{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:45:50Z","timestamp":1788493550285,"version":"build-2803163510"},"reference-count":173,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Med Res"],"DOI":"10.1186\/s40001-025-03475-6","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T05:14:20Z","timestamp":1764566060000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["NETs in ovarian cancer progression: innovative nanoparticle-based therapeutic strategies"],"prefix":"10.1186","volume":"30","author":[{"given":"Somayeh","family":"Moradpanah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab Hashem","family":"Aghaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvinsadat","family":"Eslamnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim Koochaki","family":"Goldiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Sargolzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Doosty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboubeh","family":"Barsam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Feli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Zarifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"issue":"1","key":"3475_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/ijc.32075","volume":"145","author":"RT Fortner","year":"2019","unstructured":"Fortner RT, et al. Ovarian cancer risk factors by tumor aggressiveness: an analysis from the ovarian cancer cohort consortium. Int J Cancer. 2019;145(1):58\u201369.","journal-title":"Int J Cancer"},{"key":"3475_CR2","doi-asserted-by":"publisher","first-page":"1401648","DOI":"10.3389\/fendo.2024.1401648","volume":"15","author":"L Han","year":"2024","unstructured":"Han L, et al. Unveiling the causal link between metabolic factors and ovarian cancer risk using Mendelian randomization analysis. Front Endocrinol. 2024;15:1401648.","journal-title":"Front Endocrinol"},{"issue":"2","key":"3475_CR3","first-page":"93","volume":"22","author":"AT Ali","year":"2023","unstructured":"Ali AT, Al-Ani O, Al-Ani F. Epidemiology and risk factors for ovarian cancer. Prz Menopauzalny. 2023;22(2):93\u2013104.","journal-title":"Prz Menopauzalny"},{"key":"3475_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117078","volume":"285","author":"J Lin","year":"2024","unstructured":"Lin J, et al. Metabolic changes induced by heavy metal copper exposure in human ovarian granulosa cells. Ecotoxicol Environ Saf. 2024;285:117078.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"4","key":"3475_CR5","doi-asserted-by":"publisher","first-page":"e32247","DOI":"10.34172\/jrip.2023.32247","volume":"12","author":"A Yousefnezhad","year":"2023","unstructured":"Yousefnezhad A, et al. Renal dysfunction in individuals with ovarian cancer; a review on current concepts. J Renal Inj Prev. 2023;12(4):e32247\u2013e32247.","journal-title":"J Renal Inj Prev"},{"issue":"1\u20132","key":"3475_CR6","first-page":"41","volume":"85","author":"M Kossa\u00ef","year":"2017","unstructured":"Kossa\u00ef M, et al. Ovarian cancer: a heterogeneous disease. Pathobiology. 2017;85(1\u20132):41\u20139.","journal-title":"Pathobiology"},{"key":"3475_CR7","doi-asserted-by":"publisher","DOI":"10.34172\/ipp.2023.40572","volume":"11","author":"J Sadeghi","year":"2023","unstructured":"Sadeghi J, et al. Impact of analgesics on the risk of ovarian cancer; a systematic review and meta-analysis of cohort and case-control studies. Immunopathologia Persa. 2023;11:e40572.","journal-title":"Immunopathologia Persa"},{"issue":"4","key":"3475_CR8","doi-asserted-by":"publisher","first-page":"544","DOI":"10.4103\/ijnmr.ijnmr_27_24","volume":"30","author":"M Latifi","year":"2025","unstructured":"Latifi M, et al. Health information-seeking behavior of menopausal women: an online survey of iranian menopausal women. Iran J Nurs Midwifery Res. 2025;30(4):544\u201352.","journal-title":"Iran J Nurs Midwifery Res"},{"issue":"1","key":"3475_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12935-023-02854-5","volume":"23","author":"S Mei","year":"2023","unstructured":"Mei S, et al. Tumor microenvironment in ovarian cancer peritoneal metastasis. Cancer Cell Int. 2023;23(1):11.","journal-title":"Cancer Cell Int"},{"key":"3475_CR10","doi-asserted-by":"publisher","first-page":"0371","DOI":"10.34133\/research.0371","volume":"7","author":"N Wu","year":"2024","unstructured":"Wu N, et al. Progesterone enhances niraparib efficacy in ovarian cancer by promoting palmitoleic-acid-mediated ferroptosis. Research. 2024;7:0371.","journal-title":"Research"},{"key":"3475_CR11","doi-asserted-by":"publisher","DOI":"10.34172\/ipp.2025.43842","volume":"11","author":"A Marrakchi","year":"2025","unstructured":"Marrakchi A, et al. Factor structure and measurement invariance by gender of the GHQ12 scale among parents of children with cancer. Immunopathologia Persa. 2025;11:e43842.","journal-title":"Immunopathologia Persa"},{"issue":"9","key":"3475_CR12","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.3390\/ijms21093125","volume":"21","author":"D Baci","year":"2020","unstructured":"Baci D, et al. The ovarian cancer tumor immune microenvironment (TIME) as target for therapy: a focus on innate immunity cells as therapeutic effectors. Int J Mol Sci. 2020;21(9):3125.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"3475_CR13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13(3):159\u201375.","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"3475_CR14","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41423-025-01283-w","volume":"22","author":"JA Szlachetko","year":"2025","unstructured":"Szlachetko JA, et al. Tumor cells that resist neutrophil anticancer cytotoxicity acquire a prometastatic and innate immune escape phenotype. Cell Mol Immunol. 2025;22(5):527\u201340.","journal-title":"Cell Mol Immunol"},{"issue":"9","key":"3475_CR15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/s41423-023-01058-1","volume":"20","author":"J Qu","year":"2023","unstructured":"Qu J, et al. Neutrophil diversity and plasticity: Implications for organ transplantation. Cell Mol Immunol. 2023;20(9):993\u20131001.","journal-title":"Cell Mol Immunol"},{"key":"3475_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-62703-845-4_1","volume":"1124","author":"HL Malech","year":"2014","unstructured":"Malech HL, Deleo FR, Quinn MT. The role of neutrophils in the immune system: an overview. Methods Mol Biol. 2014;1124:3\u201310.","journal-title":"Methods Mol Biol"},{"issue":"1","key":"3475_CR17","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41420-025-02287-1","volume":"11","author":"T Chen","year":"2025","unstructured":"Chen T, Ren Q, Ma F. New insights into constitutive neutrophil death. Cell Death Discov. 2025;11(1):6.","journal-title":"Cell Death Discov"},{"issue":"1","key":"3475_CR18","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41420-024-01809-7","volume":"10","author":"C Ramos","year":"2024","unstructured":"Ramos C, Oehler R. Clearance of apoptotic cells by neutrophils in inflammation and cancer. Cell Death Discov. 2024;10(1):26.","journal-title":"Cell Death Discov"},{"issue":"5","key":"3475_CR19","doi-asserted-by":"publisher","DOI":"10.4110\/in.2023.23.e38","volume":"23","author":"S Shrestha","year":"2023","unstructured":"Shrestha S, Hong CW. Extracellular mechanisms of neutrophils in immune cell crosstalk. Immune Netw. 2023;23(5):e38.","journal-title":"Immune Netw"},{"key":"3475_CR20","doi-asserted-by":"publisher","DOI":"10.18502\/ijpho.v14i3.15990","author":"AH Abdulwahid","year":"2024","unstructured":"Abdulwahid AH, et al. In silico analysis of genes and molecular pathways involved in the pathogenesis of follicular lymphoma. Iran J Pediatr Hematol Oncol. 2024. https:\/\/doi.org\/10.18502\/ijpho.v14i3.15990.","journal-title":"Iran J Pediatr Hematol Oncol"},{"key":"3475_CR21","doi-asserted-by":"publisher","first-page":"1508909","DOI":"10.3389\/fimmu.2025.1508909","volume":"16","author":"Y Li","year":"2025","unstructured":"Li Y, et al. Current perspectives and trends of neutrophil extracellular traps in organ fibrosis: a bibliometric and visualization study. Front Immunol. 2025;16:1508909.","journal-title":"Front Immunol"},{"key":"3475_CR22","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/fimmu.2016.00328","volume":"7","author":"S Yousefi","year":"2016","unstructured":"Yousefi S, Simon HU. NETosis - does it really represent nature\u2019s \u201cSuicide Bomber\u201d? Front Immunol. 2016;7:328.","journal-title":"Front Immunol"},{"key":"3475_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417583","author":"A Shafqat","year":"2023","unstructured":"Shafqat A, et al. How neutrophils shape the immune response: reassessing their multifaceted role in health and disease. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms242417583.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"3475_CR24","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1097\/MS9.0000000000003304","volume":"87","author":"EI Obeagu","year":"2025","unstructured":"Obeagu EI. Stress, neutrophils, and immunity: a dynamic interplay. Ann Med Surg. 2025;87(6):3573\u201385.","journal-title":"Ann Med Surg"},{"issue":"1","key":"3475_CR25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/imr.13153","volume":"314","author":"K Van Avondt","year":"2023","unstructured":"Van Avondt K, et al. Neutrophils in aging and aging-related pathologies. Immunol Rev. 2023;314(1):357\u201375.","journal-title":"Immunol Rev"},{"issue":"2","key":"3475_CR26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/jlb.59.2.229","volume":"59","author":"H Takei","year":"1996","unstructured":"Takei H, et al. Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis. J Leukoc Biol. 1996;59(2):229\u201340.","journal-title":"J Leukoc Biol"},{"issue":"5663","key":"3475_CR27","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532\u20135.","journal-title":"Science"},{"issue":"10","key":"3475_CR28","first-page":"1178","volume":"85","author":"NV Vorobjeva","year":"2020","unstructured":"Vorobjeva NV, Chernyak BV. NETosis: molecular mechanisms, role in physiology and pathology. Biochemistry. 2020;85(10):1178\u201390.","journal-title":"Biochemistry"},{"issue":"11","key":"3475_CR29","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/ni.2987","volume":"15","author":"N Branzk","year":"2014","unstructured":"Branzk N, et al. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nat Immunol. 2014;15(11):1017\u201325.","journal-title":"Nat Immunol"},{"issue":"1","key":"3475_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13054-025-05283-0","volume":"29","author":"A Retter","year":"2025","unstructured":"Retter A, Singer M, Annane D. \u201cThe NET effect\u201d: Neutrophil extracellular traps\u2014a potential key component of the dysregulated host immune response in sepsis. Crit Care. 2025;29(1):59.","journal-title":"Crit Care"},{"issue":"9","key":"3475_CR31","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1161\/ATVBAHA.119.312463","volume":"39","author":"C Th\u00e5lin","year":"2019","unstructured":"Th\u00e5lin C, et al. Neutrophil extracellular traps. Arterioscler Thromb Vasc Biol. 2019;39(9):1724\u201338.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"3475_CR32","doi-asserted-by":"publisher","first-page":"16556","DOI":"10.1038\/s41598-019-53058-9","volume":"9","author":"A Sofoluwe","year":"2019","unstructured":"Sofoluwe A, et al. ATP amplifies NADPH-dependent and -independent neutrophil extracellular trap formation. Sci Rep. 2019;9(1):16556.","journal-title":"Sci Rep"},{"issue":"10","key":"3475_CR33","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1134\/S0006297920100065","volume":"85","author":"NV Vorobjeva","year":"2020","unstructured":"Vorobjeva NV, Chernyak BV. NETosis: molecular mechanisms, role in physiology and pathology. Biochem Mosc. 2020;85(10):1178\u201390.","journal-title":"Biochem Mosc"},{"issue":"5","key":"3475_CR34","doi-asserted-by":"publisher","first-page":"165664","DOI":"10.1016\/j.bbadis.2020.165664","volume":"1866","author":"N Vorobjeva","year":"2020","unstructured":"Vorobjeva N, et al. Mitochondrial permeability transition pore is involved in oxidative burst and NETosis of human neutrophils. Biochimica et Biophysica Acta (BBA)-Mol Basis Dis. 2020;1866(5):165664.","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol Basis Dis"},{"issue":"3","key":"3475_CR35","first-page":"13","volume":"8","author":"C Jalili","year":"2021","unstructured":"Jalili C, Darakhshan S, Azimi M. Harmine mitigates liver injury induced by mercuric chloride via the inhibition of oxidative stress. Res J Pharmacognosy. 2021;8(3):13\u201323.","journal-title":"Res J Pharmacognosy"},{"key":"3475_CR36","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fimmu.2017.00081","volume":"8","author":"V Delgado-Rizo","year":"2017","unstructured":"Delgado-Rizo V, et al. Neutrophil extracellular traps and its implications in inflammation: an overview. Front Immunol. 2017;8:81.","journal-title":"Front Immunol"},{"key":"3475_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109448","volume":"114","author":"N Vorobjeva","year":"2023","unstructured":"Vorobjeva N, et al. Protein kinase C isoforms mediate the formation of neutrophil extracellular traps. Int Immunopharmacol. 2023;114:109448.","journal-title":"Int Immunopharmacol"},{"key":"3475_CR38","doi-asserted-by":"publisher","first-page":"1202463","DOI":"10.3389\/fendo.2023.1202463","volume":"14","author":"Y Zhu","year":"2023","unstructured":"Zhu Y, et al. Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications. Front Endocrinol. 2023;14:1202463.","journal-title":"Front Endocrinol"},{"key":"3475_CR39","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.3389\/fimmu.2019.02481","volume":"10","author":"S G\u00f6\u00dfwein","year":"2019","unstructured":"G\u00f6\u00dfwein S, et al. Citrullination licenses calpain to decondense nuclei in neutrophil extracellular trap formation. Front Immunol. 2019;10:2481.","journal-title":"Front Immunol"},{"issue":"6","key":"3475_CR40","doi-asserted-by":"publisher","first-page":"6755","DOI":"10.1007\/s00210-024-03671-x","volume":"398","author":"A Adereh","year":"2025","unstructured":"Adereh A, et al. Loc646329 sponges miR-21 to reduce RAS\/MAP kinase signaling pathway in oral squamous cell carcinoma (OSCC). Naunyn Schmiedebergs Arch Pharmacol. 2025;398(6):6755\u201363.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"21","key":"3475_CR41","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1182\/blood.2021013565","volume":"139","author":"EGG Sprenkeler","year":"2022","unstructured":"Sprenkeler EGG, et al. Formation of neutrophil extracellular traps requires actin cytoskeleton rearrangements. Blood. 2022;139(21):3166\u201380.","journal-title":"Blood"},{"key":"3475_CR42","doi-asserted-by":"publisher","first-page":"1253667","DOI":"10.3389\/fimmu.2023.1253667","volume":"14","author":"M Juha","year":"2023","unstructured":"Juha M, et al. NETosis: an emerging therapeutic target in renal diseases. Front Immunol. 2023;14:1253667.","journal-title":"Front Immunol"},{"key":"3475_CR43","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1083\/jcb.201006052","volume":"191","author":"V Papayannopoulos","year":"2010","unstructured":"Papayannopoulos V, et al. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol. 2010;191:677\u201391.","journal-title":"J Cell Biol"},{"key":"3475_CR44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae985","author":"Y-Y Li","year":"2024","unstructured":"Li Y-Y, et al. scImmOmics: a manually curated resource of single-cell multi-omics immune data. Nucleic Acids Res. 2024. https:\/\/doi.org\/10.1093\/nar\/gkae985.","journal-title":"Nucleic Acids Res"},{"key":"3475_CR45","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","volume":"3","author":"AS Rohrbach","year":"2012","unstructured":"Rohrbach AS, et al. Activation of PAD4 in NET formation. Front Immunol. 2012;3:360.","journal-title":"Front Immunol"},{"key":"3475_CR46","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3389\/fimmu.2012.00307","volume":"3","author":"M Leshner","year":"2012","unstructured":"Leshner M, et al. PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front Immunol. 2012;3:307.","journal-title":"Front Immunol"},{"key":"3475_CR47","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6689","author":"G Sollberger","year":"2018","unstructured":"Sollberger G, et al. Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sci Immunol. 2018. https:\/\/doi.org\/10.1126\/sciimmunol.aar6689.","journal-title":"Sci Immunol"},{"key":"3475_CR48","doi-asserted-by":"publisher","first-page":"1099038","DOI":"10.3389\/fcell.2022.1099038","volume":"10","author":"F Guillotin","year":"2022","unstructured":"Guillotin F, et al. Vital NETosis vs. suicidal NETosis during normal pregnancy and preeclampsia. Front Cell Dev Biol. 2022;10:1099038.","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"3475_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.162","volume":"3","author":"J Huang","year":"2022","unstructured":"Huang J, et al. Molecular mechanisms and therapeutic target of NETosis in diseases. MedComm. 2022;3(3):e162.","journal-title":"MedComm"},{"issue":"4","key":"3475_CR50","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/JLB.3RU0620-375R","volume":"110","author":"C Tan","year":"2021","unstructured":"Tan C, Aziz M, Wang P. The vitals of NETs. J Leukoc Biol. 2021;110(4):797\u2013808.","journal-title":"J Leukoc Biol"},{"issue":"1","key":"3475_CR51","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s40164-025-00670-3","volume":"14","author":"F Gao","year":"2025","unstructured":"Gao F, et al. Exploring neutrophil extracellular traps: mechanisms of immune regulation and future therapeutic potential. Exp Hematol Oncol. 2025;14(1):80.","journal-title":"Exp Hematol Oncol"},{"issue":"3","key":"3475_CR52","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.tcm.2022.12.001","volume":"34","author":"Q Zhu","year":"2024","unstructured":"Zhu Q, et al. Understanding the pathogenesis of coronary slow flow: recent advances. Trends Cardiovasc Med. 2024;34(3):137\u201344.","journal-title":"Trends Cardiovasc Med"},{"issue":"1","key":"3475_CR53","first-page":"107","volume":"77","author":"X Chen","year":"2025","unstructured":"Chen X, et al. Research progress on the impact and mechanism of neutrophil extracellular traps (NETs) components in atherosclerosis. Sheng Li Xue Bao. 2025;77(1):107\u201319.","journal-title":"Sheng Li Xue Bao"},{"key":"3475_CR54","doi-asserted-by":"publisher","first-page":"8349712","DOI":"10.1155\/2020\/8349712","volume":"2020","author":"B Yang","year":"2020","unstructured":"Yang B, et al. Significance of LL-37 on immunomodulation and disease outcome. Biomed Res Int. 2020;2020:8349712.","journal-title":"Biomed Res Int"},{"issue":"5","key":"3475_CR55","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00011-016-1010-6","volume":"66","author":"M Korabecna","year":"2017","unstructured":"Korabecna M, Tesar V. NETosis provides the link between activation of neutrophils on hemodialysis membrane and comorbidities in dialyzed patients. Inflamm Res. 2017;66(5):369\u201378.","journal-title":"Inflamm Res"},{"issue":"11","key":"3475_CR56","doi-asserted-by":"publisher","first-page":"3424","DOI":"10.3390\/cancers12113424","volume":"12","author":"M Li","year":"2020","unstructured":"Li M, et al. Quantification of citrullinated histone H3 bound DNA for detection of neutrophil extracellular traps. Cancers. 2020;12(11):3424.","journal-title":"Cancers"},{"issue":"4","key":"3475_CR57","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/cdd.2011.1","volume":"18","author":"Q Remijsen","year":"2011","unstructured":"Remijsen Q, et al. Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ. 2011;18(4):581\u20138.","journal-title":"Cell Death Differ"},{"issue":"1","key":"3475_CR58","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41423-018-0024-0","volume":"16","author":"CM de Bont","year":"2019","unstructured":"de Bont CM, Boelens WC, Pruijn GJM. NETosis, complement, and coagulation: a triangular relationship. Cell Mol Immunol. 2019;16(1):19\u201327.","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"3475_CR59","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1007\/s10753-020-01294-x","volume":"43","author":"Z Cahilog","year":"2020","unstructured":"Cahilog Z, et al. The role of neutrophil netosis in organ injury: novel inflammatory cell death mechanisms. Inflammation. 2020;43(6):2021\u201332.","journal-title":"Inflammation"},{"key":"3475_CR60","unstructured":"Determination Of bacterial profiles in children with otitis media with effusion and adenoid hypertrophy. African Journal of Biomedical Research. 2025. 28 2S 470-480."},{"issue":"8","key":"3475_CR61","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/s12032-025-02860-9","volume":"42","author":"S Amirlatifi","year":"2025","unstructured":"Amirlatifi S, et al. Ovarian cancer, neutrophil hitchhiking, and NETs: unraveling their role in pathogenesis and management. Med Oncol. 2025;42(8):302.","journal-title":"Med Oncol"},{"issue":"8","key":"3475_CR62","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1007\/s12033-022-00634-6","volume":"65","author":"P Khalili","year":"2023","unstructured":"Khalili P, et al. Evaluation of genes and molecular pathways involved in the progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma: a systems biology approach. Mol Biotechnol. 2023;65(8):1275\u201386.","journal-title":"Mol Biotechnol"},{"key":"3475_CR63","doi-asserted-by":"publisher","first-page":"1442888","DOI":"10.3389\/fphar.2024.1442888","volume":"15","author":"C Biray Avci","year":"2024","unstructured":"Biray Avci C, et al. Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications. Front Pharmacol. 2024;15:1442888.","journal-title":"Front Pharmacol"},{"issue":"3","key":"3475_CR64","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s12308-017-0306-y","volume":"10","author":"SN Hassani","year":"2017","unstructured":"Hassani SN, et al. Restoration of natural killer cell cytotoxicity in the suppressive tumor microenvironment: novel approaches to treat AML. J Hematop. 2017;10(3):109\u201316.","journal-title":"J Hematop"},{"key":"3475_CR65","doi-asserted-by":"publisher","first-page":"1517519","DOI":"10.3389\/fimmu.2025.1517519","volume":"16","author":"J Liu","year":"2025","unstructured":"Liu J, et al. Potential target within the tumor microenvironment - MT1-MMP. Front Immunol. 2025;16:1517519.","journal-title":"Front Immunol"},{"issue":"1","key":"3475_CR66","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12964-020-0530-4","volume":"18","author":"R Baghban","year":"2020","unstructured":"Baghban R, et al. Tumor microenvironment complexity and therapeutic implications at a glance. Cell Commun Signal. 2020;18(1):59.","journal-title":"Cell Commun Signal"},{"issue":"1","key":"3475_CR67","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s40001-023-01125-3","volume":"28","author":"S Rajbhandary","year":"2023","unstructured":"Rajbhandary S, Dhakal H, Shrestha S. Tumor immune microenvironment (TIME) to enhance antitumor immunity. Eur J Med Res. 2023;28(1):169.","journal-title":"Eur J Med Res"},{"issue":"1","key":"3475_CR68","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12645-025-00340-3","volume":"16","author":"J Naghinezhad","year":"2025","unstructured":"Naghinezhad J, et al. Nanodrug-based modulation of platelet\u2013leukocyte interactions in ovarian cancer: a new frontier in targeted therapy. Cancer Nanotechnol. 2025;16(1):37.","journal-title":"Cancer Nanotechnol"},{"issue":"1","key":"3475_CR69","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41420-023-01402-4","volume":"9","author":"A Bukhari","year":"2023","unstructured":"Bukhari A, Kalinina O, Knight KL. Death of tonsillar B cells by NETosis. Cell Death Discov. 2023;9(1):108.","journal-title":"Cell Death Discov"},{"key":"3475_CR70","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.matbio.2024.10.007","volume":"134","author":"T Wenta","year":"2024","unstructured":"Wenta T, et al. Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression. Matrix Biol. 2024;134:197\u2013219.","journal-title":"Matrix Biol"},{"issue":"14","key":"3475_CR71","doi-asserted-by":"publisher","first-page":"1340634","DOI":"10.3389\/fimmu.2023.1340634","volume":"25","author":"W Du","year":"2024","unstructured":"Du W, et al. Extracellular matrix remodeling in the tumor immunity. Front Immunol. 2024;25(14):1340634.","journal-title":"Front Immunol"},{"issue":"23","key":"3475_CR72","doi-asserted-by":"publisher","first-page":"6131","DOI":"10.3390\/cancers13236131","volume":"13","author":"C Kaltenmeier","year":"2021","unstructured":"Kaltenmeier C, et al. Neutroaphil extracellular traps (NETs) in cancer metastasis. Cancers. 2021;13(23):6131.","journal-title":"Cancers"},{"key":"3475_CR73","doi-asserted-by":"publisher","first-page":"5329","DOI":"10.1158\/1538-7445.AM2024-5329","volume":"84","author":"G Yamamoto","year":"2024","unstructured":"Yamamoto G, et al. Abstract 5329: ovarian cancer predisposes neutrophils to form neutrophil extracellular traps(NETs). Cancer Res. 2024;84:5329\u20135329.","journal-title":"Cancer Res"},{"issue":"1","key":"3475_CR74","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1084\/jem.20181170","volume":"216","author":"W Lee","year":"2019","unstructured":"Lee W, et al. Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum. J Exp Med. 2019;216(1):176\u201394.","journal-title":"J Exp Med"},{"issue":"17","key":"3475_CR75","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.3390\/cancers13174495","volume":"13","author":"U Demkow","year":"2021","unstructured":"Demkow U. Neutrophil extracellular traps (NETs) in cancer invasion evasion and metastasis. Cancers. 2021;13(17):4495.","journal-title":"Cancers"},{"key":"3475_CR76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.937565","volume":"13","author":"J Zhao","year":"2022","unstructured":"Zhao J, Jin J. Neutrophil extracellular traps: new players in cancer research. Front Immunol. 2022;13:937565.","journal-title":"Front Immunol"},{"issue":"11","key":"3475_CR77","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1248\/bpb.b20-00389","volume":"43","author":"R Morimoto-Kamata","year":"2020","unstructured":"Morimoto-Kamata R, Tsuji D, Yui S. Cathepsin G-induced insulin-like growth factor (IGF) elevation in MCF-7 medium is caused by proteolysis of IGF binding protein (IGFBP)-2 but Not of IGF-1. Biol Pharm Bull. 2020;43(11):1678\u201386.","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"3475_CR78","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.3390\/cancers15041282","volume":"15","author":"S Oncul","year":"2023","unstructured":"Oncul S, Cho MS. Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes. Cancers. 2023;15(4):1282.","journal-title":"Cancers"},{"key":"3475_CR79","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fnins.2018.00073","volume":"12","author":"L Yang","year":"2018","unstructured":"Yang L, et al. The Role of Insulin\/IGF-1\/PI3K\/Akt\/GSK3\u03b2 Signaling in Parkinson\u2019s Disease Dementia. Front Neurosci. 2018;12:73.","journal-title":"Front Neurosci"},{"issue":"361","key":"3475_CR80","doi-asserted-by":"publisher","first-page":"361ra138","DOI":"10.1126\/scitranslmed.aag1711","volume":"8","author":"J Park","year":"2016","unstructured":"Park J, et al. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med. 2016;8(361):361ra138.","journal-title":"Sci Transl Med"},{"issue":"2","key":"3475_CR81","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.ccr.2011.12.024","volume":"21","author":"T Muranen","year":"2012","unstructured":"Muranen T, et al. Inhibition of PI3K\/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012;21(2):227\u201339.","journal-title":"Cancer Cell"},{"issue":"21","key":"3475_CR82","doi-asserted-by":"publisher","first-page":"5626","DOI":"10.1158\/0008-5472.CAN-19-0800","volume":"79","author":"HO Yazdani","year":"2019","unstructured":"Yazdani HO, et al. Neutrophil extracellular Traps drive mitochondrial homeostasis in tumors to augment growth. Cancer Res. 2019;79(21):5626\u201339.","journal-title":"Cancer Res"},{"issue":"5","key":"3475_CR83","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s00018-018-2961-2","volume":"76","author":"DC Altieri","year":"2019","unstructured":"Altieri DC. Mitochondrial dynamics and metastasis. Cell Mol Life Sci. 2019;76(5):827\u201335.","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"3475_CR84","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.1111\/cas.14603","volume":"111","author":"M Hu","year":"2020","unstructured":"Hu M, et al. DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells. Cancer Sci. 2020;111(10):3588\u201399.","journal-title":"Cancer Sci"},{"issue":"1411","key":"3475_CR85","first-page":"28","volume":"25","author":"S Miraj","year":"2025","unstructured":"Miraj S, et al. The Cardiovascular burden of gonadotropin-releasing hormone (GnRH) therapy: mechanisms risks and interventions. Cardiovascular Toxicol. 2025;25(1411):28.","journal-title":"Cardiovascular Toxicol"},{"issue":"1","key":"3475_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40364-023-00549-7","volume":"12","author":"Y Qian","year":"2024","unstructured":"Qian Y, et al. Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities. Biomarker Research. 2024;12(1):1.","journal-title":"Biomarker Research"},{"issue":"3","key":"3475_CR87","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/s41423-021-00833-2","volume":"19","author":"DR Heintzman","year":"2022","unstructured":"Heintzman DR, Fisher EL, Rathmell JC. Microenvironmental influences on T cell immunity in cancer and inflammation. Cell Mol Immunol. 2022;19(3):316\u201326.","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"3475_CR88","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s12967-024-05033-w","volume":"22","author":"L Miao","year":"2024","unstructured":"Miao L, et al. Advances in metabolic reprogramming of NK cells in the tumor microenvironment on the impact of NK therapy. J Transl Med. 2024;22(1):229.","journal-title":"J Transl Med"},{"issue":"1","key":"3475_CR89","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s13046-023-02823-w","volume":"42","author":"F Zheng","year":"2023","unstructured":"Zheng F, et al. PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway. J Exp Clin Cancer Res. 2023;42(1):295.","journal-title":"J Exp Clin Cancer Res"},{"issue":"11","key":"3475_CR90","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202100168","volume":"43","author":"L Pollock","year":"2021","unstructured":"Pollock L, et al. The PINK1 repertoire: not just a one trick pony. BioEssays. 2021;43(11):e2100168.","journal-title":"BioEssays"},{"key":"3475_CR91","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s13046-023-02823-w","volume":"42","author":"F Zheng","year":"2023","unstructured":"Zheng F, et al. PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway. J Exp Clin Cancer Res\u202f: CR. 2023;42:295.","journal-title":"J Exp Clin Cancer Res : CR"},{"issue":"8","key":"3475_CR92","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.3390\/cells9081794","volume":"9","author":"SW Kim","year":"2020","unstructured":"Kim SW, Lee JK. Role of HMGB1 in the interplay between NETosis and thrombosis in ischemic stroke: a review. Cells. 2020;9(8):1794.","journal-title":"Cells"},{"issue":"11","key":"3475_CR93","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.3390\/cancers13112832","volume":"13","author":"Q Chen","year":"2021","unstructured":"Chen Q, et al. Neutrophil extracellular traps in tumor metastasis: pathological functions and clinical applications. Cancers. 2021;13(11):2832.","journal-title":"Cancers"},{"issue":"1","key":"3475_CR94","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3892\/ol.2022.13596","volume":"25","author":"J Deng","year":"2023","unstructured":"Deng J, et al. Research progress on the intrinsic non-immune function of PD-L1 in tumors. Oncol Lett. 2023;25(1):10.","journal-title":"Oncol Lett"},{"issue":"9","key":"3475_CR95","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.7150\/jca.57334","volume":"12","author":"C Ghosh","year":"2021","unstructured":"Ghosh C, Luong G, Sun Y. A snapshot of the PD-1\/PD-L1 pathway. J Cancer. 2021;12(9):2735\u201346.","journal-title":"J Cancer"},{"issue":"104","key":"3475_CR96","first-page":"62","volume":"3","author":"J Naghinezhad","year":"2019","unstructured":"Naghinezhad J. PI3K\/AKT\/mTOR pathway in ATLL: from basic biology to preclinical study. J Cell Mol Pharmacol. 2019;3(104):62\u20134.","journal-title":"J Cell Mol Pharmacol"},{"issue":"8","key":"3475_CR97","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.4161\/onci.21335","volume":"1","author":"L Zitvogel","year":"2012","unstructured":"Zitvogel L, Kroemer G. Targeting PD-1\/PD-L1 interactions for cancer immunotherapy. Oncoimmunology. 2012;1(8):1223\u20135.","journal-title":"Oncoimmunology"},{"issue":"2","key":"3475_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112575","volume":"402","author":"Y Wei","year":"2021","unstructured":"Wei Y, et al. PD-L1 induces macrophage polarization toward the M2 phenotype via Erk\/Akt\/mTOR. Exp Cell Res. 2021;402(2):112575.","journal-title":"Exp Cell Res"},{"key":"3475_CR99","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.874589","volume":"13","author":"Y Pu","year":"2022","unstructured":"Pu Y, Ji Q. Tumor-associated macrophages regulate PD-1\/PD-L1 immunosuppression. Front Immunol. 2022;13:874589.","journal-title":"Front Immunol"},{"issue":"5","key":"3475_CR100","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.immuni.2020.04.009","volume":"52","author":"AS Ireland","year":"2020","unstructured":"Ireland AS, Oliver TG. Neutrophils create an impenetrable shield between tumor and cytotoxic immune cells. Immunity. 2020;52(5):729\u201331.","journal-title":"Immunity"},{"issue":"2","key":"3475_CR101","doi-asserted-by":"publisher","first-page":"e40620","DOI":"10.34172\/ipp.2024.40620","volume":"10","author":"P Hedayat","year":"2024","unstructured":"Hedayat P, Derakhshan M, Ghasemi R. The frequency of SATB2 and CDX2 expression in metastatic mucinous tumors of ovarian and colonic origin. Immunopathologia Persa. 2024;10(2):e40620\u2013e40620.","journal-title":"Immunopathologia Persa"},{"issue":"10","key":"3475_CR102","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/s41423-020-0512-x","volume":"17","author":"M De Santis","year":"2020","unstructured":"De Santis M, Mantovani A, Selmi C. The other side of the innate immune system: humoral arms favoring cancer. Cell Mol Immunol. 2020;17(10):1024\u20135.","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"3475_CR103","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.jhep.2021.07.032","volume":"75","author":"H Wang","year":"2021","unstructured":"Wang H, et al. Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis. J Hepatol. 2021;75(6):1271\u201383.","journal-title":"J Hepatol"},{"key":"3475_CR104","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.crimmu.2021.08.002","volume":"2","author":"T Sarkar","year":"2021","unstructured":"Sarkar T, Dhar S, Sa G. Tumor-infiltrating T-regulatory cells adapt to altered metabolism to promote tumor-immune escape. Curr Res Immunol. 2021;2:132\u201341.","journal-title":"Curr Res Immunol"},{"key":"3475_CR105","doi-asserted-by":"publisher","first-page":"1287465","DOI":"10.3389\/fimmu.2023.1287465","volume":"14","author":"Q Ou","year":"2023","unstructured":"Ou Q, Power R, Griffin MD. Revisiting regulatory T cells as modulators of innate immune response and inflammatory diseases. Front Immunol. 2023;14:1287465.","journal-title":"Front Immunol"},{"issue":"1","key":"3475_CR106","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41540-023-00322-4","volume":"9","author":"E Yakubovich","year":"2023","unstructured":"Yakubovich E, Cook DP, Rodriguez GM, Vanderhyden BC. Mesenchymal ovarian cancer cells promote CD8+T cell exhaustion through the LGALS3-LAG3 axis. NPJ syst Biol Appl. 2023;9(1):61.","journal-title":"NPJ syst Biol Appl"},{"issue":"2","key":"3475_CR107","doi-asserted-by":"publisher","first-page":"a011908","DOI":"10.1101\/cshperspect.a011908","volume":"4","author":"P Nistic\u00f2","year":"2012","unstructured":"Nistic\u00f2 P, Bissell MJ, Radisky DC. Epithelial\u2013mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Perspect Biol. 2012;4(2):a011908.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"3475_CR108","doi-asserted-by":"publisher","first-page":"10597","DOI":"10.1038\/s41598-020-67325-7","volume":"10","author":"BN Kim","year":"2020","unstructured":"Kim BN, et al. TGF-\u03b2 induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer. Sci Rep. 2020;10(1):10597.","journal-title":"Sci Rep"},{"key":"3475_CR109","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.semcancer.2022.09.004","volume":"86","author":"JH Lee","year":"2022","unstructured":"Lee JH, Massagu\u00e9 J. TGF-\u03b2 in developmental and fibrogenic EMTs. Semin Cancer Biol. 2022;86:136\u201345.","journal-title":"Semin Cancer Biol"},{"issue":"12","key":"3475_CR110","first-page":"1469","volume":"83","author":"NA Gloushankova","year":"2018","unstructured":"Gloushankova NA, Zhitnyak IY, Rubtsova SN. Role of epithelial-mesenchymal transition in tumor progression. Biochemistry. 2018;83(12):1469\u201376.","journal-title":"Biochemistry"},{"key":"3475_CR111","doi-asserted-by":"publisher","first-page":"1170603","DOI":"10.3389\/fimmu.2023.1170603","volume":"14","author":"S Jaboury","year":"2023","unstructured":"Jaboury S, et al. NETosis as an oncologic therapeutic target: a mini review. Front Immunol. 2023;14:1170603.","journal-title":"Front Immunol"},{"issue":"6","key":"3475_CR112","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.3390\/cancers12061542","volume":"12","author":"K Martins-Cardoso","year":"2020","unstructured":"Martins-Cardoso K, et al. Neutrophil extracellular traps (NETS) promote pro-metastatic phenotype in human breast cancer cells through epithelial-mesenchymal transition. Cancers. 2020;12(6):1542.","journal-title":"Cancers"},{"key":"3475_CR113","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fcvm.2019.00085","volume":"6","author":"AZ Zucoloto","year":"2019","unstructured":"Zucoloto AZ, Jenne CN. Platelet-neutrophil interplay: insights into neutrophil extracellular trap (NET)-driven coagulation in infection. Front Cardiovasc Med. 2019;6:85.","journal-title":"Front Cardiovasc Med"},{"issue":"2","key":"3475_CR114","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/cr.2009.5","volume":"19","author":"J Xu","year":"2009","unstructured":"Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009;19(2):156\u201372.","journal-title":"Cell Res"},{"issue":"3","key":"3475_CR115","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nrm3758","volume":"15","author":"S Lamouille","year":"2014","unstructured":"Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial\u2013mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3):178\u201396.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3475_CR116","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.953129","volume":"13","author":"AK Wienkamp","year":"2022","unstructured":"Wienkamp AK, Erpenbeck L, Rossaint J. Platelets in the NETworks interweaving inflammation and thrombosis. Front Immunol. 2022;13:953129.","journal-title":"Front Immunol"},{"key":"3475_CR117","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775267","volume":"12","author":"T Chen","year":"2021","unstructured":"Chen T, et al. Receptor-mediated NETosis on neutrophils. Front Immunol. 2021;12:775267.","journal-title":"Front Immunol"},{"key":"3475_CR118","doi-asserted-by":"publisher","first-page":"9605894","DOI":"10.1155\/2017\/9605894","volume":"2017","author":"TM Vallance","year":"2017","unstructured":"Vallance TM, et al. Toll-Like receptor 4 signalling and its impact on platelet function, thrombosis, and haemostasis. Mediators Inflamm. 2017;2017:9605894.","journal-title":"Mediators Inflamm"},{"key":"3475_CR119","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/HS9.0000000000000231","volume":"3","author":"K Stark","year":"2019","unstructured":"Stark K. Platelet-neutrophil crosstalk and netosis. Hemasphere. 2019;3:89\u201391.","journal-title":"Hemasphere"},{"issue":"4","key":"3475_CR120","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.ccell.2023.03.008","volume":"41","author":"A Mousset","year":"2023","unstructured":"Mousset A, et al. Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-\u03b2 activation. Cancer Cell. 2023;41(4):757-775.e10.","journal-title":"Cancer Cell"},{"issue":"Suppl 1","key":"3475_CR121","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.4103\/jpbs.jpbs_49_23","volume":"15","author":"R Geetha","year":"2023","unstructured":"Geetha R, et al. Premetastatic niche: a novel area for research in metastasis with a potential as therapeutic targeting in oral cancer. J Pharm Bioallied Sci. 2023;15(Suppl 1):S36-s39.","journal-title":"J Pharm Bioallied Sci"},{"issue":"67","key":"3475_CR122","doi-asserted-by":"publisher","first-page":"112132","DOI":"10.18632\/oncotarget.22792","volume":"8","author":"J Jablonska","year":"2017","unstructured":"Jablonska J, et al. The regulation of pre-metastatic niche formation by neutrophils. Oncotarget. 2017;8(67):112132\u201344.","journal-title":"Oncotarget"},{"issue":"6","key":"3475_CR123","doi-asserted-by":"publisher","first-page":"5995","DOI":"10.3390\/ijms24065995","volume":"24","author":"M Casta\u00f1o","year":"2023","unstructured":"Casta\u00f1o M, et al. Neutrophil extracellular traps and cancer: trapping our attention with their involvement in ovarian cancer. Int J Mol Sci. 2023;24(6):5995.","journal-title":"Int J Mol Sci"},{"key":"3475_CR124","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181170","author":"W Lee","year":"2018","unstructured":"Lee W, et al. Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum. J Exp Med. 2018. https:\/\/doi.org\/10.1084\/jem.20181170.","journal-title":"J Exp Med"},{"key":"3475_CR125","doi-asserted-by":"publisher","first-page":"937565","DOI":"10.3389\/fimmu.2022.937565","volume":"13","author":"J Zhao","year":"2022","unstructured":"Zhao J, Jin J. Neutrophil extracellular traps: new players in cancer research. Front Immunol. 2022;13:937565.","journal-title":"Front Immunol"},{"issue":"12","key":"3475_CR126","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.3390\/cancers11121957","volume":"11","author":"S Farsinejad","year":"2019","unstructured":"Farsinejad S, et al. Ovarian cancer dissemination-a cell biologist\u2019s perspective. Cancers. 2019;11(12):1957.","journal-title":"Cancers"},{"key":"3475_CR127","doi-asserted-by":"publisher","first-page":"1111344","DOI":"10.3389\/fimmu.2023.1111344","volume":"14","author":"S Tom\u00e1s-P\u00e9rez","year":"2023","unstructured":"Tom\u00e1s-P\u00e9rez S, et al. Increased levels of NETosis biomarkers in high-grade serous ovarian cancer patients\u2019 biofluids: potential role in disease diagnosis and management. Front Immunol. 2023;14:1111344.","journal-title":"Front Immunol"},{"key":"3475_CR128","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.3389\/fimmu.2018.02456","volume":"9","author":"X Wang","year":"2018","unstructured":"Wang X, et al. Understanding the multifaceted role of neutrophils in cancer and autoimmune diseases. Front Immunol. 2018;9:2456.","journal-title":"Front Immunol"},{"issue":"5","key":"3475_CR129","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.immuni.2018.11.009","volume":"49","author":"V Sanz-Moreno","year":"2018","unstructured":"Sanz-Moreno V, Balkwill FR. Mets and NETs: the awakening force. Immunity. 2018;49(5):798\u2013800.","journal-title":"Immunity"},{"key":"3475_CR130","doi-asserted-by":"publisher","first-page":"0129","DOI":"10.34133\/cbsystems.0129","volume":"5","author":"K Li","year":"2024","unstructured":"Li K, et al. Advances in prostate cancer biomarkers and probes. Cyborg Bionic Syst. 2024;5:0129.","journal-title":"Cyborg Bionic Syst"},{"key":"3475_CR131","doi-asserted-by":"publisher","first-page":"1111344","DOI":"10.3389\/fimmu.2023.1111344","volume":"14","author":"S Tom\u00e1s-P\u00e9rez","year":"2023","unstructured":"Tom\u00e1s-P\u00e9rez S, et al. Increased levels of NETosis biomarkers in high-grade serous ovarian cancer patients\u2019 biofluids: potential role in disease diagnosis and management. Front Immunol. 2023;14:1111344.","journal-title":"Front Immunol"},{"key":"3475_CR132","doi-asserted-by":"publisher","first-page":"6685","DOI":"10.2147\/CMAR.S179189","volume":"10","author":"L Browning","year":"2018","unstructured":"Browning L, et al. IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis. Cancer Manag Res. 2018;10:6685\u201393.","journal-title":"Cancer Manag Res"},{"issue":"50","key":"3475_CR133","doi-asserted-by":"publisher","first-page":"88152","DOI":"10.18632\/oncotarget.21538","volume":"8","author":"H Sun","year":"2017","unstructured":"Sun H, et al. COX-2 expression in ovarian cancer: an updated meta-analysis. Oncotarget. 2017;8(50):88152\u201362.","journal-title":"Oncotarget"},{"key":"3475_CR134","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.992056","volume":"12","author":"JG Kim","year":"2022","unstructured":"Kim JG, et al. Diagnostic and prognostic role of circulating neutrophil extracellular trap markers and prekallikrein in patients with high-grade serous ovarian cancer. Front Oncol. 2022;12:992056.","journal-title":"Front Oncol"},{"issue":"6","key":"3475_CR135","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.3892\/ol.2015.3771","volume":"10","author":"X Shao","year":"2015","unstructured":"Shao X, et al. Quantitative analysis of cell-free DNA in ovarian cancer. Oncol Lett. 2015;10(6):3478\u201382.","journal-title":"Oncol Lett"},{"key":"3475_CR136","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2022.101595","volume":"57","author":"ML De Meo","year":"2021","unstructured":"De Meo ML, Spicer JD. The role of neutrophil extracellular traps in cancer progression and metastasis. Semin Immunol. 2021;57:101595.","journal-title":"Semin Immunol"},{"issue":"2","key":"3475_CR137","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41416-018-0339-8","volume":"120","author":"KL Singel","year":"2019","unstructured":"Singel KL, et al. Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. Br J Cancer. 2019;120(2):207\u201317.","journal-title":"Br J Cancer"},{"issue":"8","key":"3475_CR138","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1002\/cncr.24997","volume":"116","author":"AA Kamat","year":"2010","unstructured":"Kamat AA, et al. Plasma cell-free DNA in ovarian cancer: an independent prognostic biomarker. Cancer. 2010;116(8):1918\u201325.","journal-title":"Cancer"},{"issue":"15","key":"3475_CR139","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1016\/j.ejca.2014.06.022","volume":"50","author":"KD Steffensen","year":"2014","unstructured":"Steffensen KD, et al. Prognostic importance of cell-free DNA in chemotherapy resistant ovarian cancer treated with bevacizumab. Eur J Cancer. 2014;50(15):2611\u20138.","journal-title":"Eur J Cancer"},{"issue":"9","key":"3475_CR140","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1161\/ATVBAHA.114.304114","volume":"34","author":"TJ Gould","year":"2014","unstructured":"Gould TJ, et al. Neutrophil extracellular traps promote thrombin generation through platelet-dependent and platelet-independent mechanisms. Arterioscler Thromb Vasc Biol. 2014;34(9):1977\u201384.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"3475_CR141","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1170","volume":"13","author":"H Zhang","year":"2023","unstructured":"Zhang H, et al. Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis. Clin Transl Med. 2023;13(1):e1170.","journal-title":"Clin Transl Med"},{"issue":"3","key":"3475_CR142","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s11010-021-04315-x","volume":"477","author":"TM Chamardani","year":"2022","unstructured":"Chamardani TM, Amiritavassoli S. Inhibition of NETosis for treatment purposes: friend or foe? Mol Cell Biochem. 2022;477(3):673\u201388.","journal-title":"Mol Cell Biochem"},{"issue":"9","key":"3475_CR143","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.tips.2023.06.007","volume":"44","author":"CS Bonilha","year":"2023","unstructured":"Bonilha CS, Veras FP, de Queiroz Cunha F. NET-targeted therapy: effects, limitations, and potential strategies to enhance treatment efficacy. Trends Pharmacol Sci. 2023;44(9):622\u201334.","journal-title":"Trends Pharmacol Sci"},{"issue":"21","key":"3475_CR144","doi-asserted-by":"publisher","first-page":"13264","DOI":"10.3390\/ijms232113264","volume":"23","author":"H Yao","year":"2022","unstructured":"Yao H, et al. Inhibition of netosis with PAD inhibitor attenuates endotoxin shock induced systemic inflammation. Int J Mol Sci. 2022;23(21):13264.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3475_CR145","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1038\/s41598-023-30246-2","volume":"13","author":"C Gajendran","year":"2023","unstructured":"Gajendran C, et al. Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4. Sci Rep. 2023;13(1):3189.","journal-title":"Sci Rep"},{"issue":"22","key":"3475_CR146","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129687","volume":"4","author":"B Sun","year":"2019","unstructured":"Sun B, et al. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019;4(22):e129687.","journal-title":"JCI Insight"},{"issue":"23","key":"3475_CR147","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124729","volume":"3","author":"Y Liu","year":"2018","unstructured":"Liu Y, et al. Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus. JCI Insight. 2018;3(23):e124729.","journal-title":"JCI Insight"},{"key":"3475_CR148","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2021.115536","volume":"421","author":"Y Sun","year":"2021","unstructured":"Sun Y, et al. C-myc promotes miR-92a-2-5p transcription in rat ovarian granulosa cells after cadmium exposure. Toxicol Appl Pharmacol. 2021;421:115536.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"24","key":"3475_CR149","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.3390\/cells12242829","volume":"12","author":"KJ Nava-Quiroz","year":"2023","unstructured":"Nava-Quiroz KJ, et al. Peptidyl arginine deiminases in chronic diseases: a focus on rheumatoid arthritis and interstitial lung disease. Cells. 2023;12(24):2829.","journal-title":"Cells"},{"issue":"16","key":"3475_CR150","doi-asserted-by":"publisher","first-page":"7018","DOI":"10.1002\/cam4.2560","volume":"8","author":"A Chandra","year":"2019","unstructured":"Chandra A, et al. Ovarian cancer: current status and strategies for improving therapeutic outcomes. Cancer Med. 2019;8(16):7018\u201331.","journal-title":"Cancer Med"},{"issue":"1","key":"3475_CR151","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12943-016-0548-9","volume":"15","author":"J Gonzalez Bosquet","year":"2016","unstructured":"Gonzalez Bosquet J, et al. Prediction of chemo-response in serous ovarian cancer. Mol Cancer. 2016;15(1):66.","journal-title":"Mol Cancer"},{"issue":"7","key":"3475_CR152","first-page":"Cd005343","volume":"7","author":"SL Coleridge","year":"2021","unstructured":"Coleridge SL, et al. Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer. Cochrane Database Syst Rev. 2021;7(7):Cd005343.","journal-title":"Cochrane Database Syst Rev"},{"key":"3475_CR153","doi-asserted-by":"publisher","first-page":"1328651","DOI":"10.3389\/fimmu.2023.1328651","volume":"14","author":"F Blanc-Durand","year":"2023","unstructured":"Blanc-Durand F, Clemence Wei Xian L, Tan DS. Targeting the immune microenvironment for ovarian cancer therapy. Front Immunol. 2023;14:1328651.","journal-title":"Front Immunol"},{"issue":"5","key":"3475_CR154","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646\u201374.","journal-title":"Cell"},{"issue":"2","key":"3475_CR155","doi-asserted-by":"publisher","first-page":"e41724","DOI":"10.34172\/ipp.2025.41724","volume":"11","author":"S Abbasi","year":"2024","unstructured":"Abbasi S, et al. Association between metabolic syndrome and risk of endometrial cancer; a systematic review and meta-analysis. Immunopathologia Persa. 2024;11(2):e41724\u2013e41724.","journal-title":"Immunopathologia Persa"},{"issue":"4","key":"3475_CR156","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nri3405","volume":"13","author":"L Chen","year":"2013","unstructured":"Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol. 2013;13(4):227\u201342.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"3475_CR157","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40425-018-0316-z","volume":"6","author":"J Gong","year":"2018","unstructured":"Gong J, et al. Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations. J Immunother Cancer. 2018;6(1):8.","journal-title":"J Immunother Cancer"},{"issue":"9","key":"3475_CR158","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/S1470-2045(21)00342-9","volume":"22","author":"BJ Monk","year":"2021","unstructured":"Monk BJ, et al. Chemotherapy with or without avelumab followed by avelumab maintenance versus chemotherapy alone in patients with previously untreated epithelial ovarian cancer (JAVELIN Ovarian 100): an open-label, randomised, phase 3 trial. Lancet Oncol. 2021;22(9):1275\u201389.","journal-title":"Lancet Oncol"},{"issue":"17","key":"3475_CR159","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1200\/JCO.21.00306","volume":"39","author":"KN Moore","year":"2021","unstructured":"Moore KN, et al. Atezolizumab, bevacizumab, and chemotherapy for newly diagnosed stage iii or iv ovarian cancer: placebo-controlled randomized phase III trial (IMagyn050\/GOG 3015\/ENGOT-OV39). J Clin Oncol. 2021;39(17):1842\u201355.","journal-title":"J Clin Oncol"},{"issue":"7","key":"3475_CR160","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/S1470-2045(21)00216-3","volume":"22","author":"E Pujade-Lauraine","year":"2021","unstructured":"Pujade-Lauraine E, et al. Avelumab alone or in combination with chemotherapy versus chemotherapy alone in platinum-resistant or platinum-refractory ovarian cancer (JAVELIN Ovarian 200): an open-label, three-arm, randomised, phase 3 study. Lancet Oncol. 2021;22(7):1034\u201346.","journal-title":"Lancet Oncol"},{"issue":"3","key":"3475_CR161","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3390\/cancers14030631","volume":"14","author":"B Pir\u0161","year":"2022","unstructured":"Pir\u0161 B, et al. Overview of immune checkpoint inhibitors in gynecological cancer treatment. Cancers. 2022;14(3):631.","journal-title":"Cancers"},{"key":"3475_CR162","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.901772","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, et al. Current advances in pd-1\/pd-l1 blockade in recurrent epithelial ovarian cancer. Front Immunol. 2022;13:901772.","journal-title":"Front Immunol"},{"issue":"8","key":"3475_CR163","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103666","volume":"28","author":"Z Peng","year":"2023","unstructured":"Peng Z, et al. PD-1\/PD-L1 immune checkpoint blockade in ovarian cancer: dilemmas and opportunities. Drug Discov Today. 2023;28(8):103666.","journal-title":"Drug Discov Today"},{"key":"3475_CR164","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084091","author":"S Jain","year":"2021","unstructured":"Jain S, et al. The cancer stem cell niche in ovarian cancer and its impact on immune surveillance. Int J Mol Sci. 2021. https:\/\/doi.org\/10.3390\/ijms22084091.","journal-title":"Int J Mol Sci"},{"key":"3475_CR165","doi-asserted-by":"publisher","first-page":"1472430","DOI":"10.3389\/fimmu.2024.1472430","volume":"15","author":"MN Khan","year":"2024","unstructured":"Khan MN, et al. Tumor-associated macrophages and CD8+ T cells: dual players in the pathogenesis of HBV-related HCC. Front Immunol. 2024;15:1472430.","journal-title":"Front Immunol"},{"key":"3475_CR166","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2025.100309","volume":"11","author":"F Farhid","year":"2025","unstructured":"Farhid F, et al. When the victim becomes the villain: platelets as drivers of immune dysregulation in ITP. J Trans Autoimmunit. 2025;11:100309.","journal-title":"J Trans Autoimmunit"},{"issue":"16","key":"3475_CR167","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1200\/JCO.19.02059","volume":"38","author":"D Zamarin","year":"2020","unstructured":"Zamarin D, et al. Randomized phase ii trial of nivolumab versus nivolumab and ipilimumab for recurrent or persistent ovarian cancer: an NRG oncology study. J Clin Oncol. 2020;38(16):1814\u201323.","journal-title":"J Clin Oncol"},{"key":"3475_CR168","doi-asserted-by":"publisher","first-page":"985","DOI":"10.15212\/bioi-2025-0090","volume":"6","author":"Y Dange","year":"2025","unstructured":"Dange Y, et al. Anticancer efficacy of 5-fluorouracil-loaded chitin nanohydrogel in enhanced skin cancer therapy. BIO Integration. 2025;6:985.","journal-title":"BIO Integration"},{"issue":"8","key":"3475_CR169","first-page":"1678","volume":"54","author":"M Pouladzadeh","year":"2025","unstructured":"Pouladzadeh M, et al. Unveiling cadmium-induced cardiotoxicity: mechanisms, challenges, and future perspectives: a narrative review. Iran J Public Health. 2025;54(8):1678\u201388.","journal-title":"Iran J Public Health"},{"key":"3475_CR170","doi-asserted-by":"publisher","first-page":"969","DOI":"10.15212\/bioi-2024-0063","volume":"5","author":"S Ibrahim","year":"2024","unstructured":"Ibrahim S, et al. Recent progress in the green synthesis, characterization, and applications of selenium nanoparticles. BIO Integration. 2024;5:969.","journal-title":"BIO Integration"},{"issue":"4","key":"3475_CR171","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.bbamem.2007.12.021","volume":"1778","author":"S Gosk","year":"2008","unstructured":"Gosk S, et al. VCAM-1 directed immunoliposomes selectively target tumor vasculature in vivo. Biochimica Biophysica Acta (BBA) - Biomembranes. 2008;1778(4):854\u201363.","journal-title":"Biochimica Biophysica Acta (BBA) - Biomembranes"},{"key":"3475_CR172","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscia.2024.100046","volume":"2","author":"Y Yao","year":"2024","unstructured":"Yao Y, et al. Dual-targeting liposomal delivery of sorafenib and docetaxel for enhanced synergistic therapy in advanced hepatocellular carcinoma. Pharmaceut Sci Adv. 2024;2:100046.","journal-title":"Pharmaceut Sci Adv"},{"key":"3475_CR173","first-page":"68","volume":"37","author":"J Naghinezhad","year":"2023","unstructured":"Naghinezhad J, et al. Expression of DR4, DR5, FAS, Caspase-8 and DDIAS Genes in AML Patients. Med J Islam Repub Iran. 2023;37:68.","journal-title":"Med J Islam Repub Iran"}],"container-title":["European Journal of Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03475-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s40001-025-03475-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s40001-025-03475-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T09:32:27Z","timestamp":1764581547000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurjmedres.biomedcentral.com\/articles\/10.1186\/s40001-025-03475-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":173,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3475"],"URL":"https:\/\/doi.org\/10.1186\/s40001-025-03475-6","relation":{},"ISSN":["2047-783X"],"issn-type":[{"value":"2047-783X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"assertion":[{"value":"12 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1199"}}