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The study was approved by the Ethics committee of Huaian Hospital affiliated to Xuzhou Medical University (approval number: HEYLL2021082). We confirm that all experiments were performed in accordance with relevant named guidelines and regulations. Our research confirmed compliance with the ARRIVE guidelines and was conducted in accordance with the relevant designated guidelines and regulations. This research was approved by the Animal Ethics Committee of Xuzhou Medical University (approval number: 202111T011).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate."}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}