 2022;13(1):188\u201396.","journal-title":"Transl Stroke Res"},{"issue":"8","key":"3462_CR30","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1177\/0271678X21990130","volume":"41","author":"V Malinova","year":"2021","unstructured":"Malinova V, Bleuel K, Stadelmann C, Iliev B, Tsogkas I, Psychogios MN, et al. The impact of transcranial direct current stimulation on cerebral vasospasm in a rat model of subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2021;41(8):2000\u20139.","journal-title":"J Cereb Blood Flow Metab"},{"key":"3462_CR31","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.freeradbiomed.2024.10.273","volume":"225","author":"Q He","year":"2024","unstructured":"He Q, Zhou Y, Wu L, Huang L, Yuan Y, Flores JJ, et al. Inhibition of acid-sensing receptor GPR4 attenuates neuronal ferroptosis via RhoA\/YAP signaling in a rat model of subarachnoid hemorrhage. Free Radic Biol Med. 2024;225:333\u201345.","journal-title":"Free Radic Biol Med"},{"key":"3462_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216801","volume":"590","author":"M Dong","year":"2024","unstructured":"Dong M, Zhang X, Peng P, Chen Z, Zhang Y, Wan L, et al. Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages. Cancer Lett. 2024;590:216801.","journal-title":"Cancer Lett"},{"issue":"10","key":"3462_CR33","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1080\/15548627.2023.2213984","volume":"19","author":"Q Li","year":"2023","unstructured":"Li Q, Zhao Y, Guo H, Li Q, Yan C, Li Y, et al. Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment. Autophagy. 2023;19(10):2639\u201356.","journal-title":"Autophagy"},{"issue":"19","key":"3462_CR34","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202501934RR","volume":"39","author":"X Zhou","year":"2025","unstructured":"Zhou X, Bi J, Chen H, Wang Y, Li Y, Huang D, et al. Age-specific biomarkers TREM1 and KLF4 in ischemic stroke: from transcriptomic discovery to therapeutic drug screening. FASEB J. 2025;39(19):e71080.","journal-title":"FASEB J"},{"issue":"8","key":"3462_CR35","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/s41590-019-0443-9","volume":"20","author":"F Roselli","year":"2019","unstructured":"Roselli F, Huber-Lang M. TREM1-ors shake the brain and gut after stroke. Nat Immunol. 2019;20(8):950\u20132.","journal-title":"Nat Immunol"},{"issue":"8","key":"3462_CR36","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.4103\/1673-5374.303028","volume":"16","author":"J Chen","year":"2021","unstructured":"Chen J, Wong GKC. Microglia accumulation and activation after subarachnoid hemorrhage. Neural Regen Res. 2021;16(8):1531\u20132.","journal-title":"Neural Regen Res"},{"issue":"1","key":"3462_CR37","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","volume":"9","author":"HS Kwon","year":"2020","unstructured":"Kwon HS, Koh SH. Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener. 2020;9(1):42.","journal-title":"Transl Neurodegener"},{"issue":"5","key":"3462_CR38","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1007\/s11010-024-05173-z","volume":"480","author":"H Zhu","year":"2025","unstructured":"Zhu H, Gao G, Wu Y, Wang Y, Chen Y, Niu C. Activated TREM1-mediated MAPK signaling in endothelial cells caused by highly expressed STAT1 is associated with intracranial aneurysms occurrence and rupture. Mol Cell Biochem. 2025;480(5):3133\u201345.","journal-title":"Mol Cell Biochem"},{"key":"3462_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.716469","volume":"12","author":"L Barnabei","year":"2021","unstructured":"Barnabei L, Laplantine E, Mbongo W, Rieux-Laucat F, Weil R. NF-\u03baB: at the borders of autoimmunity and inflammation. Front Immunol. 2021;12:716469.","journal-title":"Front Immunol"},{"issue":"1","key":"3462_CR40","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","volume":"5","author":"H Yu","year":"2020","unstructured":"Yu H, Lin L, Zhang Z, Zhang H, Hu H. Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020;5(1):209.","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"3462_CR41","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1097\/JS9.0000000000001244","volume":"110","author":"MD Wang","year":"2024","unstructured":"Wang MD, Fu QH, Ni A, Yuan YP, Li CH, Wang ZX, et al. The role of early cerebral edema and hematoma assessment in aneurysmal subarachnoid hemorrhage (a-SAH) in predicting early brain injury (EBI) and cognitive impairment: a case controlled study. Int J Surg. 2024;110(6):3166\u201377.","journal-title":"Int J Surg"},{"key":"3462_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.870029","volume":"13","author":"C Sun","year":"2022","unstructured":"Sun C, Lin L, Yin L, Hao X, Tian J, Zhang X, et al. Acutely inhibiting AQP4 with TGN-020 improves functional outcome by attenuating edema and peri-infarct astrogliosis after cerebral ischemia. Front Immunol. 2022;13:870029.","journal-title":"Front Immunol"},{"issue":"5","key":"3462_CR43","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1007\/s12975-024-01318-w","volume":"16","author":"J Tang","year":"2025","unstructured":"Tang J, Yue J, Tao Y, Zhao G, Yi X, Zhang M, et al. Neutrophil extracellular traps induce brain edema around intracerebral hematoma via ERK-mediated regulation of MMP9 and AQP4. Transl Stroke Res. 2025;16(5):1461\u201373.","journal-title":"Transl Stroke Res"},{"issue":"4","key":"3462_CR44","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1007\/s13311-021-01126-2","volume":"18","author":"H Jeon","year":"2021","unstructured":"Jeon H, Kim M, Park W, Lim JS, Lee E, Cha H, et al. Upregulation of AQP4 improves blood-brain barrier integrity and perihematomal edema following intracerebral hemorrhage. Neurotherapeutics. 2021;18(4):2692\u2013706.","journal-title":"Neurotherapeutics"},{"key":"3462_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.766178","volume":"12","author":"X Wu","year":"2021","unstructured":"Wu X, Zeng H, Xu C, Chen H, Fan L, Zhou H, et al. TREM1 regulates neuroinflammatory injury by modulate proinflammatory subtype transition of microglia and formation of neutrophil extracellular traps via interaction with SYK in experimental subarachnoid hemorrhage. Front Immunol. 2021;12:766178.","journal-title":"Front Immunol"},{"key":"3462_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2024.111162","volume":"220","author":"H Li","year":"2025","unstructured":"Li H, Yu W, Zheng X, Zhu Z. TREM1-microglia crosstalk: neurocognitive disorders. Brain Res Bull. 2025;220:111162.","journal-title":"Brain Res Bull"},{"key":"3462_CR47","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.cca.2017.03.006","volume":"469","author":"A Uzawa","year":"2017","unstructured":"Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Sawai S, et al. Interleukin-6 analysis of 572 consecutive CSF samples from neurological disorders: a special focus on neuromyelitis optica. Clin Chim Acta. 2017;469:144\u20139.","journal-title":"Clin Chim Acta"},{"key":"3462_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114464","volume":"449","author":"A Fu","year":"2023","unstructured":"Fu A, Qiao F, Feng H, Luo Q. Inhibition of TREM-1 ameliorates lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K\/Akt signaling pathway. Behav Brain Res. 2023;449:114464.","journal-title":"Behav Brain Res"},{"issue":"1","key":"3462_CR49","doi-asserted-by":"publisher","first-page":"81","DOI":"10.4149\/gpb_2024037","volume":"44","author":"W Ke","year":"2025","unstructured":"Ke W, Ye Z, Huang Y, Ye S. Transcription factor Yy1 modulates Trem1 to control LPS-triggered neuroinflammation and oxidative stress in mouse astrocytes via the NF-\u03baB pathway. Gen Physiol Biophys. 2025;44(1):81\u201392.","journal-title":"Gen Physiol Biophys"},{"issue":"1","key":"3462_CR50","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s10194-023-01707-w","volume":"25","author":"S Sun","year":"2024","unstructured":"Sun S, Fan Z, Liu X, Wang L, Ge Z. Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-\u03baB pathway in a chronic migraine model. J Headache Pain. 2024;25(1):3.","journal-title":"J Headache Pain"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03462-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-03462-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03462-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:10:45Z","timestamp":1764173445000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-03462-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3462"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-03462-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7741776\/v1","asserted-by":"object"}]},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"29 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures in this study strictly adhered to national regulations governing the management and use of laboratory animals. They were reviewed and approved by the Animal Ethics Committee of Jinan First People\u2019s Hospital (Approval No. 2025-03-01-17), maximizing compliance with the 3Rs principle (reduction, replacement, refinement) to minimize both the number of animals used and their suffering.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"1179"}}